Sleep最新文献

{"title":"Central sleep apnea and cardiovascular disease state-of-the-art.","authors":"Shahrokh Javaheri, Alberto Giannoni, Virend K Somers, Atul Malhotra, Michele Emdin, Maria R Costanzo","doi":"10.1093/sleep/zsae307","DOIUrl":"10.1093/sleep/zsae307","url":null,"abstract":"<p><p>Central sleep apnea, a rare polysomnographic finding in the general population, is prevalent in certain cardiovascular conditions including systolic and diastolic left ventricular dysfunction, atrial fibrillation, coronary artery disease, carotid artery stenosis, stroke, and use of certain cardiac-related medications. Polysomnographic findings of central sleep apnea with adverse cardiovascular impacts include nocturnal hypoxemia and arousals, which can lead to increased sympathetic activity both at night and in the daytime. Among cardiovascular diseases, central sleep apnea is most prevalent in patients with left ventricular systolic dysfunction; a large study of more than 900 treated patients has shown a dose-dependent relationship between nocturnal desaturation and mortality. Multiple small randomized controlled trials have shown mitigation of sympathetic activity when central sleep apnea is treated with nocturnal oxygen, continuous positive airway pressure, and adaptive servoventilation. However, two early randomized controlled trials with positive airway pressure devices have shown either a neutral effect on survival or excess premature mortality in the active treatment arm, compared to untreated central sleep apnea. In contrast, the results of the most recent trial using an advanced adaptive servoventilation device showed improved quality of life and no signal for mortality suggesting that treatment of central sleep apnea was at least safe. In addition to positive airway pressure devices, multiple medications have been shown to improve central sleep apnea, but no long-term trials of pharmacologic therapy have been published. Currently, phrenic nerve stimulation is approved for the treatment of central sleep apnea, and the results of a randomized controlled trial showed significant improvement in sleep metrics and quality of life.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-individual differences and reliability of the acute effects of exercise on actigraphic sleep measures.","authors":"Shawn D Youngstedt, Giselle Soares Passos, Ryan S Falck, Marcos Gonçalves Santana","doi":"10.1093/sleep/zsaf016","DOIUrl":"10.1093/sleep/zsaf016","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleepless but vigilant: unraveling the interplay of sleep loss and threat in response inhibition.","authors":"Johanna M Boardman, Jeryl Y L Lim","doi":"10.1093/sleep/zsaf008","DOIUrl":"10.1093/sleep/zsaf008","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization in SLEEP: Avoiding Pitfalls With MR-SLEEP Guidelines.","authors":"Daniel S Evans, Allan Pack, David Gozal, Katie L Stone","doi":"10.1093/sleep/zsaf054","DOIUrl":"https://doi.org/10.1093/sleep/zsaf054","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of phenoconversion into alpha-synucleinopathy in patients with isolated REM sleep behavior disorder using event-related potentials during visuospatial attention tasks.","authors":"Kang-Min Choi, Kwang Su Cha, Tae-Gon Noh, Seolah Lee, Yong Woo Shin, Jung-Ick Byun, Jin-Sun Jun, Jung Hwan Shin, Han-Joon Kim, Ki-Young Jung","doi":"10.1093/sleep/zsae308","DOIUrl":"10.1093/sleep/zsae308","url":null,"abstract":"<p><strong>Study objectives: </strong>Isolated rapid eye movement sleep behavior disorder (iRBD) is recognized as a prodromal stage of alpha-synucleinopathies. Predicting phenoconversion in iRBD patients remains a key challenge. We aimed to investigate whether event-related potentials (ERPs) recorded during visuospatial attention tasks can serve as predictors of phenoconversion in iRBD patients.</p><p><strong>Methods: </strong>We conducted a longitudinal study with 126 iRBD patients (aged 67.1 ± 6.4, 77 males) and 41 healthy controls (aged 66.1 ± 6.9, 29 males). Among the patients, those who further developed synucleinopathies during the follow-up period (average 6.3 years) were classified as converters (iRBD-CV), while the others were non-converters (iRBD-NC). Posner's visuospatial cueing task was performed at baseline. The N2 and P3 components were acquired for both the cue and target (valid and invalid) stimuli. Based on group comparisons, Kaplan-Meier survival analysis was performed.</p><p><strong>Results: </strong>Twenty-nine patients converted to alpha-synucleinopathies (aged 69.4 ± 7.1, 14 males). iRBD patients exhibited overall reductions in N2 components for cue, valid, and invalid stimuli compared to HC (p = 0.012, 0.047, and 0.001, respectively). iRBD-CV patients displayed a significant increase in cue-elicited P3 (p < 0.001) and a decreasing trend in cue-elicited N2 (p = 0.079) compared to iRBD-NC. These ERP alterations were strongly associated with faster rate of phenoconversion (p < 0.001 for both components).</p><p><strong>Conclusion: </strong>Our findings suggest that altered cue-elicited ERPs could serve as early biomarkers for predicting phenoconversion in iRBD patients, likely reflecting attention-related neurodegeneration pathways. These biomarkers potentially enable the detection of preclinical phenotypes in alpha-synucleinopathies, facilitating timely intervention.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific associations between slow wave sleep and cardiovascular risk factors: too early to tell?","authors":"Sogol Javaheri, Susan Redline","doi":"10.1093/sleep/zsae264","DOIUrl":"10.1093/sleep/zsae264","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological and psychological stress reactivity in narcolepsy type 1.","authors":"Marieke Vringer, Denise Bijlenga, Jingru Zhou, Onno C Meijer, Christiaan H Vinkers, Gert Jan Lammers, Rolf Fronczek","doi":"10.1093/sleep/zsae265","DOIUrl":"10.1093/sleep/zsae265","url":null,"abstract":"<p><strong>Study objectives: </strong>Narcolepsy type 1 (NT1) is a chronic sleep-wake disorder, characterized by a loss of hypocretin production. Unexpectedly, in postmortem tissue of people with NT1, there is a loss of corticotrophin-releasing hormone (CRH) in the paraventricular nucleus. CRH is known as an activator of the hypothalamic-pituitary-adrenal axis in response to stress. This activation results in the release of the stress hormones adrenocorticotropic hormone (ACTH) and cortisol. We hypothesize an altered physiological and psychological stress response in NT1.</p><p><strong>Methods: </strong>Participants were people with NT1 (n = 14) and matched healthy controls (n = 12). The Trier Social Stress Test for Groups (TSST-G), a validated socially evaluated stress test in controlled settings, induced acute stress. We measured ACTH and cortisol levels in the blood before and at three timepoints after the TSST-G. We also measured subjective stress and heart rate levels.</p><p><strong>Results: </strong>In both groups, acute stress led to increases in ACTH (p = .006), cortisol (p < .001), heart rate (p < .001), and subjective stress (p < .001). Subjectively, people with NT1 experienced more stress than controls (p < .001). No differences were found in heart rate, cortisol, and ACTH between people with NT1 and controls at any timepoint. Secondary analyses showed that men with NT1 had lower cortisol levels immediately after stress induction than men in the control group (p = .002).</p><p><strong>Conclusions: </strong>People with NT1 show an increased subjective stress response, but no changes in their endocrine or cardiovascular stress reactivity. Further research is required to determine the impact of reduced CRH production and gender in NT1.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of sleep physiology using qualitative and quantitative criteria for insomnia symptoms.","authors":"Ruda Lee, Olivia Larson, Sammy Dhaliwal, Kibum Moon, Bethany Gerardy, Philip de Chazal, Peter A Cistulli, Ning-Hung Chen, Fang Han, Qing Yun Li, Greg Maislin, Nigel McArdle, Thomas Penzel, Richard J Schwab, Sergio Tufik, Ulysses J Magalang, Bhajan Singh, Thorarinn Gislason, Allan I Pack, Brendan T Keenan, Magdy Younes, Philip Gehrman","doi":"10.1093/sleep/zsae301","DOIUrl":"10.1093/sleep/zsae301","url":null,"abstract":"<p><p>Despite decades of research, defining insomnia remains challenging due to its complex and variable nature. Various diagnostic systems emphasize the chronic nature of insomnia and its impact on daily functioning, relying heavily on patient self-reporting due to limitations in objective measures such as polysomnography (PSG). Discrepancies between subjective experiences and objective PSG results highlight the need for more nuanced approaches, such as electroencephalogram (EEG) spectral analysis, which reveals distinct patterns of high-frequency activity in individuals with insomnia. This study explores EEG markers of insomnia by integrating subjective reports with objective physiological markers, specifically ORP (Odds-Ratio-Product) and spectral features, to address inconsistencies found in previous research and clinical settings. Qualitative and quantitative definitions of insomnia are contrasted to highlight differences in sleep architecture and EEG characteristics. The research aims to determine whether groups defined by weekly frequency and daily duration of symptoms have different distribution patterns and which physiological characteristics best distinguish insomnia patients from controls. Our findings suggest that ORP, as a dependent variable, captures the most significant differences in the independent variables across the model. Elevated beta power in insomnia patients indicates increased cortical arousal, supporting the perspective of insomnia as a hyperarousal disorder. Future research should focus on using ORP to enhance the understanding of sleep disturbances in insomnia. Comprehensive evaluation of insomnia requires integrating qualitative, quantitative, and neurophysiological data to fully understand its impact on sleep architecture and quality.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between hypoxic burden and the risk of cognitive impairment in patients with obstructive sleep apnea.","authors":"Xiaoyu Huang, Zhengjiao Zhang, Xiaoxin Lan, Xuefeng Song, Yanzhao Dong, Siqi Jia, Haibo Yuan","doi":"10.1093/sleep/zsae269","DOIUrl":"10.1093/sleep/zsae269","url":null,"abstract":"<p><strong>Study objectives: </strong>Obstructive sleep apnea (OSA) is associated with an increasing risk of cognitive impairment, but traditional hypoxic indicators can not accurately identify cognitive impairment. This study aimed to assess a new indicator, hypoxic burden, in cognitive impairment in OSA.</p><p><strong>Methods: </strong>A total of 116 patients with OSA were enrolled in this study. Daytime sleepiness and cognition were assessed using the Epworth Sleepiness Scales and Montreal Cognitive Assessment (MoCA), respectively. All participants underwent polysomnography (PSG). The hypoxic burden was derived from PSG and calculated according to a specific algorithm. All the participants were divided into two groups. Seventy-seven were OSA with mild cognitive impairment (OSA + MCI), and 39 were OSA without mild cognitive impairment (OSA-MCI). The relationship between hypoxic burden and cognitive impairment was analyzed by establishing a series of logistic regression models.</p><p><strong>Results: </strong>Hypoxic burden was higher in OSA + MCI group compared with OSA-MCI group, while there was no significance found for the apnea-hypopnea index between the two groups. After adjusting for various confounders, patients with OSA who had a higher total hypoxic burden and rapid eye movement-hypoxic burden in the fourth quartile were found to have an increased risk of MCI compared to those in the first quartile. The adjusted ORs were 7.69 (95% CI, 1.15 to 51.55) and 8.87 (95% CI, 1.22 to 64.34), respectively. However, There was no significant association between the other traditional hypoxic parameters and cognitive function after adjusting for various confounders.</p><p><strong>Conclusions: </strong>Compared to the conventional hypoxic parameter, a higher hypoxic burden is associated with cognition and may be an important indicator for assessing MCI in OSA.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep circuits welcome the cortex.","authors":"Emily Pickup, Franz Weber","doi":"10.1093/sleep/zsae312","DOIUrl":"10.1093/sleep/zsae312","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}