Sleep最新文献

{"title":"Sleep Architecture and REM Sleep Without Atonia in Post-COVID-19 Insomnia.","authors":"Abubaker Ibrahim, Matteo Cesari, Qi Tang, Merve Aktan Süzgün, Elisabeth Brandauer, Evi Holzknecht, Alexander Wachter, Victoria Anselmi, Anna Heidbreder, Ambra Stefani, Birgit Högl","doi":"10.1093/sleep/zsaf257","DOIUrl":"https://doi.org/10.1093/sleep/zsaf257","url":null,"abstract":"<p><strong>Study objectives: </strong>Insomnia associated with COVID-19 infection is a common complaint in long-COVID. Studies to date have predominantly examined post-COVID-19 sleep disturbances with questionnaires. We aimed to investigate whether there are distinctive polysomnographic findings in post-COVID-19 insomnia compared to non-COVID-related chronic insomnia.</p><p><strong>Methods: </strong>We included 150 patients with chronic insomnia, stratified into three groups: post-COVID-19 insomnia (n = 50), chronic insomnia during the pandemic without a history of COVID-19 infection (n = 50), and pre-pandemic chronic insomnia (n = 50). All patients underwent one-night video-polysomnography (v-PSG). The sleep architecture, respiratory variables and REM sleep without atonia (RWA) were compared across the groups.</p><p><strong>Results: </strong>Classical polysomnographic variables showed no significant differences across groups with regard to total sleep time, sleep efficiency, sleep stage percentages, and the apnea-hypopnea index. Post-COVID-19 insomnia patients had significantly increased RWA at both the chin and the flexor digitorum superficialis (FDS) (p=.020 for both), and higher nocturnal heart rates (p=.046). Sleep-bout analysis indicated shorter sustained N3-sleep periods (p=.001) and longer onset to stable REM-sleep (p=.016) in the post-COVID-19 insomnia group. Although sleep transitions did not withstand multiple comparison corrections, they revealed a trend towards decreased N3-sleep continuity and increased probabilities of transitioning to lighter stages (N3 → N3: unadjusted-p=.012; REM → N1: unadjusted-p=.027) in the post-COVID-19 insomnia.</p><p><strong>Conclusions: </strong>Classical PSG profile of post-COVID-19 insomnia does not differ from non-COVID-related chronic insomnia. However, subtle differences in RWA and sleep integrity suggest that post-COVID-19 insomnia is driven not merely by pandemic-related stress factors but by additional physiological alterations linked to viral CNS involvement.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Boston Children's Hospital Sleep Corpus: A Collection of 15,695 Annotated Pediatric Polysomnograms.","authors":"Ayush Tripathi, Wolfgang Ganglberger, Haoqi Sun, Callison Alcott, Niels Turley, Rebecca Fitzgerald, Ayan Mitra, Samuel Waters, Arnav Gupta, Aditya Gupta, Manohar Ghanta, Valdery Moura Junior, Samaneh Nasiri, Bruce Nearing, Katie L Stone, Emmanuel Mignot, Dennis Hwang, Matthew A Reyna, Zuzana Koscova, Chad Robichaux, Zhiyong Zhang, Qiao Li, Gauri Ganjoo, Lynn Marie Trotti, Gari D Clifford, Christine Tsien Silvers, Bharath Gunapati, Robert J Thomas, M Brandon Westover, Kiran Maski, Umakanth Katwa","doi":"10.1093/sleep/zsaf273","DOIUrl":"https://doi.org/10.1093/sleep/zsaf273","url":null,"abstract":"<p><p>Sleep is a fundamental biological process essential to health, particularly during early life when sleep patterns are developing and sleep disorders are common. Yet pediatric sleep research is hindered by a lack of large-scale, high-quality polysomnography (PSG) datasets. To address this need, we introduce the Boston Children's Hospital (BCH) Sleep Corpus-the largest pediatric PSG dataset available-comprising 15 695 overnight recordings from 12 640 unique patients (median age ~ 6 years). The dataset includes 16.7 million annotated sleep stages, 2.25 million respiratory, arousal, and limb movement events, and over 11 000 patient diagnoses linked through de-identified electronic health records. Each PSG has a median duration of 8.9 hours, totaling 139 208 hours of EEG data. Sleep staging follows American Academy of Sleep Medicine guidelines and reveals age-related trends: REM sleep decreases from 33.5% in neonates to 16.3% in teenagers, while N2 sleep increases from 21.7% to 35.4%. Central apneas decline with age, while obstructive hypopneas and respiratory effort related arousals events rise. Limb movements are not scored in <1 yr but remain at around 30 per PSG across older age groups. We also present age- and region-specific EEG spectral norms and respiratory event trends across the pediatric age range. The dataset is organized in Brain Imaging Data Structure (BIDS) format and publicly available via the Brain Data Science Platform. The dataset provides a valuable resource for improving our scientific understanding of pediatric sleep and developing automated PSG analysis with artificial intelligence tools.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous Versus Arterial Carbon Dioxide Monitoring in Adult Polysomnography Studies.","authors":"Keeley A Miller, Thomas J Churchward, Julie Tolson, Warren R Ruehland, Christine F Mcdonald, Christopher J Worsnop","doi":"10.1093/sleep/zsaf277","DOIUrl":"https://doi.org/10.1093/sleep/zsaf277","url":null,"abstract":"<p><strong>Study objectives: </strong>To determine the accuracy of transcutaneous carbon dioxide measurements using SenTec tcPCO2 during adult polysomnography compared to arterial PCO2.</p><p><strong>Methods: </strong>In consecutive patients having polysomnography with transcutaneous CO2 (tcPCO2) monitoring using a SenTec monitor, arterial blood gas samples were taken at the beginning and at the end of each sleep study. tcPCO2 measurements recorded at 0, 60 and 120 seconds after arterial sampling was determined in 51 participants who underwent polysomnography with tcPCO2 monitoring at the Austin Health Sleep Laboratory (Heidelberg, Victoria, Australia) during the period 01/05/22 - 10/06/22. The mean of differences between arterial carbon dioxide tension (PaCO2) and the predicted value based on tcPCO2 measurements determined at each time point for evening and morning arterial samples.</p><p><strong>Results: </strong>Data was obtained from 37 participants. A statistically significant difference in the tcPCO2 values at the point of arterial sampling was found, with tcPCO2 on average 2.2 - 2.8 mmHg less than PaCO2 at various timepoints after arterial sampling. The upper limit of measurement accuracy represented a moderate difference (2 - 4.9 mmHg), within the clinically acceptable range of -7.5 to +7.5 mmHg variation from PaCO2 values.</p><p><strong>Conclusions: </strong>The SenTec tcPCO2 electrode was found to be an appropriate alternative to arterial sampling for assessment of arterial carbon dioxide in adult patients in the polysomnography setting, with no significant difference in tcPCO2 accuracy based on the timing of transcutaneous measurements (up to two minutes) following arterial sampling.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is COMISA another opportunity for use of incretin drugs?","authors":"Allan I Pack, Ronald Grunstein, Babak Mokhlesi, Silke Ryan, Richard Schwab, David Gozal","doi":"10.1093/sleep/zsaf254","DOIUrl":"https://doi.org/10.1093/sleep/zsaf254","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between gas cooking stoves, indoor NO2 concentrations and adverse sleep outcomes in a pediatric sample.","authors":"Jing Wang, Seyni Gueye-Ndiaye, Xiaoyu Li, Sanjana Bhaskar, Le Li, Meg Tully, Michael Rueschman, Judith Owens, Diane R Gold, Jarvis T Chen, Wanda Phipatanakul, Gary Adamkiewicz, Susan Redline","doi":"10.1093/sleep/zsaf279","DOIUrl":"https://doi.org/10.1093/sleep/zsaf279","url":null,"abstract":"<p><strong>Study objectives: </strong>To investigate whether gas cooking stove exposure and elevated indoor NO2 concentration were associated with adverse sleep outcomes in a pediatric sample.</p><p><strong>Methods: </strong>Children from urban neighborhoods in Boston, Massachusetts underwent in-home sleep assessments. Indoor NO2 concentrations were measured continuously over 7 days by devices placed in the participants' living areas. Primary outcomes were short sleep duration (average 7-day sleep duration <8 hours by wrist actigraphy), and sleep-disordered breathing (SDB; ≥5 events/hour with >3% desaturation by a home sleep monitor). Associations between gas cooking stove exposure and elevated NO2 (≥ 69.48 ppb) with each sleep outcome were assessed through logistic regression models, adjusting for demographic and socioeconomic factors and season. Sensitivity analyses further adjusted for health conditions, kitchen ventilation, and various sources of indoor NO2.</p><p><strong>Results: </strong>Of the 242 children, 74% (n=178) were exposed to gas cooking stoves. The median (interquartile range) of the average daily 95th percentile indoor NO2 was 41.1 (38.4) ppb. Children exposed to elevated indoor NO2 level were at a 2.88 increased adjusted odds (95% CI: 1.27, 6.55, p=0.012) of short sleep duration compared to children exposed to lower levels. A positive but insignificant relationship between indoor NO2 exposure and SDB was found (OR=1.23, 0.61, 2.47). Gas cooking stove exposure was unassociated with any sleep outcome.</p><p><strong>Conclusions: </strong>Exposure to elevated indoor NO2 was associated with higher odds of short sleep duration in children. Interventions targeting indoor air quality may provide a novel approach for improving sleep health and reducing pediatric sleep disparities.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in sleep precede cognitive decline across two population cohorts: unlocking the potential of sleep as an early marker of dementia.","authors":"Sanne J W Hoepel, Yue Leng","doi":"10.1093/sleep/zsaf268","DOIUrl":"https://doi.org/10.1093/sleep/zsaf268","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It's not just the brain that sleeps. A commentary on \"Association of Novel EEG Biomarkers of Sleep Depth and Cortical Arousability with Cardiac Autonomic Modulation in Adolescents\" by Rahawi et al.","authors":"Ian M Colrain","doi":"10.1093/sleep/zsaf276","DOIUrl":"https://doi.org/10.1093/sleep/zsaf276","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between sound and sleep: a perspective on Sonic Sleep Aids.","authors":"Jessica Vazzaz, Faith Matcham, Marcos Economides, Kate Cavanagh","doi":"10.1093/sleep/zsaf275","DOIUrl":"https://doi.org/10.1093/sleep/zsaf275","url":null,"abstract":"<p><p>Sleep disturbances are prevalent in the general population, coinciding with a surge in the availability and use of digital sleep aids. Among these, standalone audio-based tools, termed Sonic Sleep Aids (SSA), such as sleep music, ambient sounds, bedtime stories, and sleep skills (e.g. guided meditation, positive psychology techniques), have gained popularity. This perspective piece examines the phenomenon of SSA by discussing the existing evidence and highlighting the different levels of empirical support across SSA types. Music-based relaxation has demonstrated efficacy in improving sleep quality, whereas findings on ambient sounds (e.g. white, pink noise) are inconclusive. Empirical support for narrated content as a sleep aid remains limited. Guided practices like mindfulness and self-compassion show potential, yet further research is needed to support their effectiveness, particularly when limited to bedtime practice. In the broader context, the widespread use of app-based SSA raises questions about their alignment with sleep hygiene recommendations, which typically discourage bedtime screen use. This concern is compounded by a paucity of randomized controlled trials testing their effectiveness against well-matched controls, alongside the risk of increased dependency on technology and altered relationships with rest and introspection. Against these concerns, potential benefits include accessibility and reduced reliance on pharmacological aids. A research agenda is proposed to investigate the efficacy of digitally delivered SSA in naturalistic settings, their mechanisms of action, and their impact across different populations. Understanding these factors is crucial to determine whether SSA serve as beneficial tools or divert individuals from more effective, evidence-based approaches to sleep.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and efficacy of exercise training on sleep symptoms and comorbidities in narcolepsy type 1: a prospective interventional study.","authors":"François Ricordeau, Emeric Stauffer, Benjamin Putois, Antoine Jaffiol, Anne Cheylus, Gabrielle Pouilloux, Kenny Gabriel, Eugénie Hoarau, Hélène Bastuji, Patricia Franco, Vania Herbillon, Thomas Capelle, Fanny Joubert, Pierre Pradat, Karine Spiegel, Laure Peter-Derex","doi":"10.1093/sleep/zsaf272","DOIUrl":"https://doi.org/10.1093/sleep/zsaf272","url":null,"abstract":"<p><p>Current treatments for narcolepsy type 1 (NT1) have little impact on psychiatric, cognitive and metabolic comorbidities. Here, we evaluated the feasibility, safety and efficacy of a prospective Exercise Training (ET) program on sleep-related symptoms and comorbidities in NT1. Sedentary adult with NT1 participated in a 6-week supervised ET program followed by a 18-week self-directed program. Outcomes included the Narcolepsy Severity Scale (NSS), Hospital Anxiety and Depression Scale (HADS), Insomnia Severity Index (ISI), cardiometabolic parameters (body mass index [BMI], glycemia, insulin, CRP, lipid panel with insulin resistance [IR] [TG/HDL-C] and cardiovascular risk [Total-C/HDL-C] markers), cardiorespiratory fitness, and attention (Bron/Lyon Attention Stability Test). Wilcoxon tests compared baseline, 6-week, and 6-month data. Among 30 participants (73.3% women, 39.8±13.9 years, BMI=31.0±5.1 kg/m2), 25 completed the 6-month program. Of the 379 supervised sessions (84.2% attendance), only 7 partial cataplexies occurred. At 6 weeks, significant improvements were observed in median[IQR] NSS (-2.0[-4.0;0], p=0.046), ISI (-1.0[-3.0;1.0], p=0.050), triglycerides (-0.21[-0.46;-0.09]g/L, p=0.015), IR (-0.19[-0.46;-0.04], p=0,003), cardiorespiratory fitness ((+15.0[5.0;20.0]watts, p<0.001), and in most attention scores (stability, intensity, reaction time: p<0.05). At 6 months, NSS and ISI changes were no longer significant but anxiety (-1.0[-3.0;1.0], p=0.041) and depression (-2.0[-4.0;0.0], p=0.004) decreased. Improvements in IR (-0.27[-0.44;-0.11], p=0.002), triglycerides (-0.2[-0.4;0.0]g/L, p=0.033), cardiovascular risk (-0.16[-0.41;-0.02], p=0,019), and attention scores (intensity, reaction time, number of errors p<0.05) were sustained. VO2max and BMI showed no significant changes. Physical activity is feasible and safe in NT1, enabling improvements in narcolepsy symptoms, anxiety/depression, cognition, and cardiometabolic markers. Larger randomized controlled trials are needed to confirm these findings.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronotype and psychopathology: insights from a genetically informative design.","authors":"Juan J Madrid-Valero, Juan R Ordoñana, Thalia C Eley, Alice M Gregory","doi":"10.1093/sleep/zsaf231","DOIUrl":"https://doi.org/10.1093/sleep/zsaf231","url":null,"abstract":"<p><strong>Study objectives: </strong>Chronotype has been linked to a wide variety of psychiatric conditions. In particular, evening chronotype could be a transdiagnostic risk factor for different mental health difficulties. In this study we examine how chronotype relates to psychopathology and whether it can be conceptualised as part of the global construct of psychopathology (p-factor) by studying the genetic and environmental overlap between these variables. We utilise data from a genetically informative design to study: 1) the association between chronotype and psychopathology; 2) the genetic and environmental overlap between chronotype and psychopathology; and 3) the predictive value of polygenic score (PGS) for chronotype for psychopathology.</p><p><strong>Methods: </strong>Chronotype was measured using an abbreviated version of the Munich Chronotype Questionnaire. Measures of psychopathology included: depression, anxiety, alcohol use and psychotic experiences among others. We used different psychopathology and chronotype-related polygenic scores. Association between chronotype and psychopathology were examined with three approaches: 1) phenotypic associations; 2) genetic and environmental associations using the twin design, and 3) genetic associations using PGS.</p><p><strong>Results: </strong>There were small, though largely significant, associations between chronotype and psychopathology with significant genetic and environmental overlap. Chronotype PGS significantly predicted a very small proportion of the variance for some measures of psychopathology (e.g., symptoms of ADHD). However, overall, our results also suggests that the majority of genetic/environmental influences (96%) on chronotype do not overlap with those on the psychopathology factor.</p><p><strong>Conclusions: </strong>Results from this study highlight existence of significant associations between chronotype and certain psychopathology traits. However, the very small associations do not support the idea that chronotype is a core element of the general \"p-factor\".</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}