Sleep最新文献

{"title":"Chronotype, sleep timing, sleep regularity, and cancer risk: A systematic review.","authors":"Sidney M Donzella, Benjamin N Bryer, Trang VoPham, Matthew D Weaver, Nathaniel F Watson, Charlie Zhong, Alpa V Patel, Amanda I Phipps","doi":"10.1093/sleep/zsaf059","DOIUrl":"https://doi.org/10.1093/sleep/zsaf059","url":null,"abstract":"<p><p>Sleep is a multidimensional modifiable lifestyle factor related to cancer risk. Prior research has primarily focused on sleep duration, despite the increasing importance of sleep timing and sleep regularity in the health research field. The objective of this systematic review was to synthesize the existing literature on the relationship of chronotype, sleep timing, and sleep regularity with cancer risk. We searched four databases (PubMed, CINAHL, PsychInfo, and Embase) in October 2024. The sleep exposures of interest included sleep timing, sleep regularity, sleep midpoint, social jetlag, chronotype, and weekend catch-up sleep, and the outcome of interest was cancer incidence (overall or site-specific). A total of 22 studies were included, of which 18 investigated chronotype, two investigated social jetlag, two investigated sleep midpoint, and one investigated weekend catch-up sleep as the sleep exposure. The majority of studies assessed sleep using self-reported questionnaires (95%) and investigated site-specific cancer incidence (91%). We found no consistent evidence linking late chronotype, later sleep midpoint, increased social jetlag, or weekend catch-up sleep to elevated risk of cancer. This review highlights the heterogeneity in how sleep timing and sleep regularity are assessed. Future research should standardize measures on how to quantify sleep timing and sleep regularity and replication studies in diverse populations are needed. Current evidence on linking sleep timing, sleep regularity, and chronotype with cancer risk remains inconclusive.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific associations between sleep stages and cardiovascular risk factors.","authors":"Tâmara P Taporoski, Felipe Beijamini, Shaina J Alexandria, David Aaby, Jose E Krieger, Malcolm von Schantz, Alexandre C Pereira, Kristen L Knutson","doi":"10.1093/sleep/zsae242","DOIUrl":"10.1093/sleep/zsae242","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep characteristics are associated with cardiovascular disease (CVD) risk and both sleep and CVD risk vary by gender. Our objective was to examine associations between polysomnographic sleep characteristics and CVD risk after excluding moderate-severe sleep apnea, and whether gender modifies these associations.</p><p><strong>Methods: </strong>This was a cross-sectional study with at-home polysomnography in adults in Brazil (n = 1102 participants with apnea-hypopnea index (AHI) <15 events/hour). Primary exposures were N3, REM, wake after sleep onset (WASO), arousal index, and AHI, and outcomes were blood pressure (BP) and lipid levels.</p><p><strong>Results: </strong>Associations between sleep and BP varied by gender. In women, more N3 was associated with lower systolic BP (-0.40 mmHg per 10 minutes, 95% CI: -0.71, -0.09), lower diastolic BP (-0.29 mmHg per 10 minutes, 95% CI: -0.50, -0.07), and lower odds of hypertension (OR 0.94, 95% CI: 0.89, 0.98). In men, more WASO was associated with higher systolic BP (0.41 mmHg per 10 minutes, 95% CI: 0.08, 0.74) and higher odds of hypertension (OR 1.07, 95% CI: 1.01, 1.14). No interactions by gender were observed for lipids. More WASO was associated with lower total cholesterol (-0.71 per 10 minutes, 95% CI: -1.37, -0.05). Higher AHI was associated with higher total cholesterol (+0.97 per event/hour, 95% CI: 0.24, 1.70) and higher LDL (+0.84 per event/hour, 95% CI: 0.04, 1.64).</p><p><strong>Conclusions: </strong>N3 is more strongly associated with BP in women, which is consistent with other studies demonstrating gender differences in BP control and CVD risk and adds a novel risk factor. Longitudinal and interventional studies are required to determine whether changes in N3 result in BP changes.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A replicate crossover trial on the interindividual variability of sleep indices in response to acute exercise undertaken by healthy men.","authors":"Yuting Yang, Alice E Thackray, Tonghui Shen, Tareq F Alotaibi, Turki M Alanazi, Tom Clifford, Iuliana Hartescu, James A King, Matthew J Roberts, Scott A Willis, Lorenzo Lolli, Greg Atkinson, David J Stensel","doi":"10.1093/sleep/zsae250","DOIUrl":"10.1093/sleep/zsae250","url":null,"abstract":"<p><strong>Study objectives: </strong>Using the necessary replicate-crossover design, we investigated whether there is interindividual variability in home-assessed sleep in response to acute exercise.</p><p><strong>Methods: </strong>Eighteen healthy men (mean [SD]: 26[6] years) completed two identical control (8 hour laboratory rest, 08:45-16:45) and two identical exercise (7 hour laboratory rest; 1 hour laboratory treadmill run [62(7)% peak oxygen uptake], 15:15-16:15) trials in randomized sequences. Wrist-worn actigraphy (MotionWatch 8) measured home-based sleep (total sleep time, actual wake time, sleep latency, and sleep efficiency) two nights before (nights 1 and 2) and three nights after (nights 3-5) the exercise/control day. Pearson's correlation coefficients quantified the consistency of individual differences between the replicates of control-adjusted exercise responses to explore: (1) immediate (night 3 minus night 2); (2) delayed (night 5 minus night 2); and (3) overall (average post-intervention minus average pre-intervention) exercise-related effects. Within-participant linear mixed models and a random-effects between-participant meta-analysis estimated participant-by-trial response heterogeneity.</p><p><strong>Results: </strong>For all comparisons and sleep outcomes, the between-replicate correlations were nonsignificant, ranging from trivial to moderate (r range = -0.44 to 0.41, p ≥ .065). Participant-by-trial interactions were trivial. Individual differences SDs were small, prone to uncertainty around the estimates indicated by wide 95% confidence intervals, and did not provide support for true individual response heterogeneity. Meta-analyses of the between-participant, replicate-averaged condition effect revealed that, again, heterogeneity (τ) was negligible for most sleep outcomes.</p><p><strong>Conclusions: </strong>Control-adjusted sleep in response to acute exercise was inconsistent when measured on repeated occasions. Interindividual differences in sleep in response to exercise were small compared with the natural (trial-to-trial) within-subject variability in sleep outcomes.</p><p><strong>Clinical trials information: </strong>https://clinicaltrials.gov/study/NCT05022498. Registration number: NCT05022498.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tired and out of control? Effects of total and partial sleep deprivation on response inhibition under threat and no-threat conditions.","authors":"Arne Nieuwenhuys, Corey G Wadsley, Robyn Sullivan, John Cirillo, Winston D Byblow","doi":"10.1093/sleep/zsae275","DOIUrl":"10.1093/sleep/zsae275","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep deprivation may impair top-down inhibitory control over emotional responses (e.g. under threat). The current study examined the behavioral consequences of this phenomenon and manipulated the magnitude of individuals' sleep deficit to determine effect thresholds.</p><p><strong>Methods: </strong>Twenty-four healthy human participants were provided with 0, 2, 4, and 8 hours of sleep opportunity and, subsequently, performed a bimanual anticipatory response inhibition task under threat and no-threat conditions. Behavioral responses (button presses) and surface electromyography (EMG) from task effectors were collected to examine going and stopping processes.</p><p><strong>Results: </strong>Bayesian analyses revealed that compared to 8 hours of sleep, go-trial accuracy was reduced with 0 hours of sleep. Stopping speed was reduced with 0 and 2 hours of sleep, as evidenced by longer stop-signal delays, but only in a selective stopping context. None of the outcome measures were impacted by 4 hours of sleep. Under threat, go-trial accuracy was maintained, while responses were slightly delayed and characterized by amplified EMG bursts. Stopping speed was increased under threat across both stop-all and selective stopping contexts. No evidence was observed for interactions between sleep and threat.</p><p><strong>Conclusions: </strong>Sleep deprivation negatively affected response inhibition in a selective stopping context, with stopping speed reduced following a single night of ≤2 hours of sleep. Performance-contingent threat improved response inhibition, possibly due to a prioritizing of stopping. No evidence was observed for increased threat-related responses after sleep deprivation, suggesting that sleep deprivation and threat may impact inhibitory control via independent mechanisms.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetrodotoxin-mediated inactivation of medial prefrontal cortex decreases wakefulness and rapid eye movement sleep, and increases slow-wave sleep in rat.","authors":"Trent Groenhout, Sumegha Ponnaluri, Lana Sharba, Tiecheng Liu, Amanda Nelson, Viviane S Hambrecht-Wiedbusch, Giancarlo Vanini, Dinesh Pal","doi":"10.1093/sleep/zsae260","DOIUrl":"10.1093/sleep/zsae260","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melody for a memory: sleep boosts the brain's representation of sequential events.","authors":"Sara J Aton","doi":"10.1093/sleep/zsae316","DOIUrl":"10.1093/sleep/zsae316","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissociation of subjective and physiological stress responses in orexin-deficient narcolepsy.","authors":"Zhongxing Zhang, Ramin Khatami","doi":"10.1093/sleep/zsae304","DOIUrl":"10.1093/sleep/zsae304","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glia: the cellular glue that binds circadian rhythms and sleep.","authors":"Catarina Carvalhas-Almeida, Amita Sehgal","doi":"10.1093/sleep/zsae314","DOIUrl":"10.1093/sleep/zsae314","url":null,"abstract":"<p><p>Glia are increasingly appreciated as serving an important function in the control of sleep and circadian rhythms. Glial cells in Drosophila and mammals regulate daily rhythms of locomotor activity and sleep as well as homeostatic rebound following sleep deprivation. In addition, they contribute to proposed functions of sleep, with different functions mapping to varied glial subtypes. Here, we discuss recent findings in Drosophila and rodent models establishing a role of glia in circadian or sleep regulation of synaptic plasticity, brain metabolism, removal of cellular debris, and immune challenges. These findings underscore the relevance of glia for benefits attributed to sleep and have implications for understanding the neurobiological mechanisms underlying sleep and associated disorders.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rest activity rhythm fragmentation and synchronisation are linked with reduced cortical thickness in older adults 'at risk' for dementia.","authors":"Nicole Espinosa, Camilla M Hoyos, Andrew C McKinnon, Hannes Almgren, Shantel L Duffy, Sharon L Naismith","doi":"10.1093/sleep/zsaf017","DOIUrl":"https://doi.org/10.1093/sleep/zsaf017","url":null,"abstract":"<p><strong>Study objectives: </strong>While alterations in rest-activity rhythms are common in older adults 'at risk' for dementia, it is unclear how rest-activity rhythms relate to underlying brain integrity.</p><p><strong>Methods: </strong>Older adults aged > 50 years (n=143, mean age=67) with subjective and/or objective cognitive impairment underwent MRI scanning and 14-days of actigraphy. The following non-parametric measures were computed: intra-daily variability (IV), inter-daily stability (IS), relative amplitude (RA), and average activity during the least active 5-hour period (L5). A vertex-wise analysis correcting for age, sex and clinical variables examined the association between nonparametric actigraphy measures and cortical thickness.</p><p><strong>Results: </strong>When controlling for age, sex, and body mass index (BMI), lower IV was associated with greater cortical thickness in the right cuneus (CWP< 0.001), left middle frontal gyrus (CWP< 0.001) and lateral orbital frontal cortex (CWP= 0.004). When controlling for age, sex, medical burden (CIRS-G), BMI and antidepressant use, lower IS was associated with lower cortical thickness in the left (CWP= 0.002) and right superior frontal gyrus (CWP< 0.001), left superior temporal gyrus (CWP= 0.043) and left post-central gyrus (CWP= 0.033). There were no significant associations between RA or L5 and cortical thickness.</p><p><strong>Conclusions: </strong>In older adults 'at risk' for dementia, variability and stability of rest-activity rhythms were associated with reduced cortical thickness in frontal, temporal, parietal and occipital regions. Studies are now required to determine the prognostic utility of such markers longitudinally.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disturbances in Rest-Activity Rhythms and Their Neurobiological Correlates: Implications for Alzheimer's Disease and Dementia.","authors":"Peng Li, Kun Hu","doi":"10.1093/sleep/zsaf047","DOIUrl":"https://doi.org/10.1093/sleep/zsaf047","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}