IF 5.6 2区医学

Sleep Pub Date : 2024-10-23 DOI: 10.1093/sleep/zsae249

Jennifer Zitser

引用次数: 0

The evaluation of a novel single-lead biopotential device for home sleep testing. 评估用于家庭睡眠测试的新型单导联生物电位仪。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-23 DOI: 10.1093/sleep/zsae248

Frederik Massie, Steven Vits, Johan Verbraecken, Jeroen Bergmann

{"title":"The evaluation of a novel single-lead biopotential device for home sleep testing.","authors":"Frederik Massie, Steven Vits, Johan Verbraecken, Jeroen Bergmann","doi":"10.1093/sleep/zsae248","DOIUrl":"https://doi.org/10.1093/sleep/zsae248","url":null,"abstract":"Study objectives: This paper reports on the clinical evaluation of the sleep staging performance of a novel single-lead biopotential device.Methods: 133 patients suspected of obstructive sleep apnea were included in a multi-site cohort. All patients underwent polysomnography and received the study device, a single-lead biopotential measurement device attached to the forehead. Clinical endpoint parameters were selected to evaluate the device's ability to determine sleep stages. Finally, the device's performance was compared to the clinical study results of comparable devices.Results: Concurrent PSG and study device data were successfully acquired for 106 of the 133 included patients. The results of this study demonstrated significant similarity in overall sleep staging performance (5-stage Cohen's Kappa of 0.70) to the best-performing reduced-lead biopotential device to which it was compared (5-stage Cohen's Kappa of 0.73). Contrary to the comparator devices, the study device reported a higher Cohen's Kappa for REM (0.78) compared to N3 (0.61), which can be explained by its particular measuring electrode placement (diagonally across the lateral cross-section of the eye). This placement was optimized to ensure the polarity of rapid eye movements could be adequately captured, enhancing the capacity to discriminate between N3 and REM sleep when using only a single-lead setup.Conclusions: The results of this study demonstrate the feasibility of incorporating a single-lead biopotential extension in a reduced-channel home sleep apnea testing setup. Such incorporation could narrow the gap in the functionality of reduced-channel home sleep testing and in-lab polysomnography without compromising the patient's ease of use and comfort.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological inhibition of histamine N-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy. 药理抑制组胺 N-甲基转移酶可延长嗜睡症小鼠模型的清醒时间并抑制惊厥。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-23 DOI: 10.1093/sleep/zsae244

Fumito Naganuma, Birkan Girgin, Anne Bernadette S Agu, Kyosuke Hirano, Tadaho Nakamura, Kazuhiko Yanai, Ramalingam Vetrivelan, Takatoshi Mochizuki, Masashi Yanagisawa, Takeo Yoshikawa

{"title":"Pharmacological inhibition of histamine N-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy.","authors":"Fumito Naganuma, Birkan Girgin, Anne Bernadette S Agu, Kyosuke Hirano, Tadaho Nakamura, Kazuhiko Yanai, Ramalingam Vetrivelan, Takatoshi Mochizuki, Masashi Yanagisawa, Takeo Yoshikawa","doi":"10.1093/sleep/zsae244","DOIUrl":"10.1093/sleep/zsae244","url":null,"abstract":"Histamine, a neurotransmitter, plays a predominant role in maintaining wakefulness. Further, our previous studies showed that histamine N-methyltransferase (HNMT), a histamine-metabolising enzyme, is important for regulating brain histamine concentration. However, the effects of pharmacological HNMT inhibition on mouse behaviour, including the sleep-wake cycle and cataplexy, in a mouse model of narcolepsy have not yet been investigated. In the present study, we investigated the effects of metoprine, an HNMT inhibitor with high blood-brain barrier permeability, in wild-type (WT) and orexin-deficient (OxKO) narcoleptic mice. Metoprine increased brain histamine concentration in a time- and dose-dependent manner without affecting peripheral histamine concentrations. Behavioural tests showed that metoprine increased locomotor activity in both novel and familiar environments, but did not alter anxiety-like behaviour. Sleep analysis showed that metoprine increased wakefulness and decreased non-rapid eye movement (NREM) sleep through the activation of the histamine H1 receptor (H1R) in WT mice. In contrast, the reduction of rapid eye movement (REM) sleep by metoprine occurred independent of H1R. In OxKO mice, metoprine was found to prolong wakefulness and robustly suppress cataplexy. In addition, metoprine has a greater therapeutic effect on cataplexy than pitolisant, which induces histamine release in the brain, and has been approved for patients with narcolepsy. These data demonstrate that HNMT inhibition has a strong effect on wakefulness, demonstrating therapeutic potential against cataplexy in narcolepsy.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Power of the Rocking Cradle: Improving Sleep Function by Gentle Vibration. 摇篮的力量：通过轻柔振动改善睡眠功能

IF 5.6 2区医学

Sleep Pub Date : 2024-10-23 DOI: 10.1093/sleep/zsae245

Makenzie A Hopkins, Masashi Tabuchi

引用次数: 0

Genetic variants associated with chronic fatigue syndrome predict population-level fatigue severity and actigraphic measurements. 与慢性疲劳综合征相关的基因变异可预测人群疲劳严重程度和行动测量。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-23 DOI: 10.1093/sleep/zsae243

Patrick Z Liu, David M Raizen, Carsten Skarke, Thomas G Brooks, Ron C Anafi

{"title":"Genetic variants associated with chronic fatigue syndrome predict population-level fatigue severity and actigraphic measurements.","authors":"Patrick Z Liu, David M Raizen, Carsten Skarke, Thomas G Brooks, Ron C Anafi","doi":"10.1093/sleep/zsae243","DOIUrl":"https://doi.org/10.1093/sleep/zsae243","url":null,"abstract":"Study objectives: The diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (CFS) is based on a constellation of symptoms which center around fatigue. However, fatigue is commonly reported in the general population by people without CFS. Does the biology underlying fatigue in patients with CFS also drive fatigue experienced by individuals without CFS?Methods: We used UK Biobank actigraphy data to characterize differences in physical activity patterns and daily temperature rhythms between participants diagnosed with CFS compared to controls. We then tested if single nucleotide variants (SNVs) previously associated with CFS are also associated with the variation of these actigraphic CFS correlates and/or subjective fatigue symptoms in the general population.Results: Participants diagnosed with CFS (n = 295) had significantly decreased overall movement (Cohen's d = 0.220, 95% CI of -0.335 to -0.106, p-value = 2.42x10-15), lower activity amplitudes (Cohen's d = -0.377, 95% CI of -0.492 to -0.262, p-value = 1.74x10-6), and lower wrist temperature amplitudes (Cohen's d = -0.173, 95% CI of -0.288 -0.059, p-value = 0.002) compared to controls (n = 63,133). Of 30 tested SNVs associated in the literature with CFS, one was associated in the control population with subjective fatigue and one with actigraphic measurements (FDR < 0.05).Conclusions: The genetic overlap of CFS risk with actigraphy and subjective fatigue phenotypes suggests that some biological mechanisms underlying pathologic fatigue in CFS patients also underlie fatigue symptoms at a broader population level. Therefore, understanding the biology of fatigue in general may inform our understanding of CFS pathophysiology.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absence of dysregulation in amplitude and phase of circadian rhythm of core body temperature in idiopathic hypersomnia: A case-control study. 特发性嗜睡症患者核心体温昼夜节律的振幅和相位没有失调：病例对照研究

IF 5.6 2区医学

Sleep Pub Date : 2024-10-21 DOI: 10.1093/sleep/zsae246

Tugdual Adam, Lucie Barateau, Jérôme Tanty, Yves Dauvilliers

{"title":"Absence of dysregulation in amplitude and phase of circadian rhythm of core body temperature in idiopathic hypersomnia: A case-control study.","authors":"Tugdual Adam, Lucie Barateau, Jérôme Tanty, Yves Dauvilliers","doi":"10.1093/sleep/zsae246","DOIUrl":"https://doi.org/10.1093/sleep/zsae246","url":null,"abstract":"Study objectives: To investigate amplitude and phase of the circadian rhythm of core body temperature (CBT) via the continuous measure of the gastrointestinal temperature in participants with idiopathic hypersomnia (IH), non-specified hypersomnia (NSH) compared to healthy controls (HC) in a constant routine standardized bedrest (BR) protocol.Methods: Consecutive participants evaluated in a National Reference Center for Rare Hypersomnias benefited from an extensive evaluation with one night polysomnography, followed by modified Multiple Sleep Latency Test (mMSLT), and a continuous 32-hour BR recording in standardized conditions. CBT was recorded via a telemetry pill (e-Celsius®) during the BR, modeled by a Cosinor, with extraction of MESOR, amplitude and phase. Participants with IH, diagnosed according to ICSD-3, were compared with participants with NSH (complaint of hypersomnolence but normal mMSLT and BR), and HC. Participants were divided in 4 groups based on their mMSLT mean sleep latency (mMSLT+,≤8min) and their BR total sleep time (BR+,≥19h).Results: 108 participants (80% women, 28.3±7.8 y.o) were included in the analyses, 81 IH (83% women), 16 NSH (75% women), 11 HC (64% women). Cosinor amplitude and phase of CBT did not differ between IH, NSH and HC, nor in the subgroup analysis (37 BR+/mMSLT+, 35 BR+/mMSLT-, 9 BR-/mMSLT+, 27 BR-/mMSLT-). No difference in chronotypes was observed between groups. Women had a greater MESOR and reduced CBT amplitude compared to men.Conclusion: The circadian rhythm of CBT showed no difference in amplitude or phase between IH, NSH and HC, and was not related to prolonged sleep time or objective daytime sleepiness.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incretins for obstructive sleep apnea: effects mediated fully by weight loss? 抑制剂治疗阻塞性睡眠呼吸暂停：完全通过减轻体重产生效果？

IF 5.6 2区医学

Sleep Pub Date : 2024-10-21 DOI: 10.1093/sleep/zsae232

Liang Peng, Lin Chen, Wen-Bin Lei, Wei-Ping Wen

引用次数: 0

Beyond phase shifting: Targeting circadian amplitude for light interventions in humans. 超越相移：以昼夜节律振幅为目标，对人体进行光干预。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-21 DOI: 10.1093/sleep/zsae247

Oliva Walch, Franco Tavella, Jamie M Zeitzer, Renske Lok

引用次数: 0

Gender-specific associations between sleep stages and cardiovascular risk factors. 睡眠阶段与心血管风险因素之间的性别关联。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-19 DOI: 10.1093/sleep/zsae242

Tâmara P Taporoski, Felipe Beijamini, Shaina J Alexandria, David Aaby, Jose E Krieger, Malcolm von Schantz, Alexandre C Pereira, Kristen L Knutson

{"title":"Gender-specific associations between sleep stages and cardiovascular risk factors.","authors":"Tâmara P Taporoski, Felipe Beijamini, Shaina J Alexandria, David Aaby, Jose E Krieger, Malcolm von Schantz, Alexandre C Pereira, Kristen L Knutson","doi":"10.1093/sleep/zsae242","DOIUrl":"10.1093/sleep/zsae242","url":null,"abstract":"Study objectives: Sleep characteristics are associated with cardiovascular disease (CVD) risk and both sleep and CVD risk vary by gender. Our objective was to examine associations between polysomnographic sleep characteristics and CVD risk after excluding moderate-severe sleep apnea, and whether gender modifies these associations.Methods: This was a cross-sectional study with at-home polysomnography in adults in Brazil (n= 1,102 participants with apnea-hypopnea index (AHI)<15 events/hour). Primary exposures were N3, REM, wake after sleep onset (WASO), arousal index (AI) and AHI, and outcomes were blood pressure (BP) and lipid levels.Results: Associations between sleep and BP varied by gender. In women, more N3 was associated with lower systolic BP (-0.40 mmHg per 10 minutes, 95%CI -0.71, -0.09), lower diastolic BP (-0.29 mmHg per 10 minutes, 95%CI -0.50, -0.07), and lower odds of hypertension (OR 0.94, 95%CI 0.89, 0.98). In men, more WASO was associated with higher systolic BP (0.41 mmHg per 10 minutes, 95%CI 0.08, 0.74) and higher odds of hypertension (OR 1.07, 95%CI 1.01, 1.14). No interactions by gender were observed for lipids. More WASO was associated with lower total cholesterol (-0.71 per 10 minutes, 95%CI -1.37, -0.05). Higher AHI was associated with higher total cholesterol (+0.97 per event/hour, 95%CI 0.24, 1.70) and higher LDL (+0.84 per event/hour, 95%CI 0.04, 1.64).Conclusions: N3 is more strongly associated with BP in women, which is consistent with other studies demonstrating gender differences in BP control and CVD risk and adds a novel risk factor. Longitudinal and interventional studies are required to determine whether changes in N3 result in BP changes.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired Sleep-Dependent Memory Consolidation in Pediatric Narcolepsy Type 1. 小儿 1 型嗜睡症患者依赖睡眠的记忆巩固能力受损。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-18 DOI: 10.1093/sleep/zsae238

K Maski, G Heckler, J Worhach, D Mylonas, G Wang, K Szilagyi, B Zhang, C Diniz Behn, T E Scammell, R Stickgold

{"title":"Impaired Sleep-Dependent Memory Consolidation in Pediatric Narcolepsy Type 1.","authors":"K Maski, G Heckler, J Worhach, D Mylonas, G Wang, K Szilagyi, B Zhang, C Diniz Behn, T E Scammell, R Stickgold","doi":"10.1093/sleep/zsae238","DOIUrl":"10.1093/sleep/zsae238","url":null,"abstract":"Study objectives: Disrupted nighttime sleep (DNS) is common in pediatric Narcolepsy type 1, yet its cognitive impact is unknown. As N2 sleep spindles are necessary for sleep-dependent memory consolidation, we hypothesized that Narcolepsy Type 1 impairs memory consolidation via N2 sleep fragmentation and N2 sleep spindle alterations.Methods: We trained 28 pediatric Narcolepsy Type 1 participants and 27 healthy controls (HC) on a spatial declarative memory task before a nocturnal in-lab polysomnogram and then gave them a cued recall test upon awakening in the morning. We extracted wake and sleep stage bout numbers and N2 spindle characteristics from the polysomnogram and conducted mixed model analysis of sleep-dependent memory consolidation to identify group differences.Results: Narcolepsy Type 1 participants had shorter N2 bout durations and associated shorter N2 spindles vs. HC, but other N2 spindle features were similar. Narcolepsy Type 1 participants had worse memory performance post-sleep than HCs after adjusting for age and gender (mean memory consolidation HC: -3.1% ± 18.7, NT1: -15.6 ± 24.8, main effect group x time of testing F=5.3, p=0.03). We did not find significant relationships between sleep-dependent memory consolidation and N2 spindle characteristics. Notably, increased N1% was associated with worse sleep-dependent memory consolidation with results driven by the Narcolepsy Type 1 group.Conclusions: Sleep-dependent memory consolidation is mildly impaired in youth with Narcolepsy Type 1 and findings may be attributed to increases in N1 sleep. Further studies are needed to determine if these findings are generalizable and reversible with sleep-based therapies.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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