Sleep最新文献

{"title":"Characterizing nonlinear heterogeneous sleep trajectories across the menstrual cycle in a transdiagnostic psychiatric population.","authors":"Anisha Nagpal, Anna Patterson, Ashley Ross, Loran Knol, Sajal Shukla, Adam Bryant Miller, Fiona Baker, Katja M Schmalenberger, Tory A Eisenlohr-Moul","doi":"10.1093/sleep/zsag220","DOIUrl":"10.1093/sleep/zsag220","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep disturbance is closely linked to affective symptoms and suicidal ideation (SI). These symptoms fluctuate across the menstrual cycle; however, menstrual cycle-related sleep variability remains poorly characterized in psychiatric populations. This study examined how subjective and objective sleep fluctuate across the menstrual cycle in a psychiatric sample, considering individual differences and associations with negative affective and SI symptom trajectories.</p><p><strong>Materials and methods: </strong>A transdiagnostic psychiatric sample recruited for recent suicidality provided intensive daily subjective sleep and symptom ratings (N = 142, M = 26.59 years, SD = 5.34) alongside wearable-derived (Oura) objective sleep measures (N = 39) across 1-3 menstrual cycles. Cycle timing was aligned to ovulation and menses using Phase-Aligned Cycle Time Scaling. Generalized additive mixed models quantified average cyclical effects and interindividual heterogeneity. Exploratory smooth mixture modeling (SMM) identified latent subgroups with shared temporal sleep trajectories which were compared to trait-level demographic and clinical characteristics as well as affective, SI, and pain cyclical symptom trajectory subgroups.</p><p><strong>Results: </strong>Most sleep outcomes showed substantial within-person cyclical variability. SMM identified distinct subgroups for Oura-derived sleep efficiency, and for subjective ratings of fatigue, insomnia, sleep quality, and hypersomnia, with patterns including perimenstrual or luteal worsening, as well as no cycle-related variability. Sleep subgroups, especially for subjective ratings, frequently significantly aligned with parallel affective, pain, and SI trajectories, suggesting temporally-coupled vulnerability.</p><p><strong>Conclusions: </strong>Sleep trajectories across the menstrual cycle are heterogeneous and meaningfully coupled with psychiatric symptom patterns. These findings support cycle-aware sleep monitoring and suggest that cyclical sleep disruption may help identify windows of heightened psychiatric risk, motivating replication and personalized intervention approaches.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep, mood, and the menstrual cycle: advancing precision care in women's health.","authors":"Magalie Carey, Margaret Blattner","doi":"10.1093/sleep/zsag223","DOIUrl":"10.1093/sleep/zsag223","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commonly experienced acute and cumulative 8-hour sleep loss differentially affect simulated driving during a night-time to early-morning commute: a randomized controlled crossover trial.","authors":"Stefan Lakämper, Michael Scholz, Thomas Kraemer, Hans-Peter Landolt, Kristina Keller","doi":"10.1093/sleep/zsag206","DOIUrl":"10.1093/sleep/zsag206","url":null,"abstract":"<p><p>Sleep loss is a major contributor to traffic accidents, yet the differential effects of two common real-world patterns of sleep loss, acute total sleep deprivation and cumulative sleep restriction producing an equivalent 8-h sleep loss, on vehicle control remain poorly quantified. Leveraging tightly controlled sleep manipulation and highly immersive driving simulation, we directly compared the effects of different patterns of sleep loss under naturalistic driving conditions. Twenty healthy male participants completed a randomized within-subject crossover sleep design, comprising normal sleep, cumulative sleep restriction (four nights 2 h reduced sleep per night), and acute total sleep deprivation (one night without sleep), each followed by a simulated nighttime-to-early-morning commute. Acute total sleep deprivation produced pronounced impairments in vehicle control. Most prominently, lateral control deteriorated within 4-6 min under acute deprivation, with impairments comparable to those reported at high blood alcohol concentrations (1.2-1.4 g/L). Steering instability and integrated driving performance showed convergent deterioration. In contrast, cumulative sleep restriction resulted in smaller and less consistent changes, while vigilance task performance and speed variability were comparatively preserved across all conditions. Despite graded increases in subjective sleepiness across conditions, cumulative sleep restriction produced only limited changes in driving performance, whereas acute sleep deprivation produced a disproportionate risk to driving safety by selectively and rapidly degrading operational vehicle control. These findings, obtained under ecologically relevant sleep and driving conditions, underscore functional and potentially physiological differences between acute and cumulative sleep loss and, practically, highlight the importance of distinguishing between them when considering sleep-loss-related driving impairment and safety risk. Clinical Trials-name, URL, and registration: Clinical Trial name: Study of Identification of Metabolomics-based Sleepiness Markers for Risk Prevention and Traffic Safety-ClinicalTrials.gov Identifier NCT05585515, released on 18.10.2022, https://clinicaltrials.gov/study/NCT05585515; Swiss National Clinical Trial Portal SNCTP000005089, registered on 12.08.2022, https://www.humanforschung-schweiz.ch/de/studiensuche/studien-detail/58930. IRB Statement: This study was approved by the local ethics committee (Kantonale Ethikkommission Zürich, reference number 2022-01273). No identifying images or other personal or clinical details of participants are presented here or will be presented in reports of the trial results. Informed consent materials are available from the corresponding author on request. We confirm all methods were performed in accordance with the Declaration of Helsinki and its later amendments.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The respiration-limb coactivation index: a continuous signal-based biomarker for stratifying cardiovascular disease risk in a cross-sectional sleep cohort.","authors":"Shenghan Wen, Raffaele Ferri, Qichen Li, Wanlu Deng, Michael Brandon Westover, Robert J Thomas, Samaneh Nasiri","doi":"10.1093/sleep/zsag204","DOIUrl":"10.1093/sleep/zsag204","url":null,"abstract":"<p><strong>Study objectives: </strong>Conventional respiratory-related limb movement (RRLM) metrics rely on event definitions and overlap rules that miss continuous respiratory-motor coupling intensity. We developed the respiration-limb coactivation index (RLCI), an algorithmic continuous biomarker, and evaluated its associations with cardiovascular disease (CVD).</p><p><strong>Materials and methods: </strong>In Human Sleep Project polysomnography, the RLCI was computed in S0001 (N = 20 737) as the interaction between respiratory-flow recovery and the phasic leg-EMG envelope. The locked S0001 pipeline, without parameter tuning, was applied to two independent HSP centers (I0004, I0006). Prevalent coronary heart disease (CHD), cerebrovascular disease (CER), and peripheral vascular disease (PVD) associations were assessed by multivariable logistic regression with stage-restricted comparisons against LMI, PLMI, and RRLMI and signal-processing sensitivity analyses.</p><p><strong>Results: </strong>After covariate adjustment, whole-night RRLMI was not significant for CHD or CER, whereas RLCI metrics, especially in N1 and first-half sleep, remained associated with CER and PVD. RLC N1 showed the strongest CER association (per-1-SD OR 1.11, 95% CI 1.06-1.15), and RLC FirstHalf was associated with PVD (OR 1.07, 95% CI 1.03-1.11). Stage-restricted RRLMI_N1 was significant for all four outcomes, supporting stage-matched benchmarking. Mutual adjustment suggested complementary RLCI information for CER and PVD, while conventional N1 respiratory-related movements better captured CHD. Findings were stable in sensitivity analyses and external validation.</p><p><strong>Conclusions: </strong>RLCI associations with CER and PVD suggest respiratory-linked motor coactivation captures autonomic surges distinct from cumulative hypoxia or sleep fragmentation and may complement apnea-hypopnea index-based cardiovascular risk stratification.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13682168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148607777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From sensorimotor to transmodal cortex: sleep quality aligns brain entropy with the cortical functional gradient.","authors":"Gianpaolo Del Mauro, Yiran Li, Jiaao Yu, Emerson M Wickwire, Peter Kochunov, Shuo Chen, Hengyi Rao, Ze Wang","doi":"10.1093/sleep/zsag205","DOIUrl":"10.1093/sleep/zsag205","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep is fundamental to brain health, yet the mechanisms by which habitual sleep quality shapes large-scale neural dynamics during wakefulness remain unclear. This work aims at determining whether habitual sleep quality is associated with systematic alterations in regional and cross-regional temporal complexity of spontaneous neural activity.</p><p><strong>Methods: </strong>Regional brain entropy (BEN) and cross-regional brain entropy were estimated from resting-state fMRI data of the UK Biobank, with replication in the Human Connectome Project and in a randomized total sleep deprivation experiment. Temporal complexity of spontaneous neural activity was correlated to self-reported habitual sleep quality and sleep amount in observational cohorts and experimental total sleep deprivation in the laboratory study.</p><p><strong>Results: </strong>Better sleep quality was associated with increased BEN in sensory and sensorimotor cortices and decreased BEN in frontoparietal control regions. High-quality sleep enhanced differentiation of temporal complexity among sensory networks while strengthening coordination within higher-order control systems. In the independent Human Connectome Project cohort, sleep amount predicted increased BEN in visual and somatomotor regions. Moreover, the strength of the association between sleep measures and BEN was strongly and negatively correlated with the major cortical functional gradient. Exploratory results suggest convergent effects following total sleep deprivation. Habitual sleep quality is associated with systematic reconfiguration of the brain's temporal complexity architecture at both regional and network levels.</p><p><strong>Conclusion: </strong>These findings position sleep as a fundamental determinant of the brain's dynamic operating regime and identify temporal complexity as a mechanistically informative neural signature linking sleep health to cognitive function and neuropsychiatric vulnerability.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148607792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slow-wave sleep mediates the compensatory effects of acute moderate-intensity exercise on declarative memory deficits in sleep restriction.","authors":"Emmanuel Frimpong, Melodee Mograss, Jocelyn Dautet-Plourde, Nicole Milbrath, Francois Pointeau, Manlu Xu, Ngoc Long Khang Nguyen, Tehila Zvionow, Mylene Aubertin-Leheudre, Louis Bherer, Véronique Pepin, Edwin Robertson, Arsenio Páez, Thien Thanh Dang-Vu","doi":"10.1093/sleep/zsag235","DOIUrl":"10.1093/sleep/zsag235","url":null,"abstract":"<p><p>Insufficient sleep impairs cognition, particularly hippocampal-dependent memory. However, effective strategies for addressing these effects in humans remain limited. Physical exercise enhances slow-wave sleep (SWS) and improves memory performance, suggesting it may provide a physiologically grounded buffer against sleep-loss-related memory deficits. Here, we tested whether a single session of moderate-intensity exercise may protect long-term declarative memory following sleep restriction, and whether SWS mediates this effect. Eighty-eight healthy young adults (52% female; 24.0 ± 3.8 years) were randomly assigned to one of four groups based on exercise and sleep opportunity: average sleep (S8: 8.5 hours/night), sleep restriction (S5: 4.5 hours/night), exercise before average sleep (ExS8), and exercise before sleep restriction (ExS5). Participants completed either a 30-min evening moderate-intensity cycling (7: 00 p.m.; 55%-60% VO₂max) or seated rest prior to learning 80 face-name pairs (10:00 p.m.), followed by immediate and delayed recall (120 face-name pairs: 80 studied, 40 novel) after polysomnography-recorded sleep. We found a significant exercise × sleep interaction for delayed recall performance (discriminability index, d'; p = .033, partial η2 = 0.056). The delayed recall d' of the ExS5 was significantly higher than the S5 (p = .028), but was comparable to S8 and ExS8 groups (ps > 0.05). The proportion of SWS mediated the association between exercise and delayed recall d' (B = 0.105, SE = 0.091, 95% bootstrap CI (0.073, 0.924)). These findings indicate that acute moderate-intensity exercise is associated with offsetting the negative impact of sleep restriction on long-term declarative memory in sleep restriction, an effect statistically mediated by SWS percentage.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A time for change: actigraphy in the age of consumer wearables.","authors":"Jamie M Zeitzer","doi":"10.1093/sleep/zsag238","DOIUrl":"10.1093/sleep/zsag238","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A compositional approach towards understanding recovery sleep dynamics.","authors":"David Negelspach, Alisa Huskey, Kathryn E R Kennedy, Jungwon Cha, Daniel B Forger, William D S Killgore","doi":"10.1093/sleep/zsag242","DOIUrl":"10.1093/sleep/zsag242","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Sleep spindles reveal sexually dimorphic trajectories of long-term bodily pain: a large-scale secondary analysis with implications for clinical biomarker development.","authors":"","doi":"10.1093/sleep/zsag261","DOIUrl":"10.1093/sleep/zsag261","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain MRI changes following continuous positive airway pressure therapy in adults with obstructive sleep apnea: a systematic review.","authors":"Maryam Jalali, Maziar Jalalvandi, Atefeh Tahmasebzadeh, Mahdi Mohammadi","doi":"10.1093/sleep/zsag240","DOIUrl":"10.1093/sleep/zsag240","url":null,"abstract":"<p><strong>Study objectives: </strong>Obstructive sleep apnea (OSA) is associated with structural, microstructural, functional, vascular, and metabolic brain alterations. Continuous positive airway pressure (CPAP) is the first-line treatment for OSA, but whether OSA-related abnormalities on brain magnetic resonance imaging (MRI) improve after treatment remains uncertain. This systematic review synthesized longitudinal MRI evidence on brain changes following CPAP therapy in adults with OSA.</p><p><strong>Materials and methods: </strong>PubMed/MEDLINE, Scopus, and Web of Science were searched from database inception to December 2025. Eligible studies included adults with OSA who underwent brain MRI before and after CPAP therapy or were compared with untreated, sham-treated, best-supportive-care, or healthy control groups. MRI outcomes included structural, diffusion, functional, perfusion, cerebrovascular reactivity, magnetic resonance spectroscopy, susceptibility-related, and perivascular-space measures. Risk of bias was assessed using an adapted Newcastle-Ottawa Scale. Findings were synthesized qualitatively because of substantial heterogeneity.</p><p><strong>Results: </strong>Thirty studies were included. Reported post-CPAP MRI changes were heterogeneous and included gray matter or cortical alterations, white matter microstructural changes, modified functional connectivity and regional activity, perfusion or cerebrovascular reactivity changes, and preliminary metabolic, susceptibility-related, and perivascular-space findings. Results varied across MRI techniques, anatomical targets, CPAP duration, adherence definitions, comparator groups, and analytical methods.</p><p><strong>Conclusions: </strong>The available longitudinal MRI literature suggests possible domain-specific brain changes after CPAP, but the evidence is largely exploratory because most studies were small and nonrandomized and used heterogeneous imaging and analytical approaches. The findings do not establish reproducible MRI treatment effects or support routine MRI monitoring of individual response. Larger, prospectively specified, harmonized longitudinal studies are needed.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}