Sleep最新文献

{"title":"Nightmares and Suicide Risk: Broadening the Therapeutic Frame Beyond IRT.","authors":"Baris Olten, William V McCall","doi":"10.1093/sleep/zsag129","DOIUrl":"https://doi.org/10.1093/sleep/zsag129","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rates of Sufficient Sleep Among University Students in the United States from 2000 to 2023.","authors":"Michael K Scullin, Blake K Barley, Allison E Nickel, Jason R Carter","doi":"10.1093/sleep/zsag128","DOIUrl":"https://doi.org/10.1093/sleep/zsag128","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared local brain dynamics in pediatric and adult NREM parasomnias.","authors":"Julian Amacker, Marco Veneruso, Matteo Pereno, Simone Ulzega, Samuel Wehrli, Sven Hirsch, Lino Nobili, Silvia Miano, Mauro Manconi, Anna Castelnovo","doi":"10.1093/sleep/zsag123","DOIUrl":"https://doi.org/10.1093/sleep/zsag123","url":null,"abstract":"<p><strong>Study objectives: </strong>To characterize source-level cortical oscillatory dynamics before and during disorders of arousal (DoA) compared with physiological motor arousals in children and adults.</p><p><strong>Materials and methods: </strong>Nineteen children (10.9 ± 3.0 years) and 22 adults (30.3 ± 5.2 years) with DoA underwent 256-channel high-density EEG with video-polysomnography. Source-space spectral analysis in delta (0.5-4 Hz) and beta (18-30 Hz) bands was computed during stable slow-wave-sleep (-3 to -2 minutes before movement onset) and from -5 seconds to +15 seconds around movement onset for 84 DoA episodes and 146 physiological motor arousals. Linear mixed-effects models with permutation-based cluster correction were applied.</p><p><strong>Results: </strong>Four reproducible cortical hallmarks emerged across age groups: (i) a widespread pre-onset increase in beta and delta relative to slow-wave-sleep; (ii) sustained frontal delta enhancement over anterior cingulate, dorsomedial and ventromedial prefrontal, frontopolar, and orbitofrontal cortices; (iii) concurrent centro-parietal delta suppression spanning posterior cingulate, precuneus, superior parietal, sensorimotor, and supplementary motor regions; and (iv) persistent bilateral beta enhancement. Compared with physiological arousals, DoA arose from a \"sleepier\" background (higher delta, lower beta) and displayed greater beta coexisting with frontal delta persistence. Children showed broader pre-onset delta effects and more diffuse post-onset persistence, whereas adults exhibited a more anteriorly confined pattern.</p><p><strong>Conclusion: </strong>DoA display a reproducible, age-invariant cortical signature, consistent with a spatially organized failure of arousal integration: posterior sensorimotor and awareness circuits partially reactivate, while anterior executive and emotion-regulatory regions remain sleep-like. These spatiotemporal fingerprints position hd-EEG source analysis as a translational tool for mechanistically informed diagnostic and therapeutic development.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective Sleep Traits and Cognition Across Mid- to Late-Adulthood: A Cross-Sectional Study of Gene-Environment Interplay.","authors":"Tina T Vo-Eckerle, Nathan A Gillespie, Kaare Christensen, Deborah Finkel, William S Kremen, Marianne Nygaard, Perminder S Sachdev, Anbupalam Thalamuthu, Chandra A Reynolds","doi":"10.1093/sleep/zsag119","DOIUrl":"https://doi.org/10.1093/sleep/zsag119","url":null,"abstract":"<p><p>Genetic susceptibility to Alzheimer's disease (ad) may influence the extent to which environmental factors shape cognition, with individuals at higher genetic risk potentially exhibiting greater sensitivity to environmental exposures. Sleep, an important factor for both cognitive function and ad risk, may further moderate genetic influences (A), including both measured (AP) and latent (AL) components, as well as shared (C) and non-shared environmental (E) contributions to cognition. This study leveraged data from the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium (N = 3894; 1947 complete twin pairs, 842 monozygotic (MZ) pairs and 1105 dizygotic (DZ); Average age = 62.36 years, 38.75% female). Across six cognitive abilities, we examined whether an ad polygenic score (ad-PGS) moderated environmental influences on cognitive performance. We also examined whether sleep moderated genetic and environmental contributions on cognitive performance. Although the ad-PGS accounted for a negligible proportion of genetic variance as a main effect (B's = -0.004 to 0.02), we observed environment-by-PGS interactions. Increasing genetic risk for ad was associated with lower contributions from environmental experiences unique to each individual, on episodic memory, working memory, and verbal ability (B's = -0.03 to -0.05). These interaction effects, albeit small, were primarily observed with the ad-PGS including the APOE region. Hence, the role of person-specific environments on cognitive functioning was boosted for those at lower genetic risk for ad but reduced at greater genetic risk for ad. Although sleep moderation was minimal, results suggest that poorer sleep influences genetic influences on cognitive functioning.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147780900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Event-level nocturnal blood pressure dynamics in obstructive sleep apnea assessed by cuffless monitoring.","authors":"Woo-Seok Ha, Soomi Cho, Bo Kyu Choi, Min Kyung Chu, Kyung Min Kim, Won-Joo Kim","doi":"10.1093/sleep/zsag122","DOIUrl":"https://doi.org/10.1093/sleep/zsag122","url":null,"abstract":"<p><strong>Study objectives: </strong>Obstructive sleep apnea (OSA) contributes to abnormal blood pressure (BP) variability (BPV). While OSA has been linked to increased BPV using intermittent or cuff-based measurements, the hemodynamic responses to individual respiratory events remain poorly understood. We aimed to delineate event-level BP dynamics of OSA using a cuffless continuous monitoring device.</p><p><strong>Methods: </strong>We prospectively enrolled adults who underwent overnight polysomnography for suspected OSA. Continuous systolic and diastolic BPs were recorded using a validated cuffless photoplethysmography-based ring device. Time-stamped respiratory events (apnea and hypopnea) were annotated and synchronized with cardiovascular signals. We analyzed the BP, heart rate (HR), and oxygen saturation (SpO₂) trajectories relative to each respiratory event, and applied linear mixed-effects models to evaluate factors influencing BP changes. Participant-level BPV indices, including the standard deviation and average real variability, were calculated throughout the night.</p><p><strong>Results: </strong>A total of 12,724 respiratory events from 62 patients were analyzed. Events were followed by a consistent pattern: a BP dip during the event, followed by a rebound surge that peaked at 11.4 s post-event. This peak occurred after the HR peak (8.2 s) but before the SpO₂ nadir (14.7 s). In mixed-effects analyses, longer event duration, apnea (vs. hypopnea), and REM sleep were associated with larger BP fluctuations. At the participant-level, the mean upward duration of event-related BP surges correlated with the SpO₂ nadir.</p><p><strong>Conclusion: </strong>OSA induces BP fluctuations at the level of individual respiratory events. These findings demonstrate that OSA influences cardiovascular dynamics at event-level, beyond traditional measures of nocturnal BPV.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Polygenic scores in sleep research.","authors":"Juan J Madrid-Valero, Brad Verhulst, Juan R Ordoñana","doi":"10.1093/sleep/zsag086","DOIUrl":"https://doi.org/10.1093/sleep/zsag086","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Future of Periodic Limb Movements during Sleep: Beyond the PLMI.","authors":"Lourdes M DelRosso","doi":"10.1093/sleep/zsag121","DOIUrl":"https://doi.org/10.1093/sleep/zsag121","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Autopilot Dilemma: Can Algorithms Truly Replace the Clinician's Touch in Home Ventilation?","authors":"João Carlos Winck, Miguel Guia","doi":"10.1093/sleep/zsag120","DOIUrl":"https://doi.org/10.1093/sleep/zsag120","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic depletion of CD11b+ cells improves metabolic function in murine model of sleep apnea induced by intermittent hypoxia.","authors":"Abdelnaby Khalyfa, Sarfraz Ahmed, Zhuanhong Qiao, Rajan Lamichhane, David Gozal","doi":"10.1093/sleep/zsag117","DOIUrl":"https://doi.org/10.1093/sleep/zsag117","url":null,"abstract":"<p><p>Intermittent hypoxia (IH), a hallmark feature of obstructive sleep apnea (OSA), is associated with a range of physiological alterations that contribute to metabolic dysfunction and insulin resistance. IH induces adipose tissue inflammation and macrophages may play a key role in such homeostatic derangements. To examine the role of monocytes/macrophages in OSA, CD11b-diphtheria toxin receptor transgenic (DTR) mice were treated with diphtheria toxin (DT) to selectively eliminate these cells and assess changes in the metabolic function of IH-exposed mice. Transgenic homozygous male and female DTR mice were exposed to IH or room air (RA) for 6 weeks during which insulin sensitivity and other metabolic measures were assessed. Immunofluorescence analysis was performed for CD11b+ expression in metabolic tissues such as liver and visceral white adipose tissue (vWAT). Gene expression patterns associated with senescence-associated secretory phenotypes (SASPs) as well as adipokines and cytokines were evaluated. Depletion of CD11b+ cells in mice exposed to IH resulted in significant improvements in metabolic function and insulin sensitivity. Macrophage infiltration, assessed by F4/80 or CD11b immunostaining, was significantly reduced following CD11b ablation in IH exposed mice compared with controls in both males and females. Moreover, CD11b+ cell ablation led to a marked decrease in SASPs markers (p16 and Il-16) at both transcriptional and protein levels in vWAT and liver. Thus, depletion of CD11b+ cells in mice exposed to IH can significantly modulate the inflammatory response in multiple metabolic organs including visceral adipose tissues and markedly mitigate metabolic dysfunction. Targeted interventions aimed at some of the functional roles played by activated CD11b+ cells or SASPs within metabolic organs may improve metabolic regulation in OSA patients.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respond article to SLEEP-2026-0370.","authors":"Shuangyu Zhao, Jing Wang, Seyni Gueye-Ndiaye, Susan Redline","doi":"10.1093/sleep/zsag110","DOIUrl":"https://doi.org/10.1093/sleep/zsag110","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147780652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}