Sleep最新文献

{"title":"Physical Activity, Sedentary Time, and Sleep from Childhood to Young Adulthood: A Seven-Wave Cohort Study of Within-person Relations.","authors":"Seffetullah Kuldas, Bror Morten Ranum, Nils Petter Aspvik, Lars Wichstrøm, Silje Steinsbekk","doi":"10.1093/sleep/zsaf221","DOIUrl":"https://doi.org/10.1093/sleep/zsaf221","url":null,"abstract":"<p><strong>Study objectives: </strong>To determine whether within-person changes in total physical activity (PA), moderate-to-vigorous physical activity (MVPA), and sedentary time from ages 6 to 18 predict changes in sleep duration and insomnia symptoms, and vice versa.</p><p><strong>Methods: </strong>Seven waves of biennially collected data from a birth cohort study were used, capturing ages 6 to 18 years (N = 880). Every second year, objective data on PA, sedentary time, and sleep duration were collected using accelerometers, while insomnia symptoms were assessed through clinical interviews. Random Intercept Cross-Lagged Panel Models (RI-CLPMs) were estimated to test the within-person relations between PA/MVPA/sedentary time and sleep. Potential sex- and age-differences were also examined.</p><p><strong>Results: </strong>We found no evidence for within-person relations between the study variables, nor for any sex- or age-differences.</p><p><strong>Conclusions: </strong>Children and adolescents who become more physically active or spend less time in sedentary activities are probably not more likely to sleep longer or better than they typically would.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forecasting Psychomotor Vigilance Test Performance from Facial Videos.","authors":"Takashi Abe","doi":"10.1093/sleep/zsaf220","DOIUrl":"https://doi.org/10.1093/sleep/zsaf220","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rest-activity rhythms are stronger in Mexican American compared to Non-Hispanic White and Black participants: a cross-sectional study.","authors":"Clémence Cavaillès, Katie L Stone, Yue Leng, Kristine Yaffe","doi":"10.1093/sleep/zsaf219","DOIUrl":"https://doi.org/10.1093/sleep/zsaf219","url":null,"abstract":"<p><strong>Study objectives: </strong>This study aimed to investigate differences in rest-activity rhythms (RAR), key circadian rhythm markers, across race/ethnicity and sex in a diverse community-based cohort of older adults.</p><p><strong>Methods: </strong>We examined RAR (amplitude [strength of activity], mesor [level of activity], acrophase [time of peak activity], and pseudo-F [robustness of activity]) derived from the extended cosinor model based on ≥4 24-hour periods of wrist actigraphy among 856 participants (≥50 years) in the Dormir Study. We conducted linear and multinomial logistic regression models adjusted for socioeconomic status, health conditions, and sleep-related factors.</p><p><strong>Results: </strong>We studied 218 (28.8%) Black, 221 (29.2%) Mexican American (MA), and 317 (42.0%) non-Hispanic White (NHW) participants, with a mean age of 66.3 ± 8.4 years, and 66.8% women. Compared to NHW adults, MA participants exhibited healthier RAR, with lower odds of being in the lowest tertile for amplitude and mesor, and higher odds of being in the later tertile for acrophase. Black participants had lower odds of being in the earlier tertile for acrophase. Overall, women had better RAR values than men, with lower odds of being in the lowest tertile for amplitude and mesor, and higher odds of being in the later tertile for acrophase. Among subgroups, MA women exhibited the strongest RAR, while NHW men displayed the weakest patterns.</p><p><strong>Conclusions: </strong>RAR vary by race/ethnicity and sex, with MA participants and women exhibiting stronger rhythms. Further research is needed to understand if these different RAR patterns translate to other health outcomes and the mechanism underlying these differences.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide Gene by Sleepiness Interaction Analysis for Sleep Apnea.","authors":"Pavithra Nagarajan, Nuzulul Kurniansyah, Jiwon Lee, Sina A Gharib, Yushan Xu, Yiyan Zhang, Brian Spitzer, Tariq Faquih, Hufeng Zhou, Eric Boerwinkle, Han Chen, Daniel J Gottlieb, Xiuqing Guo, Nancy L Heard-Costa, Bertha A Hidalgo, Daniel Levy, Peter Y Liu, Hao Mei, Rebecca Montalvan, Sutapa Mukherjee, Kari E North, George T O'Conner, Lyle J Palmer, Sanjay R Patel, Bruce M Psaty, Shaun M Purcell, Laura M Raffield, Stephen S Rich, Jerome I Rotter, Richa Saxena, Albert V Smith, Katie L Stone, Xiaofeng Zhu, Brian E Cade, Tamar Sofer, Susan Redline, Heming Wang","doi":"10.1093/sleep/zsaf212","DOIUrl":"https://doi.org/10.1093/sleep/zsaf212","url":null,"abstract":"<p><strong>Study objectives: </strong>Excessive daytime sleepiness (EDS), influenced by environmental and social-behavioral factors, is reported by a subset of patients with sleep apnea - a group that may be at elevated cardiovascular risk. However, it is unclear whether sleep apnea with and without EDS have distinct genetic underpinnings. In this study, we perform gene-by-EDS interaction analyses for apnea hypopnea index (AHI), a diagnostic marker of sleep apnea severity, to understand EDS's influence on its underlying genetic risk.</p><p><strong>Methods: </strong>Discovery interaction analyses for common variants and gene-based rare variants were conducted respectively using multi-ethnic Trans-Omics for Precision Medicine (TOPMed) (N=11619) data, followed by replication and subsequent meta-analysis in additional TOPMed-imputed data (N=8904). The 1 degree-of-freedom (1df) GxE test and the 2df joint G, GxE tests were utilized. Sex-stratified analyses were additionally performed.</p><p><strong>Results: </strong>Discovery analysis revealed two common intronic variants- rs13118183 (CCDC3) and rs281851 (MARCHF1) - and three rare variant gene sets mapped to SCUBE2, TMEM26, and CPS4FL - to exhibit interaction with EDS. Meta-analysis revealed EDS interaction with 11 rare variant gene sets mapped to UBLCP1, MED31, RAP1GAP, CPNE5, MYMX, YY1, ZNF773, YBEY, IQCB1, PI4K2B, and CORO1A.</p><p><strong>Conclusion: </strong>Genetic loci reveal connections to cardiovascular risk, insulin resistance, thiamine deficiency, and resveratrol mechanism. Discovered genetic signals may offer insight into pertinent biological pathways for sleep apnea patients with an excessively sleepy subtype.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In pursuit of the cognitive functions of sleep spindles.","authors":"Rebecca M C Spencer","doi":"10.1093/sleep/zsaf217","DOIUrl":"https://doi.org/10.1093/sleep/zsaf217","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsupervised Machine Learning in Sleep Research: A Scoping Review.","authors":"Luka Biedebach, Daniela Ferreira-Santos, Marie-Ange Stefanos, Alva Lindhagen, Gabriel Natan Pires, Erna Sif Arnardóttir, Anna Sigridur Islind","doi":"10.1093/sleep/zsaf189","DOIUrl":"https://doi.org/10.1093/sleep/zsaf189","url":null,"abstract":"<p><strong>Study objectives: </strong>Unsupervised machine learning -an approach that identifies patterns and structures within data without relying on labels- has demonstrated remarkable success in various domains of sleep research. This underscores the broader utility of machine learning, suggesting that its capabilities extend beyond current applications and warrant further exploration for novel insights in sleep studies, focusing specifically on unsupervised machine learning.</p><p><strong>Methods: </strong>This paper outlines a scoping review conducted according to the PRISMA guidelines for scoping reviews. A comprehensive search covering various search terms focusing on the intersection between unsupervised machine learning and sleep led to 3960 publications. After screening all titles and abstracts with two independent reviewers, ultimately, 356 publications were included in the full-text review. The data extracted from the full-texts included information about the machine learning methods and types of sleep data, as well the the study population.</p><p><strong>Results: </strong>There has been a steep increase in the number of publications in this research area in the past 10 years. Clustering is the most commonly used method, but other methods are gaining popularity. Apart from classical polysomnography, data from wearable devices, nearables, video, audio, and medical imaging techniques have been used as input to unsupervised machine learning. The broad search allowed us to explore various applications within sleep research ranging from the general population to populations with various sleep disorders.</p><p><strong>Conclusion: </strong>The review mapped existing research on unsupervised learning in sleep research, identified gaps in the literature, and derived directions for future research.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between sleep parameters, cognitive functioning, and markers of brain morphology: The Maastricht Study.","authors":"Tessa L van Baal, Sebastian Köhler, Annemarie Koster, Ree M Meertens, Hans Bosma, Miranda T Schram, Jacobus F A Jansen, Sami O Simons, Bastiaan E de Galan, Simone J P M Eussen, Niels Janssen, Kay Deckers","doi":"10.1093/sleep/zsaf218","DOIUrl":"https://doi.org/10.1093/sleep/zsaf218","url":null,"abstract":"<p><strong>Study objectives: </strong>To examine the association of objective and subjective sleep parameters with cognitive functioning and markers of brain morphology.</p><p><strong>Methods: </strong>This cross-sectional study included 3360 participants (mean age: 59.5 ± 8.5 years; 51.1% female) from The Maastricht Study. Time in bed (TIB) and sleep breaks were objectively estimated using a thigh-worn accelerometer. Subjective sleep continuity was assessed via a single-item, and excessive daytime sleepiness was evaluated using the Epworth Sleepiness Scale. Cognitive testing was administered across three domains- memory, information processing speed, and executive functioning and attention. Markers of brain morphology (e.g., hippocampal volume, grey matter (GM) volume and white matter volume) were assessed with 3 Tesla magnetic resonance imaging. Linear and logistic regression analyses modelled the associations.</p><p><strong>Results: </strong>Longer TIB (h/night) was associated with worse executive functioning and attention (Blinear = -0.052, 95%CI = -0.084 to -0.019). Categorical analyses showed that a longer TIB (≥9 h/night) was associated with worse executive functioning and attention (B = -0.088, 95%CI = -0.166 to -0.010) compared to a mid-range TIB (≥7 to <9 h/night). A curvilinear association was found between TIB and lower GM volume (Bquadratic = -0.013, 95%CI = - 0.025 to -0.001). Sleep breaks (≥2/night) were associated with worse overall cognition (B = -0.069, 95%CI = -0.124 to -0.013), information processing speed (B = -0.125, 95%CI = -0.212 to -0.039), and reduced GM volume (B = -0.068, 95%CI = -0.118 to -0.018). No significant associations were found for memory or other markers of brain morphology. Subjective sleep parameters showed no associations with cognitive functioning or markers of brain morphology.</p><p><strong>Conclusions: </strong>Adequate and uninterrupted TIB was associated with better cognitive functioning and brain morphology.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of sleep-associated variants with wearable-derived sleep stages in the all of us research program.","authors":"Irene N Chan, Seyed Mehdi Nouraie, Stephen Y Chan, Neil J Kelly","doi":"10.1093/sleep/zsaf209","DOIUrl":"https://doi.org/10.1093/sleep/zsaf209","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms and suicidal thoughts in Idiopathic Hypersomnia: A cross-sectional and longitudinal study.","authors":"Lucie Barateau, Marie-Gwenaëlle Paryl, Sofiene Chenini, Carole Pesenti, Lily Giraud, Séverine Béziat, Isabelle Jaussent, Yves Dauvilliers","doi":"10.1093/sleep/zsaf215","DOIUrl":"https://doi.org/10.1093/sleep/zsaf215","url":null,"abstract":"<p><strong>Study objectives: </strong>To assess the frequency and factors associated with depressive symptoms, major depressive episode(MDE), suicidal thoughts and risk in patients with idiopathic hypersomnia(IH), a rare hypersomnolence disorder, compared to controls, and to evaluate their changes after management.</p><p><strong>Methods: </strong>Consecutive untreated adult IH patients, diagnosed in a Reference Center for Rare Hypersomnias, were compared to controls from the general population. All participants completed the Beck Depression Inventory-II(BDI-II), including one item on suicidal thoughts. Patients underwent standardized evaluations with polysomnography(PSG), completed the IH Severity Scale(IHSS), and self-questionnaires on fatigue, anxiety and quality of life(QoL). A subgroup underwent the face-to-face Mini-International Neuropsychiatric Interview (MINI), to diagnose past/current MDE and identify suicidal risk.Another subgroup completed the BDI-II again during follow-up, after months of stable treatment.</p><p><strong>Results: </strong>729 participants were included: 265 IH(30.6 ± 9.7yo) and 464 controls(30.5 ± 10.1yo) with no differences in age, sex or body mass index. Patients had higher odds of moderate/severe depressive symptoms (OR = 7.68;95CI = [4.31;13.7],p<.0001) and suicidal thoughts (OR = 1.68[1.05;2.68],p=.03).Patients with moderate/severe BDI-II scores had more severe IH symptoms, more anxiety, fatigue and lower QoL, without PSG differences. Suicidal thoughts were associated with more anxiety and severe IH symptoms. Patients evaluated by MINI(n = 175) had current MDE in 8%, past MDE in 44% and suicidal risk in 18.6%.In the 111 patients re-evaluated after treatment, BDI-II scores and fatigue decreased, QoL improved, but suicidal thoughts and anxiety remained unchanged.</p><p><strong>Conclusions: </strong>Depressive symptoms, past depressive episodes, suicidal ideation and risk were frequent in IH. Depressive symptoms and suicidal thoughts were associated with IH severity.IH management decreased depressive symptoms without effect on suicidal thoughts.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal circadian desynchronization disrupts sleep and prefrontal cortex function in adult offspring.","authors":"Brandon L Roberts, Jiexin Wang, Haifa Chargui, Nathan C Cupertino, Walker Sorensen, Ilia N Karatsoreos","doi":"10.1093/sleep/zsaf210","DOIUrl":"https://doi.org/10.1093/sleep/zsaf210","url":null,"abstract":"<p><p>Sleep and circadian rhythms impact nearly all aspects of physiology and are critical for optimal organismal function. Disruption of the clock can lead to significant metabolic disorders, neuropsychiatric illness, and cognitive dysfunction. Our lab has shown that environmental circadian desynchronization (ECD) in adults alters the anatomical structure and neurophysiological function of prefrontal cortex (PFC) neurons, PFC mediated behaviors, and sleep quality. As the PFC undergoes significant development in utero and early life, and maternal disturbances during this period can have significant long-term ramifications, we hypothesized that disrupting the circadian environment during the perinatal period would alter sleep and PFC function in adult offspring. Using a mouse model of ECD we investigated how perinatal ECD (pECD) modulates sleep quality in adult offspring. We also determined how pECD impacts PFC neural function in adult offspring using ex vivo patch-clamp electrophysiology, exploring how pECD alters synaptic function and action potential dynamics. We found that male pECD mice trended toward increased total sleep during the inactive (light) period with shorter sleep bouts during the active (dark) period, with no changes in female mice. Independent of time of day, pECD altered post-synaptic dynamics of excitatory release onto PFC pyramidal neurons. There was also a loss of time-of-day effects on cell endogenous properties in male pECD mice. Thus, pECD clearly alters sleep behavior and PFC function in male mice. However, female mice appear protected against the effects of pECD. Together, these experiments form the foundation for future studies to understand the lifelong neurobehavioral impact of pECD.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}