Sleep最新文献 - Book学术

The Tasmania-London (TASLON) protocol to detect isolated REM sleep behaviour disorder using home-based video-polysomnography. 塔斯马尼亚-伦敦（TASLON）协议使用基于家庭的视频多导睡眠仪检测孤立的快速眼动睡眠行为障碍。

IF 4.9 2区医学

Sleep Pub Date : 2025-10-07 DOI: 10.1093/sleep/zsaf313

Samantha Bramich, Alastair J Noyce, Anna E King, Séan Higgins, Cristina Simonet, Aidan Bindoff, Sharon L Naismith, James C Vickers, Laura Pérez-Carbonell, Jane Alty

{"title":"The Tasmania-London (TASLON) protocol to detect isolated REM sleep behaviour disorder using home-based video-polysomnography.","authors":"Samantha Bramich, Alastair J Noyce, Anna E King, Séan Higgins, Cristina Simonet, Aidan Bindoff, Sharon L Naismith, James C Vickers, Laura Pérez-Carbonell, Jane Alty","doi":"10.1093/sleep/zsaf313","DOIUrl":"https://doi.org/10.1093/sleep/zsaf313","url":null,"abstract":"Study objectives: Isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is an early manifestation of alpha-synuclein-related neurodegenerative diseases (NDD). There is an average delay in iRBD diagnosis of 9 years from the onset of symptoms, showing that we need easier methods of detection to improve access to specialist care and potential disease modifying clinical trials. We designed a multi-step approach to detect iRBD in a community of older adults (≥50 years) in Tasmania, Australia using home-based video-polysomnography (vPSG).Methods: The Tasmania-London (TASLON) protocol for iRBD detection comprised 3 key steps: participants completed an online iRBD screening question; those who screened positive were invited to undertake the TASLON iRBD Screening Interview by telephone; a sample then completed a home-based vPSG based on iRBD screening risk level.Results: A total of 2891 participants (mean [SD] age 64 [7.7] years; 74% female) without any known NDD were recruited from throughout Tasmania. 267 (9%; age 63[7.7] years; 55% female) were identified as having 'probable' RBD through positive online screening; 87 (33%) agreed to complete the clinical screening interview; 47 (55%) underwent home-based vPSG; and 21 (45%; age 68[7] years; 52% female) were found to have iRBD.Conclusions: The TASLON protocol is a feasible method of improving timely access to iRBD diagnoses in the community. It streamlines the path to vPSG by identifying those at highest risk of iRBD, thus improving access to diagnostic testing and clinical trial opportunities for those who otherwise may not have been identified.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Deprivation Adds an "I" in "Team". 睡眠剥夺在“团队”中增加一个“我”。

IF 4.9 2区医学

Sleep Pub Date : 2025-10-07 DOI: 10.1093/sleep/zsaf314

Allison J Brager, Ankur Kumar Tanwar

引用次数: 0

From Hypoxia to Hepatic Injury: Obstructive Sleep Apnea as a Driver of Liver Fibrosis. 从缺氧到肝损伤：阻塞性睡眠呼吸暂停是肝纤维化的驱动因素。

IF 4.9 2区医学

Sleep Pub Date : 2025-10-07 DOI: 10.1093/sleep/zsaf311

Omar Kanbr, Siraj Omar Wali

引用次数: 0

IF 4.9 2区医学

Sleep Pub Date : 2025-10-04 DOI: 10.1093/sleep/zsaf310

Neda Esmaeili, Sayaka Aritake, Susan Redline, John W Winkelman, Ali Azarbarzin

{"title":"Respiratory-Related Leg Movement as a predictor of mortality: the Osteoporotic Fractures in Men (MrOS) sleep study.","authors":"Neda Esmaeili, Sayaka Aritake, Susan Redline, John W Winkelman, Ali Azarbarzin","doi":"10.1093/sleep/zsaf310","DOIUrl":"https://doi.org/10.1093/sleep/zsaf310","url":null,"abstract":"Study objectives: Respiratory event-related leg movements (RRLMs) in obstructive sleep apnea (OSA) may reflect event severity and predict adverse outcomes. This study examines the association between RRLM frequency and mortality.Methods: A sample of 571 men (median [IQR] age: 76.0 [72.0-81.0] years; BMI: 28.0 [25.0-30.0] kg/m2) with an apnea-hypopnea index (AHI, ≥3% desaturation) ≥10 events/hour was selected based on available incident data and annotations of RRLMs, from the Osteoporotic Fractures in Men (MrOS) studies. RRLMs were scored if they occurred within ±5 seconds of respiratory event termination lasting 0.5-10 seconds; the average number of RRLMs per hour of sleep (RRLMI) was measured. For comparison, the number of periodic leg movements (PLMS) per hour of sleep (PLMI) was also quantified. Cox regression models estimated the adjusted hazard ratios (aHR) for mortality per SD increase in RRLMI and PLMI. Secondary analyses assessed the relationship between RRLM duration (i.e. a measure of RRLM strength) and measures of event severity (i.e. desaturation area, arousal, heart rate response, and event duration).Results: There were 287 all-cause deaths during 11.4[6.9;12.5] years of follow-up. RRLMI and PLMI were 6.0[3.4;9.3] and 22.0[2.0;54.0] events/hour, respectively. In an adjusted model, every 1SD increase in RRLMI was associated with all-cause mortality (aHR:1.17[95% CI:1.01-1.34], p-value=0.03). In contrast, PLMI was not associated with mortality (aHR:1.04[95% CI:0.92-1.17], p-value=0.5). Furthermore, RRLM duration was linked to measures of event severity.Conclusions: In a sample of older men with OSA, RRLMI was independently associated with all-cause mortality, whereas PLMI was not, though confirmatory studies are needed.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simplified and Accurate Approach to Sleep Disorder Prediction Using Body Composition Metrics: A Development and Validation Study. 使用身体成分指标预测睡眠障碍的简化和准确方法：一项开发和验证研究。

IF 4.9 2区医学

Sleep Pub Date : 2025-10-04 DOI: 10.1093/sleep/zsaf312

Olive R Cawiding, Heewon Bae, Jee Hyun Kim, Eun Yeon Joo, Jae Kyoung Kim

{"title":"Simplified and Accurate Approach to Sleep Disorder Prediction Using Body Composition Metrics: A Development and Validation Study.","authors":"Olive R Cawiding, Heewon Bae, Jee Hyun Kim, Eun Yeon Joo, Jae Kyoung Kim","doi":"10.1093/sleep/zsaf312","DOIUrl":"https://doi.org/10.1093/sleep/zsaf312","url":null,"abstract":"Predicting the risk of sleep disorders such as insomnia, obstructive sleep apnea (OSA), and comorbid insomnia and sleep apnea (COMISA) typically requires costly and time-consuming assessments. The SLEEPS algorithm simplifies this process using only nine questions, including body mass index (BMI). However, BMI alone cannot capture differences in body composition, as individuals with the same BMI may have different muscle and fat distribution. This study aims to improve sleep disorder prediction by incorporating body composition metrics. To achieve this, we applied a tree-based machine learning algorithm to a dataset of 3,291 patients, evaluating demographic data, sleep-related questions, and body composition metrics as potential features for the model. The final feature selection was performed using Shapley additive explanations (SHAP) method. The resulting model, I-SLEEPS (InBody-based SimpLE quEstionnairE Predicting Sleep disorders), used a total of 10 features, including skeletal muscle index (SMI) and fat-free mass index (FFMI) instead of BMI, along with the original SLEEPS questionnaire items. I-SLEEPS achieved superior predictive accuracy (AUROC > 0.93 for insomnia, OSA, and COMISA) compared to SLEEPS (AUROC > 0.90). Additionally, our approach significantly enhanced area under the precision-recall curve (AUPRC) values, which is critical for addressing the imbalanced datasets of insomnia and COMISA. Furthermore, our analysis revealed distinct relationships between muscle mass indices (SMI and FFMI) and the risks of insomnia, OSA, and COMISA, providing new insights into the role of body composition in sleep disorders. By leveraging InBody analysis, I-SLEEPS offers a practical, non-invasive alternative to traditional screening methods such as polysomnography.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional implications of sleeping little in the wild. 野外少睡的功能含义。

IF 4.9 2区医学

Sleep Pub Date : 2025-10-04 DOI: 10.1093/sleep/zsaf309

Niels C Rattenborg

引用次数: 0

Time to Regularize Sleep Regularity. 是时候调整睡眠规律了。

IF 4.9 2区医学

Sleep Pub Date : 2025-10-04 DOI: 10.1093/sleep/zsaf289

Jonathan Cedernaes, Bettina Sielaff, Christian Benedict

引用次数: 0

Feeding the night shift: Timing, cortisol, and what to do next. 喂夜班：时间，皮质醇，以及下一步该怎么做。

IF 4.9 2区医学

Sleep Pub Date : 2025-10-02 DOI: 10.1093/sleep/zsaf307

Minghui Wang, Marie-Pierre St-Onge

引用次数: 0

On the mechanisms of dopamine receptor agonists in restless legs syndrome. 多巴胺受体激动剂治疗不宁腿综合征的机制探讨。

IF 4.9 2区医学

Sleep Pub Date : 2025-09-29 DOI: 10.1093/sleep/zsaf305

Sergi Ferré, Diego García-Borreguero, Christopher J Earley

{"title":"On the mechanisms of dopamine receptor agonists in restless legs syndrome.","authors":"Sergi Ferré, Diego García-Borreguero, Christopher J Earley","doi":"10.1093/sleep/zsaf305","DOIUrl":"https://doi.org/10.1093/sleep/zsaf305","url":null,"abstract":"Several dopaminergic compounds, including the clinically used pramipexole, are labelled as preferential dopamine D3 receptor (D3R) agonists based on their moderately higher affinity for the D3R versus other D2-like receptor subtypes. It is therefore generally believed that D3R is the main target for their initial therapeutic response in restless legs syndrome (RLS). Here, we review the results of recent comprehensive pharmacological studies that demonstrate that in addition to their binding affinities, their functional responses at the different D2-like receptors depend on other pharmacodynamic factors, including intrinsic efficacy, biased agonism, functional efficacy and receptor heteromerization, and pharmacokinetic factors, including brain penetrability. When considering all these factors, the short isoform of the D2 receptor (D2SR) localized in the dopaminergic neurons and D2SRs and D4Rs localized in corticostriatal glutamatergic terminals become preferential targets of low doses of these D2-like receptor agonists. On the other hand, higher doses are necessary to promote activation of postsynaptic striatal D3Rs forming heteromers with D1Rs, which can be associated with the phenomenon of augmentation, the worsening of the RLS symptoms with their chronic use. The putative role of spinal D3Rs, specially with the periodic leg movements of sleep (PLMS) component of RLS, is also discussed. This analysis should provide therapeutic clues for a better targeting of the dopamine receptor subtypes involved in the therapeutic and not in the secondary effects of D2-like receptor agonists in RLS.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of CPAP on Weight Gain and Metabolism: Time for The Muscles to Step In!!! CPAP对体重增加和新陈代谢的影响：是时候让肌肉参与进来了！！

IF 4.9 2区医学

Sleep Pub Date : 2025-09-29 DOI: 10.1093/sleep/zsaf302

Akira Umeda, David Gozal

引用次数: 0