Sleep最新文献

{"title":"SIK3 isoforms and PKA phosphorylation sites differentially regulate sleep and circadian rhythms.","authors":"Minjeong Park, Aya Ikkyu, Kei Nishida, Noriko Hotta-Hirashima, Miyo Kakizaki, Tomoyuki Fujiyama, Shinya Nakata, Takato Honda, Jing Ma, Zhiqiang Wang, Satomi Kanno, Seiya Mizuno, Satoru Takahashi, Chika Miyoshi, Masashi Yanagisawa, Hiromasa Funato","doi":"10.1093/sleep/zsag244","DOIUrl":"https://doi.org/10.1093/sleep/zsag244","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep is regulated by conserved kinase signaling pathways, yet how specific molecular variants encode sleep need, sleep intensity, and circadian timing remains unclear. We investigated the functional specialization of SIK3 isoforms and protein kinase A (PKA)-phosphorylation sites in mouse sleep/wake and circadian regulation.</p><p><strong>Methods: </strong>We first generated isoform-selective Sik3 knock-in mice expressing either the 150 kDa or 70 kDa SIK3 isoform. To determine the isoform-specific effects of the Sleepy (Slp) mutation, which causes exon 13 skipping and deletes a region containing S551, we introduced the mutation separately into the 150 kDa-specific or 70 kDa-specific allele. In addition, we generated knock-in mice carrying alanine substitutions at the PKA-phosphorylation sites T469, S551, or S674. Sleep/wake states were quantified by EEG/EMG recording, and circadian behavior was assessed by wheel-running under light-dark and constant-dark conditions.</p><p><strong>Results: </strong>The mouse brain expressed two major SIK3 isoforms: a 150 kDa isoform and a 70 kDa isoform generated by intron 14 retention. Isoform-selective knock-in analyses showed that the 150 kDa isoform was required for normal wakefulness at dark onset and circadian period regulation, whereas the 70 kDa isoform contributed predominantly to NREM sleep EEG delta power. Introducing the Sleepy mutation into either isoform increased NREM sleep time and delta power. Alanine substitution of T469 or S551, but not S674, produced a Sleepy-like hypersomnia phenotype.</p><p><strong>Conclusion: </strong>Partially separable molecular features of SIK3, including its isoforms and phosphorylation sites, contribute to sleep and circadian regulation.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG spectral analysis of nighttime sleep and daytime MSLTs and neurocognitive evaluations in obstructive sleep apnea patients with residual sleepiness.","authors":"Yuan Shi, Xujun Feng, Fei Lei, Siqi Guan, Zhaohua Chen, Yihui Zhang, Xiaomin Zhang, Yuting Jiang, Yang Yang, Longhua Sun, Michael V Vitiello, Xiangdong Tang","doi":"10.1093/sleep/zsag241","DOIUrl":"https://doi.org/10.1093/sleep/zsag241","url":null,"abstract":"<p><strong>Study objectives: </strong>To explore neurophysiological and neurocognitive characteristics of OSA patients with residual excessive sleepiness (RES) using EEG spectral analysis and multidimensional cognitive assessments.</p><p><strong>Methods: </strong>This case-control study included 76 participants (38 RES, 38 Non-RES) from our RES cohort. Polysomnography (PSG) and multiple sleep latency tests (MSLTs) were recorded and used to obtain relative EEG spectral power. A series of standard neurocognitive assessments were conducted during the first MSLT interval (approximately 09:00-11:00 AM).</p><p><strong>Results: </strong>In PSG and MSLTs, RES patients showed increased delta and theta power and decreased alpha and beta power (all FDR-adjusted q<0.05). RES patients demonstrated multidimensional cognitive impairments, including longer WCST reaction time (mean difference [MD] = -642.71 ms, 95% CI: -1045.70 to -239.72, p = 0.002, partial η2 = 0.130), longer SCWT color-word reaction time (MD = -16.02 s, 95% CI: -25.32 to -6.71, p = 0.001, partial η2 = 0.148), and more PVT lapses (MD = -3.65, 95% CI: -5.28 to -2.03, p < 0.001, partial η2 = 0.228). The EEG spectral patterns of increased delta-theta power and decreased alpha-beta power were significantly associated with impairments in executive function, processing speed, working memory and selective attention, while the decreased alpha-beta power was more related to impairment of vigilance and sustained attention.</p><p><strong>Conclusions: </strong>RES patients exhibit a characteristic EEG power spectrum marked by increased delta-theta and decreased alpha-beta power values, indicating sleep-wake dysregulation. RES patients also demonstrate multidimensional cognitive impairments, including deficits in processing speed, working memory, attention, and executive function, with distinct neurophysiological correlates.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep difficulties in autistic adults: high prevalence, low evidence, urgent need.","authors":"Amanda L Richdale, Eric M J Morris","doi":"10.1093/sleep/zsag230","DOIUrl":"https://doi.org/10.1093/sleep/zsag230","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Compositional Approach Towards Understanding Recovery Sleep Dynamics.","authors":"David Negelspach, Alisa Huskey, Kathryn E R Kennedy, Jungwon Cha, Daniel B Forger, William D S Killgore","doi":"10.1093/sleep/zsag242","DOIUrl":"https://doi.org/10.1093/sleep/zsag242","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ups and downs of heart rate during sleep: a source of heterogeneity in individuals with obstructive sleep apnoea.","authors":"Gian Domenico Pinna, Elena Robbi, Francesco Fanfulla, Anna Eugenia Taurino, Maria Teresa La Rovere, Maria R Bonsignore, Roberto Maestri","doi":"10.1093/sleep/zsag239","DOIUrl":"https://doi.org/10.1093/sleep/zsag239","url":null,"abstract":"<p><strong>Study objectives: </strong>The heart rate (HR) of patients with obstructive sleep apnea (OSA) exhibits cyclical variation during sleep-disordered breathing (SDB), decreasing during apnoeas/hypopnoeas and increasing abruptly when air exchange resumes. It is not yet known whether this variation exceeds spontaneous HR variation during periods without SDB (noSDB), thereby giving rise to measurable chronotropic effects. This study aimed to address this knowledge gap by comparing the distribution of HR during SDB and noSDB.</p><p><strong>Methods: </strong>Instantaneous HR was derived from the ECG signal recorded during standard polysomnography in 135 patients with moderate-to-severe OSA. HR distributions during noSDB and SDB were characterized using a set of relevant percentiles and probabilities for each state. Four dominant chronotropic effects were defined based on changes in these descriptors from noSDB to SDB: bradycardic (B), tachycardic (T), bradycardic and tachycardic (B-T), and neither (noB-T).</p><p><strong>Results: </strong>15.5%, 48.9%, 32.6%, and 3.0% of the patients were classified into groups B, T, noB-T and B-T (excluded due to negligible sample size). The frequency of troughs below spontaneous HR variation was higher in group B than in groups T and noB-T (p<0.0001). Furthermore, patients in group B had a higher apnoea/hypopnoea index (p<0.01), oxygen desaturation index (p<0.01) and hypoxic burden (p<0.05). There was no significant difference in age, sex, or BMI between the groups.</p><p><strong>Conclusions: </strong>Patients with OSA exhibit clear heterogeneity in the overall chronotropic effects elicited by respiratory events. These different responses are associated with different degrees of OSA severity and hypoxic burden, although anthropometric and clinical characteristics remain consistent.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain MRI Changes Following Continuous Positive Airway Pressure Therapy in Adults with Obstructive Sleep Apnea: A Systematic Review.","authors":"Maryam Jalali, Maziar Jalalvandi, Atefeh Tahmasebzadeh, Mahdi Mohammadi","doi":"10.1093/sleep/zsag240","DOIUrl":"https://doi.org/10.1093/sleep/zsag240","url":null,"abstract":"<p><strong>Study objectives: </strong>Obstructive sleep apnea (OSA) is associated with structural, microstructural, functional, vascular, and metabolic brain alterations. Continuous positive airway pressure (CPAP) is the first-line treatment for OSA, but whether OSA-related abnormalities on brain magnetic resonance imaging (MRI) improve after treatment remains uncertain. This systematic review synthesized longitudinal MRI evidence on brain changes following CPAP therapy in adults with OSA.</p><p><strong>Methods: </strong>PubMed/MEDLINE, Scopus, and Web of Science were searched from database inception to December 2025. Eligible studies included adults with OSA who underwent brain MRI before and after CPAP therapy or were compared with untreated, sham-treated, best-supportive-care, or healthy control groups. MRI outcomes included structural, diffusion, functional, perfusion, cerebrovascular reactivity, magnetic resonance spectroscopy, susceptibility-related, and perivascular-space measures. Risk of bias was assessed using an adapted Newcastle-Ottawa Scale. Findings were synthesized qualitatively because of substantial heterogeneity.</p><p><strong>Results: </strong>Thirty studies were included. Reported post-CPAP MRI changes were heterogeneous and included gray matter or cortical alterations, white matter microstructural changes, modified functional connectivity and regional activity, perfusion or cerebrovascular reactivity changes, and preliminary metabolic, susceptibility-related, and perivascular-space findings. Results varied across MRI techniques, anatomical targets, CPAP duration, adherence definitions, comparator groups, and analytical methods.</p><p><strong>Conclusions: </strong>The available longitudinal MRI literature suggests possible domain-specific brain changes after CPAP, but the evidence is largely exploratory because most studies were small and nonrandomized and used heterogeneous imaging and analytical approaches. The findings do not establish reproducible MRI treatment effects or support routine MRI monitoring of individual response. Larger, prospectively specified, harmonized longitudinal studies are needed.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A time for change: actigraphy in the age of consumer wearables.","authors":"Jamie M Zeitzer","doi":"10.1093/sleep/zsag238","DOIUrl":"https://doi.org/10.1093/sleep/zsag238","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep in Context.","authors":"Christian Benedict","doi":"10.1093/sleep/zsag236","DOIUrl":"https://doi.org/10.1093/sleep/zsag236","url":null,"abstract":"<p><p>Sleep has undergone a remarkable shift in scientific and public perception, moving from a relatively overlooked biological process to a widely recognized component of health. This growing recognition reflects substantial advances in sleep science, but it has also created a translational challenge: while contemporary research increasingly recognizes sleep as a multidimensional and context-dependent construct, these nuances can be attenuated as findings are communicated to clinicians, policymakers, commercial stakeholders, and the public. This Perspective examines how sleep can be promoted as an important component of health without overstating its effects or presenting it as a universal solution to complex health problems. It argues for communication approaches that preserve evidentiary nuance, acknowledge relevant uncertainty, and situate sleep within the broader behavioral, biological, social, and environmental contexts that shape its relationship with health. Such communication can help ensure that the growing prominence of sleep evolves into a mature and appropriately contextualized component of health, rather than simply becoming the latest target of health optimization and overstatement.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slow-Wave Sleep Mediates the Compensatory Effects of Acute Moderate-Intensity Exercise on Declarative Memory Deficits in Sleep Restriction.","authors":"Emmanuel Frimpong, Melodee Mograss, Jocelyn Dautet-Plourde, Nicole Milbrath, Francois Pointeau, Manlu Xu, Ngoc Long Khang Nguyen, Tehila Zvionow, Mylene Aubertin-Leheudre, Louis Bherer, Veronique Pepin, Edwin Robertson, Arsenio Paez, Thien Thanh Dang-Vu","doi":"10.1093/sleep/zsag235","DOIUrl":"https://doi.org/10.1093/sleep/zsag235","url":null,"abstract":"<p><p>Insufficient sleep impairs cognition, particularly hippocampal-dependent memory. However, effective strategies for addressing these effects in humans remain limited. Physical exercise enhances slow-wave sleep (SWS) and improves memory performance, suggesting it may provide a physiologically grounded buffer against sleep-loss-related memory deficits. Here, we tested whether a single session of moderate-intensity exercise may protect long-term declarative memory following sleep restriction, and whether SWS mediates this effect. Eighty-eight healthy young adults (52% female; 24.0 ± 3.8 years) were randomly assigned to one of four groups based on exercise and sleep opportunity: average sleep (S8: 8.5 hours/night), sleep restriction (S5: 4.5 hours/night), exercise before average sleep (ExS8), and exercise before sleep restriction (ExS5). Participants completed either a 30-min evening moderate-intensity cycling (7:00 p.m.; 55-60% VO₂max) or seated rest prior to learning 80 face-name pairs (10:00 p.m.), followed by immediate and delayed recall (120 face-name pairs: 80 studied, 40 novel) after polysomnography-recorded sleep. We found a significant exercise × sleep interaction for delayed recall performance (discriminability index, d'; p = 0.033, partial η2 = 0.056). The delayed recall d' of the ExS5 was significantly higher than the S5 (p = 0.028), but was comparable to S8 and ExS8 groups (ps > 0.05). The proportion of SWS mediated the association between exercise and delayed recall d' (B = 0.105, SE = 0.091, 95% bootstrap CI (0.073, 0.924)). These findings indicate that acute moderate-intensity exercise is associated with offsetting the negative impact of sleep restriction on long-term declarative memory in sleep restriction, an effect statistically mediated by SWS percentage.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep, mood, and the menstrual cycle: advancing precision care in women's health.","authors":"Magalie Carey, Margaret Blattner","doi":"10.1093/sleep/zsag223","DOIUrl":"https://doi.org/10.1093/sleep/zsag223","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}