Sleep最新文献

{"title":"Sleep architecture and dementia risk in adults: An analysis of 5 cohorts from the Sleep and Dementia Consortium.","authors":"Stephanie Yiallourou, Andree-Ann Baril, Crystal Wiedner, Jeffrey R Misialek, Christopher E Kline, Stephanie Harrison, Ethan Cannon, Qiong Yang, Rebecca Bernal, Alycia Bisson, Dibya Himali, Marina Cavuoto, Antoine Weihs, Alexa Beiser, Rebecca F Gottesman, Yue Leng, Oscar Lopez, Pamela L Lutsey, Shaun M Purcell, Susan Redline, Sudha Seshadri, Katie L Stone, Kristine Yaffe, Sonia Ancoli-Israel, Qian Xiao, Eleni Okeanis Vaou, Jayandra J Himali, Matthew P Pase","doi":"10.1093/sleep/zsaf129","DOIUrl":"https://doi.org/10.1093/sleep/zsaf129","url":null,"abstract":"<p><strong>Study objectives: </strong>Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship between sleep architecture and dementia incidence across five US-based cohort studies from the Sleep and Dementia Consortium (SDC).</p><p><strong>Methods: </strong>Percent of time spent in stages of sleep (N1, N2, N3, REM sleep), wake after sleep onset, sleep maintenance efficiency, apnea hypopnea index and relative delta power were derived from a single night home-based PSG. Dementia was ascertained in each cohort using its cohort-specific criteria. Each cohort performed Cox proportional hazard regressions for each sleep exposure and incident dementia, adjusting for age, sex, body mass index, anti-depressant use, sedative use, and APOE e4 status. Results were then pooled in random effects model.</p><p><strong>Results: </strong>The pooled sample comprised 4,657 participants (30% women) aged ≥60 years (mean age was 74 years at sleep assessment). There were 998 (21.4%) dementia cases (median follow-up time of 5 to 19 years). Pooled effects of the five cohorts showed no association between sleep architecture and incident dementia. When pooled analysis was restricted to the three cohorts which had dementia case ascertainment based on DSM-IV/V criteria (n=2,374), higher N3% was marginally associated with an increased risk of dementia (HR: 1.06; 95%CI: 1.00-1.12, per percent increase N3, p=0.050).</p><p><strong>Conclusions: </strong>There were no consistent associations between sleep architecture measured and the risk of incident dementia. Implementing more nuanced sleep metrics and examination of associations with dementia sub-types remains an important next step for uncovering more about sleep-dementia associations.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep as a Window into Brain Health: Clinical Implications of Sleeping Brain Wave-Structure Associations.","authors":"Haoqi Sun, Wolfgang Ganglberger, M Brandon Westover, Robert J Thomas","doi":"10.1093/sleep/zsaf127","DOIUrl":"https://doi.org/10.1093/sleep/zsaf127","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing Iron to the Brain for Restless Legs.","authors":"Michael H Silber","doi":"10.1093/sleep/zsaf128","DOIUrl":"https://doi.org/10.1093/sleep/zsaf128","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Exploding head syndrome- It's not as benign as we think, with the company it keeps\".","authors":"Gautam Ganguly","doi":"10.1093/sleep/zsaf044","DOIUrl":"10.1093/sleep/zsaf044","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and impact of exploding head syndrome in a Japanese working population.","authors":"Uyanga Tsovoosed, Yukiyoshi Sumi, Yuji Ozeki, Akiko Harada, Hiroshi Kadotani","doi":"10.1093/sleep/zsaf007","DOIUrl":"10.1093/sleep/zsaf007","url":null,"abstract":"<p><strong>Study objectives: </strong>Exploding head syndrome (EHS) is a parasomnia characterized by the perception of loud noises, or explosions inside the head during the sleep-to-wake transition. The prevalence of EHS remains unclear. This survey aimed to elucidate the prevalence of and factors associated with EHS in this cohort.</p><p><strong>Methods: </strong>As part of the Night in Japan Home Sleep Monitoring Study (NinjaSleep study), a cross-sectional survey was conducted among government employees in Koka City, Shiga Prefecture, Japan, in 2022. Participants were queried regarding their experiences with EHS as defined in the International Classification of Sleep Disorders, 3rd Edition, including sudden loud noises or sensations of explosions, subsequent abrupt awakenings and feelings of fright. Various standardized instruments were employed to evaluate depression, anxiety, insomnia, quality of life, and fatigue.</p><p><strong>Results: </strong>Of the 2081 employees invited to participate, 1878 completed the survey. After excluding respondents with epilepsy and incomplete responses, 1843 participants were deemed eligible for analysis. Among them, 46 (2.49%) reported experiencing sudden noises or sensations of explosions, with 23 (1.25%) meeting the diagnostic criteria for EHS. The EHS was significantly related to the scores on the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Athens insomnia scale, and Chalder fatigue scale, even after adjusting for age, sex, body mass index, and categorized mean sleep duration.</p><p><strong>Conclusion: </strong>This study elucidates the prevalence of EHS among the Japanese population and underscores its potential association with insomnia symptoms and various psychological factors.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TCF4's role in sleep/wake state and sleep function.","authors":"Robert Greene","doi":"10.1093/sleep/zsaf049","DOIUrl":"10.1093/sleep/zsaf049","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekend sleep extension, social jetlag, and incidence of coronary calcium score: the ELSA-Brasil study.","authors":"Érique J F Peixoto de Miranda, Barbara K Parise, Ronaldo B Santos, Soraya Giatti, Aline N Aielo, Lorenna F Cunha, Wagner A Silva, Silvana P Souza, Paulo A Lotufo, Isabela M Bensenor, Márcio S Bittencourt, Luciano F Drager","doi":"10.1093/sleep/zsaf039","DOIUrl":"10.1093/sleep/zsaf039","url":null,"abstract":"<p><strong>Study objectives: </strong>Insufficient/irregular sleep patterns are common conditions, but their cardiovascular consequences and strategies to minimize these risks are poorly explored. We aimed to determine whether weekend sleep extension (catch-up sleep) and social jetlag may impact the incidence of subclinical atherosclerosis.</p><p><strong>Methods: </strong>We performed a 7-day wrist actigraphy in this cohort study to monitor sleep parameters. Coronary artery calcium (CAC) was measured at two different time points. Catch-up-sleep was measured by calculating weekend minus weekday sleep duration. Social jetlag was calculated by the difference between the mean sleep midpoint on weekend days minus weekdays. The incidence of subclinical atherosclerosis was defined as baseline CAC = 0, followed by CAC > 0 at the follow-up. The association of incident CAC outcome was assessed using logistic regression adjusting for traditional confounders plus sleep apnea.</p><p><strong>Results: </strong>We analyzed 1832 participants (age: 48.8 ± 8.0 years; 57.8% women). Incidence of CAC among subjects with catch-up sleep >90 and ≤90 minutes were 19.1% vs. 31.7%, respectively (p < .001). In covariate-adjusted analyses (follow-up = 5.4 ± 0.90 years), we found a lower incidence of CAC in those participants with catch-up-sleep > 90 minutes (odds ratio [OR] = 0.62; 95% confidence interval [CI] 0.52-0.74). Interestingly, stratified analysis revealed that these results are modified by sleep duration (≤6.55 hours: OR = 0.42; 95% CI 0.33-0.54; > 6.55 hours: OR = 0.96; 95% CI 0.75-1.24). In contrast, social jet lag was weakly associated with incident CAC: 0.1% increasing risk/minute.</p><p><strong>Conclusions: </strong>Extending sleep time during the weekend is independently associated with lower 5-year CAC incidence, providing relevant insights into the cardiovascular benefits of this common sleep habit Worldwide.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disturbances in rest-activity rhythms and their neurobiological correlates: implications for Alzheimer's disease and dementia.","authors":"Peng Li, Kun Hu","doi":"10.1093/sleep/zsaf047","DOIUrl":"10.1093/sleep/zsaf047","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rest-activity rhythm fragmentation and synchronization are linked with reduced cortical thickness in older adults \"at risk\" for dementia.","authors":"Nicole Espinosa, Camilla M Hoyos, Andrew C McKinnon, Hannes Almgren, Shantel L Duffy, Sharon L Naismith","doi":"10.1093/sleep/zsaf017","DOIUrl":"10.1093/sleep/zsaf017","url":null,"abstract":"<p><strong>Study objectives: </strong>While alterations in rest-activity rhythms are common in older adults \"at risk\" for dementia, it is unclear how rest-activity rhythms relate to underlying brain integrity.</p><p><strong>Methods: </strong>Older adults aged ≥50 years (n = 143, mean age = 67) with subjective and/or objective cognitive impairment underwent magnetic resonance imaging scanning and 14 days of actigraphy. The following nonparametric measures were computed: intra-daily variability (IV), inter-daily stability (IS), relative amplitude (RA), and average activity during the least active 5-h period (L5). A vertex-wise analysis correcting for age, sex, and clinical variables examined the association between nonparametric actigraphy measures and cortical thickness.</p><p><strong>Results: </strong>When controlling for age, sex, and body mass index (BMI), lower IV was associated with greater cortical thickness in the right cuneus (cluster-wise p-values [CWP] < 0.001), left middle frontal gyrus (CWP < 0.001), and lateral orbital frontal cortex (CWP = 0.004). When controlling for age, sex, medical burden (CIRS-G), BMI, and antidepressant use, lower IS was associated with lower cortical thickness in the left (CWP = 0.002) and right superior frontal gyrus (CWP < 0.001), left superior temporal gyrus (CWP = 0.043), and left post-central gyrus (CWP = 0.033). There were no significant associations between RA or L5 and cortical thickness.</p><p><strong>Conclusions: </strong>In older adults \"at risk\" for dementia, variability and stability of rest-activity rhythms were associated with reduced cortical thickness in frontal, temporal, parietal, and occipital regions. Further studies could focus on determining the prognostic utility of such markers longitudinally.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fingertip wearables and obstructive sleep apnea: is event level precision the key?","authors":"Steven Holfinger, M Jeffery Mador","doi":"10.1093/sleep/zsaf026","DOIUrl":"10.1093/sleep/zsaf026","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}