Sleep最新文献

{"title":"Region-specific NREM delta activity is associated with stroke recovery.","authors":"Eric C Landsness, Hanyang Miao, Wei Chen, Ryan M Bowen, Spencer Blackwood, Michelle Tang, David Lee, Jonah Padawer-Curry, Xiaodan Wang, Kimun Park, Rachel X Hua, Kathleen Schoch, Joe C Culver, Adam Q Bauer, Jin-Moo Lee","doi":"10.1093/sleep/zsaf076","DOIUrl":"https://doi.org/10.1093/sleep/zsaf076","url":null,"abstract":"<p><p>Neural activity in the delta range (1.0-4.5 Hz) during non-rapid eye movement (NREM) sleep is crucial for brain plasticity and overall brain health. Recent research has shown that changes in NREM delta activity can occur locally, and activity can vary across different brain regions. Ischemic stroke results in focal brain injury and long-term disability. While sleep disruption during the acute phase of stroke is known to hinder recovery, the relationship between region-specific changes in NREM delta activity and functional recovery remains poorly understood. To investigate these localized changes in NREM delta activity with high spatial resolution, we utilized wide-field optical imaging (WFOI) in mice that expressed GCaMP6f, a fluorescent calcium indicator, in cortical excitatory pyramidal neurons. Sleep was longitudinally recorded before and at 24 hours, one week, and four weeks after photothrombotic stroke in the left somatosensory forepaw cortex. In the acute phase of stroke (24 hours post stroke), mice exhibited decreased delta activity in the infarct and peri-infarct regions during NREM sleep. Increased delta activity in the contralesional hemisphere and decreased delta activity in the perilesional region during NREM sleep in the acute phase were associated with poor behavioral recovery, as measured by performance on the cylinder rearing test. These findings suggest that region-specific NREM delta activity may play a crucial role in stroke recovery and warrant further investigation to determine whether modulating delta activity in targeted brain areas during NREM sleep could aid recovery.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of glymphatic function and cognition in chronic insomnia using low-frequency rTMS.","authors":"Chanjuan Zhang, Yadan Zheng, Guihua Jiang, Jing Luo, Liujie Su, Yinan Ai, Chenyang Feng, Chao Li, Shumei Li, Xiquan Hu","doi":"10.1093/sleep/zsaf083","DOIUrl":"https://doi.org/10.1093/sleep/zsaf083","url":null,"abstract":"<p><strong>Study objectives: </strong>Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) is a promising treatment for chronic insomnia, however; its effectiveness in improving cognitive and glymphatic clearance functions remains unclear. We aimed to investigate the effects of chronic insomnia on glymphatic clearance function and effectiveness of LF-rTMS on chronic insomnia.</p><p><strong>Methods: </strong>Thirty-two patients with chronic insomnia and 40 healthy controls underwent baseline assessments of clinical measures and glymphatic functions using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS). Thereafter, 22 patients underwent 10 sessions of LF-rTMS over 2 consecutive weeks, sleep assessments at week 2 and months 1, 2, and 3, and DTI-ALPS and cognitive-related assessments at week 2 and month 3.</p><p><strong>Results: </strong>Compared to healthy controls, patients showed significant differences in the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Montreal Cognitive Assessment scale (MoCA), digit symbol substitution test (DSST), color trails test (CTT), Digital Span (DST), Stroop tests, and DTI-ALPS index (all p<0.05). After LF-rTMS, patients showed a significant decrease in PSQI and ISI scores from week 2 onwards, and significant improvement in MoCA, DSST, DST, CTT-B tests, and DTI-ALPS index by month 3 (all p<0.05). Furthermore, the increase in DTI-ALPS index was significantly associated with improvements in PSQI, ISI, MoCA and DST-Backward at month 3 (r=0.579, 0.558, 0.836 and 0.642, respectively, and p=0.038, 0.047, <0.001 and 0.018, respectively).</p><p><strong>Conclusions: </strong>This study provided preliminary evidence for LF-rTMS' valuable effects on glymphatic clearance and cognitive function in patients with chronic insomnia, which supports LF-rTMS' clinical application in those population.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG-Based Prediction of Reaction Time during Sleep Deprivation.","authors":"Asaf Harel, Anna Levkovsky, Idan Nakdimon, Barak Gordon, Oren Shriki","doi":"10.1093/sleep/zsaf080","DOIUrl":"https://doi.org/10.1093/sleep/zsaf080","url":null,"abstract":"<p><p>Prolonged wakefulness is known to adversely affect basic cognitive abilities such as object recognition and decision making. It affects the dynamics of neuronal networks in the brain and can even lead to hallucinations and epileptic seizures. In cognitive-intensive workplaces, there is a requirement to refine an objective method of quantifying the current level of cognitive capabilities, rather than relying on subjective self-reporting. In this study, we compiled EEG recordings from several sleep deprivation workshops held by the Israeli Air Force (IAF), done by flight cadets and unmanned aerial vehicle (UAV) operators. By extracting a wide range of EEG features and applying machine-learning techniques, we were able to accurately predict the reaction time of participants undergoing a simple psycho-motor vigilance task, which acted as a stand-in for basic cognitive functions. Furthermore, through the use of interpretability methods, we examined the importance of different EEG features and their contribution to changes in the behavioral metrics.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Effects of rTMS in Chronic Insomnia: Is Glymphatic System Modulation the Key Player?","authors":"Giuseppe Lanza, Maria P Mogavero, Raffaele Ferri","doi":"10.1093/sleep/zsaf084","DOIUrl":"https://doi.org/10.1093/sleep/zsaf084","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giving sleep research away: Promoting sleep and circadian science beyond peer-reviewed articles.","authors":"Rebecca Robbins","doi":"10.1093/sleep/zsaf075","DOIUrl":"https://doi.org/10.1093/sleep/zsaf075","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term welfare consequences of sleep apnea in 20-64-year-olds - influence of gender: A nationwide cohort study.","authors":"Poul Jennum, Rikke Ibsen, Michael Ibsen, Susan Andersen, Jakob Kjellberg","doi":"10.1093/sleep/zsaf057","DOIUrl":"https://doi.org/10.1093/sleep/zsaf057","url":null,"abstract":"<p><strong>Study objectives: </strong>Obstructive sleep apnea (OSA) is associated with a significant welfare burden. Little information is available about long-term welfare consequences for women and men. Here we evaluated the long-term gender-associated welfare of patients with OSA.</p><p><strong>Methods: </strong>Using data from the Danish National Patient Registry and other public databases, all patients aged 20-64 years with a diagnosis of OSA were included. They were compared with citizens matched by age, sex, marital status, and community location, in a ratio of 1:4. All health and social costs were included from public registries.</p><p><strong>Results: </strong>A total of 55,783 men and 19,241 women with OSA were compared with 223,783 and 76,961 controls, respectively. As a group, people with OSA had significantly higher morbidity, mortality, health costs, transfer incomes, sickness benefits, whereas their educational level, and professional affiliation were lower, and patients retired earlier than their corresponding controls. These patterns could be identified as much as 15 years before diagnosis, with changes becoming more pronounced after diagnosis and management. There was a significant gender difference, whereby women had higher morbidity and mortality rates and social welfare social costs than men in all domains, before and after diagnosis. The total case patient net costs for men/women were 4217/8259 €/year before diagnosis and 8749/13730 €/year after diagnosis.</p><p><strong>Conclusions: </strong>OSA is associated with a significant welfare burden (morbidity, mortality, healthcare cost, social impact). These effects are present years before diagnosis and increase thereafter. There are significant gender differences, whereby women tend to experience a significantly higher health and welfare burden than men before and after diagnosis. The study highlights a need to pay closer attention to OSA, particularly in women, in whom the disease is probably underdiagnosed.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enduring NREM sleep fragmentation following methotrexate chemotherapy in cancer-naïve mice.","authors":"Leah Boyd, Adrian Berisha, Adrian M Gomez, Erin M Gibson, Jeremy C Borniger","doi":"10.1093/sleep/zsaf073","DOIUrl":"https://doi.org/10.1093/sleep/zsaf073","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep disruption is common in people with cancer and survivors, but understanding the mechanisms driving these problems is difficult due to heterogeneity among cancers, patients, and treatment modalities. We investigated whether the common antifolate chemotherapeutic agent methotrexate (MTX) promotes changes in sleep independent of cancer in adult mice.</p><p><strong>Methods: </strong>Adult mice (> 7 weeks old, both sexes, n=13) were exposed to either a clinically relevant chemotherapy regimen with methotrexate (n=7) or saline (control, n=6) accompanied by continuous EEG/EMG telemetry recording. Sleep states were scored as either wake, NREM sleep, or REM sleep in 5-second epochs weekly during MTX or saline treatment and then two weeks following the last injection to examine enduring changes in sleep/wake cycles.</p><p><strong>Results: </strong>MTX exposure caused NREM sleep fragmentation, indicated by (1) shorter and more frequent NREM sleep bouts, (2) more transitions between wake & NREM sleep, and (3) more accumulated NREM sleep bouts over time. These effects were first detected after the second MTX injection and lasted into the two-week follow-up recording. MTX did not alter delta power in NREM sleep, indicating no changes to sleep quality. The total time spent in each vigilance state remained unaffected by MTX use. Finally, when given MTX, male mice displayed more fragmented sleep compared to female mice.</p><p><strong>Conclusions: </strong>Methotrexate promotes NREM sleep fragmentation, without affecting sleep quality or time spent asleep. This effect is stronger in males. These data suggest that chemotherapy can cause long-term sleep disruption independent of cancer presence.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Features of the Physical Environment as Contributors to Racial and Ethnic Disparities in Sleep Duration and Efficiency among Older Adults.","authors":"Dayna A Johnson, Laura Ward, Krysta Medearis, Kari Moore, Susan Redline","doi":"10.1093/sleep/zsaf048","DOIUrl":"https://doi.org/10.1093/sleep/zsaf048","url":null,"abstract":"<p><strong>Study objectives: </strong>Racial and ethnic sleep disparities have been documented; however, the mechanisms are unclear. In a cross-sectional analysis, we examined the contribution of features of the physical environment to sleep disparities among Black, Chinese, Hispanic, and White adults (N=1945, average age:68.5+9.1).</p><p><strong>Methods: </strong>Physical environment measures were self-reported (aesthetic quality, walking environment) and objectively-measured via Geographic Information Systems (walking destination density, proportion of land dedicated to retail space, overall built environment score). Sleep duration (short:<6 hours) and sleep efficiency were measured via 7-day actigraphy. Multi-level linear and Poisson regression models with robust variance were fit to examine associations with adjustment for covariates. Direct and indirect mediation was tested via path models.</p><p><strong>Results: </strong>Insufficient sleep was highest for minoritized individuals (short sleep: 32.5-44.1%, <85% sleep efficiency: 9.3-10.5%). Living in neighborhoods with higher aesthetic quality scores was associated with sleeping 5.8 minutes (0.67, 10.85) longer on average. Higher walking destination density, proportion retail, and built environment scores were associated with shorter sleep duration and higher prevalence of short sleep (adjusted prevalence ratio: 1.0001 [1.0005,1.0016], 1.02 [1.01,1.04], and 1.06 [1.02,1.09], respectively). Proportion retail partially explained the Black-White (2.8%) and Chinese-White (11.3%) difference in sleep duration. The Hispanic-White difference in sleep duration was partially (5.8-26.5%) explained by differences in aesthetic quality, walking destination density, proportion retail, and built environment score. There were no associations between features of the physical environment and sleep efficiency.</p><p><strong>Conclusions: </strong>Features of the physical environment partially contributed to racial disparities in sleep duration and is a likely target for intervention.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Sleep Regularity and Timing to Prevent Cognitive Decline in Older Women: In Search of Evidence for Efficacy and Sufficiency.","authors":"Jessica R Lunsford-Avery, Andrew Sherwood","doi":"10.1093/sleep/zsaf072","DOIUrl":"https://doi.org/10.1093/sleep/zsaf072","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Moderating Role of Subjective Daytime Sleepiness in the Associations Between Sleep Duration and Brain Morphology in School-Aged Children.","authors":"Elie Yu Tong Guo, Marie-Pier Côté, Miriam H Beauchamp, Julie Carrier, Véronique Daneault, Annie Bernier","doi":"10.1093/sleep/zsaf070","DOIUrl":"https://doi.org/10.1093/sleep/zsaf070","url":null,"abstract":"<p><strong>Study objectives: </strong>The alignment between greater sleep demands and heightened neuroplasticity in childhood suggests that sleep plays a key role in brain maturation. While sleep duration is commonly accepted as a marker for adequate sleep, this indicator overlooks differences in individual sleep needs. Subjective perception of sleepiness may offer additional insight into sleep insufficiency relative to individual needs. This study aimed to investigate the associations between sleep duration and brain morphology in typically developing children, and the moderating effect of subjective sleepiness in these associations.</p><p><strong>Methods: </strong>In 81 children (45 boys, 10.53 years old), actigraphy-derived estimates of sleep duration were obtained over 5 to 7 days and subjective daytime sleepiness was self-reported. Gray matter volume (GMV) was estimated for 11 brain regions. Linear associations between sleep duration and regional GMV were tested, along with the interaction between sleepiness and sleep duration in relation to regional GMV.</p><p><strong>Results: </strong>Sleep duration negatively correlated with GMV in the insula at the group level. Subjective sleepiness moderated the relationship between sleep duration and GMV, with associations found in the hippocampus and middle temporal gyrus for children prone to sleepiness, and in the precuneus for those without sleepiness.</p><p><strong>Conclusion: </strong>The current results suggest that normative variations in sleep duration may bear on child brain morphology, with distinct associations at varying levels of subjective daytime sleepiness in regions subsuming executive functioning and memory consolidation. These findings highlight the importance of incorporating both objective and subjective aspects of sleep in future research on sleep health and neurodevelopment.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}