Sleep最新文献

{"title":"Peering beyond hypersomnia and cataplexy of childhood narcolepsy: the role of sleep-dependent memory consolidation.","authors":"Suresh Kotagal","doi":"10.1093/sleep/zsae261","DOIUrl":"10.1093/sleep/zsae261","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of objective daytime sleepiness with impaired glucose metabolism in patients with obstructive sleep apnea: a multi-omics study.","authors":"Le Chen, Baixin Chen, Yanyuan Dai, Qimeng Sun, Jun Wu, Dandan Zheng, Alexandros N Vgontzas, Xiangdong Tang, Yun Li","doi":"10.1093/sleep/zsae240","DOIUrl":"10.1093/sleep/zsae240","url":null,"abstract":"<p><strong>Study objectives: </strong>To examine the joint effect of obstructive sleep apnea (OSA) and objective excessive daytime sleepiness (EDS) on glucose metabolism and the underlying mechanisms.</p><p><strong>Methods: </strong>We included 127 patients with OSA. The multiple sleep latency test (MSLT) and Epworth sleepiness scale (ESS) were used to assess objective and subjective EDS, respectively. Disordered glucose metabolism was defined as either a physician diagnosis or having fasting blood glucose levels ≥5.6 mmol/L. Values of fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) higher than the median values of our sample were defined as high fasting insulin and insulin resistance. Serum metabolomics and fecal microbiota were used to explore underlying mechanisms.</p><p><strong>Results: </strong>Lower MSLT values were associated with higher levels of fasting blood glucose, fasting insulin, and HOMA-IR. Furthermore, objective EDS was associated with increased odds of disordered glucose metabolism, elevated fasting insulin, and insulin resistance. Dysregulation of serum valine degradation and dysbiosis of fecal Bacteroides thetaiotaomicron were associated with impaired glucose metabolism in OSA with objective EDS. No association between subjective EDS and impaired glucose metabolism was observed.</p><p><strong>Conclusions: </strong>OSA with objective, but not subjective, EDS is associated with an increased risk of disordered glucose metabolism and insulin resistance. Dysregulation of valine degradation and dysbiosis of B. thetaiotaomicron appear to link objective EDS and disordered glucose metabolism in OSA.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep EEG biomarkers of psychopathology: are we finally making progress?","authors":"Elizabeth A Klingaman, Philip R Gehrman","doi":"10.1093/sleep/zsae270","DOIUrl":"10.1093/sleep/zsae270","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality risk assessment using deep learning-based frequency analysis of electroencephalography and electrooculography in sleep.","authors":"Teitur Óli Kristjánsson, Katie L Stone, Helge B D Sorensen, Andreas Brink-Kjaer, Emmanuel Mignot, Poul Jennum","doi":"10.1093/sleep/zsae219","DOIUrl":"10.1093/sleep/zsae219","url":null,"abstract":"<p><strong>Study objectives: </strong>To assess whether the frequency content of electroencephalography (EEG) and electrooculography (EOG) during nocturnal polysomnography (PSG) can predict all-cause mortality.</p><p><strong>Methods: </strong>Power spectra from PSGs of 8716 participants, including from the MrOS Sleep Study and the Sleep Heart Health Study, were analyzed in deep learning-based survival models. The best-performing model was further examined using SHapley Additive Explanation (SHAP) for data-driven sleep-stage specific definitions of power bands, which were evaluated in predicting mortality using Cox Proportional Hazards models.</p><p><strong>Results: </strong>Survival analyses, adjusted for known covariates, identified multiple EEG frequency bands across all sleep stages predicting all-cause mortality. For EEG, we found an all-cause mortality hazard ratio (HR) of 0.90 (CI: 95% 0.85 to 0.96) for 12-15 Hz in N2, 0.86 (CI: 95% 0.82 to 0.91) for 0.75-1.5 Hz in N3, and 0.87 (CI: 95% 0.83 to 0.92) for 14.75-33.5 Hz in rapid-eye-movement sleep. For EOG, we found several low-frequency effects including an all-cause mortality HR of 1.19 (CI: 95% 1.11 to 1.28) for 0.25 Hz in N3, 1.11 (CI: 95% 1.03 to 1.21) for 0.75 Hz in N1, and 1.11 (CI: 95% 1.03 to 1.20) for 1.25-1.75 Hz in wake. The gain in the concordance index (C-index) for all-cause mortality is minimal, with only a 0.24% increase: The best single mortality predictor was EEG N3 (0-0.5 Hz) with a C-index of 77.78% compared to 77.54% for confounders alone.</p><p><strong>Conclusions: </strong>Spectral power features, possibly reflecting abnormal sleep microstructure, are associated with mortality risk. These findings add to a growing literature suggesting that sleep contains incipient predictors of health and mortality.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuated melanopsin-mediated post-illumination pupillary response is associated with reduced actigraphic amplitude and mesor in older adults.","authors":"Joey W Y Chan, Chun-Tung Li, Steven Wai Ho Chau, Ngan Yin Chan, Tim Man-Ho Li, Bei Huang, Joshua Tsoh, Shirley X Li, Kelvin K L Chong, Kathryn A Roecklein, Yun Kwok Wing","doi":"10.1093/sleep/zsae239","DOIUrl":"10.1093/sleep/zsae239","url":null,"abstract":"<p><strong>Study objectives: </strong>This study aimed to explore the relationship between post-illumination pupillary response (PIPR) with sleep and circadian measures in a community sample of healthy older adults.</p><p><strong>Methods: </strong>Eligible participants were invited to complete a 1 week sleep diary and actigraphy, and provide an overnight urine sample to measure urinary 6-sulfatoxymelatonin (aMT6s). PIPR was defined as the (1) pupil constriction at 6 second poststimulus (PIPR-6s) and (2) for -30s beginning 10 seconds after stimulus (PIPR-30s), normalized as a percentage to the baseline pupil diameter, after 1 second of blue and 1 second of red light stimulus, respectively. The Net-PIPRs were reported by subtracting the PIPR to red stimulus from the PIPR to blue stimulus. The relationship between PIPR metrics to aMT6s and actigraphic rest-activity rhythm parameters was examined by generalized linear models.</p><p><strong>Results: </strong>A total of 48 participants were recruited (mean age: 62.6 ± 7.1 years, male: 44%). Both Net PIPR-6s and Net PIPR-30s were significantly associated with actigraphic rest-activity amplitude (B = 0.03, p = .001 and B = 0.03, p = .01, respectively) and actigraphic rest-activity mesor (B = 0.02, p = .001 and B = 0.03, p = .004, respectively). Additionally, the Net PIPR-30s were positively associated with overnight aMT6s level (B = 0.04, p = .03) and negatively associated with actigraphic rest-activity acrophase (B = -0.01, p = .004) in the fully adjusted models.</p><p><strong>Conclusions: </strong>Attenuated PIPR is associated with a reduced actigraphic amplitude and mesor. The reduced retinal light responsivity may be a potential pathway contributing to impaired photic input to the circadian clock and resulted in age-related circadian changes in older adults.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A spectrum of altered non-rapid eye movement sleep in schizophrenia.","authors":"Nataliia Kozhemiako, Chenguang Jiang, Yifan Sun, Zhenglin Guo, Sinéad Chapman, Guanchen Gai, Zhe Wang, Lin Zhou, Shen Li, Robert G Law, Lei A Wang, Dimitrios Mylonas, Lu Shen, Michael Murphy, Shengying Qin, Wei Zhu, Zhenhe Zhou, Robert Stickgold, Hailiang Huang, Shuping Tan, Dara S Manoach, Jun Wang, Mei-Hua Hall, Jen Q Pan, Shaun M Purcell","doi":"10.1093/sleep/zsae218","DOIUrl":"10.1093/sleep/zsae218","url":null,"abstract":"<p><p>Multiple facets of sleep neurophysiology, including electroencephalography (EEG) metrics such as non-rapid eye movement (NREM) spindles and slow oscillations, are altered in individuals with schizophrenia (SCZ). However, beyond group-level analyses, the extent to which NREM deficits vary among patients is unclear, as are their relationships to other sources of heterogeneity including clinical factors, aging, cognitive profiles, and medication regimens. Using newly collected high-density sleep EEG data on 103 individuals with SCZ and 68 controls, we first sought to replicate our previously reported group-level differences between patients and controls (original N = 130) during the N2 stage. Then in the combined sample (N = 301 including 175 patients), we characterized patient-to-patient variability. We replicated all group-level mean differences and confirmed the high accuracy of our predictive model (area under the receiver operating characteristic curve [AUC] = 0.93 for diagnosis). Compared to controls, patients showed significantly increased between-individual variability across many (26%) sleep metrics. Although multiple clinical and cognitive factors were associated with NREM metrics, collectively they did not account for much of the general increase in patient-to-patient variability. The medication regimen was a greater contributor to variability. Some sleep metrics including fast spindle density showed exaggerated age-related effects in SCZ, and patients exhibited older predicted biological ages based on the sleep EEG; further, among patients, certain medications exacerbated these effects, in particular olanzapine. Collectively, our results point to a spectrum of N2 sleep deficits among SCZ patients that can be measured objectively and at scale, with relevance to both the etiological heterogeneity of SCZ as well as potential iatrogenic effects of antipsychotic medication.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of obstructive sleep apnea/hypopnea for leukoaraiosis and its cognitive consequences: a discussion still open!","authors":"Frédéric Roche, Sébastien Celle, Nathalie Perek, Pauline Guillot","doi":"10.1093/sleep/zsae283","DOIUrl":"10.1093/sleep/zsae283","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inferring causality: Mendelian randomization in biomarker studies in obstructive sleep apnea.","authors":"Rene Cortese","doi":"10.1093/sleep/zsae274","DOIUrl":"10.1093/sleep/zsae274","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in circadian timing following a 1-week in-home sleep extension manipulation in habitually short-sleeping adolescents.","authors":"Sydney Holtman, Emily Cooper, John T Brinton, Anne E Bowen, Stephen Hawkins, Melanie G Cree, Kristen J Nadeau, Kenneth P Wright, Stacey L Simon","doi":"10.1093/sleep/zsae273","DOIUrl":"10.1093/sleep/zsae273","url":null,"abstract":"<p><strong>Study objectives: </strong>Evaluate objectively measured circadian rhythms following 1-week of at-home sleep extension in habitually short-sleeping adolescents.</p><p><strong>Methods: </strong>Twenty-six participants (16.1 ± 1.2 years, 69% female, and 65% White non-Hispanic) with insufficient sleep (≤7 h on school nights) were randomized to 1 week of typical sleep (TS; usual school schedule) and sleep extension (EXT; ≥1-h additional time in bed) in counterbalanced order with a 1-month washout between conditions. Home monitoring of actigraphy-estimated sleep and light exposure was assessed during both weeks. Hourly in-laboratory evening/morning dim-light salivary melatonin samples were obtained and onset (DLMOn) and offset (DLMOff) were calculated following each condition.</p><p><strong>Results: </strong>Sleep duration increased by 1.37 h (95% CI = 1.09, 1.66; p < 0.001), bedtimes advanced by 1.40 (95% CI = -1.75, -1.06; p < 0.001), and waketimes did not significantly change (p = 0.055) during EXT compared to TS. There was no change in DLMOn or DLMOff following EXT (both p > 0.05). The DLMOn-sleep onset phase angle narrowed by 0.72 h (95% CI = -1.39, -0.07; p = 0.04) during EXT. Light exposure within 2-h of bedtime was significantly higher during EXT compared to TS (23.37 vs. 7.73 lux; p = 0.048).</p><p><strong>Conclusions: </strong>Sleep extension did not change melatonin onset or offset but may have increased circadian alignment. Further research should evaluate the addition of specific strategies to improve circadian timing such as morning bright light in combination with sleep extension.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep reactivity and variability: further evidence why it makes \"cents\" to look beyond the means.","authors":"Kelly Glazer Baron","doi":"10.1093/sleep/zsae268","DOIUrl":"10.1093/sleep/zsae268","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}