IF 5.6 2区医学

Sleep Pub Date : 2025-02-10 DOI: 10.1093/sleep/zsae199

Tian Xie, Ning Ma

{"title":"Tracking vigilance fluctuations in real-time: a sliding-window heart rate variability-based machine-learning approach.","authors":"Tian Xie, Ning Ma","doi":"10.1093/sleep/zsae199","DOIUrl":"10.1093/sleep/zsae199","url":null,"abstract":"Study objectives: Heart rate variability (HRV)-based machine learning models hold promise for real-world vigilance evaluation, yet their real-time applicability is limited by lengthy feature extraction times and reliance on subjective benchmarks. This study aimed to improve the objectivity and efficiency of HRV-based vigilance evaluation by associating HRV and behavior metrics through a sliding window approach.Methods: Forty-four healthy adults underwent psychomotor vigilance tasks under both well-rested and sleep-deprived conditions, with simultaneous electrocardiogram recording. A sliding-window approach (30 seconds length, 10 seconds step) was used for HRV feature extraction and behavior assessment. Repeated-measures ANOVA was used to examine how HRV related to objective vigilance levels. Stability selection technique was applied for feature selection, and the vigilance ground truth-high (fastest 40%), intermediate (middle 20%), and low (slowest 40%)-was determined based on each participant's range of performance. Four machine-learning classifiers-k-nearest neighbors, support vector machine (SVM), AdaBoost, and random forest-were trained and tested using cross-validation.Results: Fluctuated vigilance performance indicated pronounced state instability, particularly after sleep deprivation. Temporary decrements in performance were associated with a decrease in heart rate and an increase in time-domain heart rate variability. SVM achieved the best performance, with a cross-validated accuracy of 89% for binary classification of high versus low vigilance epochs. Overall accuracy dropped to 72% for three-class classification in leave-one-participant-out cross-validation, but SVM maintained a precision of 84% in identifying low-vigilance epochs.Conclusions: Sliding-window-based HRV metrics would effectively capture the fluctuations in vigilance during task execution, enabling more timely and accurate detection of performance decrement.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dangers of sleeping, and not sleeping enough, in war. 战争中睡眠和睡眠不足的危险。

IF 5.6 2区医学

Sleep Pub Date : 2025-02-10 DOI: 10.1093/sleep/zsae298

John A Lesku

引用次数: 0

Talking to sleepwalkers? Response to communication efforts in disorders of arousals. 与梦游者交谈？唤醒障碍患者对沟通努力的反应。

IF 5.6 2区医学

Sleep Pub Date : 2025-02-10 DOI: 10.1093/sleep/zsae272

Yannis Idir, Régis Lopez, Amélie Barbier, Sony Saint-Auret, Emmanuel Morain, Raphaël Vollhardt, Inès Ben Haj Kacem, Arthur Le Coz, Ana Gales, Pauline Dodet, Smaranda Leu-Semenescu, Yves Dauvilliers, Isabelle Arnulf, Delphine Oudiette

{"title":"Talking to sleepwalkers? Response to communication efforts in disorders of arousals.","authors":"Yannis Idir, Régis Lopez, Amélie Barbier, Sony Saint-Auret, Emmanuel Morain, Raphaël Vollhardt, Inès Ben Haj Kacem, Arthur Le Coz, Ana Gales, Pauline Dodet, Smaranda Leu-Semenescu, Yves Dauvilliers, Isabelle Arnulf, Delphine Oudiette","doi":"10.1093/sleep/zsae272","DOIUrl":"10.1093/sleep/zsae272","url":null,"abstract":"Study objectives: Disorders of arousal (DoA) are diagnosed on the basis of clinical criteria, including inappropriate or absent responsiveness to communication attempts. Surprisingly, the ability of patients to interact with others during DoA episodes has not been systematically investigated. To address this gap, we conducted three studies.Methods: First, we used a retrospective questionnaire to assess verbal responsiveness during episodes in 61 adult patients with DoA (Study 1). Second, we used auditory stimulation during polysomnographically verified N3 sleep to trigger DoA episodes in 14 patients. We then asked questions to test the possibility of verbal interactions during the episodes (Study 2). Third, we assessed the presence and quality of conversations with a bed partner in 364 home video-recorded episodes from 19 patients (Study 3).Results: In Study 1, most patients (81%) reported occasional conversations during parasomnia episodes. Patients' ongoing mental content influenced both their responses to questions during episodes and their perception of the outside world (including their surroundings and the identity of their interlocutor ). In Study 2, auditory stimulation had a limited effect in inducing episodes (7/157 trials). One patient indirectly responded to our verbal prompts in a DoA episode. In Study 3, we found 37 video instances of discussion between patients and their partner.Conclusions: Overall, our findings suggest that DoA episodes are not a uniform state but may instead encompass varying states of consciousness, characterized by different levels of responsiveness and a complex interplay between internal and external information processing. These results highlight the limitations of current diagnostic criteria for DoA.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probabilistic sleep staging in MSLTs across hypersomnia disorders. 不同失眠症患者在 MSLT 中的概率睡眠分期

IF 5.6 2区医学

Sleep Pub Date : 2025-02-10 DOI: 10.1093/sleep/zsae241

Louise Hjuler Andersen, Andreas Brink-Kjaer, Oliver Sum-Ping, Fabio Pizza, Francesco Biscarini, Niels Christian Haubjerg Østerby, Emmanuel Mignot, Giuseppe Plazzi, Poul J Jennum

{"title":"Probabilistic sleep staging in MSLTs across hypersomnia disorders.","authors":"Louise Hjuler Andersen, Andreas Brink-Kjaer, Oliver Sum-Ping, Fabio Pizza, Francesco Biscarini, Niels Christian Haubjerg Østerby, Emmanuel Mignot, Giuseppe Plazzi, Poul J Jennum","doi":"10.1093/sleep/zsae241","DOIUrl":"10.1093/sleep/zsae241","url":null,"abstract":"Study objectives: This study aimed to identify novel markers of narcolepsy type 1 (NT1) using between-nap opportunity periods (\"lights on\") and in-nap opportunity periods (\"lights off\") features of Multiple Sleep Latency Test (MSLT) recordings. We hypothesized that NT1 could be identified both from sleep-wake instability and patterns of sleepiness during wakefulness. Further, we explored if MSLTs from NT1 and narcolepsy type 2 (NT2) patients could be distinguished despite having the same diagnostic thresholds.Methods: We analyzed \"lights on\" and \"lights off\" periods of the MSLT, extracting 163 features describing sleepiness, microsleep, and sleep stage mixing using data from 177 patients with NT1, NT2, idiopathic hypersomnia (IH), and subjective hypersomnia (sH) from three sleep centers. These features were based on automated probabilistic sleep staging, also denoted as hypnodensities, using U-Sleep. Hypersomnias were differentiated using either or both features from \"lights on\" and \"lights off.\"Results: Patients with NT1 could be distinguished from NT2, IH, and sH using features solely from \"lights on\" periods with a sensitivity of 0.76 and specificity of 0.71. When using features from all periods of the MSLT, NT1 was distinguished from NT2 alone with a sensitivity of 0.77 and a specificity of 0.84.Conclusions: The findings of this study demonstrate microsleeps and sleep stage mixing as potential markers of sleep attacks and unstable sleep-wake states common in NT1. Further, NT1 and NT2 could be frequently distinguished using \"lights off\" features.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partial activation of salt-inducible kinase 3 delays the onset of wakefulness and alleviates hypersomnia due to the lack of protein kinase A-phosphorylation site. 由于缺乏蛋白激酶a -磷酸化位点，SIK3的部分激活延迟了觉醒的发生，减轻了嗜睡。

IF 5.6 2区医学

Sleep Pub Date : 2025-02-10 DOI: 10.1093/sleep/zsae279

Shinya Nakata, Tomoyuki Fujiyama, Fuyuki Asano, Haruna Komiya, Noriko Hotta-Hirashima, Motoki Juichi, Daiki Komine, Miyo Kakizaki, Aya Ikkyu, Seiya Mizuno, Satoru Takahashi, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa

{"title":"Partial activation of salt-inducible kinase 3 delays the onset of wakefulness and alleviates hypersomnia due to the lack of protein kinase A-phosphorylation site.","authors":"Shinya Nakata, Tomoyuki Fujiyama, Fuyuki Asano, Haruna Komiya, Noriko Hotta-Hirashima, Motoki Juichi, Daiki Komine, Miyo Kakizaki, Aya Ikkyu, Seiya Mizuno, Satoru Takahashi, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa","doi":"10.1093/sleep/zsae279","DOIUrl":"10.1093/sleep/zsae279","url":null,"abstract":"Study objectives: Sleep/wakefulness is regulated by intracellular signaling pathways composed of protein kinases such as salt-inducible kinase 3 (Sik3). Sik3-deficiency in neurons decreases nonrapid eye movement (NREM) sleep time and electroencephalogram (EEG) delta power during NREM sleep, while Sik3Slp mice lacking a protein kinase A (PKA)-phosphorylation site, S551, show hypersomnia phenotype. In this study, we examined how a phosphomimetic mutation of the 221st threonine residue (T221E), which provides a partial (weak) constitutive activity of the kinase, affects sleep/wakefulness and circadian behavior. We also examined the effect of T221E substitution on the hypersomnia phenotype of Sik3Slp mice.Methods: We examined the sleep/wake behavior of heterozygous and homozygous Sik3T221E mice and Sik3T221E;Slp mice using EEG and electromyogram recording. We also examined the circadian behavior of Sik3T221E mice using a running wheel under the light-dark cycle and constant darkness.Results: Heterozygous and homozygous Sik3T221E mice showed normal sleep time and sleep homeostatic responses. Homozygous Sik3T221E mice exhibited a delayed onset of wakefulness at the early dark phase and longer circadian periods. Sik3T221E;Slp mice showed decreased NREM sleep time and homeostatic responses compared to Sik3Slp mice.Conclusions: Our results suggest that the peak onset of wakefulness is sensitive to disturbed kinase activity of SIK3, and the relationship between phosphorylation at T221 and S551 is critical for regulating sleep need.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning identification of sleep EEG and EOG biomarkers for mortality risk. 通过机器学习识别睡眠脑电图和脑电图生物标志物，确定死亡风险。

IF 5.6 2区医学

Sleep Pub Date : 2025-02-10 DOI: 10.1093/sleep/zsae231

Wolfgang Ganglberger

引用次数: 0

Genetic variants associated with chronic fatigue syndrome predict population-level fatigue severity and actigraphic measurements. 与慢性疲劳综合征相关的基因变异可预测人群疲劳严重程度和行动测量。

IF 5.6 2区医学

Sleep Pub Date : 2025-02-10 DOI: 10.1093/sleep/zsae243

Patrick Z Liu, David M Raizen, Carsten Skarke, Thomas G Brooks, Ron C Anafi

{"title":"Genetic variants associated with chronic fatigue syndrome predict population-level fatigue severity and actigraphic measurements.","authors":"Patrick Z Liu, David M Raizen, Carsten Skarke, Thomas G Brooks, Ron C Anafi","doi":"10.1093/sleep/zsae243","DOIUrl":"10.1093/sleep/zsae243","url":null,"abstract":"Study objectives: The diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (CFS) is based on a constellation of symptoms which center around fatigue. However, fatigue is commonly reported in the general population by people without CFS. Does the biology underlying fatigue in patients with CFS also drive fatigue experienced by individuals without CFS?Methods: We used UK Biobank actigraphy data to characterize differences in physical activity patterns and daily temperature rhythms between participants diagnosed with CFS compared to controls. We then tested if single nucleotide variants (SNVs) previously associated with CFS are also associated with the variation of these actigraphic CFS correlates and/or subjective fatigue symptoms in the general population.Results: Participants diagnosed with CFS (n = 295) had significantly decreased overall movement (Cohen's d = 0.220, 95% CI of -0.335 to -0.106, p-value = 2.42 × 10-15), lower activity amplitudes (Cohen's d = -0.377, 95% CI of -0.492 to -0.262, p-value = 1.74 × 10-6), and lower wrist temperature amplitudes (Cohen's d = -0.173, 95% CI of -0.288 to -0.059, p-value = .002) compared to controls (n = 63,133). Of 30 tested SNVs associated in the literature with CFS, one was associated in the control population with subjective fatigue and one with actigraphic measurements (FDR < 0.05).Conclusions: The genetic overlap of CFS risk with actigraphy and subjective fatigue phenotypes suggests that some biological mechanisms underlying pathologic fatigue in patients with CFS also underlie fatigue symptoms at a broader population level. Therefore, understanding the biology of fatigue in general may inform our understanding of CFS pathophysiology.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The eyes have it: pupillary assessment as a measure of sleep and circadian health. 眼睛有它-瞳孔评估作为睡眠和昼夜健康的衡量标准。

IF 5.6 2区医学

Sleep Pub Date : 2025-02-10 DOI: 10.1093/sleep/zsae285

Sabra M Abbott

引用次数: 0

Factors influencing the PAP adherence of elderly European sleep apnea patients in the ESADA cohort. 影响 ESADA 队列中欧洲老年睡眠呼吸暂停患者坚持 PAP 的因素。

IF 5.6 2区医学

Sleep Pub Date : 2025-02-10 DOI: 10.1093/sleep/zsae266

Aino Lammintausta, Ulla Anttalainen, Izolde Bouloukaki, Sophia E Schiza, Athanasia Pataka, Francesco Fanfulla, Stefan A Mihaicuta, Sébastien Bailly, Ludger Grote, Jan A Hedner, Tarja Saaresranta

引用次数: 0

Advancements in vigilance monitoring: addressing fatigue and sleepiness in driving. 警觉性监测的进展：解决疲劳和困倦驾驶。

IF 5.6 2区医学

Sleep Pub Date : 2025-02-10 DOI: 10.1093/sleep/zsae294

Thomas Penzel, Matthew Salanitro

引用次数: 0

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