Sleep最新文献_第10页

Role of subjective snoring in dementia risk. 主观打鼾在痴呆症风险中的作用。

IF 5.6 2区医学

Sleep Pub Date : 2024-07-15 DOI: 10.1093/sleep/zsae162

Naomi L Gaggi, Donald L Bliwise, Andrew W Varga

引用次数: 0

Associations of Accelerometer-measured Sleep Duration with Incident Cardiovascular Disease and Cardiovascular Mortality. 加速计测量的睡眠时间与心血管疾病和心血管疾病死亡率的关系

IF 5.6 2区医学

Sleep Pub Date : 2024-07-12 DOI: 10.1093/sleep/zsae157

Mingqing Zhou, Yannis Yan Liang, Sizhi Ai, Hongliang Feng, Yujing Zhou, Yaping Liu, Jihui Zhang, Fujun Jia, Binbin Lei

{"title":"Associations of Accelerometer-measured Sleep Duration with Incident Cardiovascular Disease and Cardiovascular Mortality.","authors":"Mingqing Zhou, Yannis Yan Liang, Sizhi Ai, Hongliang Feng, Yujing Zhou, Yaping Liu, Jihui Zhang, Fujun Jia, Binbin Lei","doi":"10.1093/sleep/zsae157","DOIUrl":"https://doi.org/10.1093/sleep/zsae157","url":null,"abstract":"Study objectives: This study aimed to determine the associations between accelerometer-measured sleep durations and the risks of incident cardiovascular disease (CVD) and CVD-related mortality.Methods: A total of 92,261 participants (mean age: 62.4±7.8 years, 56.4% female) were included in UK Biobank between 2013 and 2015. Average daily sleep durations were measured using wrist-worn accelerometers over a seven-day period. Sleep durations were categorized as <7 hours/day, 7-9 hours/day (reference), and >9 hours/day. The incidence of CVD and CVD-related mortality were ascertained by hospital records and death registries.Results: During a median follow-up period of 7.0 years, a total of 13,167 participants developed CVD, and 1,079 participants died of CVD. Compared with a sleep duration 7-9 hours/day, an accelerometer-measured sleep duration <7 hours/day but not >9 hours/day was associated with higher risks of incident CVD (HR 1.06, 95% CI: 1.02-1.10), CVD-related mortality (HR 1.29, 95% CI: 1.14-1.47), coronary heart disease (HR 1.11, 95% CI: 1.03-1.19), myocardial infarction (HR 1.14, 95% CI: 1.03-1.27), heart failure (HR 1.20, 95% CI: 1.08-1.34), and atrial fibrillation (HR 1.15, 95% CI: 1.07-1.24). A curvilinear dose‒response pattern was observed between accelerometer-measured sleep durations and incident CVD (Poverall<0.001), with L-shaped associations found for incident CVD and CVD-related mortality.Conclusions: An accelerometer-measured sleep duration <7 hours/day but not >9 hours/day was associated with elevated risks of incident CVD and CVD-related mortality. Maintaining adequate sleep may help promote cardiovascular health.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the weekend sleep dilemma: the health impacts of catching up on sleep. 破解周末睡眠难题：补觉对健康的影响。

IF 5.6 2区医学

Sleep Pub Date : 2024-07-12 DOI: 10.1093/sleep/zsae159

Chenlu Gao, Lei Gao, Kun Hu, Peng Li

引用次数: 0

Obstructive sleep apnea, cognitive impairment, and dementia: is sleep microstructure an important feature? 阻塞性睡眠呼吸暂停、认知障碍和痴呆症：睡眠微观结构是重要特征吗？

IF 5.6 2区医学

Sleep Pub Date : 2024-07-12 DOI: 10.1093/sleep/zsae161

Nicola Andrea Marchi, Gilles Allali, Raphael Heinzer

引用次数: 0

Circadian Transcriptome Oscillations In Human Adipose Tissue Depend On Napping Status And Link To Metabolic And Inflammatory Pathways. 人体脂肪组织的昼夜节律转录组振荡取决于午睡状态，并与代谢和炎症途径有关。

IF 5.6 2区医学

Sleep Pub Date : 2024-07-12 DOI: 10.1093/sleep/zsae160

María Rodríguez-Martín, Fernando Pérez-Sanz, Carolina Zambrano, Juan Luján, Mikael Ryden, Frank A J L Scheer, Marta Garaulet

{"title":"Circadian Transcriptome Oscillations In Human Adipose Tissue Depend On Napping Status And Link To Metabolic And Inflammatory Pathways.","authors":"María Rodríguez-Martín, Fernando Pérez-Sanz, Carolina Zambrano, Juan Luján, Mikael Ryden, Frank A J L Scheer, Marta Garaulet","doi":"10.1093/sleep/zsae160","DOIUrl":"https://doi.org/10.1093/sleep/zsae160","url":null,"abstract":"Study objectives: Napping is a common habit in many countries. Nevertheless, studies about the chronic effects of napping on obesity are contradictory, and the molecular link between napping and metabolic alterations has yet to be studied. We aim to identify molecular mechanisms in adipose tissue (AT) that may connect napping and abdominal obesity.Methods: In this cross-sectional study, we extracted the RNA repeatedly across 24h from cultured AT explants and performed RNA sequencing. Circadian rhythms were analyzed using 6 consecutive time points across 24 hours. We also assessed global gene expression in each group (nappers vs. non-nappers).Results: With napping, there was a loss of rhythmicity in 88% of genes that showed circadian rhythmicity among non-nappers, a reduction in rhythm amplitudes of 29%, and significant phase changes from a coherent unimodal acrophase in non-nappers, towards a scattered and bimodal acrophase in nappers. Those genes that lost rhythmicity with napping were mainly involved in pathways of glucose and lipid metabolism, and of the circadian clock. Additionally, we found differential global gene expression between nappers and non-nappers with 34 genes down- and 32 genes up-regulated in nappers. The top up-regulated gene (IER3) and top down-regulated pseudogene (VDAC2P2) in nappers have been previously shown to be involved in inflammation.Conclusion: These new findings may have implications for our understanding of napping's effects on obesity and metabolic disorders.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STOP-Bang questionnaire in patients hospitalized with acute symptomatic pulmonary embolism. 急性无症状肺栓塞住院患者的 STOP-Bang 问卷调查。

IF 5.6 2区医学

Sleep Pub Date : 2024-07-12 DOI: 10.1093/sleep/zsae158

Winnifer Briceño, Esther Barbero, Eva Mañas, Sara González, Alberto García-Ortega, Grace Oscullo, Aldara García-Sánchez, Irene Cano-Pumarega, Miguel Ángel Martinez-Garcia, David Jimenez

{"title":"STOP-Bang questionnaire in patients hospitalized with acute symptomatic pulmonary embolism.","authors":"Winnifer Briceño, Esther Barbero, Eva Mañas, Sara González, Alberto García-Ortega, Grace Oscullo, Aldara García-Sánchez, Irene Cano-Pumarega, Miguel Ángel Martinez-Garcia, David Jimenez","doi":"10.1093/sleep/zsae158","DOIUrl":"https://doi.org/10.1093/sleep/zsae158","url":null,"abstract":"Study objectives: The STOP-Bang questionnaire is a validated screening tool for obstructive sleep apnea (OSA). We conducted this study to validate it among patients hospitalized with acute symptomatic pulmonary embolism (PE).Methods: This prospective cohort study enrolled consecutive stable patients with acute PE who underwent an overnight sleep study within 7 days after diagnosis. Our outcomes were: i) the STOP-Bang questionnaire's utility for risk stratification, ii) the discrimination of the STOP-Bang questionnaire categories, iii) the false negative rate of STOP-Bang questionnaire prediction, and iv) the clinical utility of the STOP-Bang questionnaire to exclude OSA. We also calculated the test performance characteristics to predict OSA.Results: During the study period, 268 patients completed a sleep study. OSA was found in 47% of patients. OSA incidence in low-, moderate-, and high-risk STOP-Bang groups was 22.4%, 48.2%, and 61.5%, respectively (P <0.001). The area under the receiver operating characteristics curve of the STOP-Bang questionnaire for risk of OSA was 0.65. The false negative rate of a low-risk STOP-Bang questionnaire result to rule out OSA was 22.4% and the clinical utility was 21.6%. The sensitivity was 89.8% (97.2% for men and 80.4% for women).Conclusions: The STOP-Bang questionnaire showed poor discrimination for the risk of OSA in hospitalized patients with acute symptomatic PE. It had a high false negative rate and a low clinical utility. The STOP-Bang questionnaire had a good sensitivity in men, and might be used to rule out OSA in this population.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of large-muscle movements in the diagnosis of possible restless sleep disorder in adult population. 分析大肌肉运动以诊断成人群体中可能存在的睡眠不安症

IF 5.6 2区医学

Sleep Pub Date : 2024-07-11 DOI: 10.1093/sleep/zsae102

Merve Aktan Suzgun, Gulcin Benbir Senel, Lourdes DelRosso, Derya Karadeniz

引用次数: 0

Spindle-slow wave coupling and problem-solving skills: impact of age. 主轴-慢波耦合与解决问题的能力：年龄的影响

IF 5.6 2区医学

Sleep Pub Date : 2024-07-11 DOI: 10.1093/sleep/zsae072

Daniel Baena, Balmeet Toor, Nicholas H van den Berg, Laura B Ray, Stuart M Fogel

{"title":"Spindle-slow wave coupling and problem-solving skills: impact of age.","authors":"Daniel Baena, Balmeet Toor, Nicholas H van den Berg, Laura B Ray, Stuart M Fogel","doi":"10.1093/sleep/zsae072","DOIUrl":"10.1093/sleep/zsae072","url":null,"abstract":"We examined how aging affects the role of sleep in the consolidation of newly learned cognitive strategies. Forty healthy young adults (20-35 years) and 30 healthy older adults (60-85 years) were included. Participants were trained on the Tower of Hanoi (ToH) task, then, half of each age group were assigned to either the 90-minute nap condition, or stayed awake, before retesting. The temporal co-occurrence between slow waves (SW) and sleep spindles (SP) during non-rapid eye movement sleep was examined as a function of age in relation to memory consolidation of problem-solving skills. We found that despite intact learning, older adults derived a reduced benefit of sleep for problem-solving skills relative to younger adults. As expected, the percentage of coupled spindles was lower in older compared to younger individuals from control to testing sessions. Furthermore, coupled spindles in young adults were more strongly coupled to the SW upstate compared to older individuals. Coupled spindles in older individuals were lower in amplitude (mean area under the curve; μV) compared to the young group. Lastly, there was a significant relationship between offline gains in accuracy on the ToH and percent change of spindles coupled to the upstate of the slow wave in older, but not younger adults. Multiple regression revealed that age accounted for differences in offline gains in accuracy, as did spindle coupling during the upstate. These results suggest that with aging, spindle-slow wave coupling decreases. However, the degree of the preservation of coupling with age correlates with the extent of problem-solving skill consolidation during sleep.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large muscle group movements during sleep in restless leg syndrome: neurophysiological and clinical implications. 不宁腿综合征患者睡眠时的大肌肉群运动：神经生理学和临床意义

IF 5.6 2区医学

Sleep Pub Date : 2024-07-11 DOI: 10.1093/sleep/zsae113

Maria P Mogavero, Patrizia Congiu, Giuseppe Lanza, Sara Marelli, Alessandra Castelnuovo, Monica Puligheddu, Lourdes M DelRosso, Luigi Ferini Strambi, Raffaele Ferri

{"title":"Large muscle group movements during sleep in restless leg syndrome: neurophysiological and clinical implications.","authors":"Maria P Mogavero, Patrizia Congiu, Giuseppe Lanza, Sara Marelli, Alessandra Castelnuovo, Monica Puligheddu, Lourdes M DelRosso, Luigi Ferini Strambi, Raffaele Ferri","doi":"10.1093/sleep/zsae113","DOIUrl":"10.1093/sleep/zsae113","url":null,"abstract":"Study objectives: Recently, criteria have been drawn up for large muscle group movements during sleep (LMM), defined as movements lasting for 3-45 seconds in adults, which are often accompanied by changes in sleep stage, arousals, and increases in heart rate. The aim of this study was to characterize LMM in restless legs syndrome (RLS) in order to better evaluate their impact on the neurophysiology of the disorder and, therefore, the possible clinical implications.Methods: Consecutive, drug-free patients diagnosed with RLS and controls, aged 18 years or more, were retrospectively enrolled. Leg movement activity-short-interval (SILMS), periodic (PLMS), and isolated (ISOLMS) leg movements during sleep-and LMM were detected and scored.Results: In total, 100 patients and 67 controls were recruited. All movement measures were significantly higher in RLS. A significant positive correlation was found between LMM and ISOLMS index but not PLMS index in both groups. LMM index showed a significant negative correlation with total sleep time, sleep efficiency, and percentage of sleep stages N3 and R, as well as a significant positive correlation with the number of awakenings, and percentage of sleep stages N1 and N2 only in patients with RLS. No significant correlation was found between either LMM or PLMS index and RLS severity.Conclusions: Different types of movements, including SILMS, ISOLMS, and LMM, play somewhat distinct roles in sleep neurophysiology in RLS. Notably, LMM, a newly recognized category of movements, demonstrates associations with sleep architecture instability and fragmentation, arousals, and awakenings, suggesting potential clinical implications.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Cerebrospinal-fluid biomarkers for predicting phenoconversion in patients with isolated rapid-eye movement sleep behavior disorder. 更正：预测孤立性快速眼动睡眠行为障碍患者表型转换的脑脊液生物标志物。

IF 5.6 2区医学

Sleep Pub Date : 2024-07-11 DOI: 10.1093/sleep/zsae108

引用次数: 0