Sleep最新文献

{"title":"A Novel Method to Identify Endotypes and Risk Factors Related to Co-Occurring Obstructive Sleep Apnea and Sleep Bruxism.","authors":"Miguel Meira E Cruz","doi":"10.1093/sleep/zsaf238","DOIUrl":"https://doi.org/10.1093/sleep/zsaf238","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narcolepsy and Risk of Cardiovascular Outcomes: Getting to the Heart of the Matter.","authors":"Alessandro Silvani","doi":"10.1093/sleep/zsaf244","DOIUrl":"https://doi.org/10.1093/sleep/zsaf244","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep as a Key to Understanding Racial and Ethnic Health Disparities.","authors":"Soomi Lee","doi":"10.1093/sleep/zsaf241","DOIUrl":"https://doi.org/10.1093/sleep/zsaf241","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectral and network investigation reveals distinct power and connectivity patterns between phasic and tonic REM sleep.","authors":"Tamir Avigdor, Laure Peter-Derex, Alyssa Ho, Katharina Schiller, Yingqi Wang, Chifaou Abdallah, Edouard Delaire, Kassem Jaber, Vojtech Travnicek, Christophe Grova, Birgit Frauscher","doi":"10.1093/sleep/zsaf133","DOIUrl":"10.1093/sleep/zsaf133","url":null,"abstract":"<p><p>Although rapid eye movement (REM) sleep is often thought of as a singular state, it consists of two substates, phasic and tonic REM, defined by the presence (respectively absence) of bursts of rapid eye movements. These two substates have distinct EEG signatures and functional properties. However, whether they exhibit regional specificities remains unknown. Using intracranial EEG recordings from 31 patients, we analyzed expert-labeled segments from tonic and phasic REM and contrasted them with wakefulness segments. We assessed the spectral and connectivity content of these segments using Welch's method to estimate power spectral density and the phase locking value to assess functional connectivity. Overall, we found a widespread power gradient between low and high frequencies (p < 0.05, Cohen's d = 0.17 ± 0.20), with tonic REM being dominated by lower frequencies (p < 0.01, d = 0.18 ± 0.08), and phasic REM by higher frequencies (p < 0.01, d = 0.18 ± 0.19). However, some regions, such as the occipito-temporal areas as well as medial frontal regions, exhibit opposite trends. Connectivity was overall higher in all bands except in the low and high ripple frequency bands in most networks during tonic REM (p < 0.01, d = 0.08 ± 0.09) compared to phasic REM. Yet, functional connections involving the visual network were always stronger during phasic REM when compared to tonic REM. These findings highlight the spatiotemporal heterogeneity of REM sleep which is consistent with the concept of focal sleep in humans.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep as a window into brain health: clinical implications of sleeping brain wave-structure associations.","authors":"Haoqi Sun, Wolfgang Ganglberger, M Brandon Westover, Robert J Thomas","doi":"10.1093/sleep/zsaf127","DOIUrl":"10.1093/sleep/zsaf127","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Night shift work and lung cancer risk: a prospective cohort study with mediator analysis from the UK Biobank.","authors":"Xiangyuan Zheng, Yi Feng, Juan He, Xusen Zou, Jie Liang, Xinyi Wu, Zixun Wang, Xin Bi, Bo Cheng, Kexin Chen, Chengfu Xian, Xianzhe Fan, Xiaohong Xie, Jianxing He, Wenhua Liang","doi":"10.1093/sleep/zsaf159","DOIUrl":"10.1093/sleep/zsaf159","url":null,"abstract":"<p><strong>Study objectives: </strong>This study investigated the association between night shift work and lung cancer risk using data from the UK Biobank cohort of 278 650 participants, while exploring potential biological mediators and gene-environment interactions.</p><p><strong>Methods: </strong>Cox proportional hazards models assessed relationships between current night shift status, lifetime duration, and frequency of night shifts with lung cancer incidence. Mediation analyses examined physical measurements, lifestyle habits, blood immune cell parameters, and plasma proteins as potential mediating pathways. Polygenic risk scores evaluated genetic predisposition interactions.</p><p><strong>Results: </strong>During a median follow-up of 10.64 years, 1524 incident lung cancer cases were identified. A significant dose-response relationship was observed between increasing categories of current night shift work and lung cancer risk (Shift but never/rarely night shifts HR 1.18, 95% CI = 1.00 to 1.39, p = .047; Some night shifts HR 1.28, 95% CI = 1.06 to 1.55, p = .010; Some night shifts HR 1.19, 95% CI = 0.90 to 1.57, p = .220; p for trend = .004). Smoking plays a significant mediating role in this association. Mediation analysis also identified prostasin (PRSS8), alkaline phosphatase (ALPP), and carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) as key mediators, collectively explaining over 25 per cent of the total effect.</p><p><strong>Conclusions: </strong>This study suggests that night shift work, particularly when combined with smoking, is associated with an increased risk of lung cancer. The identification of potential mediators such as prostasin, ALPP and CEACAM5 provides insights into the underlying biological mechanisms. Future research should validate these findings and explore targeted prevention strategies for high-risk populations.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG slow oscillations and overnight spatial navigational memory performance in CPAP-treated obstructive sleep apnea.","authors":"Anna E Mullins, Ankit Parekh, Korey Kam, Daphne I Valencia, Reagan Schoenholz, Ahmad Fakhoury, Bresne Castillo, Zachary J Roberts, Sajila Wickramaratne, Thomas M Tolbert, Jeongyeon Hwang, Esther M Blessing, Omonigho M Bubu, David M Rapoport, Indu Ayappa, Ricardo S Osorio, Andrew W Varga","doi":"10.1093/sleep/zsaf046","DOIUrl":"10.1093/sleep/zsaf046","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) exerts pathogenic effects through a combination of sleep fragmentation (SF) and intermittent hypoxia (IH). The mechanisms through which sleep disruption impacts memory might arise by investigating disruption of specific sleep stages and, when such disruption occurs through OSA, by evaluating the individual contributions of SF and IH. Given that region-specific EEG slow activity during non-REM sleep has been associated with overnight declarative, motor, and spatial memory formation, we investigated the effects of disrupting slow wave sleep (SWS) on a virtual maze navigation task. Thirty-three participants (24 male, 56 years old [range 28-68 years] with OSA (baseline AHI4%>20/h) who were habitually well-treated and adherent to continuous positive airway pressure (CPAP) completed 3 timed trials on a 3D spatial maze before and after polysomnographically (PSG) recorded sleep. We restricted CPAP withdrawal to SWS through real-time monitoring of the PSG under three conditions: (1) stable SWS on therapeutic CPAP, (2) SWS-CPAP withdrawal containing SF and IH, and (3) SWS-CPAP withdrawal with supplemental oxygen containing SF with reduced IH. SWS-specific CPAP withdrawal (with or without supplemental oxygen) did not significantly impact EEG slow oscillation or spatial navigational memory despite effectively reducing %SWS and SWS bout length. Greater regional EEG slow oscillation (0.6-1 Hz), but not delta (1-4 Hz) activity, was associated with improvements in overnight memory during stable SWS in the CPAP condition. These observations suggest that slow oscillations may be important for overnight memory processing, and sleep disruptions of sufficient magnitude to reduce slow oscillations may be required to capture demonstrable change in spatial navigation performance.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A daytime nap improves performance on a novel aerial flight maneuvering task.","authors":"Kara J Blacker, Nicole L Beasley, Sara E Alger, J Lynn Caldwell","doi":"10.1093/sleep/zsaf062","DOIUrl":"10.1093/sleep/zsaf062","url":null,"abstract":"<p><p>Previous work has shown the positive effects of sleep on learning and memory. While most have focused on the effects of a full night of sleep, evidence suggests that a daytime nap has similar effects on improving learning. Here we examined the effects of a nap on three learning tasks. Participants (n = 66; 42 males) were randomly assigned to either a nap or rest group. Both groups completed paired associates, finger tapping, and novel aerial flight maneuvering (AFM) tasks. All tasks were performed in the morning (i.e., test), followed by a 2-hour nap or rest opportunity, and again 30 min after the nap/rest (i.e., retest). EEG was recorded throughout, including polysomnography during the nap. For the AFM task, the nap group demonstrated improved performance at retest compared to the rest group. Within the nap group, we found that the amount of stage N2 sleep was significantly associated with better learning. The EEG recordings during the AFM task demonstrated significant changes in beta power. The rest group saw a significant increase at retest compared to the test; the nap group saw a significant decrease. The paired associates and finger-tapping tasks did not elicit any significant behavioral or EEG results. We found that a daytime nap significantly improved learning performance on a novel aviation task compared to an equivalent rest period. This improvement was evident in both behavioral performance and EEG results, suggesting that a daytime nap could be incorporated into work/rest guidance as a strategy to improve new occupational training.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-life disability may increase with more frequent insomnia symptoms and sleep medications use over time.","authors":"Tuo-Yu Chen, Soomi Lee, Orfeu M Buxton","doi":"10.1093/sleep/zsaf098","DOIUrl":"10.1093/sleep/zsaf098","url":null,"abstract":"<p><strong>Study objectives: </strong>This study investigated whether disability status increased with the frequency of insomnia symptoms and sleep medication usage over a 5-year period and whether frequent use of sleep medication modified the longitudinal effects of insomnia symptoms on disability among community-dwelling older adults.</p><p><strong>Methods: </strong>Data were from the National Health and Aging Trends Study (2011-2015; n = 6722). Disability was assessed with a validated disability index. Insomnia symptoms were assessed by the average frequency of longer sleep onset latency and trouble staying asleep. General sleep medication usage frequency was assessed. Multilevel modeling was used to analyze the data, considering health status, demographic information, and risky health behavior.</p><p><strong>Results: </strong>In the conditional growth model, for every one-unit higher in the frequency of insomnia symptoms and sleep medication usage, disability scores increased by 0.20 (SE = .02, p < .001) and 0.19 (SE = .02, p < .001) every year, respectively, adjusting for covariates. Moreover, the frequency of sleep medication usage influenced the relationship between insomnia symptoms and disability. Specifically, more frequent insomnia symptoms were associated with higher disability scores, and using sleep medications more often led to an even greater increase in disability scores than insomnia symptoms alone.</p><p><strong>Conclusions: </strong>Disability increased with more frequent insomnia symptoms and more frequent sleep medication usage each year. More frequent sleep medication usage has detrimental implications on disability beyond insomnia symptoms. Treating insomnia and managing sleep medication properly may help prevent disability among older adults.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micronutrients and midnight: the diet-sleep link.","authors":"Sharon Tamir, Marc D Ruben","doi":"10.1093/sleep/zsaf143","DOIUrl":"10.1093/sleep/zsaf143","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}