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Lending a Helping Hand: The complementary role of actigraphy in the assessment of Central Disorders of Hypersomnolence. 伸出援助之手:行动记录仪在评估中枢性嗜睡症中的辅助作用。
IF 5.6 2区 医学
Sleep Pub Date : 2024-09-27 DOI: 10.1093/sleep/zsae228
Jesse D Cook, Cathy Goldstein, David T Plante
{"title":"Lending a Helping Hand: The complementary role of actigraphy in the assessment of Central Disorders of Hypersomnolence.","authors":"Jesse D Cook, Cathy Goldstein, David T Plante","doi":"10.1093/sleep/zsae228","DOIUrl":"https://doi.org/10.1093/sleep/zsae228","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep induced by mechanosensory stimulation provides cognitive and health benefits in Drosophila. 机械感官刺激诱导睡眠对果蝇的认知和健康有益
IF 5.6 2区 医学
Sleep Pub Date : 2024-09-27 DOI: 10.1093/sleep/zsae226
Sho Inami, Kyunghee Koh
{"title":"Sleep induced by mechanosensory stimulation provides cognitive and health benefits in Drosophila.","authors":"Sho Inami, Kyunghee Koh","doi":"10.1093/sleep/zsae226","DOIUrl":"10.1093/sleep/zsae226","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep is a complex phenomenon regulated by various factors, including sensory input. Anecdotal observations have suggested that gentle rocking helps babies fall asleep, and experimental studies have verified that rocking promotes sleep in both humans and mice. Recent studies have expanded this understanding, demonstrating that gentle vibration also induces sleep in Drosophila. Natural sleep serves multiple functions, including learning and memory, synaptic downscaling, and reduction of harmful substances associated with neurodegenerative diseases. Here, we investigated whether vibration-induced sleep (VIS) provides similar cognitive and health benefits in Drosophila.</p><p><strong>Methods: </strong>We administered gentle vibration to flies that slept very little due to a forced activation of wake-promoting neurons and investigated how the vibration influenced learning and memory in the courtship conditioning paradigm. Additionally, we examined the effects of VIS on synaptic downscaling by counting synaptic varicosities of select neurons. Finally, we determined whether vibration could induce sleep in Drosophila models of Alzheimer's disease (AD) and suppress the accumulation of Amyloid β (Aβ) and Tubulin Associated Unit (TAU).</p><p><strong>Results: </strong>Vibration-induced sleep enhanced performance in a courtship conditioning paradigm and reduced the number of synaptic varicosities in select neurons. Moreover, vibration improved sleep in Drosophila models of AD, reducing Aβ and TAU levels.</p><p><strong>Conclusion: </strong>Mechanosensory stimulation offers a promising non-invasive avenue for enhancing sleep, potentially providing associated cognitive and health benefits.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of night-to-night variations in objectively measured sleep on blood glucose in healthy university students. 客观测量的睡眠时间每晚变化对健康大学生血糖的影响。
IF 5.6 2区 医学
Sleep Pub Date : 2024-09-26 DOI: 10.1093/sleep/zsae224
Alyssa S C Ng, E Shyong Tai, Michael W L Chee
{"title":"Effects of night-to-night variations in objectively measured sleep on blood glucose in healthy university students.","authors":"Alyssa S C Ng, E Shyong Tai, Michael W L Chee","doi":"10.1093/sleep/zsae224","DOIUrl":"10.1093/sleep/zsae224","url":null,"abstract":"<p><strong>Study objectives: </strong>We examined associations between daily variations in objectively measured sleep and blood glucose in a sample of non-diabetic young adults to complement laboratory studies on how sleep affects blood glucose levels.</p><p><strong>Methods: </strong>119 university students underwent sleep measurement using an Oura Ring 2 and continuous glucose monitoring (CGM) for up to 14 days. In 69 individuals who consumed a standardised diet across the study, multilevel models examined associations between sleep duration, timing and efficiency and daily CGM profiles. Separately, in 58 individuals, multilevel models were used to evaluate postprandial glycaemic responses to a test meal challenge on 7 days. Participants also underwent oral glucose tolerance testing once after a night of ad libitum sleep, and again following a night of sleep restriction by 1-2 hours relative to that individual's habitual sleep duration. Between-condition glucose and insulin excursions, HOMA-IR and Matsuda index were compared.</p><p><strong>Results: </strong>Nocturnal sleep did not significantly influence following-day CGM profiles, postprandial glucose, or nocturnal mean glucose levels (all Ps>0.05). Longer sleep durations were associated with lower same-night glucose variability (all Ps<0.001). However, the range of variation of sugar levels was small and unlikely to be of functional significance. Considering naps in the analysis did not alter the findings. Sleep restriction by an average of 1.73 hours (SD=0.97) did not significantly impact excursions in glucose or insulin or insulin sensitivity the following morning (all Ps>0.05).</p><p><strong>Conclusions: </strong>Glucose handling in young, healthy adults may be more resilient to real-life fluctuations in sleep patterns than previously thought.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep state-dependent development of resting state functional connectivity during the preterm period. 早产儿静息状态功能连接的发展与睡眠状态有关。
IF 5.6 2区 医学
Sleep Pub Date : 2024-09-25 DOI: 10.1093/sleep/zsae225
Anna Shiraki, Hiroyuki Kidokoro, Hama Watanabe, Gentaro Taga, Takafumi Ushida, Hajime Narita, Takamasa Mitsumatsu, Sumire Kumai, Ryosuke Suzui, Fumi Sawamura, Yuji Ito, Hiroyuki Yamamoto, Tomohiko Nakata, Yoshiaki Sato, Masahiro Hayakawa, Yoshiyuki Takahashi, Jun Natsume
{"title":"Sleep state-dependent development of resting state functional connectivity during the preterm period.","authors":"Anna Shiraki, Hiroyuki Kidokoro, Hama Watanabe, Gentaro Taga, Takafumi Ushida, Hajime Narita, Takamasa Mitsumatsu, Sumire Kumai, Ryosuke Suzui, Fumi Sawamura, Yuji Ito, Hiroyuki Yamamoto, Tomohiko Nakata, Yoshiaki Sato, Masahiro Hayakawa, Yoshiyuki Takahashi, Jun Natsume","doi":"10.1093/sleep/zsae225","DOIUrl":"https://doi.org/10.1093/sleep/zsae225","url":null,"abstract":"<p><strong>Study objectives: </strong>The brains of preterm infants exhibit altered functional connectivity (FC) networks, but the potential variation in sleep states and the impact of breathing patterns on FC networks are unclear. This study explores the evolution of resting-state FC from preterm to term, focusing on breathing patterns and distinguishing between active sleep and quiet sleep.</p><p><strong>Methods: </strong>We recruited 63 preterm infants and 44 healthy-term infants and performed simultaneous electroencephalography and functional near-infrared spectroscopy. FC was calculated using oxy- and deoxyhemoglobin signals across eight channels. First, FC was compared between periodic breathing (PB) and non-PB segments. Then sleep state-dependent FC development was explored. FC was compared between active sleep and quiet sleep segments and between preterm infants at term and term-born infants in each sleep state. Finally, associations between FC at term, clinical characteristics, and neurodevelopmental outcomes in late infancy were assessed in preterm infants.</p><p><strong>Results: </strong>In total, 148 records from preterm infants and 44 from term-born infants were analyzed. PB inflated FC values. After excluding PB segments, FC was found to be elevated during active sleep compared to quiet sleep, particularly in connections involving occipital regions. Preterm infants had significantly higher FC in both sleep states compared to term-born infants. Furthermore, stronger FC in specific connections during active sleep at term was associated with unfavorable neurodevelopment in preterm infants.</p><p><strong>Conclusions: </strong>Sleep states play a critical role in FC development and preterm infants show observable changes in FC.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Why are we not working to prevent OSA?" "我们为什么不努力预防 OSA?
IF 5.6 2区 医学
Sleep Pub Date : 2024-09-23 DOI: 10.1093/sleep/zsae222
Dimple Goel, Ivan Ling, Nigel McArdle
{"title":"\"Why are we not working to prevent OSA?\"","authors":"Dimple Goel, Ivan Ling, Nigel McArdle","doi":"10.1093/sleep/zsae222","DOIUrl":"https://doi.org/10.1093/sleep/zsae222","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mortality Risk Assessment Using Deep Learning-Based Frequency Analysis of EEG and EOG in Sleep. 利用基于深度学习的睡眠脑电图和眼电图频率分析进行死亡率风险评估。
IF 5.6 2区 医学
Sleep Pub Date : 2024-09-20 DOI: 10.1093/sleep/zsae219
Teitur Óli Kristjánsson, Katie L Stone, Helge B D Sorensen, Andreas Brink-Kjaer, Emmanuel Mignot, Poul Jennum
{"title":"Mortality Risk Assessment Using Deep Learning-Based Frequency Analysis of EEG and EOG in Sleep.","authors":"Teitur Óli Kristjánsson, Katie L Stone, Helge B D Sorensen, Andreas Brink-Kjaer, Emmanuel Mignot, Poul Jennum","doi":"10.1093/sleep/zsae219","DOIUrl":"https://doi.org/10.1093/sleep/zsae219","url":null,"abstract":"<p><strong>Study objectives: </strong>To assess whether the frequency content of electroencephalography (EEG) and electrooculography (EOG) during nocturnal polysomnography (PSG) can predict all-cause mortality.</p><p><strong>Methods: </strong>Power spectra from PSGs of 8,716 participants, included from the MrOS Sleep Study and the Sleep Heart Health Study (SHHS), were analyzed in deep learning-based survival models. The best-performing model was further examined using SHapley Additive Explanation (SHAP) for data-driven sleep-stage specific definitions of power bands, which were evaluated in predicting mortality using Cox Proportional Hazards models.</p><p><strong>Results: </strong>Survival analyses, adjusted for known covariates, identified multiple EEG frequency bands across all sleep stages predicting all-cause mortality. For EEG, we found an all-cause mortality hazard ratio (HR) of 0.90 (CI95% 0.85-0.96) for 12-15 Hz in N2, 0.86 (CI95% 0.82-0.91) for 0.75-1.5 Hz in N3, and 0.87 (CI95% 0.83-0.92) for 14.75-33.5 Hz in REM sleep. For EOG, we found several low-frequency effects including an all-cause mortality HR of 1.19 (CI95% 1.11-1.28) for 0.25 Hz in N3, 1.11 (CI95% 1.03-1.21) for 0.75 Hz in N1, and 1.11 (CI95% 1.03-1.20) for 1.25-1.75 Hz in Wake. The gain in the concordance index (C-index) for all-cause mortality is minimal, with only a 0.24% increase: The best single mortality predictor was EEG N3 (0-0.5 Hz) with C-index of 77.78% compared to 77.54% for confounders alone.</p><p><strong>Conclusion: </strong>Spectral power features, possibly reflecting abnormal sleep microstructure, are associated with mortality risk. These findings add to a growing literature suggesting that sleep contains incipient predictors of health and mortality.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obstructive Sleep Apnea and Cerebral Small Vessel disease in Community-based Older People: An ASPREE Imaging Substudy. 社区老年人的阻塞性睡眠呼吸暂停和脑小血管疾病:ASPREE 成像子研究。
IF 5.6 2区 医学
Sleep Pub Date : 2024-09-20 DOI: 10.1093/sleep/zsae204
Stephanie A Ward, Elsdon Storey, Matthew T Naughton, Rory Wolfe, Garun S Hamilton, Meng Law, Ryo Kawasaki, Walter P Abhayaratna, Katherine L Webb, Fergal J O'Donoghue, Danijela Gasevic, Nigel P Stocks, Ruth E Trevaks, Liubov D Robman, Scott Kolbe, Sharyn M Fitzgerald, Suzanne G Orchard, Tien Wong, John McNeil, Christopher M Reid, Ben Sinclair, Robyn L Woods
{"title":"Obstructive Sleep Apnea and Cerebral Small Vessel disease in Community-based Older People: An ASPREE Imaging Substudy.","authors":"Stephanie A Ward, Elsdon Storey, Matthew T Naughton, Rory Wolfe, Garun S Hamilton, Meng Law, Ryo Kawasaki, Walter P Abhayaratna, Katherine L Webb, Fergal J O'Donoghue, Danijela Gasevic, Nigel P Stocks, Ruth E Trevaks, Liubov D Robman, Scott Kolbe, Sharyn M Fitzgerald, Suzanne G Orchard, Tien Wong, John McNeil, Christopher M Reid, Ben Sinclair, Robyn L Woods","doi":"10.1093/sleep/zsae204","DOIUrl":"https://doi.org/10.1093/sleep/zsae204","url":null,"abstract":"<p><strong>Study objectives: </strong>Obstructive sleep apnea (OSA) may increase risk of dementia. A potential pathway for this risk is through cerebral small vessel disease (CSVD). In the context of an existing randomized trial of aspirin for primary prevention, we aimed to investigate OSA's impact on CSVD imaging measures and explore whether aspirin effects these measures over 3 years that differ in the presence or absence of OSA.</p><p><strong>Methods: </strong>A sub-study of the ASPirin in Reducing Events in the Elderly randomized placebo-controlled trial of low-dose aspirin. Community-dwelling participants aged 70 years and above, without cognitive impairment, cardiovascular disease or known OSA completed an unattended limited-channel sleep study that calculated the oxygen desaturation index and apnea-hypopnea index. At baseline and 3 years later, volumes of white matter hyperintensities (WMH) and silent brain infarctions (SBI) were measured on 1.5 Tesla brain magnetic resonance imaging, and retinal vessel calibers were calculated from retinal vascular imaging.</p><p><strong>Results: </strong>Mild and moderate/severe OSA was detected in 48.9% and 29.9%, respectively, of the 311 participants, who had a mean age of 73.7 years (SD 3.4 years), 38.6% female. OSA of any severity did not associate with WMH volumes, SBI, nor with retinal vessel calibers at baseline, nor with change in these measures in the 277 participants with repeated measures acquired after 3 years. OSA of any severity did not interact with aspirin on change in these measures over 3 years.</p><p><strong>Conclusion: </strong>In healthy older adults undiagnosed OSA was not associated with retinal vascular calibers and neuroimaging measures of CSVD.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A spectrum of altered non-rapid eye movement sleep in schizophrenia. 精神分裂症患者非快速眼动睡眠的改变谱系。
IF 5.6 2区 医学
Sleep Pub Date : 2024-09-19 DOI: 10.1093/sleep/zsae218
Nataliia Kozhemiako, Chenguang Jiang, Yifan Sun, Zhenglin Guo, Sinéad Chapman, Guanchen Gai, Zhe Wang, Lin Zhou, Shen Li, Robert G Law, Lei A Wang, Dimitrios Mylonas, Lu Shen, Michael Murphy, Shengying Qin, Wei Zhu, Zhenhe Zhou, Robert Stickgold, Hailiang Huang, Shuping Tan, Dara S Manoach, Jun Wang, Mei-Hua Hall, Jen Q Pan, Shaun M Purcell
{"title":"A spectrum of altered non-rapid eye movement sleep in schizophrenia.","authors":"Nataliia Kozhemiako, Chenguang Jiang, Yifan Sun, Zhenglin Guo, Sinéad Chapman, Guanchen Gai, Zhe Wang, Lin Zhou, Shen Li, Robert G Law, Lei A Wang, Dimitrios Mylonas, Lu Shen, Michael Murphy, Shengying Qin, Wei Zhu, Zhenhe Zhou, Robert Stickgold, Hailiang Huang, Shuping Tan, Dara S Manoach, Jun Wang, Mei-Hua Hall, Jen Q Pan, Shaun M Purcell","doi":"10.1093/sleep/zsae218","DOIUrl":"10.1093/sleep/zsae218","url":null,"abstract":"<p><p>Multiple facets of sleep neurophysiology, including electroencephalography (EEG) metrics such as non-rapid eye movement (NREM) spindles and slow oscillations, are altered in individuals with schizophrenia (SCZ). However, beyond group-level analyses, the extent to which NREM deficits vary among patients is unclear, as are their relationships to other sources of heterogeneity including clinical factors, ageing, cognitive profiles and medication regimens. Using newly collected high-density sleep EEG data on 103 individuals with SCZ and 68 controls, we first sought to replicate our previously reported group-level differences between patients and controls (original N=130) during N2 stage. Then in the combined sample (N=301 including 175 patients), we characterized patient-to-patient variability. We replicated all group-level mean differences and confirmed the high accuracy of our predictive model (AUC=0.93 for diagnosis). Compared to controls, patients showed significantly increased between-individual variability across many (26%) sleep metrics. Although multiple clinical and cognitive factors were associated with NREM metrics, collectively they did not account for much of the general increase in patient-to-patient variability. Medication regimen was a greater contributor to variability. Some sleep metrics including fast spindle density showed exaggerated age-related effects in SCZ, and patients exhibited older predicted biological ages based on the sleep EEG; further, among patients, certain medications exacerbated these effects, in particular olanzapine. Collectively, our results point to a spectrum of N2 sleep deficits among SCZ patients that can be measured objectively and at scale, with relevance to both the etiological heterogeneity of SCZ as well as potential iatrogenic effects of antipsychotic medication.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142295976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expiratory Muscle Strength Training Reduces Oxidative Stress and Systemic Inflammation in Men with Obstructive Sleep Apnea Syndrome: A Double-Blinded, Randomized Parallel Trial 呼气肌力量训练可降低阻塞性睡眠呼吸暂停综合征男性患者的氧化应激和全身炎症:双盲随机平行试验
IF 5.6 2区 医学
Sleep Pub Date : 2024-09-19 DOI: 10.1093/sleep/zsae221
Nurel Erturk, Adem Celik, Sevim Kahraman Yaman, Huseyin Yaman, Ferhat Unal, Ebru Calik Kutukcu
{"title":"Expiratory Muscle Strength Training Reduces Oxidative Stress and Systemic Inflammation in Men with Obstructive Sleep Apnea Syndrome: A Double-Blinded, Randomized Parallel Trial","authors":"Nurel Erturk, Adem Celik, Sevim Kahraman Yaman, Huseyin Yaman, Ferhat Unal, Ebru Calik Kutukcu","doi":"10.1093/sleep/zsae221","DOIUrl":"https://doi.org/10.1093/sleep/zsae221","url":null,"abstract":"Study Objectives This study aimed to evaluate and compare the effects of high and low-intensity expiratory muscle strength training (EMST) on disease severity, systemic inflammation, oxidative stress, respiratory muscle strength, exercise capacity, symptoms, daytime sleepiness, fatigue severity, and sleep quality in male patients with obstructive sleep apnea syndrome (OSAS). Methods Thirty-one male patients diagnosed with moderate OSAS were included in this double-blind, randomized, parallel study. Patients were randomized into two groups: High-EMST and Low-EMST groups. EMST was used at home 7 days/week, once a day, for 25 breaths, 12 weeks. Respiratory muscle strength was measured using a mouth pressure device. Disease severity (Apne Hipopne Index-AHI) and, respiratory sleep events by polysomnography, total oxidant level(TOS), total antioxidant level(TAS), oxidative stress index (OSI), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels by blood serum were evaluated. Results The percentage of AHI change in the High-EMST group(50.8%) was significantly higher than in the Low-EMST group(6.3%) (p=0.002, d=1.31). In general, as MEP increased by one unit, AHI decreased by 0.149 points (b=-0.149; CR=-3.065; p=0.002), and as AHI increased by one unit, ODI increased by 0.746 points (b=0.746; CR=10.604; p&amp;lt;0.001). TOS, OSI, TNF-α and IL-6 levels decreased at similar rates in both groups. Conclusion EMST significantly reduces systemic inflammation and oxidative stress while improving expiratory muscle strength in male patients with moderate OSAS. High-EMST is more effective in enhancing the severity of disease than Low-EMST. EMST is a practical, effective, and promising treatment for pulmonary rehabilitation in patients with moderate OSAS.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":"57 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The benefits and pitfalls of advanced driver assistance systems for mitigating drowsy driving crashes. 高级驾驶辅助系统在减少瞌睡驾驶撞车事故方面的益处和隐患。
IF 5.6 2区 医学
Sleep Pub Date : 2024-09-18 DOI: 10.1093/sleep/zsae220
Mark E Howard,William J Horrey
{"title":"The benefits and pitfalls of advanced driver assistance systems for mitigating drowsy driving crashes.","authors":"Mark E Howard,William J Horrey","doi":"10.1093/sleep/zsae220","DOIUrl":"https://doi.org/10.1093/sleep/zsae220","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":"38 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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