Sleep最新文献

{"title":"TCF4's role in sleep/wake state and sleep function.","authors":"Robert Greene","doi":"10.1093/sleep/zsaf049","DOIUrl":"10.1093/sleep/zsaf049","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekend sleep extension, social jetlag, and incidence of coronary calcium score: the ELSA-Brasil study.","authors":"Érique J F Peixoto de Miranda, Barbara K Parise, Ronaldo B Santos, Soraya Giatti, Aline N Aielo, Lorenna F Cunha, Wagner A Silva, Silvana P Souza, Paulo A Lotufo, Isabela M Bensenor, Márcio S Bittencourt, Luciano F Drager","doi":"10.1093/sleep/zsaf039","DOIUrl":"10.1093/sleep/zsaf039","url":null,"abstract":"<p><strong>Study objectives: </strong>Insufficient/irregular sleep patterns are common conditions, but their cardiovascular consequences and strategies to minimize these risks are poorly explored. We aimed to determine whether weekend sleep extension (catch-up sleep) and social jetlag may impact the incidence of subclinical atherosclerosis.</p><p><strong>Methods: </strong>We performed a 7-day wrist actigraphy in this cohort study to monitor sleep parameters. Coronary artery calcium (CAC) was measured at two different time points. Catch-up-sleep was measured by calculating weekend minus weekday sleep duration. Social jetlag was calculated by the difference between the mean sleep midpoint on weekend days minus weekdays. The incidence of subclinical atherosclerosis was defined as baseline CAC = 0, followed by CAC > 0 at the follow-up. The association of incident CAC outcome was assessed using logistic regression adjusting for traditional confounders plus sleep apnea.</p><p><strong>Results: </strong>We analyzed 1832 participants (age: 48.8 ± 8.0 years; 57.8% women). Incidence of CAC among subjects with catch-up sleep >90 and ≤90 minutes were 19.1% vs. 31.7%, respectively (p < .001). In covariate-adjusted analyses (follow-up = 5.4 ± 0.90 years), we found a lower incidence of CAC in those participants with catch-up-sleep > 90 minutes (odds ratio [OR] = 0.62; 95% confidence interval [CI] 0.52-0.74). Interestingly, stratified analysis revealed that these results are modified by sleep duration (≤6.55 hours: OR = 0.42; 95% CI 0.33-0.54; > 6.55 hours: OR = 0.96; 95% CI 0.75-1.24). In contrast, social jet lag was weakly associated with incident CAC: 0.1% increasing risk/minute.</p><p><strong>Conclusions: </strong>Extending sleep time during the weekend is independently associated with lower 5-year CAC incidence, providing relevant insights into the cardiovascular benefits of this common sleep habit Worldwide.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disturbances in rest-activity rhythms and their neurobiological correlates: implications for Alzheimer's disease and dementia.","authors":"Peng Li, Kun Hu","doi":"10.1093/sleep/zsaf047","DOIUrl":"10.1093/sleep/zsaf047","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rest-activity rhythm fragmentation and synchronization are linked with reduced cortical thickness in older adults \"at risk\" for dementia.","authors":"Nicole Espinosa, Camilla M Hoyos, Andrew C McKinnon, Hannes Almgren, Shantel L Duffy, Sharon L Naismith","doi":"10.1093/sleep/zsaf017","DOIUrl":"10.1093/sleep/zsaf017","url":null,"abstract":"<p><strong>Study objectives: </strong>While alterations in rest-activity rhythms are common in older adults \"at risk\" for dementia, it is unclear how rest-activity rhythms relate to underlying brain integrity.</p><p><strong>Methods: </strong>Older adults aged ≥50 years (n = 143, mean age = 67) with subjective and/or objective cognitive impairment underwent magnetic resonance imaging scanning and 14 days of actigraphy. The following nonparametric measures were computed: intra-daily variability (IV), inter-daily stability (IS), relative amplitude (RA), and average activity during the least active 5-h period (L5). A vertex-wise analysis correcting for age, sex, and clinical variables examined the association between nonparametric actigraphy measures and cortical thickness.</p><p><strong>Results: </strong>When controlling for age, sex, and body mass index (BMI), lower IV was associated with greater cortical thickness in the right cuneus (cluster-wise p-values [CWP] < 0.001), left middle frontal gyrus (CWP < 0.001), and lateral orbital frontal cortex (CWP = 0.004). When controlling for age, sex, medical burden (CIRS-G), BMI, and antidepressant use, lower IS was associated with lower cortical thickness in the left (CWP = 0.002) and right superior frontal gyrus (CWP < 0.001), left superior temporal gyrus (CWP = 0.043), and left post-central gyrus (CWP = 0.033). There were no significant associations between RA or L5 and cortical thickness.</p><p><strong>Conclusions: </strong>In older adults \"at risk\" for dementia, variability and stability of rest-activity rhythms were associated with reduced cortical thickness in frontal, temporal, parietal, and occipital regions. Further studies could focus on determining the prognostic utility of such markers longitudinally.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fingertip wearables and obstructive sleep apnea: is event level precision the key?","authors":"Steven Holfinger, M Jeffery Mador","doi":"10.1093/sleep/zsaf026","DOIUrl":"10.1093/sleep/zsaf026","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysomnographic endotypes of successful multilevel upper airway surgery for obstructive sleep apnea.","authors":"Xiaoting Wang, Jingyu Zhang, Jianyin Zou, Tianjiao Zhou, Enhui Zhou, Li Shen, Siyu Yang, Weijun Huang, Huaming Zhu, Jian Guan, Hongliang Yi, Shankai Yin","doi":"10.1093/sleep/zsaf012","DOIUrl":"10.1093/sleep/zsaf012","url":null,"abstract":"<p><strong>Study objectives: </strong>Multilevel upper airway surgery is effective for some patients with obstructive sleep apnea (OSA), but predicting the response to surgery remains a challenge. The underlying endotypes of OSA include upper airway collapsibility, muscle compensation, loop gain, and the arousal threshold. This study aimed to explore the effect of surgery on polysomnography (PSG)-derived OSA endotypes and establish a surgical response prediction model.</p><p><strong>Methods: </strong>Our study included 54 Chinese patients with OSA who underwent multilevel upper airway surgery. Participants underwent PSG before and after surgery with a median follow-up time of 6.5 months. Using AHIBaseline/AHIpost-surgery ≥ 2 and AHIpost-surgery < 10 events/h as criteria, participants were classified as surgery responders and non-responders. The surgical success rate was 26%. These endotypic traits were derived from a standard PSG data by validated methods.</p><p><strong>Results: </strong>The surgery altered both anatomical and non-anatomical endotypic traits, including increased Vpassive (baseline vs post-surgery: 51.5 [18.7-84.2] vs 86.8 [67.4-93.7] %Veupnea, p < .001), decreased loop gain (baseline vs post-surgery: 0.7 [0.7-0.8] vs 0.6 [0.5-0.6]; p < .001), and a higher arousal threshold (baseline vs post-surgery: 202.9 [183.7-222.0] vs 160.7 [143.9-177.4] %Veupnea; p < .001). However, it did not significantly affect muscle compensation. Fully adjusted logistic regression analyses indicated that a favorable response to surgery was independently associated with a lower LG (OR [CI 95%], 0.1 [0.0-0.5], p = .032). In patients with improved muscle compensation or a more collapsible airway (lower Vpassive), a lower loop gain was more strongly indicative of success. However, when muscle compensation was lower or collapsibility was less severe (higher Vpassive), a lower loop gain was less predictive of success.</p><p><strong>Conclusions: </strong>This study demonstrated that multilevel upper airway surgery altered both anatomical and non-anatomical endotypes in Chinese patients with OSA. An endotype based regression model may meaningfully predict surgical success.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations of catch-up sleep for cardiometabolic health: is it time for personalized recommendations?","authors":"Kristen L Knutson, Brooke Aggarwal, Julio Fernandez-Mendoza","doi":"10.1093/sleep/zsaf033","DOIUrl":"10.1093/sleep/zsaf033","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic obstructive pulmonary disease exacerbations, obstructive sleep apnea and CPAP treatment. A prospective study.","authors":"Grace Oscullo, Amina Bekki, Thais Beaperthuy, Jose Daniel Gómez-Olivas, Marina Anglés, Sergio Mompeán, Rosalía Martínez, Miguel Angel Martinez-Garcia","doi":"10.1093/sleep/zsaf037","DOIUrl":"10.1093/sleep/zsaf037","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-omics study of the association between insomnia with objective short sleep duration phenotype and high blood pressure.","authors":"Yanyuan Dai, Alexandros N Vgontzas, Le Chen, Dandan Zheng, Baixin Chen, Jun Wu, Ruifan Shao, Yun Li","doi":"10.1093/sleep/zsaf030","DOIUrl":"10.1093/sleep/zsaf030","url":null,"abstract":"<p><strong>Study objectives: </strong>Insomnia with objective short sleep duration is associated with increased hypertension risk. We aimed to explore the mechanism underlying the association between objective short sleep duration and hypertension in patients with chronic insomnia disorder (CID) by multi-omics.</p><p><strong>Methods: </strong>CID was defined according to International Classification of Sleep Disorders-3, and objective short sleep duration was based on the median value of total sleep time of the overall subjects during an overnight polysomnography. We used the mean values of measured nighttime and morning systolic (SBP) and diastolic blood pressure (DBP) for analysis. Serum metabolomics and fecal 16S rDNA amplicon sequencing were used to explore characteristic metabolites and analyze gut microbiota distribution, respectively.</p><p><strong>Results: </strong>One hundred and three patients with CID and 70 normal sleepers were included. We found 52 objective short sleep duration insomnia phenotype (ISSD)-related serum metabolites. Among the 52 ISSD-related serum metabolites, indoxyl sulfate was positively correlated with BP after adjusting for confounding factors (SBP: β = 0.250, p = .028; DBP: β = 0.256, p = .030) in ISSD. In addition, the level of serum indoxyl sulfate was significantly correlated with the genera Prevotella 9 (r = .378, p = .027), CAG-56 (r = -.359, p = .037), Ruminiclostridium 9 (r = -.340, p = .049), and Ruminococcus 2 (r = -.356, p = .039) in ISSD.</p><p><strong>Conclusions: </strong>Our study suggests that the ISSD phenotype is associated with significant changes in serum metabolic profile, including high levels of indoxyl sulfate. The latter molecule correlates both with BP and gut microbiota in patients with the ISSD phenotype, suggesting that indoxyl sulfate may be the molecular path resulting in increased hypertension risk in this phenotype.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term γ-aminobutyric acid antagonist treatment improves long-term sleep quality, memory, and decision-making in a Down syndrome mouse model.","authors":"Elsa C Pittaras, Jonathan M Artal, Grace Ajibola, Giancarlo Allocca, Mia Bennett, Alexandra Camargo, Angelica Carpio, Nicholas Gessner, Myles Hinton, Rebecca Pizzitola, Natalie Tan, Evelyn Zhang, Alan Zhong, Horace C Heller","doi":"10.1093/sleep/zsae300","DOIUrl":"10.1093/sleep/zsae300","url":null,"abstract":"<p><p>Down syndrome (DS) is a common genetic condition affecting people worldwide. It involves cognitive disabilities for which there are no drug therapies. The Ts65Dn mouse model of DS shows cognitive impairment due to a reduction in neuron number and connectivity as well as excessive neuronal activity, as γ-aminobutyric acid (GABA) antagonist treatment restores memory in these mice. Our study showed the effects of GABA antagonist treatment on sleep and decision-making in Ts65Dn mice. We administered a daily, low oral dose of pentylenetetrazol (PTZ) in milk to Ts65Dn mice for 17 days. Decision-making was tested with and without PTZ treatment. Short and long-term memories were tested before, immediately after, and 1 month following PTZ treatment. Electro-encephalography was also recorded at these three time points to study the effect of the treatment on sleep. We showed that PTZ treatment improved long-term recognition, but not short term memory and led to more Ts65Dn mice showing safer decision-making behavior. PTZ treatment showed a moderate and only global beneficial effect on sleep by decreasing the global amount of wake and increasing non-rapid eye movement sleep in the Ts65Dn mice, which may explain the observed cognitive improvements. These results bring new knowledge on the role of GABA in sleep, memory consolidation, and decision-making abilities in DS.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}