IF 5.6 2区医学

Sleep Pub Date : 2024-12-04 DOI: 10.1093/sleep/zsae279

Shinya Nakata, Tomoyuki Fujiyama, Fuyuki Asano, Haruna Komiya, Noriko Hotta-Hirashima, Motoki Juichi, Daiki Komine, Miyo Kakizaki, Aya Ikkyu, Seiya Mizuno, Satoru Takahashi, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa

{"title":"Partial activation of SIK3 delays the onset of wakefulness and alleviates hypersomnia due to the lack of protein kinase A-phosphorylation site.","authors":"Shinya Nakata, Tomoyuki Fujiyama, Fuyuki Asano, Haruna Komiya, Noriko Hotta-Hirashima, Motoki Juichi, Daiki Komine, Miyo Kakizaki, Aya Ikkyu, Seiya Mizuno, Satoru Takahashi, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa","doi":"10.1093/sleep/zsae279","DOIUrl":"https://doi.org/10.1093/sleep/zsae279","url":null,"abstract":"Study objectives: Sleep/wakefulness is regulated by intracellular signaling pathways composed of protein kinases such as salt-inducible kinase 3 (Sik3). Sik3-deficiency in neurons decreases NREM sleep time and electroencephalogram (EEG) delta power during NREM sleep, while Sik3Slp mice lacking a protein kinase A (PKA)-phosphorylation site, S551, show hypersomnia phenotype. In this study, we examined how a phosphomimetic mutation of the 221st threonine residue (T221E), which provides a partial (weak) constitutive activity of the kinase, affects sleep/wakefulness and circadian behavior. We also examined the effect of T221E substitution on the hypersomnia phenotype of Sik3Slp mice.Methods: We examined the sleep/wake behavior of heterozygous and homozygous Sik3T221E mice and Sik3T221E;Slp mice using EEG and electromyogram (EMG) recording. We also examined the circadian behavior of Sik3T221E mice using a running wheel under the light-dark cycle and constant darkness.Results: Heterozygous and homozygous Sik3T221E mice showed normal sleep time and sleep homeostatic responses. Homozygous Sik3T221E mice exhibited a delayed onset of wakefulness at the early dark phase and longer circadian periods. Sik3T221E;Slp mice showed decreased NREM sleep time and homeostatic responses compared to Sik3Slp mice.Conclusion: Our results suggest that the peak onset of wakefulness is sensitive to disturbed kinase activity of SIK3, and the relationship between phosphorylation at T221 and S551 is critical for regulating sleep need.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstructive sleep apnea and chronic kidney disease: Time to move from association to causality and intervention.

IF 5.6 2区医学

Sleep Pub Date : 2024-11-29 DOI: 10.1093/sleep/zsae254

Patrick J Hanly, Sofia B Ahmed

引用次数: 0

Glucagon-like Peptide 1 Receptor Agonists for the Treatment of Obstructive Sleep Apnea：a meta-analysis.

IF 5.6 2区医学

Sleep Pub Date : 2024-11-29 DOI: 10.1093/sleep/zsae280

Mingxia Li, Hong Lin, Qianru Yang, Xiaolong Zhang, Qiong Zhou, Jiankuan Shi, Fangfang Ge

{"title":"Glucagon-like Peptide 1 Receptor Agonists for the Treatment of Obstructive Sleep Apnea：a meta-analysis.","authors":"Mingxia Li, Hong Lin, Qianru Yang, Xiaolong Zhang, Qiong Zhou, Jiankuan Shi, Fangfang Ge","doi":"10.1093/sleep/zsae280","DOIUrl":"https://doi.org/10.1093/sleep/zsae280","url":null,"abstract":"Study objectives: Obstructive sleep apnea (OSA) is characterized by disordered breathing during sleep and is associated with major cardiovascular complications. Glucagon-like peptide 1 receptor agonists (GLP-1RA) as an important treatment for obesity and diabetes mellitus show promising therapeutic prospect in OSA. We conducted a meta-analysis to evaluate the effect of GLP-1RA intervention in OSA individuals.Methods: We searched the PubMed and Web of Science databases (published until July 1, 2024), The included studies evaluated the GLP-1RA in OSA individuals and the efficacy outcomes measured by apnea-hypopnea index (AHI).Results: Six studies with a total of 1067 participants enrolled. GLP-1RA significantly decreased AHI with an estimated treatment difference of-9.48 events per hour (95% CI, -12.56 to -6.40, I2=92%). The change in weight was -10.99kg and BMI was -1.60kg/m2. The mean difference in SBP was -4.81mmHg and in DBP was -0.32 mmHg. Tirzepatide significantly reduced AHI more than liraglutide with an estimated treatment difference of -21.86 events per hour (95% CI, -25.93 to-17.79) vs -5.10 events per hour (95% CI, -6.95 to-3.26). Obese individuals experienced a more significant decrease in AHI with an estimated treatment difference of-12.93 events per hour vs -4.31 events per hour. The application of CPAP and the duration of follow-up did not affect the therapeutic effect.Conclusion: GLP-1RA could significantly reduce the severity of OSA, and also lead to weight loss and lower blood pressure. Further high-quality RCTs are needed to explore different GLP-1RA treatments and durations in OSA, and identify patient subgroups that may benefit the most.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep reactivity and variability: further evidence why it makes "cents" to look beyond the means. 睡眠反应性和可变性：进一步证明了为什么要 "美分 "地看待手段之外的东西。

IF 5.6 2区医学

Sleep Pub Date : 2024-11-26 DOI: 10.1093/sleep/zsae268

Kelly Glazer Baron

引用次数: 0

A randomised dose finding study of combination dronabinol and acetazolamide for the treatment of obstructive sleep apnoea. 一项关于屈大麻酚和乙酰唑胺联合治疗阻塞性睡眠呼吸暂停的随机剂量发现研究。

IF 5.6 2区医学

Sleep Pub Date : 2024-11-26 DOI: 10.1093/sleep/zsae276

Jennifer Walsh, Timothy Rankin, Sumit Mehra, Matthew T Naughton, Teanau Roebuck, Elizabeth McDermott, Andreas Pattichis, Rafael Smith, Rosemarie Walsh, Mark Bleackley, Kathleen Maddison, Terence J O'Brien

{"title":"A randomised dose finding study of combination dronabinol and acetazolamide for the treatment of obstructive sleep apnoea.","authors":"Jennifer Walsh, Timothy Rankin, Sumit Mehra, Matthew T Naughton, Teanau Roebuck, Elizabeth McDermott, Andreas Pattichis, Rafael Smith, Rosemarie Walsh, Mark Bleackley, Kathleen Maddison, Terence J O'Brien","doi":"10.1093/sleep/zsae276","DOIUrl":"https://doi.org/10.1093/sleep/zsae276","url":null,"abstract":"Study objectives: Current treatments for obstructive sleep apnoea (OSA) are ineffective or not tolerated in a proportion of patients. Other therapeutic options are needed and pharmaceuticals may provide an alternative. This randomised, double-blind, placebo-controlled, cross-over study examined the effect of combination acetazolamide and dronabinol (IHL-42X) at low, medium and high doses on OSA severity.Methods: Participants with OSA (apnoea-hypopnoea index; AHI≥15events/hr) received 1-week of IHL-42X at each of 3 doses, and placebo, each separated by 1-week washout. The change from baseline in AHI, oxygen desaturation index (ODI), Epworth sleepiness score (ESS), and mood (profile of mood states) on the final night of each treatment arm relative to the change from baseline to placebo were the major endpoints. Adverse events (AEs) were monitored throughout.Results: Ten of 11 participants completed the final night of at least one treatment arm. IHL-42X demonstrated a greater reduction in AHI from baseline compared with placebo (low, -19.7±27.1; medium, -17.5±23.3; high, -16.4±23.8 versus placebo, -2.8±21.0 events/hr; all p<0.05). The change from baseline in ODI3% was greater for the medium IHL-42X dose when compared with placebo (-15.4±19.0 versus placebo, -2.8±21.0 events/hr; p<0.05) but not the low or high doses (low, -15.2±24.8; high, -8.3±13.2 events/hr). IHL-42X did not change ESS or mood. No serious AEs occurred however 35 mild-moderate possibly, probably or treatment related AEs occurred during IHL-42X dosing and 5 occurred during placebo.Conclusions: One week of nightly IHL-42X at low, medium, and high doses was well tolerated, safe and associated with significant reductions in OSA severity.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Circadian Timing Following a One-Week In-Home Sleep Extension Manipulation in Habitually Short-Sleeping Adolescents. 对习惯性短睡眠的青少年进行为期一周的居家睡眠延长操作后昼夜节律时间的变化。

IF 5.6 2区医学

Sleep Pub Date : 2024-11-25 DOI: 10.1093/sleep/zsae273

Sydney Holtman, Emily Cooper, John T Brinton, Anne E Bowen, Stephen Hawkins, Melanie G Cree, Kristen J Nadeau, Kenneth P Wright, Stacey L Simon

{"title":"Changes in Circadian Timing Following a One-Week In-Home Sleep Extension Manipulation in Habitually Short-Sleeping Adolescents.","authors":"Sydney Holtman, Emily Cooper, John T Brinton, Anne E Bowen, Stephen Hawkins, Melanie G Cree, Kristen J Nadeau, Kenneth P Wright, Stacey L Simon","doi":"10.1093/sleep/zsae273","DOIUrl":"https://doi.org/10.1093/sleep/zsae273","url":null,"abstract":"Study objectives: Evaluate objectively-measured circadian rhythms following one-week of at-home sleep extension in habitually short-sleeping adolescents.Methods: Twenty-six participants (16.1±1.2 years, 69% female, and 65% White Non-Hispanic) with insufficient sleep (<7 hours on school nights) were randomized to one week of typical sleep (TS; usual school schedule) and sleep extension (EXT; ≥1-hour additional time in bed) in counterbalanced order with a 1-month washout between conditions. Home monitoring of actigraphy-estimated sleep and light exposure was assessed during both weeks. Hourly in-laboratory evening/morning dim-light salivary melatonin samples were obtained and onset (DLMOn) and offset (DLMOff) were calculated following each condition.Results: Sleep duration increased by 1.37 hours (95% CI: 1.09, 1.66; p<0.001), bedtimes advanced by 1.40 (95% CI: -1.75, -1.06; p<0.001), and waketimes did not significantly change (p=0.055) during EXT compared to TS. There was no change in DLMOn or DLMOff following EXT (both p>0.05). The DLMOn-sleep onset phase angle narrowed by 0.72 hours (95% CI: -1.39, -0.07; p=0.04) during EXT. Light exposure within 2-hours of bedtime was significantly higher during EXT compared to TS (23.37 vs. 7.73 lux; p=0.048).Conclusion: Sleep extension did not change melatonin onset or offset but may have increased circadian alignment. Further research should evaluate the addition of specific strategies to improve circadian timing such as morning bright light in combination with sleep extension.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy-onset obstructive sleep apnea and ambulatory blood pressure. 妊娠期阻塞性睡眠呼吸暂停与卧床血压。

IF 5.6 2区医学

Sleep Pub Date : 2024-11-25 DOI: 10.1093/sleep/zsae277

Laura Sanapo, Christina Raker, Basma Merhi, Melissa Guillen, Ashanti Avalos, Annaly Aldana, Margaret Bublitz, Alice Bai, Ghada Bourjeily

{"title":"Pregnancy-onset obstructive sleep apnea and ambulatory blood pressure.","authors":"Laura Sanapo, Christina Raker, Basma Merhi, Melissa Guillen, Ashanti Avalos, Annaly Aldana, Margaret Bublitz, Alice Bai, Ghada Bourjeily","doi":"10.1093/sleep/zsae277","DOIUrl":"10.1093/sleep/zsae277","url":null,"abstract":"Study objective: Elevated nocturnal blood pressure (BP) increases the risk for hypertensive disorders of pregnancy (HDP). Though obstructive sleep apnea (OSA) increases the risk for HDP, data on OSA and 24-hour ambulatory blood pressure monitoring (ABPM) in pregnancy are scarce. We aim to examine the BP profile of women with pregnancy-onset OSA.Methods: Pregnant women with overweight / obesity and snoring were recruited at <13 weeks gestation and underwent level III home sleep apnea testing and 24-hour ABPM at enrollment and at 31-34 weeks' gestation. Women with OSA at enrollment were excluded . Mean differences in nocturnal BP and 24-hour BP measurements, between women with pregnancy-onset OSA and women without OSA, were computed by multivariable linear regression.Results: 40 / 101 participants had pregnancy-onset OSA (respiratory event index (REI) >5 events per hour) in the third trimester. Despite no significant differences in baseline BP, nocturnal systolic and diastolic BP were significantly higher in women with pregnancy-onset OSA compared to women without OSA, after adjusting for multiple covariates (mean difference 5.49 (1.45-9.52) and 3.89 (0.19-7.60), respectively). Differences in systolic BP persisted into the daytime in the OSA group. Lack of nocturnal dipping was highly prevalent in both groups, but the difference was not significant in the adjusted model.Conclusion: Pregnancy-onset OSA in the 3rd trimester is associated with elevated nocturnal BP and daytime systolic BP. The lack of nocturnal dipping irrespective of REI cut-off in pregnant women at risk for SDB further demonstrates limitations of REI in defining pathology in pregnancy.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tired and out of control? Effects of total and partial sleep deprivation on response inhibition under threat and no-threat conditions. 疲劳和失控？完全和部分剥夺睡眠对威胁和无威胁条件下反应抑制的影响。

IF 5.6 2区医学

Sleep Pub Date : 2024-11-23 DOI: 10.1093/sleep/zsae275

Arne Nieuwenhuys, Corey G Wadsley, Robyn Sullivan, John Cirillo, Winston D Byblow

{"title":"Tired and out of control? Effects of total and partial sleep deprivation on response inhibition under threat and no-threat conditions.","authors":"Arne Nieuwenhuys, Corey G Wadsley, Robyn Sullivan, John Cirillo, Winston D Byblow","doi":"10.1093/sleep/zsae275","DOIUrl":"10.1093/sleep/zsae275","url":null,"abstract":"Study objectives: Sleep deprivation may impair top-down inhibitory control over emotional responses (e.g., under threat). The current study examined behavioral consequences of this phenomenon and manipulated the magnitude of individuals' sleep deficit to determine effect thresholds.Methods: Twenty-four healthy human participants were provided with 0hr, 2hr, 4hr and 8hr of sleep opportunity and, subsequently, performed a bimanual anticipatory response inhibition task under threat and no-threat conditions. Behavioral responses (button presses) and surface electromyography (EMG) from task effectors were collected to examine going and stopping processes.Results: Bayesian analyses revealed that compared to 8hr sleep, go trial accuracy was reduced with 0hr sleep. Stopping speed was reduced with 0hr and 2hr of sleep, as evidenced by longer stop-signal delays, but only in a selective stopping context. None of the outcome measures were impacted with 4hr sleep. Under threat, go trial accuracy was maintained, whilst responses were slightly delayed and characterized by amplified EMG-bursts. Stopping speed was increased under threat across both stop-all and selective stopping contexts. No evidence was observed for interactions between sleep and threat.Conclusion: Sleep deprivation negatively affected response inhibition in a selective stopping context, with stopping speed reduced following a single night of ≤ 2hr sleep. Performance-contingent threat improved response inhibition, possibly due to a prioritizing of stopping. No evidence was observed for increased threat-related responding after sleep deprivation, suggesting that sleep deprivation and threat may impact inhibitory control via independent mechanisms.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inferring Causality: Mendelian Randomization in Biomarker Studies in Obstructive Sleep Apnea. 推断因果关系：阻塞性睡眠呼吸暂停生物标记物研究中的孟德尔随机化。

IF 5.6 2区医学

Sleep Pub Date : 2024-11-22 DOI: 10.1093/sleep/zsae274

Rene Cortese

引用次数: 0

Talking to sleepwalkers? Response to communication efforts in Disorders of Arousals. 与梦游者交谈？唤醒障碍患者对沟通努力的反应。

IF 5.6 2区医学

Sleep Pub Date : 2024-11-21 DOI: 10.1093/sleep/zsae272

Yannis Idir, Régis Lopez, Amélie Barbier, Sony Saint-Auret, Emmanuel Morain, Raphaël Vollhardt, Inès Ben Haj Kacem, Arthur Le Coz, Ana Gales, Pauline Dodet, Smaranda Leu-Semenescu, Yves Dauvilliers, Isabelle Arnulf, Delphine Oudiette

{"title":"Talking to sleepwalkers? Response to communication efforts in Disorders of Arousals.","authors":"Yannis Idir, Régis Lopez, Amélie Barbier, Sony Saint-Auret, Emmanuel Morain, Raphaël Vollhardt, Inès Ben Haj Kacem, Arthur Le Coz, Ana Gales, Pauline Dodet, Smaranda Leu-Semenescu, Yves Dauvilliers, Isabelle Arnulf, Delphine Oudiette","doi":"10.1093/sleep/zsae272","DOIUrl":"https://doi.org/10.1093/sleep/zsae272","url":null,"abstract":"Study objectives: Disorders of arousal (DoA) are diagnosed on the basis of clinical criteria including inappropriate or absent responsiveness to communication attempts. Surprisingly, the ability of patients to interact with others during DoA episodes has not been systematically investigated. To address this gap, we conducted three studies.Methods: First, we used a retrospective questionnaire to assess verbal responsiveness during episodes in 61 adult patients with DoA (Study 1). Second, we used auditory stimulation during polysomnographically-verified N3 sleep to trigger DoA episodes in 14 patients. We then asked questions to test the possibility of verbal interactions during the episodes (Study 2). Third, we assessed the presence and quality of conversations with a bed partner in 364 home video-recorded episodes from 19 patients (Study 3).Results: In Study 1, most patients (81%) reported occasional conversations during parasomnia episodes. Patients' ongoing mental content influenced both their responses to questions during episodes and their perceptions of the outside world (including the identity of their interlocutor their environment). In study 2, auditory stimulation had a limited effect in inducing episodes (7/157 trials). One patient indirectly responded to our verbal prompts in a DoA episode. In Study 3, we found 37 video instances of discussion between patients and their partner.Conclusions: Overall, our findings suggest that DoA episodes are not a uniform state, but may instead encompass varying states of consciousness, characterized by different levels of responsiveness and a complex interplay between internal and external information processing. These results highlight the limitations of current diagnostic criteria for DoA.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep最新文献