Sleep最新文献

{"title":"Lending a helping hand: the complementary role of actigraphy in the assessment of central disorders of hypersomnolence.","authors":"Jesse D Cook, Cathy Goldstein, David T Plante","doi":"10.1093/sleep/zsae228","DOIUrl":"10.1093/sleep/zsae228","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep induced by mechanosensory stimulation provides cognitive and health benefits in Drosophila.","authors":"Sho Inami, Kyunghee Koh","doi":"10.1093/sleep/zsae226","DOIUrl":"10.1093/sleep/zsae226","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep is a complex phenomenon regulated by various factors, including sensory input. Anecdotal observations have suggested that gentle rocking helps babies fall asleep, and experimental studies have verified that rocking promotes sleep in both humans and mice. Recent studies have expanded this understanding, demonstrating that gentle vibration also induces sleep in Drosophila. Natural sleep serves multiple functions, including learning and memory, synaptic downscaling, and reduction of harmful substances associated with neurodegenerative diseases. Here, we investigated whether vibration-induced sleep (VIS) provides similar cognitive and health benefits in Drosophila.</p><p><strong>Methods: </strong>We administered gentle vibration to flies that slept very little due to a forced activation of wake-promoting neurons and investigated how the vibration influenced learning and memory in the courtship conditioning paradigm. Additionally, we examined the effects of VIS on synaptic downscaling by counting synaptic varicosities of select neurons. Finally, we determined whether vibration could induce sleep in Drosophila models of Alzheimer's disease (AD) and suppress the accumulation of Amyloid β (Aβ) and Tubulin Associated Unit (TAU).</p><p><strong>Results: </strong>VIS enhanced performance in a courtship conditioning paradigm and reduced the number of synaptic varicosities in select neurons. Moreover, vibration improved sleep in Drosophila models of AD, reducing Aβ and TAU levels.</p><p><strong>Conclusions: </strong>Mechanosensory stimulation offers a promising noninvasive avenue for enhancing sleep, potentially providing associated cognitive and health benefits.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalogram rhythmic and arrhythmic spectral components and functional connectivity at resting state may predict the development of synucleinopathies in idiopathic rapid eye movement sleep behavior disorder.","authors":"Jimmy Hernandez, Jean-Marc Lina, Jonathan Dubé, Alexandre Lafrenière, Jean-François Gagnon, Jacques-Yves Montplaisir, Ronald B Postuma, Julie Carrier","doi":"10.1093/sleep/zsae074","DOIUrl":"10.1093/sleep/zsae074","url":null,"abstract":"<p><strong>Study objectives: </strong>Idiopathic/isolated rapid eye movement-sleep behavior disorder (iRBD) often precedes the onset of synucleinopathies. Here, we investigated whether baseline resting-state EEG advanced spectral power and functional connectivity differed between iRBD patients who converted towards a synucleinopathy at follow-up and those who did not.</p><p><strong>Methods: </strong>Eighty-one participants with iRBD (66.89 ± 6.91 years) underwent a baseline resting-state EEG recording, a neuropsychological assessment, and a neurological examination. We estimated EEG power spectral density using standard analyses and derived spectral estimates of rhythmic and arrhythmic components. Global and pairwise EEG functional connectivity analyses were computed using the weighted phase-lag index (wPLI). Pixel-based permutation tests were used to compare groups.</p><p><strong>Results: </strong>After a mean follow-up of 5.01 ± 2.76 years, 34 patients were diagnosed with a synucleinopathy (67.81 ± 7.34 years) and 47 remained disease-free (65.53 ± 7.09 years). Among patients who converted, 22 were diagnosed with Parkinson's disease and 12 with dementia with Lewy bodies. As compared to patients who did not convert, patients who converted exhibited at baseline higher relative theta standard power, steeper slopes of the arrhythmic component and higher theta rhythmic power mostly in occipital regions. Furthermore, patients who converted showed higher beta global wPLI but lower alpha wPLI between left temporal and occipital regions.</p><p><strong>Conclusions: </strong>Analyses of resting-state EEG rhythmic and arrhythmic components and functional connectivity suggest an imbalanced excitatory-to-inhibitory activity within large-scale networks, which is associated with later development of a synucleinopathy in patients with iRBD.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep state-dependent development of resting-state functional connectivity during the preterm period.","authors":"Anna Shiraki, Hiroyuki Kidokoro, Hama Watanabe, Gentaro Taga, Takafumi Ushida, Hajime Narita, Takamasa Mitsumatsu, Sumire Kumai, Ryosuke Suzui, Fumi Sawamura, Yuji Ito, Hiroyuki Yamamoto, Tomohiko Nakata, Yoshiaki Sato, Masahiro Hayakawa, Yoshiyuki Takahashi, Jun Natsume","doi":"10.1093/sleep/zsae225","DOIUrl":"10.1093/sleep/zsae225","url":null,"abstract":"<p><strong>Study objectives: </strong>The brains of preterm infants exhibit altered functional connectivity (FC) networks, but the potential variation in sleep states and the impact of breathing patterns on FC networks are unclear. This study explores the evolution of resting-state FC from preterm to term, focusing on breathing patterns and distinguishing between active sleep (AS) and quiet sleep (QS).</p><p><strong>Methods: </strong>We recruited 63 preterm infants and 44 healthy-term infants and performed simultaneous electroencephalography and functional near-infrared spectroscopy. FC was calculated using oxy- and deoxyhemoglobin signals across eight channels. First, FC was compared between periodic breathing (PB) and non-PB segments. Then sleep state-dependent FC development was explored. FC was compared between AS and QS segments and between preterm infants at term and term-born infants in each sleep state. Finally, associations between FC at term, clinical characteristics, and neurodevelopmental outcomes in late infancy were assessed in preterm infants.</p><p><strong>Results: </strong>In total, 148 records from preterm infants and 44 from term-born infants were analyzed. PB inflated FC values. After excluding PB segments, FC was found to be elevated during AS compared to QS, particularly in connections involving occipital regions. Preterm infants had significantly higher FC in both sleep states compared to term-born infants. Furthermore, stronger FC in specific connections during AS at term was associated with unfavorable neurodevelopment in preterm infants.</p><p><strong>Conclusions: </strong>Sleep states play a critical role in FC development and preterm infants show observable changes in FC.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"I know when to stop\": sentinels and counterstrategies against drowsy driving in narcolepsy and idiopathic hypersomnia.","authors":"Elsa Beguin, Jean Baptiste Maranci, Smaranda Leu-Semenescu, Pauline Dodet, Ana Gales, Delphine Oudiette, Thomas Andrillon, Isabelle Arnulf","doi":"10.1093/sleep/zsae168","DOIUrl":"10.1093/sleep/zsae168","url":null,"abstract":"<p><strong>Study objectives: </strong>To collect prodromal symptoms experienced by participants with narcolepsy and idiopathic hypersomnia (considered \"hypersomnolence experts\") prior to drowsy driving and counterstrategies used to maintain alertness.</p><p><strong>Methods: </strong>Systematic, face-to-face interview (using a semi-structured questionnaire), including clinical measures, frequency of car accidents/near misses, and symptoms experienced before impending drowsy driving episodes and counterstrategies.</p><p><strong>Results: </strong>Among 61 participants (32 with narcolepsy, 29 with idiopathic hypersomnia; 56 drivers), 61% of drivers had at least one lifetime accident/near miss. They had a higher sleepiness score (14 ± 4 vs. 11 ± 5, p < .04) than those without an accident/near miss, but no other differences in demographics, driving experience, medical conditions, symptoms, sleep tests, and treatment. All but three participants experienced prodromal symptoms of drowsy driving, which included postural and motor changes (86.9%: axial hypotonia-e.g. eyelid droop, stereotyped movements), cognitive impairment (53.3%: automatic steering, difficulty concentrating/shifting, dissociation, mind wandering, dreaming), sensory (65%: paresthesia, pain, stiffness, heaviness, blunted perceptions such as a flat dashboard with loss of 3D, illusions and hallucinations), and autonomic symptoms (10%, altered heart/breath rate, penile erection). Counterstrategies included self-stimulation from external sources (pain, cold air, music, drinks, and driving with bare feet), motor changes (upright posture and movements), and surprise (sudden braking).</p><p><strong>Conclusions: </strong>Drowsy driving symptoms can result from \"local\" NREM, entry in N1 sleep, and hybrid wake/REM sleep states. These rich qualitative insights from participants with narcolepsy and idiopathic hypersomnia, as well as sophisticated counterstrategies, can be gathered to reduce the crash risk in this population, but also in inexperienced healthy drivers.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the borders of wakefulness and sleep-the search for novel biomarkers to quantify sleepiness.","authors":"David R Schreier, Veronique E C Vael, Gert Jan Lammers","doi":"10.1093/sleep/zsae167","DOIUrl":"10.1093/sleep/zsae167","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoxyl Sulfate and Altered Gut Microbiome Heightened the Risk of Chronic Kidney Disease in Obstructive Sleep Apnea.","authors":"Mohit, Pooran Chand, Sheetal Verma","doi":"10.1093/sleep/zsae286","DOIUrl":"https://doi.org/10.1093/sleep/zsae286","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between childhood maltreatment and multidimensional sleep health in adolescents at high-risk of emotional and behavioral problems.","authors":"Milan Zarchev, Astrid M Kamperman, Sanne J W Hoepel, Witte J G Hoogendijk, Cornelis L Mulder, Nina H Grootendorst-van Mil","doi":"10.1093/sleep/zsae281","DOIUrl":"https://doi.org/10.1093/sleep/zsae281","url":null,"abstract":"<p><strong>Study objectives: </strong>Impaired sleep following trauma such as childhood maltreatment is both a prognostic factor for future mental illness and a feasible intervention point. Yet, associations between childhood maltreatment and objectively measured sleep components are rarely found. New approaches advance the use of multidimensional sleep health scores instead of individual sleep components. However, no such methodology has been used to study the consequences of maltreatment on sleep health in adolescent cohorts so far. We hypothesized that childhood maltreatment will be associated with poorer sleep health in adolescence.</p><p><strong>Methods: </strong>a cross-sectional sample of 494 adolescents at high-risk of emotional and behavioral problems (mean age 17.9) completed the Childhood Trauma Questionnaire short form (CTQ-SF) to assess five forms of maltreatment (emotional and physical abuse/neglect and sexual abuse) assessed as continuous sum scores. During 9 nights of actigraphy and sleep diary measurements data on sleep regularity, satisfaction, alertness, timing, efficiency, and duration was collected, which were combined into a sleep health composite score ranging from 0 to 6. Linear regression models were adjusted for age, sex, household income, ethnic origin, educational level, urbanization of living environment and parental psychopathological problems.</p><p><strong>Results: </strong>associations were found between all forms of maltreatment and poorer sleep health (p<.031), except for sexual abuse (p=.224). Partial r effect sizes ranged from -0.12 [95%CI = -0.22, -0.01] for emotional neglect to -0.18 [-0.28, -0.08] for total maltreatment.</p><p><strong>Conclusions: </strong>maltreatment was associated with impairment in everyday sleep health, reflected in both subjective and objective measurements of sleep.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia Symptoms are Associated with Return to use and Non-fatal Overdose following Opioid Use Disorder Treatment.","authors":"Martin Hochheimer, Jennifer D Ellis, Justin C Strickland, Jill A Rabinowitz, J Gregory Hobelmann, Andrew S Huhn","doi":"10.1093/sleep/zsae284","DOIUrl":"10.1093/sleep/zsae284","url":null,"abstract":"<p><strong>Study objectives: </strong>Opioid use disorder (OUD) is a chronic, relapse-prone condition, often accompanied by sleep disturbances such as insomnia. While sleep disturbances have been implicated in negative treatment outcomes, no large-scale studies have examined the relationship between insomnia disorder and outcomes for persons completing an acute OUD treatment episode. This study assessed the association between insomnia symptoms at treatment intake, during treatment, and following acute treatment with post-treatment episode return to use, and non-fatal overdose outcomes.</p><p><strong>Methods: </strong>This study analyzed data from 1,905 individuals with OUD who received one of three forms of acute OUD treatment: supervised withdrawal, intensive outpatient, or residential treatment at 70 programs in the U.S. in 2021. Insomnia was assessed using the Insomnia Severity Index (ISI). Logistic regression and mixed regression analyses were performed to evaluate the association between insomnia and return to substance use or non-fatal overdose following a treatment episode.</p><p><strong>Results: </strong>Higher ISI scores at intake were significantly associated with increased odds of return to use one-month post-treatment episode (p-value=.006). Reduction in ISI scores during treatment correlated with lower return to use rates (p-value=.015). Post-treatment episode, ISI scores indicative of insomnia were associated with return to use (p-values<0.001) and non-fatal overdose (p-values<0.004) at months one, three, and six.</p><p><strong>Conclusion: </strong>These findings underscore the significant role of insomnia in return to opioid use following OUD treatment, highlighting the importance of addressing sleep disturbances early in OUD treatment. This study also suggests that maintaining sleep health during and after treatment could improve long-term prognosis for OUD. Interventions targeting insomnia are a promising avenue to improve OUD treatment outcomes.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of OSA for leukoaraiosis and its cognitive consequences: a discussion still open!","authors":"Frédéric Roche, Sébastien Celle, Nathalie Perek, Pauline Guillot","doi":"10.1093/sleep/zsae283","DOIUrl":"https://doi.org/10.1093/sleep/zsae283","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}