Sleep最新文献

{"title":"Multicenter evaluation of the Waveband System for automated sleep assessment in patients with insomnia symptoms.","authors":"Silvia Frati Savietto, Antoine Guillot, Mason Harris, Jay Pathmanathan, Alexander M Chan, M Brandon Westover, Derek Hill, Valérie Bertaina-Anglade, Geoffrey Viardot, Pierrick Arnal, Jacob Donoghue","doi":"10.1093/sleep/zsag069","DOIUrl":"https://doi.org/10.1093/sleep/zsag069","url":null,"abstract":"<p><strong>Study objectives: </strong>This study (Octave-3) aimed to validate the performance of the Waveband dry-EEG sensor device for automatic sleep staging and sleep parameter estimation as compared to gold-standard in-lab polysomnography (PSG).</p><p><strong>Methods: </strong>45 participants were enrolled and 38 completed simultaneous PSG and Waveband recordings. PSG data was scored by 6 human technologists while Waveband data was scored algorithmically. Agreement between sleep staging results and derived sleep parameters (total sleep time (TST), sleep efficiency (SE), sleep onset latency (SOL), wake after sleep onset (WASO), and time spent in each sleep stage) was measured using the Intraclass Correlation Coefficient (ICC) and Overall Agreement (OA). Waveband OA was compared to each human rater using the leave one out consensus of the remaining 5 human experts.</p><p><strong>Results: </strong>Average OA between Waveband vs the leave one out consensuses was 87.3+/-5.4%, equivalent to the average OA for individual human experts of 85.9+/-7.6% (p>.1). Waveband and humans had better OA over the second half of the night, but Waveband had superior OA. ICCs for TST, SE, LPS, and WASO exceeded 0.9, indicating excellent agreement between automated Waveband and human PSG scoring. Lower agreement was found for time spent in N1, N3, and REM, with ICCs ranging from 0.65 to 0.73.</p><p><strong>Conclusions: </strong>Waveband provides accurate sleep staging and estimation of TST, SE, SOL, LPS, and WASO, with comparable performance to human expert staging of PSG. Its reduced form-factor and good performance should make it a valuable tool for automated assessment of sleep in patients with disturbed sleep.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic alveolar ventilation-targeted NIV mode vs polysomnographic titration of fixed pressure in naive patients with chronic respiratory failure.","authors":"Mónica Matute-Villacís, Marta Puig Dupre, Dunia Gascueña, Anabel Moraleda, Gemma Guerrero Romero, Lidia López Escuredo, Mireia Dalmases, Àlvar Agustí, Cristina Embid","doi":"10.1093/sleep/zsag085","DOIUrl":"https://doi.org/10.1093/sleep/zsag085","url":null,"abstract":"<p><strong>Study objectives: </strong>Polysomnographic titration of fixed pressures of NIV is recommended for patients with chronic hypercapnic respiratory failure (CHRF). Here we compared the effects of NIV titrated manually by PSG vs. fully automatic mode (iVAPS AE) in sleep quality, respiratory events manually scored and estimated by built-in software, nocturnal hypoventilation, daytime arterial blood gases and patient comfort.</p><p><strong>Methods: </strong>We studied 26 adult patients (13 female) with CHRF due to COPD (n=13), neuromuscular disease (n=8), obesity hypoventilation syndrome (n=3) and chest wall disorders (n=2), all naïve to NIV. They were randomised to standard PSG titration of fixed NIV pressures or PSG using \"learn target\" iVAPS AE mode in two separate nights, both under PSG monitoring.</p><p><strong>Results: </strong>Main results showed that: (1) there were no significant differences in the reduction of diurnal PaCO2, nocturnal hypoventilation, sleep quality, upper airway obstruction events with both ventilatory modes; (2) the apnea-hypopnea index from built-in software underestimated that manually scored in both ventilatory modes; (3) ventilatory pressures were lower in fixed mode than iVAPS AE mode; (4) patient comfort was higher in fixed mode than iVAPS AE.</p><p><strong>Conclusions: </strong>This study shows that iVAPS AE initiated with the 'learned target' procedure achieved similar short and long-term ventilatory efficacy to PSG manual bilevel titration. However, its higher pressure levels and lower comfort indicate that the modes are not fully equivalent. Moreover, underestimation of the AHI by the built-in software demands careful interpretation before changing ventilatory settings. Further studies are required to determine the long-term clinical relevance of these differences.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoiding Variability in Sleep Variability Assessments: How Many Nights Are Enough?","authors":"Chun Siong Soon, Michael W L Chee","doi":"10.1093/sleep/zsag083","DOIUrl":"https://doi.org/10.1093/sleep/zsag083","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High night-to-night variability in OSA severity is associated with prevalent cardiovascular disease.","authors":"Bastien Lechat, Lucia Pinilla, Kelly Sansom, Andrew Vakulin, Pierre Escourrou, Jean-Louis Pepin, Sebastien Bailly, Sebastien Baillieul, Amy C Reynolds, Hannah Scott, Jack Manners, Peter Catcheside, Robert J Adams, Danny J Eckert","doi":"10.1093/sleep/zsag084","DOIUrl":"https://doi.org/10.1093/sleep/zsag084","url":null,"abstract":"<p><strong>Study objectives: </strong>High night-to-night variability in obstructive sleep apnea (OSA) severity is associated with cardiovascular risk factors such as high blood pressure and pulse wave velocity, yet associations with cardiovascular events remains unknown. This study investigates the association of multi-night OSA severity and night-to-night variability with the prevalence of non-fatal major adverse cardiovascular and cerebrovascular events (MACCEs).</p><p><strong>Methods: </strong>Multi-night data were collected from people who purchased and used an FDA-cleared under- mattress sensor to track nightly OSA severity (apnoea-hypopnea index-AHI) and completed questionnaires on physician-diagnosed health conditions between 10/2022-12/2024. Mean OSA severity and variability (AHI standard deviation) were calculated over 6-months preceding questionnaire data collection. The primary outcome was a composite of non-fatal MACCEs, including myocardial infarction or heart attack, stroke, angina pectoris or coronary artery disease, and congestive heart failure. Logistic models assessed associations between OSA severity and variability with MACCE prevalence.</p><p><strong>Results: </strong>Among 3,159 participants (19% female, aged 49±13 years, BMI of 29±6 kg/m2), 142 (4.5%) MACCE cases were reported. Participants with moderate-severe OSA had a higher odds of MACCEs versus those without OSA (OR [95%CI]; 1.45[0.93, 2.25]). High night-to-night OSA variability (75th vs. 25th; 8.0 vs. 2.8 events/h) was associated with 34% higher odds of having a MACCE, independent of OSA severity and other confounders (1.34[1.04, 1.72]).</p><p><strong>Conclusions: </strong>High night-to-night variability in OSA severity is associated with higher odds of non-fatal MACCEs. These novel findings underscore the need for prospective trials to investigate the potential causal mechanisms between variability in OSA severity and incident cardiovascular events.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Association of Mild Obstructive Sleep Apnea With Cognitive Performance, Excessive Daytime Sleepiness, and Quality of Life in the General Population: The Korean Genome and Epidemiology Study (KoGES).","authors":"","doi":"10.1093/sleep/zsag059","DOIUrl":"https://doi.org/10.1093/sleep/zsag059","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Adverse effects of 21 antidepressants on sleep during acute-phase treatment in major depressive disorder: a systemic review and dose-effect network meta-analys.","authors":"","doi":"10.1093/sleep/zsag042","DOIUrl":"https://doi.org/10.1093/sleep/zsag042","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent sleep: a bulwark for healthy brain development.","authors":"Kathleen P O'Hora, Jared M Saletin","doi":"10.1093/sleep/zsag081","DOIUrl":"https://doi.org/10.1093/sleep/zsag081","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern lights on neuropathology of Alzheimer's Disease.","authors":"Ludovic S Mure","doi":"10.1093/sleep/zsag080","DOIUrl":"https://doi.org/10.1093/sleep/zsag080","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A wake-up call for a global climate and sleep task force.","authors":"Kelton Minor, Christine Blume, Aric Prather, Michelle Escobar Carias, Jamie T Mullins, Breanne Aylward, Joshua R Wortzel, Godfred O Boateng, Benedict Weobong, Jodi A Mindell, Stephanie J Crowley, Lara R Dugas, Sherilee Harper, Susan D Clayton, Paul Gringras, Thomas Penzel","doi":"10.1093/sleep/zsag075","DOIUrl":"https://doi.org/10.1093/sleep/zsag075","url":null,"abstract":"<p><p>The nighttime ambient environment in which humanity sleeps is heating up due to human-induced climatic changes. Convergent global observational evidence links higher ambient temperatures to accelerated sleep impacts within-individuals, while in-lab evidence confirms that high temperatures mechanistically harm sleep initiation and maintenance. Despite marked methodological and evidentiary advances, the global sensitivity of sleep health to climate impact drivers remains imprecisely characterized and conservatively estimated. Indeed, we show that prior observational temperature and sleep research is nonrepresentative of the global human population, and that the most vulnerable remain undersampled despite evidence of their likely greater sleep sensitivity to heat. Here we sound a worldwide wake-up call for the sleep, climate and health research communities to address these needs through the formation of a global climate and sleep taskforce. This effort can perform a unified global assessment of climate-sleep relationships, impact pathways, and adaptation options in a variable and warming world. It can seek to integrate sleep health and methodological advances into global climate and health monitoring systems and economic assessments, and to translate these findings into scalable action. Persistent climate-sleep impacts and their downstream consequences to human health, wellbeing and performance warrant urgent study, mitigation and adaptation at the same global scale and across all levels of society. The international sleep research community must now act with the rigor, attention and resources needed to protect our nights.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic recovery and persistence patterns reveal the biological cost of sleep debt in healthy adult males.","authors":"Jiaoni Cheng, Ke Zhu, Ju Wang, Qi Huang, Jie Shen, Yue Xiong, Qingqing Yang, Zeyu Zhang, Fubing Li, Linbo Fan","doi":"10.1093/sleep/zsag071","DOIUrl":"https://doi.org/10.1093/sleep/zsag071","url":null,"abstract":"<p><p>Sleep restriction and deprivation are highly prevalent in modern society and are associated with systemic health risks. However, the molecular basis distinguishing reversible from long-lasting transcriptomic effects of insufficient sleep remains poorly understood. In this study, we systematically investigated the transcriptomic impacts of one-week sleep restriction (SR-1wk), two-week sleep restriction (SR-2wk), subsequent five-week recovery sleep (SR-recovery), and chronic sleep deprivation (SD) in in healthy adult males. Whole-blood RNA sequencing and temporal expression profiling identified two distinct gene groups: 74 genes exhibiting persistent dysregulation even after 5 weeks of recovery sleep, and 68 genes demonstrating complete restoration. Functional annotation revealed that recovery-associated genes were enriched in immune rebalancing, metabolic adaptation, and epigenetic regulation, whereas not fully recovered within the study timeframe genes were predominantly linked to inflammation, ribosomal activity, and poorly characterized molecular networks. Additionally, we uncovered 59 uncharacterized transcripts, including antisense RNAs, novel lncRNAs, and miRNAs, which may represent previously unrecognized regulatory pathways in sleep biology. Our findings suggest that recovery sleep alone cannot fully reverse the molecular scars induced by prolonged sleep restriction. The contrast between recoverable and not fully recovered within the study timeframe genes highlights both the adaptive and vulnerable aspects of biological systems under sleep loss. Our findings provide a basis for identifying biomarkers of chronic sleep debt and highlight targeted interventions-such as anti-inflammatory, circadian, and antioxidant strategies-as potential means to mitigate long-term risks. At the same time, they establish a foundation for future functional studies to uncover novel mechanisms of sleep-related pathophysiology.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}