IF 5.6 2区医学

Sleep Pub Date : 2024-10-09 DOI: 10.1093/sleep/zsae239

Joey W Y Chan, Chun-Tung Li, Steven Wai Ho Chau, Ngan Yin Chan, Tim Man-Ho Li, Bei Huang, Joshua Tsoh, Shirley X Li, Kelvin K L Chong, Kathryn A Roecklein, Yun Kwok Wing

{"title":"Attenuated melanopsin-mediated post-illumination pupillary response (PIPR) is associated with reduced actigraphic amplitude and mesor in older adults.","authors":"Joey W Y Chan, Chun-Tung Li, Steven Wai Ho Chau, Ngan Yin Chan, Tim Man-Ho Li, Bei Huang, Joshua Tsoh, Shirley X Li, Kelvin K L Chong, Kathryn A Roecklein, Yun Kwok Wing","doi":"10.1093/sleep/zsae239","DOIUrl":"https://doi.org/10.1093/sleep/zsae239","url":null,"abstract":"Study objectives: This study aimed to explore the relationship between post-illumination pupillary response (PIPR) with sleep and circadian measures in a community sample of healthy older adults.Methods: Eligible participants were invited to complete a one-week sleep diary, actigraphy and provide an overnight urine sample to measure urinary 6-sulfatoxymelatonin (aMT6s). PIPR was defined as the as the pupil constriction at 6s post-stimulus (PIPR-6s), and ii) for 30s beginning 10s after stimulus (PIPR-30s) normalized as a percentage to the baseline pupil diameter, after 1s of blue and 1s of red-light stimulus, respectively. The Net-PIPRs were reported by subtracting the PIPR to red stimulus from the PIPR to blue stimulus. The relationship between PIPR metrics to aMT6s and actigraphic rest-activity rhythm parameters was examined by generalized linear models.Results: A total of 48 participants were recruited (Mean age: 62.6 ± 7.1 years, Male: 44%). Both Net PIPR-6s and Net PIPR-30s were significantly associated with actigraphic rest-activity amplitude (B=0.03, p=0.001 and B=0.03, p=0.01, respectively), and actigraphic rest-activity mesor (B=0.02, p=0.001 and B=0.03, p=0.004, respectively). Additionally, the Net PIPR-30s were positively associated with overnight aMT6s level (B=0.04, p=0.03), and negatively associated with actigraphic rest-activity acrophase (B=-0.01, p=0.004) in the fully adjusted models.Conclusion: Attenuated PIPR is associated with a reduced actigraphic amplitude and mesor. The reduced retinal light responsivity may be a potential pathway contributing to impaired photic input to the circadian clock and resulted in the age-related circadian changes in older adults.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose and timing effects of caffeine on subsequent sleep: A randomised clinical crossover trial. 咖啡因的剂量和时间对后续睡眠的影响：随机临床交叉试验。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-08 DOI: 10.1093/sleep/zsae230

Carissa L Gardiner, Jonathon Weakley, Louise M Burke, Francesca Fernandez, Rich D Johnston, Josh Leota, Suzanna Russell, Gabriella Munteanu, Andrew Townshend, Shona L Halson

{"title":"Dose and timing effects of caffeine on subsequent sleep: A randomised clinical crossover trial.","authors":"Carissa L Gardiner, Jonathon Weakley, Louise M Burke, Francesca Fernandez, Rich D Johnston, Josh Leota, Suzanna Russell, Gabriella Munteanu, Andrew Townshend, Shona L Halson","doi":"10.1093/sleep/zsae230","DOIUrl":"https://doi.org/10.1093/sleep/zsae230","url":null,"abstract":"Study objectives: To investigate the effect of a typical dose of caffeine and a high dose of caffeine consumed in the morning, afternoon, and evening on subsequent sleep.Methods: Using a placebo-controlled, double-blind, randomised crossover design, 23 males (25.3±5.0 years) with a moderate habitual caffeine intake (<300mg∙day-1) completed seven conditions: placebo, and 100 and 400mg of caffeine consumed 12, eight, and four hours prior to bedtime, with a 48-hour washout. In-home partial polysomnography and sleep diaries were used to assess sleep. Linear mixed models estimated the effect of each condition.Results: No significant effect on objective or subjective sleep occurred with the 100mg dose of caffeine compared to the placebo (p>0.05) but significant effects occurred with the 400mg dose (p<0.05). Significant delays in sleep initiation and alterations to sleep architecture were observed when 400mg was consumed within 12 hours of bedtime (p<0.05), and significantly greater sleep fragmentation occurred when 400mg was consumed within eight hours of bedtime (p<0.05). Additionally, perceived sleep quality was significantly reduced when 400mg was consumed four hours prior to bedtime (-34.02%, p=.006) but not at eight or 12 hours.Conclusions: A 100mg dose of caffeine can be consumed up to four hours prior to bedtime, but 400mg may negatively impact sleep when consumed as one dose within 12 hours of bedtime, with the adverse influence on sleep increasing the closer consumption occurs to bedtime. The discrepancy between objective and subjective sleep quality suggests individuals may have difficulty accurately perceiving the influence of caffeine on sleep quality.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T2 MRI visible Perivascular Spaces in Parkinson`s Disease: clinical significance and association with polysomnography measured sleep. T2 MRI 可见帕金森病血管周围间隙：临床意义及与多导睡眠图测量睡眠的关联。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-08 DOI: 10.1093/sleep/zsae233

Lena Meinhold, Antonio G Gennari, Heide Baumann-Vogel, Esther Werth, Simon J Schreiner, Christian Ineichen, Christian R Baumann, Ruth O'Gorman Tuura

{"title":"T2 MRI visible Perivascular Spaces in Parkinson`s Disease: clinical significance and association with polysomnography measured sleep.","authors":"Lena Meinhold, Antonio G Gennari, Heide Baumann-Vogel, Esther Werth, Simon J Schreiner, Christian Ineichen, Christian R Baumann, Ruth O'Gorman Tuura","doi":"10.1093/sleep/zsae233","DOIUrl":"10.1093/sleep/zsae233","url":null,"abstract":"Poor sleep quality might contribute to the risk and progression of neurodegenerative disorders via deficient cerebral waste clearance functions during sleep. In this retrospective cross-sectional study, we explore the link between enlarged perivascular spaces (PVS), a putative marker of sleep-dependent glymphatic clearance, with sleep quality and motor symptoms in Parkinson`s disease (PD) patients. T2-weighted MRI images of 20 patients and 17 healthy control subjects were estimated visually for PVS in the basal ganglia (BG) and centrum semiovale (CSO). The patient group additionally underwent a single-night polysomnography. Readouts included polsyomnographic sleep features and slow-wave activity (SWA), a quantitative EEG marker of sleep depth. Associations between PVS counts, PD symptoms (MDS-UPDRS scores) and sleep parameters were evaluated using correlation and regression analyses. Intra- and inter-rater reproducibility was assessed with weighted Cohen`s kappa coefficient. BG and CSO PVS counts in both patients and controls did not differ significantly between groups. In patients, PVS in both brain regions were negatively associated with SWA (1-2Hz) (BG: r(15)=-0.58, padj=0.015 and CSO: r(15)=-0.6, padj=0.015). Basal ganglia PVS counts were positively associated with motor symptoms of daily living (IRR=1.05, CI [1.01, 1.09], p=0.007, padj=0.026) and antidepressant use (IRR=1.37, CI [1.05, 1.80], p=0.021, padj=0.043) after controlling for age. Centrum Semiovale PVS counts in patients were positively associated with a diagnosis of REM sleep behaviour disorder (IRR=1.39, CI [1.06 , 1.84]), p=0.018, padj=0.11). These results add evidence that sleep deterioration may play a role in impairing glymphatic clearance via altered perivascular function, potentially contributing to disease severity in PD patients.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal early pregnancy body mass index and risk of insomnia in the offspring. 母亲孕早期体重指数与后代失眠的风险。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-07 DOI: 10.1093/sleep/zsae236

Mia Q Zhu, Sven Cnattingius, Louise M O'Brien, Eduardo Villamor

{"title":"Maternal early pregnancy body mass index and risk of insomnia in the offspring.","authors":"Mia Q Zhu, Sven Cnattingius, Louise M O'Brien, Eduardo Villamor","doi":"10.1093/sleep/zsae236","DOIUrl":"10.1093/sleep/zsae236","url":null,"abstract":"Study objectives: To investigate the association between maternal early pregnancy body mass index (BMI) and risk of offspring insomnia.Methods: We conducted a nationwide cohort study among 3,281,803 singleton live births in Sweden born 1983-2015. Using national registries with prospectively recorded information, we followed participants for an insomnia diagnosis from 2 to up to 35 years of age. We compared insomnia risks by early pregnancy BMI categories using hazard ratios (HR) with 95% confidence intervals (CI) from adjusted Cox models. To assess unmeasured shared familial confounding, we conducted sibling-controlled analyses among 1,724,473 full siblings and studied the relation of maternal full sisters' BMI and insomnia risk in 1,185,998 offspring.Results: There were 7,154 insomnia diagnoses over a median follow-up age of 17.9 years. Compared with women with normal BMI, adjusted HR (95% CI) of offspring insomnia for early pregnancy BMI categories overweight, obesity class I, and obesity classes II or III were, respectively, 1.22 (1.14, 1.30), 1.60 (1.45, 1.77), and 2.11 (1.83, 2.45). Corresponding adjusted HR (95% CI) in sibling comparisons were, respectively, 1.32 (1.05, 1.65), 1.48 (1.03, 2.14), and 1.56 (0.91, 2.65). Associations with maternal sisters' BMI were attenuated, suggesting a weak role for unmeasured shared factors. Other pregnancy, birth, and neonatal complications were associated with risk of insomnia in offspring but did not substantially mediate the association.Conclusions: The dose-response relation between maternal overweight and obesity severity with offspring insomnia risk is not fully explained by shared familial factors.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Change begins with awareness - a greater need to understand awareness of sleepiness in vulnerable drivers. 改变始于认识--更需要了解弱势驾驶员的嗜睡意识。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-05 DOI: 10.1093/sleep/zsae237

C Anderson

引用次数: 0

Bridging sleep with psychiatric disorders through genetics. 通过遗传学连接睡眠与精神疾病。

IF 5.6 2区医学

Sleep Pub Date : 2024-10-04 DOI: 10.1093/sleep/zsae235

Amber J Zimmerman, Struan F A Grant

引用次数: 0

Can't touch this: the emergence of contactless sleep technology. 触摸不到：非接触式睡眠技术的出现。