Sleep最新文献

{"title":"In reponse to the Commentary by Cirelli et al to our recent meta-analysis in spine changes following sleep deprivation.","authors":"Alvin T S Brodin, Franziska Liesecke, Julia Spielbauer, Tobias E Karlsson","doi":"10.1093/sleep/zsaf270","DOIUrl":"https://doi.org/10.1093/sleep/zsaf270","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekly sleep loss is associated with reduced cortical glutathione (GSH) and antioxidant capacity in adolescents.","authors":"Jiyoung Ma, Andrew P Prescot, Punitha Subramaniam, Erin C McGlade, Perry F Renshaw, Deborah A Yurgelun-Todd","doi":"10.1093/sleep/zsaf245","DOIUrl":"https://doi.org/10.1093/sleep/zsaf245","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-based Video-Polysomnography for Sleep-Related Motor Behaviors: Development, Feasibility, and Diagnostic Performance at the Bologna Sleep Center.","authors":"Greta Mainieri, Luca Baldelli, Francesco Mignani, Francesca Cotichelli, Giuseppe Loddo, Filomena Miele, Ezechiele Foschini, Angelica Montini, Felice Di Laudo, Caterina Pazzaglia, Monica Sala, Federica Provini","doi":"10.1093/sleep/zsaf264","DOIUrl":"https://doi.org/10.1093/sleep/zsaf264","url":null,"abstract":"<p><strong>Study objectives: </strong>For most sleep disorders, in-laboratory video-polysomnography (VPSG) is currently considered the gold diagnostic standard. However, a growing need for more accessible diagnostic tools has been highlighted. This study aims to describe the experience of the Bologna Sleep Center in evaluating sleep-related motor behaviors using home VPSG.</p><p><strong>Methods: </strong>Consecutive patients referred to the Bologna Sleep Center between April 2016 and May 2024 for suspected sleep-related motor behaviors were recorded. Based on clinical suspicion, patients underwent either a 48-hour monitoring with a full EEG montage (for NREM parasomnias/epilepsy) or a 24-hour monitoring with a sleep montage (for REM sleep Behavior Disorder patients). Patients were equipped in the sleep lab by expert sleep technicians, who also provided instructions for continuing the recording in the home setting. A technical evaluation of recording quality was conducted on the first 50 recordings.</p><p><strong>Results: </strong>We included 305 patients, resulting in a total of 489 home VPSGs. Overall, 82% of the recordings were diagnostic (either confirming or excluding the clinical suspicion), while 18% were non-diagnostic due to insufficient evidence to confirm a diagnosis or technical issues. A detailed technical evaluation of the quality of the tracings in the first 50 recordings revealed a mean artefact percentage of 8% on polygraphic channels.</p><p><strong>Conclusions: </strong>Home VPSG demonstrated good diagnostic accuracy and exhibited limited technical issues that do not significantly interfere with its diagnostic capability. Recording in the patient's natural environment may increase the likelihood of capturing habitual episodes.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The quest for biomarkers in isolated REM sleep behavior disorder. Comment on Bruschi et al.","authors":"Matteo Carpi, Mariana Fernandes, Claudio Liguori","doi":"10.1093/sleep/zsaf261","DOIUrl":"https://doi.org/10.1093/sleep/zsaf261","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Epigenetic Responses to Sleep in Adolescence: Insights, Unanswered Causal Questions, and a Call for Targeted Research.","authors":"Chenyu Zhao, Keqiang Ma, Zhaoqi Wu, Wei Wang, Wen-Yang Li","doi":"10.1093/sleep/zsaf267","DOIUrl":"https://doi.org/10.1093/sleep/zsaf267","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Don't Shake It Off: The Importance of Restless Legs Syndrome in Pregnancy.","authors":"Michael Setteducato, Donald L Bliwise, Lynn Marie Trotti","doi":"10.1093/sleep/zsaf266","DOIUrl":"https://doi.org/10.1093/sleep/zsaf266","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between obstructive sleep apnoea and liver fibrosis in patients with suspected nonalcoholic fatty liver disease.","authors":"Wojciech Trzepizur, Jérôme Boursier, Jérémie Poilane, Christophe Bureau, Kamila Sedkaoui, Sandrine Pontier, Charlotte Costentin, Jean-Louis Pépin, Matthieu Schnee, Acya Bizieux, Maeva Guillaume, Jean-François Hamel, Frédéric Gagnadoux","doi":"10.1093/sleep/zsaf265","DOIUrl":"https://doi.org/10.1093/sleep/zsaf265","url":null,"abstract":"<p><strong>Study objectives: </strong>The association between obstructive sleep apnea (OSA) and liver fibrosis has been primarily evaluated using noninvasive tools or in selected populations (bariatric surgery). The aim of the study was to determine whether OSA is associated with liver fibrosis in patients with suspected nonalcoholic fatty liver disease (NAFLD) referred for liver biopsy.</p><p><strong>Methods: </strong>Patients who underwent percutaneous liver biopsy for suspected NAFLD were prospectively included and investigated by in-lab polysomnography. Liver lesions were evaluated using the NASH-CRN scoring system and advanced fibrosis was defined as F ≥ 3. Moderate to severe OSA was defined by an apnoea-hypopnoea index (AHI) ≥15 events/h.</p><p><strong>Results: </strong>Among the 97 patients included in the study, 40 exhibited advanced fibrosis, while 63 demonstrated moderate to severe OSA. The prevalence of moderate to severe OSA in patients with advanced fibrosis was 82% versus 52% in patients with F0-2 fibrosis stage (p<.0037). The association between moderate to severe OSA and advanced fibrosis remained significant after adjustment for sex, age, diabetes and obesity with an OR of 3.48 (confidence interval, 1.03-11.83; p=.045). Similar association was found with nocturnal hypoxia markers (oxygen desaturation index and the time spent under 90% of saturation). No association was observed between moderate to severe OSA and steatosis or nonalcoholic steatohepatitis.</p><p><strong>Conclusions: </strong>Utilizing the gold-standard tools for OSA and NAFLD diagnosis in a multicentric cohort of biopsy-proven NAFLD patients, an independent association between OSA and liver fibrosis was confirmed.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diurnal variation in neurovascular coupling and the impact of sleep quality: a UK Biobank study.","authors":"Sheng Yang, Alastair John Stewart Webb","doi":"10.1093/sleep/zsaf256","DOIUrl":"https://doi.org/10.1093/sleep/zsaf256","url":null,"abstract":"<p><strong>Study objectives: </strong>Cerebrovascular events are more frequent in the morning, coinciding with disturbed circadian rhythms and poor sleep quality. Neurovascular coupling (NVC), a marker of neuronal activity and endothelium-dependent cerebrovascular function, may mediate the relationship between cerebrovascular dysfunction and chronic cerebrovascular disease. This study aims to determine whether NVC shows circadian variation and whether it is associated with sleep quality.</p><p><strong>Methods: </strong>Functional MRI scans from the UK Biobank were adapted to assess NVC at different time points throughout the day. ANOVA with Tukey post-hoc tests examined NVC differences between 3-hour and 2-hour time blocks starting at 8 a.m. Cosinor models assessed rhythmicity in NVC. General linear models evaluated the impact of sleep quality (a composite score and individual markers: snoring, insomnia, duration, chronotype, and daytime sleepiness) on NVC, adjusting for age, sex, and vascular risk factors.</p><p><strong>Results: </strong>Among 36 801 participants, NVC was significantly lower between 11 a.m. and 2 p.m., with a consistent pattern across ages in men but a midday decline in younger women (< 60 years). While the composite measure of sleep quality risk was not associated with a change in NVC (p=.12), a diagnosis of insomnia (p=.04) or sleep apnoea (p=.03) was associated with lower NVC.</p><p><strong>Conclusions: </strong>The observed reduction in NVC in the late morning and its association with objective measures of impaired sleep quality suggest a potential role for endothelial dysfunction, potentially contributing to the associated increased cerebrovascular risk.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Wearable Data for Genetic Sleep Research.","authors":"Jonathan Mitchell","doi":"10.1093/sleep/zsaf263","DOIUrl":"https://doi.org/10.1093/sleep/zsaf263","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CPAP Effects on Energy Expenditure, Intake, Hormonal Regulation, and Body Composition: A Randomized Trial.","authors":"Pei-Lin Lee, Meng-Yueh Chien, Shang-Ru Lai, Joshua J Gooley, Hsin-Chun Feng, Shih-Kuo Chen, Ming-Tzer Lin, Yung-Hsuan Chen, Hung-Chih Chiu, Po-Kang Liu, Bo-Wen Ku, Su-Mei Wang, Chin-Hao Chang, Wei-Shiung Yang, Chong-Jen Yu","doi":"10.1093/sleep/zsaf259","DOIUrl":"https://doi.org/10.1093/sleep/zsaf259","url":null,"abstract":"<p><strong>Study objectives: </strong>Weight gain after continuous positive airway pressure (CPAP) initiation in obstructive sleep apnea (OSA) is common, but its mechanism and relevance remain unclear. This open-label randomized trial evaluated CPAP effects on energy expenditure, intake, body composition, physical activity, and appetite-regulatory hormones.</p><p><strong>Methods: </strong>Patients with OSA were randomized (1:1) to 12-week CPAP or inactive control. The primary outcome was resting energy expenditure (REE). Secondary outcomes included dietary intake, eating behavior, fat mass (FM), fat-free mass (FFM), and activity count. Tertiary outcomes included appetite-regulatory hormones. CPAP effects were assessed as baseline-adjusted between-group differences using intention-to-treat (ITT) analysis; Per-protocol analysis (completers) served as sensitivity analysis.</p><p><strong>Results: </strong>Of 52 randomized participants, 45 completed the study. In ITT analysis, CPAP had no effect on REE (8.6 kcal/day [95% CI: -51.5, 68.7]; P=0.774) or caloric intake (144.4 kcal/day [95% CI: -123.1, 411.9]; P=0.283). Although insignificant in morning, CPAP significantly increased evening body weight (P=0.017) and body mass index in morning and evening (P=0.040 and 0.030). CPAP also increased FFM, raised acylated ghrelin and insulin-like growth factor 1, and reduced cortisol and cognitive restraint. No changes were observed in macronutrient intake, FM, activity, insulin resistance, leptin, or neuropeptide Y. Per-protocol findings were similar.</p><p><strong>Conclusions: </strong>CPAP-induced weight gain, probably primarily from FFM, occurred without measurable changes in REE, activity, or significant increases in caloric intake. Accompanying hormonal and behavioral changes suggest a subtle positive energy balance. This gain may not reflect adverse metabolic effects and support evaluating CPAP's metabolic impact through body composition, not weight alone.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}