Sleep最新文献

{"title":"Trajectories of sleep health during the perinatal period: A systematic review and meta-analysis.","authors":"Man Wang, Jialu Qian, Youngmin Cho, Zhiting Guo, Xiaoyan Yu, Junxin Li","doi":"10.1093/sleep/zsaf095","DOIUrl":"https://doi.org/10.1093/sleep/zsaf095","url":null,"abstract":"<p><strong>Study objectives: </strong>This review aims to summarize trajectories of sleep quality, duration, efficiency, timing and insomnia symptoms from pregnancy to one year postpartum, with a specific focus on identifying the number, proportion, shape, associated factors and outcomes of these trajectories.</p><p><strong>Methods: </strong>We conducted a systematic search across eight databases from inception to August 13, 2024. Longitudinal studies who recruited 100 or more pregnant or postpartum women with at least three sleep assessments during pregnancy and one year postpartum, and modeled independent sleep health trajectories using trajectory analysis methods were included. Meta-analyses were performed to assess the pooled prevalence of nonoptimal sleep health trajectories. The prevalence was compared across geographical regions by subgroup meta-analysis. Group-based trajectory model (GBTM) was used to reidentify clusters of sleep health trajectories if available.</p><p><strong>Results: </strong>Five studies modeled a single trajectory, and the other 12 studies identified two to four distinct trajectories. The pooled prevalence of nonoptimal sleep quality and duration trajectories was 36% and 22%, respectively. The mean prevalence of the nonoptimal sleep efficiency trajectory was 15%, while the prevalence of delayed bedtime, late wake-up time, and clinical insomnia trajectories was reported as 51%, 17%, and 13%, respectively. Nonoptimal sleep trajectories were associated with higher risks of adverse maternal and infant outcomes. Low socioeconomic status, high pre-pregnancy body mass index, poor baseline sleep quality and self-reported health, and high initial levels of fatigue, anxiety and depressive symptoms were key factors associated with these trajectories. Additionally, GBTM identified three trajectory groups of perinatal sleep quality: consistently good (38.9%), increasingly poor (37.6%) and decreasingly poor (23.5%).</p><p><strong>Conclusions: </strong>Perinatal sleep health trajectories demonstrate significant heterogeneity, with a notable proportion of women following high-risk trajectories. Further research should focus on identifying key risk factors for sleep health trajectories early in the perinatal period, and developing targeted public health strategies and interventions to address these factors.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards proactively improving sleep: machine learning and wearable device data forecast sleep efficiency 4-8 hours before sleep onset.","authors":"Collin Sakal, Tong Chen, Wenxin Xu, Wei Zhang, Yu Yang, Xinyue Li","doi":"10.1093/sleep/zsaf113","DOIUrl":"10.1093/sleep/zsaf113","url":null,"abstract":"<p><p>Wearable devices with sleep tracking functionalities can prompt behavioral changes to promote sleep, but proactively preventing poor sleep when it is likely to occur remains a challenge due to a lack of prediction models that can forecast sleep parameters prior to sleep onset. We developed models that forecast low sleep efficiency 4 and 8 hours prior to sleep onset using gradient boosting (CatBoost) and deep learning (Convolutional Neural Network Long Short-Term Memory, CNN-LSTM) algorithms trained exclusively on accelerometer data from 80,811 adults in the UK Biobank. Associations of various sleep and activity parameters with sleep efficiency were further examined. During repeated cross-validation, both CatBoost and CNN-LSTM exhibited excellent predictive performance (median AUCs > 0.90, median AUPRCs > 0.79). U-shaped relationships were observed between total activity within 4 and 8 hours of sleep onset and low sleep efficiency. Functional data analyses revealed higher activity 6 to 8 hours prior to sleep onset had negligible associations with sleep efficiency. Higher activity 4 to 6 hours prior had moderate beneficial associations, while higher activity within 4 hours had detrimental associations. Additional analyses showed that increased variability in sleep duration, efficiency, onset timing, and offset timing over the preceding four days was associated with lower sleep efficiency. Our study represents a first step towards wearable-based machine learning systems that proactively prevent poor sleep by demonstrating that sleep efficiency can be accurately forecasted prior to bedtime and by identifying pre-bed activity targets for subsequent intervention.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human sleep spindles track experimentally excited brain circuits.","authors":"Jude L Thom, Bernhard P Staresina","doi":"10.1093/sleep/zsaf114","DOIUrl":"https://doi.org/10.1093/sleep/zsaf114","url":null,"abstract":"<p><p>Spindles are hallmark oscillations during non-rapid-eye-movement (NREM) sleep. Together with slow oscillations (SOs), they are thought to play a mechanistic role in the consolidation of learned information. The quantity and spatial distribution of spindles has been linked to brain activity during learning before sleep and to memory performance after sleep. If spindles are drawn to cortical areas excited through pre-sleep learning tasks, this begs the question whether the spatial distribution of spindles is flexible, and whether their regional expression can also be manipulated with experimental brain stimulation. We used excitatory transcranial direct current stimulation (tDCS) to stimulate the left and right motor cortex in a repeated-measures experimental design. After stimulation, we recorded high-density electroencephalography (EEG) during sleep to test how local stimulation modulated the regional expression of sleep spindles. Indeed, we show that excitatory tDCS of local cortical sites before sleep biases the expression of spindles to the excited locations during subsequent sleep. No effects of localised tDCS excitation were seen for SOs. These results demonstrate that the spatial topography of sleep spindles is neither hard-wired nor random, with spindles being flexibly directed to exogenously excited cortical circuits.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Around the world in 1.5 million nights.","authors":"Oliva Walch","doi":"10.1093/sleep/zsaf119","DOIUrl":"https://doi.org/10.1093/sleep/zsaf119","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Cerebrospinal Fluid Proteomics of Patients with Restless Legs Syndrome.","authors":"Maria P Mogavero, Gang Peng, Giovanna Marchese, Giuseppe Lanza, Luigi Ferini-Strambi, Raffaele Ferri, Brian B Koo","doi":"10.1093/sleep/zsaf112","DOIUrl":"https://doi.org/10.1093/sleep/zsaf112","url":null,"abstract":"<p><strong>Study objectives: </strong>The pathobiology of restless legs syndrome (RLS) remains poorly understood, complicating effective treatment. This observational cross-sectional study aimed to identify a cerebrospinal fluid proteomic signature of RLS and to explore sex-specific differences in cerebrospinal fluid proteomics.</p><p><strong>Methods: </strong>Cerebrospinal fluid samples were collected from 22 untreated RLS patients and 18 controls, matched for age, body mass index, and sex. Proteomic analysis was conducted using the SOMAscan® platform, assessing over 7,000 peptides.</p><p><strong>Results: </strong>Eight proteins were differentially abundant between patients and controls, with CRP and JAML increased, and TAPBPL and IL1RL1 decreased. Pathway analysis highlighted significant involvement in immune response, coagulation, and cytoskeletal regulation. Analyses were then carried out with sex stratification, comparing separately men and women. Sex-specific analyses revealed more pronounced proteomic alterations in males (68 differentially abundant proteins vs. control males) than females (17 proteins). Gene enrichment analysis revealed that men with RLS had more involvement of gene regulation and epigenetic factors than control males and women with restless legs syndrome had greater involvement of systemic inflammatory and vascular processes than control females.</p><p><strong>Conclusions: </strong>This study identified a cerebrospinal fluid proteomic signature in RLS, implicating immune and inflammatory pathways in the disease's pathophysiology. Significant sex differences in protein level suggest potential sex-specific mechanisms in RLS, warranting further investigation. These findings contribute to the current understanding of RLS and could inform future therapeutic strategies.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state functional connectivity and fast spindle temporal organization contribute to episodic memory consolidation in healthy aging.","authors":"Anaïs Hamel, Pierre Champetier, Stéphane Rehel, Claire André, Brigitte Landeau, Florence Mézenge, Sacha Haudry, Daniel Roquet, Denis Vivien, Vincent de La Sayette, Gaël Chételat, Géraldine Rauchs, Alison Mary","doi":"10.1093/sleep/zsaf105","DOIUrl":"https://doi.org/10.1093/sleep/zsaf105","url":null,"abstract":"<p><p>Episodic memory consolidation relies on the functional specialization of brain networks and sleep quality, both of which are affected by aging. Functional connectivity during wakefulness is crucial to support the integration of newly acquired information into memory networks. Additionally, the temporal dynamics of sleep spindles facilitates overnight memory consolidation by promoting hippocampal replay and integration of memories within neocortical structures. This study aimed at exploring how resting-state functional connectivity during wakefulness contributes to sleep-dependent memory consolidation in aging, and whether spindles clustered in trains modulates this relationship. Forty-two healthy older adults (68.82 ± 3.03 years), enrolled in the Age-Well clinical trial, were included. Sleep-dependent memory consolidation was assessed using a visuo-spatial memory task performed before and after a polysomnography night. Resting-state functional connectivity data were analyzed using graph theory applied to the whole brain, specific brain networks and the hippocampus. Lower limbic network integration and higher centrality of the anterior hippocampus were associated with better memory consolidation. Spindle trains modulated these effects, such that older participants with longer spindle trains exhibited a stronger negative association between limbic network integration and memory consolidation. These results indicate that lower functional specialization at rest is associated with weaker memory consolidation during sleep. This aligns with the dedifferentiation hypothesis, which posits that aging is associated with reduced brain specificity, leading to less efficient cognitive functioning. These findings reveal a novel mechanism linking daytime brain network organization and sleep-dependent memory consolidation, and suggest that targeting spindle dynamics could help preserve cognitive functioning in aging.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in symptomatic CPAP efficacy in OSA patients.","authors":"Wojciech Trzepizur, Clémence Moreau, Nicole Meslier, François Goupil, Thierry Pigeanne, Frédéric Gagnadoux","doi":"10.1093/sleep/zsaf108","DOIUrl":"10.1093/sleep/zsaf108","url":null,"abstract":"<p><strong>Study objectives: </strong>Limited data suggest a stronger association between AHI and sleepiness and a larger impact of CPAP on symptoms in younger patients. We aimed to evaluate the impact of 6 months treatment with CPAP on sleepiness and quality of life according to age in a large prospective clinical cohort of patients adherent to treatment.</p><p><strong>Methods: </strong>Within the multicentre IRSR Pays de la Loire Sleep Cohort, we identified PAP adherent OSA patients (mean use >4h/days at 6 months follow-up). Univariate and multivariate linear regression models were used to assess predictors of a change in the Epworth Sleepiness Scale (ESS) score, SF-S6 and Pichot score (difference between score at 6-month follow-up and at inclusion).</p><p><strong>Results: </strong>In response to CPAP treatment, the ESS score significantly decreased compared to baseline by 3.9 (95% CI, 3.7,4.1) in the 3298 included patients. In the univariate analysis, the baseline values of age, BMI, AHI and ESS were associated with changes in ESS score. In the multivariate analysis, the association between age and changes in ESS score remained significant after adjustments on BMI, sex, comorbidities, CPAP adherence and AHI (Coef. [95% CI] 0.062 [0.048, 0.076], p<0.001) but not after further adjustment on baseline ESS. The impact of CPAP on fatigue and depression symptoms was stronger in younger patients and persisted after further adjustments.</p><p><strong>Conclusions: </strong>In real-world settings, younger patients experienced a more pronounced impact of CPAP treatment on sleepiness and quality of life compared to older patients partly attributable to a lower baseline level of sleepiness in older age groups.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large muscle group movements are a marker of sleep instability.","authors":"Silvia Miano, Sandra Hackethal","doi":"10.1093/sleep/zsaf058","DOIUrl":"https://doi.org/10.1093/sleep/zsaf058","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of chronic sleep restriction on the hypothalamic-pituitary-adrenal axis and its interaction with abstinence from opioid use.","authors":"Carol A Everson, Aniko Szabo, Christopher M Olsen, Breanna L Glaeser, Hershel Raff","doi":"10.1093/sleep/zsaf107","DOIUrl":"https://doi.org/10.1093/sleep/zsaf107","url":null,"abstract":"<p><strong>Study objectives: </strong>The hypothalamic-pituitary-adrenal (HPA) axis is critical in regulating responses to physiological and psychological disturbances. Chronic sleep restriction (SR) interacts with the HPA axis in ways that are poorly delineated. The present study evaluated how chronic SR alters pituitary and adrenal function. Chronic SR was studied both alone and in a model of opioid use disorder as a potential cause of HPA axis abnormalities during abstinence.</p><p><strong>Methods: </strong>After established self-administration of oxycodone or a saline control, male and female rats were either chronically sleep restricted or allowed to sleep ad libitum for five weeks to permit changes in phenotype to manifest. Tests of pituitary and adrenal function were then carried out using acute CRH and dexamethasone-ACTH stimulation testing.</p><p><strong>Results: </strong>Sexual dimorphisms were prominent in the effects of chronic SR on the HPA axis which did not vary by prior opioid exposure. There were essentially no abnormalities in the HPA axis that were due to prior opioid exposure alone. In male SR rats, basal corticosterone concentrations decreased, ACTH responses to stimulation were enhanced, and ACTH suppression by dexamethasone was reduced. In female SR rats, the corticosterone response to CRH-stimulated ACTH release peaked early. Both male and female SR rats consumed more food relative to body weight than comparison rats, indicating homeostatic disruption that is known to require HPA axis mediation.</p><p><strong>Conclusions: </strong>Chronic SR interferes with HPA axis dynamics in sexually dimorphic ways that are expected to differentially affect SR-induced pathophysiology and disease risks. Chronic SR caused the HPA axis abnormalities observed during abstinence, providing biological linkage between two hypothesized risk factors in vulnerability to drug taking and relapse that demonstrate sexual dimorphisms.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemotherapy's Hidden Side Effect: Sleepless Nights Without Cancer.","authors":"Jessica A Mong","doi":"10.1093/sleep/zsaf110","DOIUrl":"https://doi.org/10.1093/sleep/zsaf110","url":null,"abstract":"","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}