Depressive symptoms and suicidal thoughts in Idiopathic Hypersomnia: A cross-sectional and longitudinal study.

IF 4.9 2区医学 Q1 Medicine

Sleep Pub Date : 2025-07-26 DOI:10.1093/sleep/zsaf215

Lucie Barateau, Marie-Gwenaëlle Paryl, Sofiene Chenini, Carole Pesenti, Lily Giraud, Séverine Béziat, Isabelle Jaussent, Yves Dauvilliers

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引用次数: 0

Abstract

Study objectives: To assess the frequency and factors associated with depressive symptoms, major depressive episode(MDE), suicidal thoughts and risk in patients with idiopathic hypersomnia(IH), a rare hypersomnolence disorder, compared to controls, and to evaluate their changes after management.

Methods: Consecutive untreated adult IH patients, diagnosed in a Reference Center for Rare Hypersomnias, were compared to controls from the general population. All participants completed the Beck Depression Inventory-II(BDI-II), including one item on suicidal thoughts. Patients underwent standardized evaluations with polysomnography(PSG), completed the IH Severity Scale(IHSS), and self-questionnaires on fatigue, anxiety and quality of life(QoL). A subgroup underwent the face-to-face Mini-International Neuropsychiatric Interview (MINI), to diagnose past/current MDE and identify suicidal risk.Another subgroup completed the BDI-II again during follow-up, after months of stable treatment.

Results: 729 participants were included: 265 IH(30.6 ± 9.7yo) and 464 controls(30.5 ± 10.1yo) with no differences in age, sex or body mass index. Patients had higher odds of moderate/severe depressive symptoms (OR = 7.68;95CI = [4.31;13.7],p<.0001) and suicidal thoughts (OR = 1.68[1.05;2.68],p=.03).Patients with moderate/severe BDI-II scores had more severe IH symptoms, more anxiety, fatigue and lower QoL, without PSG differences. Suicidal thoughts were associated with more anxiety and severe IH symptoms. Patients evaluated by MINI(n = 175) had current MDE in 8%, past MDE in 44% and suicidal risk in 18.6%.In the 111 patients re-evaluated after treatment, BDI-II scores and fatigue decreased, QoL improved, but suicidal thoughts and anxiety remained unchanged.

Conclusions: Depressive symptoms, past depressive episodes, suicidal ideation and risk were frequent in IH. Depressive symptoms and suicidal thoughts were associated with IH severity.IH management decreased depressive symptoms without effect on suicidal thoughts.

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特发性嗜睡症的抑郁症状和自杀念头：一项横断面和纵向研究

研究目的：评估与对照组相比，特发性嗜睡（IH）患者抑郁症状、重度抑郁发作（MDE）、自杀念头和风险相关的频率和因素，并评估其治疗后的变化。IH是一种罕见的嗜睡障碍。方法：在罕见嗜睡参考中心诊断的连续未经治疗的成人IH患者与普通人群的对照组进行比较。所有的参与者都完成了贝克抑郁量表ii (BDI-II)，其中包括一个关于自杀念头的项目。患者接受标准化的多导睡眠图（PSG）评估，完成IH严重程度量表（IHSS），并进行疲劳、焦虑和生活质量（QoL）自我问卷调查。一个亚组接受了面对面的迷你国际神经精神病学访谈（MINI），以诊断过去/现在的MDE并确定自杀风险。另一个亚组在稳定治疗数月后，在随访期间再次完成BDI-II。结果：纳入729名参与者：265名健康组（30.6±9.7岁）和464名对照组（30.5±10.1岁），年龄、性别和体重指数无差异。患者出现中度/重度抑郁症状的几率较高（OR = 7.68;95CI =[4.31;13.7]）。结论：IH患者出现抑郁症状、既往抑郁发作、自杀意念和自杀风险较高。抑郁症状和自杀念头与IH严重程度相关。IH管理减少了抑郁症状，但对自杀念头没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.