Rest-activity rhythms are stronger in Mexican American compared to Non-Hispanic White and Black participants: a cross-sectional study.

IF 4.9 2区医学 Q1 Medicine

Sleep Pub Date : 2025-07-29 DOI:10.1093/sleep/zsaf219

Clémence Cavaillès, Katie L Stone, Yue Leng, Kristine Yaffe

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引用次数: 0

Abstract

Study objectives: This study aimed to investigate differences in rest-activity rhythms (RAR), key circadian rhythm markers, across race/ethnicity and sex in a diverse community-based cohort of older adults.

Methods: We examined RAR (amplitude [strength of activity], mesor [level of activity], acrophase [time of peak activity], and pseudo-F [robustness of activity]) derived from the extended cosinor model based on ≥4 24-hour periods of wrist actigraphy among 856 participants (≥50 years) in the Dormir Study. We conducted linear and multinomial logistic regression models adjusted for socioeconomic status, health conditions, and sleep-related factors.

Results: We studied 218 (28.8%) Black, 221 (29.2%) Mexican American (MA), and 317 (42.0%) non-Hispanic White (NHW) participants, with a mean age of 66.3 ± 8.4 years, and 66.8% women. Compared to NHW adults, MA participants exhibited healthier RAR, with lower odds of being in the lowest tertile for amplitude and mesor, and higher odds of being in the later tertile for acrophase. Black participants had lower odds of being in the earlier tertile for acrophase. Overall, women had better RAR values than men, with lower odds of being in the lowest tertile for amplitude and mesor, and higher odds of being in the later tertile for acrophase. Among subgroups, MA women exhibited the strongest RAR, while NHW men displayed the weakest patterns.

Conclusions: RAR vary by race/ethnicity and sex, with MA participants and women exhibiting stronger rhythms. Further research is needed to understand if these different RAR patterns translate to other health outcomes and the mechanism underlying these differences.

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与非西班牙裔白人和黑人参与者相比，墨西哥裔美国人的休息活动节奏更强：一项横断面研究。

研究目的：本研究旨在调查不同种族/民族和性别的老年人休止-活动节律（RAR）的差异，这是关键的昼夜节律标记。方法：我们检查了在Dormir研究中856名参与者（≥50岁）的≥4小时腕关节活动记录基础上的扩展余弦模型得出的RAR（振幅[活动强度]、中观[活动水平]、肢相[活动峰值时间]和伪f[活动稳健性]）。我们进行了线性和多项逻辑回归模型，调整了社会经济地位、健康状况和睡眠相关因素。结果：我们研究了218名（28.8%）黑人，221名（29.2%）墨西哥裔美国人（MA）和317名（42.0%）非西班牙裔白人（NHW）参与者，平均年龄为66.3±8.4岁，其中66.8%为女性。与NHW的成年人相比，MA的参与者表现出更健康的RAR，在振幅和中轴上处于最低分蘖的几率较低，而在顶相处于较晚分蘖的几率较高。黑人受试者处于顶相早期的几率较低。总的来说，女性的RAR值比男性好，在振幅和中量值上处于最低不育系的几率较低，而在顶相上处于较晚不育系的几率较高。在亚组中，MA女性表现出最强的RAR模式，而NHW男性表现出最弱的RAR模式。结论：RAR因种族/民族和性别而异，MA参与者和女性表现出更强的节奏。需要进一步研究以了解这些不同的RAR模式是否转化为其他健康结果以及这些差异背后的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.