Sleep Science最新文献

{"title":"The AASM Guidelines for the Treatment of Restless Legs Syndrome (RLS) in the Context of Latin America.","authors":"Karem Parejo, Ulises Jimenez-Correa, Lourdes M DelRosso","doi":"10.1055/s-0045-1813730","DOIUrl":"10.1055/s-0045-1813730","url":null,"abstract":"<p><p>Restless Legs Syndrome (RLS) represents a significant clinical challenge globally, with management varying by region due to differences in healthcare resources. The American Academy of Sleep Medicine (AASM) has established guidelines for the treatment of RLS;1 however, their applicability in Latin America is influenced by medication availability, healthcare infrastructure, and the specific characteristics of the region's health systems. The prevalence of RLS in Latin America shows substantial variability among countries. The American Association of Sleep Disorders (ALADS), explores diagnostic challenges, emphasizing the importance of evaluating iron status, which remains limited in many regions. Additionally, pharmacological treatment options are examined, highlighting the difficulty in accessing first-line therapies such as gabapentinoids, while dopamine agonists continue to be used despite the risk of symptom augmentation. The frequent use of benzodiazepines and the limited availability of opioids are also discussed. Alternative therapies, including lifestyle modifications and traditional medicine, are considered as complementary strategies in resource-limited settings. Finally, the need to adapt international guidelines to local realities and to promote research to optimize RLS management in Latin America is underscored.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 4","pages":"e447-e450"},"PeriodicalIF":1.8,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Functional Jaw Orthopedics on Sleep-Related Breathing and Sleep-Related Bruxism: Case Series Study.","authors":"Denise Fernandes Barbosa, Almiro José Machado Júnior","doi":"10.1055/s-0045-1808071","DOIUrl":"10.1055/s-0045-1808071","url":null,"abstract":"<p><p>Sleep-related breathing disorders (SRBDs) in children can lead to obstructive sleep apnea (OSA) in adulthood and sleep-related bruxism (SRB). Neuro occlusal rehabilitation and functional jaw orthopedics (NOR-FJO) show promise in addressing SRBDs and SRB to prevent OSA progression. However, consistent evidence for managing these conditions in children is lacking, highlighting the need for early intervention to mitigate long-term complications. The present article explores NOR-FJO's effects in preventing SRBDs and their progression to OSA. We report two cases of brothers with SRBD and SRB and the case of their father with OSA. The brothers, who had overjet and overbite, were treated with NOR-FJO. The third patient had a similar history in childhood, without treatment, and developed OSA, subsequently treated with a mandibular advancement device (MAD). Timely intervention for SRBDs is essential in preventing long-term health complications, and understanding treatment strategies is crucial for early intervention.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e358-e364"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial - The Diversity of Advances in Sleep Science.","authors":"Claudia Roberta de Castro Moreno","doi":"10.1055/s-0045-1811247","DOIUrl":"https://doi.org/10.1055/s-0045-1811247","url":null,"abstract":"","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e245"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in the Association between Sleep Quality and Excess Weight: Exploring Lifestyle and Health-Related Mediators.","authors":"Thauanny Heslley Lima Dos Santos, Júlia Souza de Melo, Márcia de Oliveira Lima, Risia Cristina Egito de Menezes, Renan Serenini, Giovana Longo-Silva","doi":"10.1055/s-0045-1809062","DOIUrl":"10.1055/s-0045-1809062","url":null,"abstract":"<p><strong>Objective: </strong>To compare the associations between sleep quality and body mass index (BMI), as well as excess weight status, in male and female subjects, while exploring potential mediating factors, including lifestyle and health-related variables.</p><p><strong>Materials and methods: </strong>The present cross-sectional study analyzed data from 5,260 (29.7% male and 70.3% female) Brazilian adults collected through a virtual survey applied from 2023 to 2024. Sleep quality and duration were assessed using the Pittsburgh Sleep Quality Index (PSQI). The BMI was derived from self-reported weight and height, with excess weight defined as BMI > 24.9 kg/m ² . Associations were explored using multiple linear and logistic regression models, marginal probabilities for being overweight, and restricted cubic splines. Potential mediating variables were identified through mediation analysis.</p><p><strong>Results: </strong>Among the female subjects, poor sleep quality (β = 0.46; 95%CI: 0.15-0.77) and short sleep duration (β = 0.62; 95%CI: 0.27-0.97) were associated with higher BMI and 21% of increased odds of excess weight after adjusting for all covariates (age, depression, chronic conditions, level of schooling, marriage status, smoking, alcohol consumption, screen time before bed, physical activity, diet quality, and whether dinner is the largest meal of the day). The mediation analysis showed that chronic conditions (20%), depression (16%), and diet quality (14%) mediated the total effect of poor sleep quality on BMI in female participants. Screen time before bed was the only significant mediator for short sleep duration, accounting for ∼ 5% of the total effect. No significant associations were found in male subjects.</p><p><strong>Conclusion: </strong>Our findings highlight sex differences in the relationship between sleep and BMI, emphasizing the need for sex-specific approaches to sleep and weight management, focusing on health and lifestyle improvements.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e307-e316"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia Improved by Intravenous Mesenchymal Stem Cell Transplant: A Case Report.","authors":"Takahiro Honda Pazili","doi":"10.1055/s-0045-1809993","DOIUrl":"10.1055/s-0045-1809993","url":null,"abstract":"<p><p>While several therapeutic options for insomnia are currently available, they often require long-term use and come with certain disadvantages. Given insomnia's significant impact on health overall, more effective treatments are warranted. Here, we report two patients with moderate to severe insomnia whose symptoms significantly improved following the intravenous administration of <i>ex vivo</i> -expanded bone marrow-derived mesenchymal stem cells (MSC). The cases were 50-year-old and 38-year-old men with mild diabetes. They both developed insomnia several years ago and suffered from it despite taking some medications. We cultured their bone-marrow-derived MSCs and intravenously administered 1,5 × 10 ⁸ cells to each patient. After the treatment, the insomnia of both patients was drastically improved, while diabetes itself showed only mild improvement. Notably, their improvements were associated with an increase in plasma interleukin-4 levels. This is the first case report demonstrating the therapeutic effects of MSCs on insomnia.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e365-e368"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic Cardiovascular Assessment in Obstructive Sleep Apnea Using Beat-to-Beat Blood Pressure: A Pilot Study.","authors":"Renata Carvalho Cremaschi, Natalia Buitrago-Ricaute, Peter Novak, Fernando Morgadinho Santos Coelho, Vanderci Borges","doi":"10.1055/s-0045-1811200","DOIUrl":"10.1055/s-0045-1811200","url":null,"abstract":"<p><strong>Objective: </strong>To perform autonomic cardiovascular tests on patients with suspected OSA.</p><p><strong>Materials and methods: </strong>In 2020, patients aged ≥18 years without difficult-to-control hypertension, cardiopathy, or pulmonary disease executed 6Hz deep breathing, 15-second Valsalva maneuver (40mmHg), and 5-minute active standing after the type 1 polysomnography at the Neurology (Federal University of São Paulo). The tests recorded blood pressure using beat-to-beat plethysmography, an electrocardiogram, and respiratory effort.</p><p><strong>Results: </strong>Among the seventeen patients, ten had moderate OSA, and twelve were male. The mean age and disease duration were 52 and 14 years. Hypertension and obesity were frequent. They had mild autonomic symptom burden, mainly adrenergic sympathetic overactivity, and at least one-third of them had cardiovagal abnormalities.</p><p><strong>Conclusion: </strong>A small sample of patients with untreated moderate-to-severe OSA had autonomic abnormalities in tests using beat-to-beat blood pressure. Sympathetic overdrive in long-term daytime was manifested as orthostatic hypertension. Emerging technologies contributed to diagnosing the OSA-related autonomic dysfunction beyond the polysomnographic approach.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 4","pages":"e430-e435"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dream Recall, Nightmares, and Aggression-Related Dream Content in Patients with REM Sleep Behavior Disorder (RBD).","authors":"Ruben Jigalin, Michael Schredl","doi":"10.1055/s-0045-1809924","DOIUrl":"10.1055/s-0045-1809924","url":null,"abstract":"<p><p>Patients with REM sleep behavior disorder (RBD) enact their dreams, leading to enhanced dream recall. They report more negative emotions in their dreams, recall retrospective nightmares more frequently, and often experience more aggressive dreams. This study aims to understand dream characteristics in REM sleep behavior disorder using both retrospective and prospective measures in a controlled sleep laboratory setting to address possible recall biases in retrospective dream recall frequency. The sample comprises 102 iRBD-diagnosed patients (21 women, 81 men; M = 64.08, SD = 11.27) and 208 healthy controls (136 women, 72 men; M = 30.08, SD = 12.03), all undergoing identical procedures of two consecutive nights in the sleep laboratory, enabling a robust comparative examination of dream patterns. Retrospective assessments revealed a higher frequency of dream recall in patients with iRBD, while no significant difference was observed in prospective assessments. Nightmares were also reported more frequently in retrospective assessments in iRBD patients compared to healthy controls. Aggressive dream content was more frequent in patients with iRBD compared to controls, a future prospective diary study might clarify whether this heightened aggression in dreams is related to waking-life traits.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 4","pages":"e379-e386"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When You Don't Have Chronotype Data: Sleep Questionnaires as a Circadian Window.","authors":"Matteo Carpi","doi":"10.1055/s-0045-1809926","DOIUrl":"10.1055/s-0045-1809926","url":null,"abstract":"","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 4","pages":"e453-e454"},"PeriodicalIF":1.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial - A New Chapter for <i>Sleep Science</i>.","authors":"Claudia Roberta de Castro Moreno","doi":"10.1055/s-0045-1809667","DOIUrl":"https://doi.org/10.1055/s-0045-1809667","url":null,"abstract":"","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 2","pages":"e119"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Sexual Behavior During Sleep in an Adolescent: Sexsomnia and Defecation.","authors":"Oya Güleşen Kapan, Zeynep Ihtiyar Aydilek, Mustafa Kapan, Mehmet Baştemur, Güray Koç, Şahin Bodur, Sinan Yetkin, Mehmet Ayhan Cöngöloğlu","doi":"10.1055/s-0045-1809927","DOIUrl":"10.1055/s-0045-1809927","url":null,"abstract":"<p><p>Sexsomnia is characterized by sexual behaviors ranging from masturbation, sexual sounds, and verbalizations, to touching and full sexual intercourse during NREM sleep, with subsequent amnesia. Autonomic activation occurs with sexual arousal. Sexsomnia has been described mostly in adult males and is still an underrecognized condition. Treatment is often effective but without current consensus. In a case now reported of an adolescent male with sexsomnia, which is rarely reported in the literature, a novel feature that is now first reported is defecation accompanying sexsomnia as a co-occurring autonomic disturbance during sleep.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 4","pages":"e444-e446"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}