Sleep SciencePub Date : 2025-09-16eCollection Date: 2025-09-01DOI: 10.1055/s-0045-1808071
Denise Fernandes Barbosa, Almiro José Machado Júnior
{"title":"The Impact of Functional Jaw Orthopedics on Sleep-Related Breathing and Sleep-Related Bruxism: Case Series Study.","authors":"Denise Fernandes Barbosa, Almiro José Machado Júnior","doi":"10.1055/s-0045-1808071","DOIUrl":"10.1055/s-0045-1808071","url":null,"abstract":"<p><p>Sleep-related breathing disorders (SRBDs) in children can lead to obstructive sleep apnea (OSA) in adulthood and sleep-related bruxism (SRB). Neuro occlusal rehabilitation and functional jaw orthopedics (NOR-FJO) show promise in addressing SRBDs and SRB to prevent OSA progression. However, consistent evidence for managing these conditions in children is lacking, highlighting the need for early intervention to mitigate long-term complications. The present article explores NOR-FJO's effects in preventing SRBDs and their progression to OSA. We report two cases of brothers with SRBD and SRB and the case of their father with OSA. The brothers, who had overjet and overbite, were treated with NOR-FJO. The third patient had a similar history in childhood, without treatment, and developed OSA, subsequently treated with a mandibular advancement device (MAD). Timely intervention for SRBDs is essential in preventing long-term health complications, and understanding treatment strategies is crucial for early intervention.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e358-e364"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2025-09-16eCollection Date: 2025-09-01DOI: 10.1055/s-0045-1811247
Claudia Roberta de Castro Moreno
{"title":"Editorial - The Diversity of Advances in Sleep Science.","authors":"Claudia Roberta de Castro Moreno","doi":"10.1055/s-0045-1811247","DOIUrl":"https://doi.org/10.1055/s-0045-1811247","url":null,"abstract":"","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e245"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2025-09-16eCollection Date: 2025-09-01DOI: 10.1055/s-0045-1809062
Thauanny Heslley Lima Dos Santos, Júlia Souza de Melo, Márcia de Oliveira Lima, Risia Cristina Egito de Menezes, Renan Serenini, Giovana Longo-Silva
{"title":"Sex Differences in the Association between Sleep Quality and Excess Weight: Exploring Lifestyle and Health-Related Mediators.","authors":"Thauanny Heslley Lima Dos Santos, Júlia Souza de Melo, Márcia de Oliveira Lima, Risia Cristina Egito de Menezes, Renan Serenini, Giovana Longo-Silva","doi":"10.1055/s-0045-1809062","DOIUrl":"10.1055/s-0045-1809062","url":null,"abstract":"<p><strong>Objective: </strong>To compare the associations between sleep quality and body mass index (BMI), as well as excess weight status, in male and female subjects, while exploring potential mediating factors, including lifestyle and health-related variables.</p><p><strong>Materials and methods: </strong>The present cross-sectional study analyzed data from 5,260 (29.7% male and 70.3% female) Brazilian adults collected through a virtual survey applied from 2023 to 2024. Sleep quality and duration were assessed using the Pittsburgh Sleep Quality Index (PSQI). The BMI was derived from self-reported weight and height, with excess weight defined as BMI > 24.9 kg/m <sup>2</sup> . Associations were explored using multiple linear and logistic regression models, marginal probabilities for being overweight, and restricted cubic splines. Potential mediating variables were identified through mediation analysis.</p><p><strong>Results: </strong>Among the female subjects, poor sleep quality (β = 0.46; 95%CI: 0.15-0.77) and short sleep duration (β = 0.62; 95%CI: 0.27-0.97) were associated with higher BMI and 21% of increased odds of excess weight after adjusting for all covariates (age, depression, chronic conditions, level of schooling, marriage status, smoking, alcohol consumption, screen time before bed, physical activity, diet quality, and whether dinner is the largest meal of the day). The mediation analysis showed that chronic conditions (20%), depression (16%), and diet quality (14%) mediated the total effect of poor sleep quality on BMI in female participants. Screen time before bed was the only significant mediator for short sleep duration, accounting for ∼ 5% of the total effect. No significant associations were found in male subjects.</p><p><strong>Conclusion: </strong>Our findings highlight sex differences in the relationship between sleep and BMI, emphasizing the need for sex-specific approaches to sleep and weight management, focusing on health and lifestyle improvements.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e307-e316"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2025-09-16eCollection Date: 2025-09-01DOI: 10.1055/s-0045-1809993
Takahiro Honda Pazili
{"title":"Insomnia Improved by Intravenous Mesenchymal Stem Cell Transplant: A Case Report.","authors":"Takahiro Honda Pazili","doi":"10.1055/s-0045-1809993","DOIUrl":"10.1055/s-0045-1809993","url":null,"abstract":"<p><p>While several therapeutic options for insomnia are currently available, they often require long-term use and come with certain disadvantages. Given insomnia's significant impact on health overall, more effective treatments are warranted. Here, we report two patients with moderate to severe insomnia whose symptoms significantly improved following the intravenous administration of <i>ex vivo</i> -expanded bone marrow-derived mesenchymal stem cells (MSC). The cases were 50-year-old and 38-year-old men with mild diabetes. They both developed insomnia several years ago and suffered from it despite taking some medications. We cultured their bone-marrow-derived MSCs and intravenously administered 1,5 × 10 <sup>8</sup> cells to each patient. After the treatment, the insomnia of both patients was drastically improved, while diabetes itself showed only mild improvement. Notably, their improvements were associated with an increase in plasma interleukin-4 levels. This is the first case report demonstrating the therapeutic effects of MSCs on insomnia.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e365-e368"},"PeriodicalIF":1.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2025-07-15eCollection Date: 2025-06-01DOI: 10.1055/s-0045-1809667
Claudia Roberta de Castro Moreno
{"title":"Editorial - A New Chapter for <i>Sleep Science</i>.","authors":"Claudia Roberta de Castro Moreno","doi":"10.1055/s-0045-1809667","DOIUrl":"https://doi.org/10.1055/s-0045-1809667","url":null,"abstract":"","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 2","pages":"e119"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2025-07-08eCollection Date: 2025-09-01DOI: 10.1055/s-0045-1809061
Eduardo López-Ramírez, Gabriela Millán-Rosas, Rafael Santana-Miranda, Daniel Santana-Vargas, Adrián Poblano, Romel Gutiérrez-Escobar
{"title":"Sleep Architecture, Muscle Function, and Daily Life Activities in Patients with Sarcopenia.","authors":"Eduardo López-Ramírez, Gabriela Millán-Rosas, Rafael Santana-Miranda, Daniel Santana-Vargas, Adrián Poblano, Romel Gutiérrez-Escobar","doi":"10.1055/s-0045-1809061","DOIUrl":"10.1055/s-0045-1809061","url":null,"abstract":"<p><strong>Objective: </strong>To examine associations between polysomnography, muscle mass and strength, and daily life activity index (DLAI) in patients with sarcopenia.</p><p><strong>Materials and methods: </strong>We measured polysomnography, muscle mass and strength, and DLAI in 16 patients with sarcopenia and 26 controls > 60 years old and then compared variables and correlations in the patients with sarcopenia.</p><p><strong>Results: </strong>We found no differences in polysomnography between patients with sarcopenia and controls. Among patients with sarcopenia, latency to rapid eye-movement (REM) sleep was positively correlated with weight, REM %, and total sleep time was positively correlated with grip strength. Latency of REM sleep was negatively correlated with body mass index, NREM sleep, and apnea index was negatively correlated with grip strength. Daily life activity index correlated positively with grip strength.</p><p><strong>Conclusion: </strong>Patients with sarcopenia showed significant correlations between polysomnography and weight, body mass index, and grip strength, suggesting a complex relationship involving sleep architecture, muscle function, and DLAI that deserves more research.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e317-e322"},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Continuous Positive Airway Pressure on the Degree of Sleepiness, Functional Quality of Sleep, and Electrophysiological Hearing Responses in Individuals with Obstructive Sleep Apnea.","authors":"Marisa Mizrahi Farber, Liliane Aparecida Fagundes Silva, Geraldo Lorenzi-Filho, Carla Gentile Matas","doi":"10.1055/s-0045-1809060","DOIUrl":"10.1055/s-0045-1809060","url":null,"abstract":"<p><strong>Introduction: </strong>Obstructive sleep apnea (OSA) affects nerve impulse transmission in the auditory pathway due to oxygen supply. Continuous positive airway pressure (CPAP) therapy improves oxygen levels, potentially alleviating sleepiness and enhancing central auditory pathway function.</p><p><strong>Objective: </strong>To longitudinally evaluate the effect of CPAP on the degree of sleepiness, functional quality of sleep, and electrophysiological hearing responses of the central auditory pathways of patients with moderate to severe OSA.</p><p><strong>Materials and methods: </strong>There were 31 adults (21 men and 10 women), aged 20 to 70 years, of which 18 were from the group with and 13 from the one without CPAP. All patients underwent three assessments: the first one performed immediately after CPAP prescription; the second, 3 months later; and the third, 6 months after the initial assessment. The Epworth Sleepiness Scale (ESS), the Functional Outcomes of Sleep Questionnaire-10 (FOSQ-10), auditory brainstem response (ABR), and long-latency auditory evoked potentials (LLAEP) were used for these assessments.</p><p><strong>Results: </strong>The ESS did not detect any changes in excessive daytime sleepiness levels and the FOSQ-10 showed no improvement in either group. Analysis from ABR revealed a high proportion of altered results in both groups at the three assessment times. During the LLAEP, it was observed that the CPAP group exhibited reduced P2 latencies compared with the non-CPAP group in the second assessment. However, this improvement was not sustained in the subsequent assessment, possibly attributed to OSA-induced damage.</p><p><strong>Conclusion: </strong>Treatment with CPAP for 6 months did not improve the degree of sleepiness, functional quality of sleep, or electrophysiological response of hearing, demonstrating that OSA can irreversibly harm the individual.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e281-e291"},"PeriodicalIF":1.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2025-06-26eCollection Date: 2025-06-01DOI: 10.1055/s-0044-1793927
Khatereh Khamenehpour, Isa Mohammadi Zeidi, Saeed Shahsavari, Alireza Razzaghi
{"title":"Effective Factors Related to Sleep Disorder in Infants Under 12 Months Old.","authors":"Khatereh Khamenehpour, Isa Mohammadi Zeidi, Saeed Shahsavari, Alireza Razzaghi","doi":"10.1055/s-0044-1793927","DOIUrl":"10.1055/s-0044-1793927","url":null,"abstract":"<p><p><b>Objective</b> Infant sleep problems are ranked as one of the leading sources of stress for many families. The present study was conducted to determine the effective factors related to sleep disorders in infants under 12 months old. <b>Materials and Methods</b> In this cross-sectional study, 410 infants who were referred to the sleep department were evaluated. The Brief Infant Sleep Questionnaire (BISQ) was used to assess the infants' sleep patterns. Statistical tests such as analysis of variance (ANOVA), Chi-squared, and linear regression analysis were used to compare the mean and percentage across the infant age groups and to determine the risk factors related to infant sleep disorders. <b>Results</b> Out of 410 infants, 289 (70.5%) had at least 1 of the symptoms of sleep disorder. The highest and lowest percentages for sleep disorders were related to \"waking for more than 1 hour at night\" and \"sleeping less than 540 minutes in 24 hours\" with 50% and 23.7%, respectively. The results of the linear regression analysis showed that the factors of age (β = -1.04; 95% CI; -1.55-0.53) and parent perception (β = -0.31; 95% CI; 0.24-0.37) had significant effects on infant sleep disorders. <b>Conclusion</b> The percentage of infant sleep disorder was rather high among the samples studied, and the age and parent perception variables were recognized as effective factors related to sleep disorder. Health providers and medical staff need to pay more attention to providing the necessary interventions considering infants' age and parents' perception.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 2","pages":"e190-e196"},"PeriodicalIF":1.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2025-06-12eCollection Date: 2025-09-01DOI: 10.1055/s-0044-1801337
Samir Sumant Barve, Sonopant Ganapatrao Joshi, Prashant Sharad Duraphe
{"title":"Exploring the Relationship between Chronotype and Waist Circumference: A Scoping Review.","authors":"Samir Sumant Barve, Sonopant Ganapatrao Joshi, Prashant Sharad Duraphe","doi":"10.1055/s-0044-1801337","DOIUrl":"10.1055/s-0044-1801337","url":null,"abstract":"<p><p>Understanding the relationship between chronotype and waist circumference (WC) has implications for metabolic health management. The present article overviews the available literature, the knowledge gaps, and the insights for future research. We conducted a search on the Scopus, Web of Science, and PubMed electronic databases and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews. A total of 33 articles were included in the review. The studies primarily identified that people with the evening chronotype presented a higher mean WC compared to those with the morning chronotype. However, the difference was not significant in all studies. A significant positive correlation of the WC with chronotype scores denoting eveningness was found in 88% of the studies. The cut-off values on the scales to categorize subjects into different chronotypes may need to be defined for communities living across the globe. We conclude that higher WC values are associated with eveningness. However, this finding should be validated using objective measures of chronotype assessment.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e323-e335"},"PeriodicalIF":1.8,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2025-06-12eCollection Date: 2025-09-01DOI: 10.1055/s-0045-1806955
Liang Chye Goh, Nesha Rajendram, Bryan Way Wern Lim, Jeyanthi Kulasegarah, Revadi Govindaraju, Chun Ian Soo, Chee Kuan Wong
{"title":"Comparative Study on CPAP Compliance: PAP-NAP Followed by CPAP Trial vs. CPAP Trial Alone.","authors":"Liang Chye Goh, Nesha Rajendram, Bryan Way Wern Lim, Jeyanthi Kulasegarah, Revadi Govindaraju, Chun Ian Soo, Chee Kuan Wong","doi":"10.1055/s-0045-1806955","DOIUrl":"10.1055/s-0045-1806955","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of allocating positive airway pressure nap (PAP-NAP) prior to continuous positive airway pressure (CPAP) trial compared with CPAP trial alone in improving CPAP therapy adherence among individuals diagnosed with obstructive sleep apnea (OSA) in our Southeast Asian cohort.</p><p><strong>Materials and methods: </strong>A total of 133 adults with OSA were divided into 2 groups: 1 received PAP-NAP before a CPAP trial, and the other underwent a CPAP trial alone. The correlation between CPAP adherence and polysomnographic data was investigated.</p><p><strong>Results: </strong>The PAP-NAP group showed better CPAP compliance (above 90%) and adherence (66.64% ± 31.96%) compared with the CPAP-only group (57.90% ± 34.86%). Both groups experienced reductions in apnea hypopnea index (AHI), with the PAP-NAP group having lower residual AHI. Compliance was defined as usage of CPAP > 4H in 14 days.</p><p><strong>Conclusion: </strong>Positive airway pressure naps prior to a CPAP trial increases short-term CPAP adherence and influences mask selection. Personalized CPAP approaches like PAP-NAP can enhance patient acceptance and motivation. Further research is recommended to investigate long-term adherence.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"18 3","pages":"e301-e306"},"PeriodicalIF":1.8,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}