Sleep SciencePub Date : 2026-10-20eCollection Date: 2026-09-01DOI: 10.1055/s-0046-1829640
Michael Todd, Carlos H Schenck, Erin Golden, Ranji Varghese
{"title":"A First Case of Compulsive Amnestic Sleep-Related Shopping Induced by Pramipexole Therapy of Restless Legs Syndrome.","authors":"Michael Todd, Carlos H Schenck, Erin Golden, Ranji Varghese","doi":"10.1055/s-0046-1829640","DOIUrl":"https://doi.org/10.1055/s-0046-1829640","url":null,"abstract":"<p><p>Dopamine receptor agonists (DAs) such as pramipexole/ropinirole are recognized treatments for restless legs syndrome (RLS) and Parkinson's disease (PD). It is well established that these medications can cause impulse control disorders (ICDs) during wakefulness, side effects with serious and potentially life-altering consequences. Impulse control disorders are recurrent difficult-to-resist behaviors that can be harmful to the patient or others around them. Common examples include pathologic gambling and compulsive sexual behaviors, eating, and shopping. We present the case of a patient with RLS who developed pathologic nocturnal sleep-related shopping, without recalling the events, which resolved after discontinuing pramipexole. This case illustrates the devastating consequences that unrecognized medically-induced ICDs can have on patients' lives and the importance of counseling patients about ICDs during wake and sleep prior to starting DA therapy.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"19 3","pages":"1-3"},"PeriodicalIF":1.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13682852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2026-10-19eCollection Date: 2026-06-01DOI: 10.1055/s-0046-1829073
Robson Salviano de Matos, Paulo Iury Gomes Nunes, Bruna Rafaele Diógenes da Silva, Daniel Vieira Pinto, Pedro Felipe Carvalhedo de Bruin, Reinaldo Barreto Oriá, Veralice Meireles Sales de Bruin
{"title":"Effect of Long-Term Physical Exercise on Memory, Anxiety-Like Behavior, and Depression in Young and Aged Male Mice Subjected to Sleep Deprivation.","authors":"Robson Salviano de Matos, Paulo Iury Gomes Nunes, Bruna Rafaele Diógenes da Silva, Daniel Vieira Pinto, Pedro Felipe Carvalhedo de Bruin, Reinaldo Barreto Oriá, Veralice Meireles Sales de Bruin","doi":"10.1055/s-0046-1829073","DOIUrl":"10.1055/s-0046-1829073","url":null,"abstract":"<p><p>This study evaluated whether chronic aerobic exercise could attenuate behavioral impairments associated with sleep deprivation (SD) in young and aged male mice. Young (3 months) and aged (18 months) Swiss mice were assigned to four groups: control, exercise (EXE), sleep deprivation (SD), and exercise followed by SD (EXE + SD). Animals performed treadmill training for 8 weeks and then underwent 72-hour SD. Behavioral tests assessed working memory (Y-maze), depression-like behavior (tail suspension), and anxiety-like behavior (elevated plus maze). The results suggest that age influences the effectiveness of exercise in mitigating sleep deprivation-induced behavioral deficits, opening avenues for future studies on the interaction between physical exercise, sleep, and aging.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"19 2","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2026-10-19eCollection Date: 2026-06-01DOI: 10.1055/s-0046-1829079
Marjan Zahernia, Zahra Banafsheh Alemohammad, Arezu Najafi
{"title":"Glycemic Indices and Polysomnographic Parameters in an Iranian Population Referred to a Sleep Clinic.","authors":"Marjan Zahernia, Zahra Banafsheh Alemohammad, Arezu Najafi","doi":"10.1055/s-0046-1829079","DOIUrl":"10.1055/s-0046-1829079","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes remains a significant global health burden, with sleep breathing disorders increasingly implicated in its development and progression. In this study, we aimed to assess the relationship between glycemic indices and polysomnography (PSG) parameters among patients referred to a sleep clinic in Iran.</p><p><strong>Methods: </strong>We retrospectively studied adults at the Baharloo Hospital sleep clinic who completed overnight PSG and a recent metabolic panel, as well as validated questionnaires on sleepiness, obstructive sleep apnea (OSA) risk, and insomnia, between March 2024 and March 2025. We examined associations using Pearson correlations and adjusted linear regression models.</p><p><strong>Results: </strong>A total of 409 participants (115 females) were included. Correlation analyses revealed that higher HbA1c and fasting blood glucose (FBS) were associated with worse nocturnal oxygenation profiles, with HbA1c showing a more selective pattern. Moreover, after adjusting for confounding factors, higher HbA1c was independently associated with lower mean nocturnal oxygen saturation (beta = -0.159, p = 0.013) and lower non-REM oxygen saturation (beta = -0.179, p = 0.007). Meanwhile, higher FBS was independently associated with lower average oxygen saturation during wake (beta = -0.688, p = 0.018) and during REM sleep (beta = -0.890, p = 0.001).</p><p><strong>Conclusion: </strong>Our study highlights the relationship between glycemic measures and sleep parameters in a relatively large population of Iranian sleep clinic patients. More studies are needed to unravel the association between diabetes and sleep breathing disorders to identify their shared mechanisms.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"19 2","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute Onset of Suicidal Ideation after Starting Lemborexant in a Patient with a Mood Disorder.","authors":"Renato Rodrigo Silva, Marjorie Mastellaro Baruzzi, Bianca Besteti Fernandes Damiano, Rodolfo Furlan Damiano","doi":"10.1055/s-0046-1829078","DOIUrl":"https://doi.org/10.1055/s-0046-1829078","url":null,"abstract":"<p><p>A 24-year-old woman with treatment-resistant depressive symptoms and chronic insomnia developed acute, intrusive suicidal ideation with intent on day 5 after starting lemborexant 10 mg nightly. Emergency assessment did not identify intoxication, metabolic disturbance, psychosis, mania, akathisia, or other acute precipitants. Pretreatment polysomnography showed severe insomnia with a sleep efficiency of 14.5% and absent REM sleep, without sleep-disordered breathing. Lemborexant was discontinued immediately, and suicidal ideation resolved completely within 24 hours without additional pharmacological intervention. The Naranjo Adverse Drug Reaction Probability Scale yielded a score of 6, consistent with a probable adverse drug reaction. At 6-month follow-up, the patient remained free of suicidal ideation with sustained functional stability. This case adds clinically relevant documentation to pharmacovigilance concerns about potential suicidality with dual orexin receptor antagonists and supports structured suicide risk assessment and early follow-up when initiating these agents in patients with mood disorders.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"19 2","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2026-10-09eCollection Date: 2026-06-01DOI: 10.1055/s-0046-1827497
Fernando Alberto Ceballos-Fuentes, Sanket Meghpara, Rijesh Niraula, Lourdes M DelRosso
{"title":"Cognitive Performance and Adherence to Treatment in Patients with Obstructive Sleep Apnea.","authors":"Fernando Alberto Ceballos-Fuentes, Sanket Meghpara, Rijesh Niraula, Lourdes M DelRosso","doi":"10.1055/s-0046-1827497","DOIUrl":"https://doi.org/10.1055/s-0046-1827497","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive impairment is common in obstructive sleep apnea (OSA), but how cognition relates to positive airway pressure (PAP) adherence among asymptomatic referrals is less clear. We evaluated whether global cognition using the Montreal Cognitive Assessment (MoCA) is associated with continuous PAP (CPAP) adherence.</p><p><strong>Materials and methods: </strong>In total, 29 OSA patients underwent the MoCA test. Data on CPAP adherence was obtained at 3 months. The Pearson correlations quantified associations between MoCA scores and adherence/effectiveness measures.</p><p><strong>Results: </strong>The mean age of the participants was of 64.3 ± 8.0 years, and 51.7% of them had MoCA scores < 26. Among those with mild OSA, who scored 5 to 15 on the apnea-hypopnea index (AHI), 57.1% were impaired despite being asymptomatic by history. Higher MoCA correlated with higher CPAP use (r = 0.65, <i>p</i> = 0.023) and showed a positive trend with nights used > 4 hours (r = 0.54, <i>p</i> = 0.073). The attention domain correlated with both average hours/day and percent nights > 4 hours, while lower language scores correlated with higher residual AHI (r = -0.69, <i>p</i> = 0.019).</p><p><strong>Discussion: </strong>The high prevalence of cognitive impairment despite the absence of self-reported symptoms suggests that cognitive deficits may be underrecognized in patients undergoing evaluation for OSA. The association of global cognition and attention with CPAP use further suggests that cognitive function may influence patients' ability to successfully engage with treatment.</p><p><strong>Conclusion: </strong>Cognitive impairment was present in 51.7% of this asymptomatic cohort and in 57.1% of participants with mild OSA. Higher global MoCA and attention scores were associated with greater CPAP use, while lower language scores were associated with higher residual AHI.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"19 2","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2026-10-09eCollection Date: 2026-06-01DOI: 10.1055/s-0046-1829072
Amir Ali Mazandarani, Masoomeh Karimi
{"title":"The Interplay of Child Sleep Disturbances, Maternal Burnout, and Marital Quality in Iranian Mothers.","authors":"Amir Ali Mazandarani, Masoomeh Karimi","doi":"10.1055/s-0046-1829072","DOIUrl":"https://doi.org/10.1055/s-0046-1829072","url":null,"abstract":"<p><p>This study examined the relationships between child sleep disturbances, maternal burnout, and marital quality among Iranian mothers. Using a cross-sectional design, data were collected from 564 married mothers of preschool-aged children (aged 5-6 years) through validated questionnaires: the <i>Children's Sleep Habits Questionnaire</i> , the <i>Parental Burnout Assessment</i> , and the <i>Quality of Marriage Index</i> . A structural equation model (SEM) was used to test hypothesized associations among the variables. The final model demonstrated excellent fit to the data. Results indicated a significant positive correlation between child sleep disturbances and maternal burnout ( <i>r</i> = 0.374, <i>p</i> < 0.001) and significant negative correlations between maternal burnout and marital quality ( <i>r</i> = -0.368, <i>p</i> < 0.001) and between child sleep disturbances and marital quality ( <i>r</i> = -0.217, <i>p</i> < 0.001). In the measurement model, strong indicators were identified for each latent variable, including night wakings (β = 0.683) and parasomnias (β = 0.533) for child sleep disturbances, and contrast with the previous maternal self (β = 0.909) and emotional exhaustion (β = 0.864) for maternal burnout. These findings advance theoretical understanding by highlighting key interconnections between child sleep, maternal well-being, and relational outcomes within a specific cultural context. The results underscore the importance of a systemic approach in examining how child sleep disturbances and maternal burnout jointly relate to marital quality, with implications for family well-being interventions.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"19 2","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2026-10-09eCollection Date: 2026-06-01DOI: 10.1055/s-0046-1829074
Ekow Essien, Abena Agyekum, Abraham Carboo, Gloria Amoako, Justice Owusu-Achiaw, Samuel B Governor
{"title":"C-Reactive Protein as a Predictor of Cardiovascular Events and Mortality in Obstructive Sleep Apnea: A Propensity-Matched Analysis Using the TriNetX Research Network.","authors":"Ekow Essien, Abena Agyekum, Abraham Carboo, Gloria Amoako, Justice Owusu-Achiaw, Samuel B Governor","doi":"10.1055/s-0046-1829074","DOIUrl":"https://doi.org/10.1055/s-0046-1829074","url":null,"abstract":"<p><strong>Introduction: </strong>Obstructive sleep apnea (OSA) increases cardiovascular disease risk through systemic inflammation, particularly through elevated C-reactive protein (CRP). This study investigated whether CRP stratification predicts mortality and cardiovascular events in OSA patients.</p><p><strong>Methods: </strong>We conducted a retrospective cohort analysis using the TriNetX Research Network, encompassing electronic health records from 130 healthcare institutions. Adults (ages 18-90 years) with OSA were stratified by CRP concentration: elevated (≥ 3.0 mg/L) versus low (≤ 2.9 mg/L). After propensity score matching for demographics and comorbidities, 240,727 participants per cohort were followed for five years. Primary outcome was all-cause mortality; secondary outcomes included cardiovascular events, arrhythmias, and acute kidney injury.</p><p><strong>Results: </strong>Elevated CRP was associated with significantly higher all-cause mortality (11.3% versus 7.0%; HR 1.695, 95% CI 1.662-1.727; <i>p</i> < 0.001). The elevated CRP group demonstrated heightened cardiovascular risk: cardiogenic shock (1.0% versus 0.5%; HR 2.003), heart failure (9.8% versus 6.5%; HR 1.594), pulmonary hypertension (4.9% versus 3.4%; HR 1.508), and acute kidney injury (11.0% versus 6.4%; HR 1.825), all <i>p</i> < 0.001. Arrhythmic complications were also increased: atrial fibrillation/flutter (6.3% versus 4.8%; HR 1.372) and ventricular tachycardia (2.3% versus 1.8%; HR 1.388), both <i>p</i> < 0.001.</p><p><strong>Conclusion: </strong>Elevated CRP constitutes a robust predictor of mortality and cardiovascular morbidity in OSA populations. Assessment of inflammatory biomarkers may enhance risk stratification, informing intensified monitoring and targeted therapeutic interventions.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"19 2","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2026-10-09eCollection Date: 2026-06-01DOI: 10.1055/s-0046-1829075
Lauren Sofia Yepes Fernández, Mariana Almonacid Garzón, Mayra Alexandra Téllez Corral, Francisco Sir-Mendoza, Liliana Otero, Mauricio Rey Buitrago
{"title":"Exploring the Link Between Inflammatory Gene Variants and Phenotypes of Periodontal Disease and Obstructive Sleep Apnea.","authors":"Lauren Sofia Yepes Fernández, Mariana Almonacid Garzón, Mayra Alexandra Téllez Corral, Francisco Sir-Mendoza, Liliana Otero, Mauricio Rey Buitrago","doi":"10.1055/s-0046-1829075","DOIUrl":"https://doi.org/10.1055/s-0046-1829075","url":null,"abstract":"<p><p>Periodontal disease (PD) and obstructive sleep apnea (OSA) are prevalent chronic inflammatory conditions affecting over 50% of Colombians and a substantial proportion of the global population. This study investigated genetic associations between interleukin (IL) gene variants (IL-1β, IL-10, IL-17) and the risk of PD, OSA, or their coexistence in 129 Colombian individuals, including cases (PD, OSA, PD + OSA) and healthy controls. Genotyping was performed using PCR amplification and Sanger sequencing. Key findings revealed that IL-1β variants (rs1143627, rs16944) significantly increased OSA risk (OR = 3.6 and 3.36; <i>p</i> = 0.004 and 0.008). The IL-10 (rs1800896) also elevated OSA risk (OR = 4.44; <i>p</i> = 0.004), whereas the IL-17 (rs2275913) showed a protective effect (OR = 0.21; <i>p</i> = 0.0003). Among individuals with PD + OSA, IL-1β variants (rs1143627, rs16944) conferred an even higher risk (OR = 4.8; <i>p</i> = 0.0007-0.0008). No significant genetic associations were found for PD alone. In conclusion, these findings highlight the central role of inflammation in PD-OSA comorbidity, driven by dysregulated interleukin signaling pathways. Variants in IL-1β and IL-10 may predispose individuals to both conditions, suggesting shared inflammatory mechanisms. These insights could inform the development of targeted therapies addressing inflammatory pathways underlying PD and OSA. The study underscores the importance of genetic and molecular research in advancing personalized treatment strategies for overlapping chronic diseases.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"19 2","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2026-09-15eCollection Date: 2026-06-01DOI: 10.1055/s-0046-1824546
Mark S Rea, John D Bullough, Mariana G Figueiro
{"title":"Circadian Biomarkers Before and After the Transition to Spring Daylight Saving Time.","authors":"Mark S Rea, John D Bullough, Mariana G Figueiro","doi":"10.1055/s-0046-1824546","DOIUrl":"10.1055/s-0046-1824546","url":null,"abstract":"<p><strong>Objective: </strong>Periodically, concerns are raised within the research community about the effects on circadian and sleep-related outcomes resulting from changes to and from daylight saving time (DST). To better understand these concerns, we collected varied circadian and sleep-related outcomes from healthy individuals immediately before and after the spring DST transition.</p><p><strong>Materials and methods: </strong>Subjects wore calibrated, personal light sensors that measured light exposure (amount, duration, time) and wrist actigraphs to quantify the synchrony between the 24-hour light-dark exposure and the 24-hour activity-rest cycles. Sleep onset, offset, and time in bed were obtained from the wrist actigraphs. Dim light melatonin onset (DLMO) was also measured before and after DST transition. Predicted minimum core body temperature (CBT <sub>min</sub> <sup>p</sup> ) times were calculated from the light exposure data. Karolinska Sleepiness Score (KSS) ratings were collected four times a day. Health-related outcomes were not examined.</p><p><strong>Results: </strong>The spring DST transition had modest (statistically insignificant) effects on the weekly averages of time in bed (≤ 21 min), subjective sleepiness (KSS < 0.48), and the synchrony between the light and activity cycles (phasor magnitude ≤ 0.08 units). After the transition to DST, CBT <sub>min</sub> <sup>p</sup> was slightly delayed, whereas DLMO and mid-sleep were slightly advanced.</p><p><strong>Conclusion: </strong>For this cohort, the spring transition to DST had little if any effect on a variety of circadian and sleep-related outcomes. The transition appears to have caused a small disassociation in the relative timing of the circadian phase markers, which may or may not be of some significance for health and wellbeing.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"19 2","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sleep SciencePub Date : 2026-09-02eCollection Date: 2026-06-01DOI: 10.1055/s-0046-1825528
Luiz J R Oliveira, Maria L R Guimarães, Luiz De Marco, Nathália S Guimarães, Luciana Bastos-Rodrigues
{"title":"Influence of Ancestry and Molecular Markers on the Severity of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.","authors":"Luiz J R Oliveira, Maria L R Guimarães, Luiz De Marco, Nathália S Guimarães, Luciana Bastos-Rodrigues","doi":"10.1055/s-0046-1825528","DOIUrl":"10.1055/s-0046-1825528","url":null,"abstract":"<p><p>Genetic susceptibility to obstructive sleep apnea (OSA) may vary by ancestry. We have conducted a systematic review and random-effects meta-analysis of observational studies (International Prospective Register of Systematic Reviews [PROSPERO] CRD42024548801) to test whether ancestry modifies the associations involving specific genetic polymorphisms and OSA risk and severity. We searched databases until June 2024 for studies examining variants (interleukin-6 (IL6) rs1800795, tumor necrosis factor (TNF) rs1800629, solute carrier family 6 member 4 (serotonin-transporter gene) (SLC6A4) serotonin-transporter-linked polymorphic region (5-HTTLPR)/serotonin transporter intron 2 (VNTR) (STin2), 5-hydroxytryptamine (serotonin) receptor 2A gene (HTR2A) rs9526240, leptin receptor (LEPR) rs3790435) and pooled odds ratios (ORs) with 95% confidence interval (CIs); ancestry-specific effects were explored. Five studies included 3,606 participants. The overall association showed an OR = 1.25 (95%CI: 0.85-1.86; I <sup>2</sup> = 76%). By ancestry, Brazilian participants of European descent demonstrated higher risk (OR = 2.80; 95%CI: 1.11-7.08), while those of West-African ancestry showed protection (OR = 0.26; 95%CI: 0.09-0.74). Genetic associations with OSA differ significantly by ancestry, supporting ancestry-informed study designs and larger multiethnic cohorts for personalized OSA management.</p>","PeriodicalId":21848,"journal":{"name":"Sleep Science","volume":"19 2","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}