Sexually transmitted diseases最新文献_第8页

Effect of Same-Day, Direct HIV PrEP Dispensation on PrEP Initiation and Early Retention in a Sexual Health Clinic. 当日直接发放HIV PrEP对性健康诊所PrEP启动和早期保留的影响

IF 1.9 4区医学

Sexually transmitted diseases Pub Date : 2026-09-15 DOI: 10.1097/OLQ.0000000000002406

Nikhil Harikrishnan, Kaitlin A Zinsli, Christine M Khosropour, Julia C Dombrowski, Chase A Cannon

{"title":"Effect of Same-Day, Direct HIV PrEP Dispensation on PrEP Initiation and Early Retention in a Sexual Health Clinic.","authors":"Nikhil Harikrishnan, Kaitlin A Zinsli, Christine M Khosropour, Julia C Dombrowski, Chase A Cannon","doi":"10.1097/OLQ.0000000000002406","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002406","url":null,"abstract":"Background: Daily oral pre-exposure prophylaxis (PrEP) is highly effective at preventing HIV but remains underutilized in the United States. Various factors, including limited access, contribute to drop-offs across the PrEP care continuum. In 2021, Seattle-King County's sexual health clinic (SHC) introduced same-day, in-clinic dispensing of an initial bottle of oral emtricitabine/tenofovir disoproxil fumarate at no out-of-pocket cost as an alternative to electronic prescribing to external community pharmacies (e-prescribing).Methods: We conducted a retrospective observational study using routinely collected SHC data to identify patients who completed ≥1 initial PrEP visit from November 1, 2020, to May 30, 2023. Successful early PrEP retention was defined as an initial visit, a PrEP prescription within 14 days, and a follow-up visit within 6 months. We compared the proportion achieving early retention across three phases: Phase 1 (e-prescribing only), Phase 2 (transition period), and Phase 3 (same-day dispensing with some e-prescribing), using two-sample tests of proportions.Results: Of 917 eligible patients, 649 (70.8%) were successfully retained on PrEP; 25.0% were uninsured. Early retention was similar across phases: 71.9% (210/292) in Phase 1, 70.0% (194/277) in Phase 2, and 70.4% (245/348) in Phase 3. Compared with Phase 1, retention did not differ significantly in Phase 2 (P=0.62) or Phase 3 (P=0.67), nor by dispensing modality within Phases 2 and 3.Conclusions: In this urban SHC, early PrEP retention remained stable at approximately 70%. Same-day, in-clinic dispensing was not associated with improved early retention but may reduce barriers and delays, representing a feasible low-barrier delivery model in resourced SHCs.","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unknown Duration, Uncertain Epidemiology: The Conundrum of High-Titer Unknown Duration or Late Syphilis. 未知持续时间，不确定流行病学：高滴度未知持续时间或晚期梅毒的难题。

IF 1.9 4区医学

Sexually transmitted diseases Pub Date : 2026-09-15 DOI: 10.1097/OLQ.0000000000002414

Brittany Liebhard, Abigail Norris Turner, Khalil G Ghanem, William C Miller

引用次数: 0

Interventions to Improve Care for Bacterial Sexually Transmitted Infections in Emergency Departments: A Narrative Review. 改善急诊科细菌性传播感染护理的干预措施：综述

IF 1.9 4区医学

Sexually transmitted diseases Pub Date : 2026-09-15 DOI: 10.1097/OLQ.0000000000002415

Kylie S Andonian, Harshvardhan Giri, Georgia R Goodman, Clara Pavesi-Krieger, Arrianna S Lister, Annette M Dekker, Elizabeth A Samuels, Paul C Adamson

{"title":"Interventions to Improve Care for Bacterial Sexually Transmitted Infections in Emergency Departments: A Narrative Review.","authors":"Kylie S Andonian, Harshvardhan Giri, Georgia R Goodman, Clara Pavesi-Krieger, Arrianna S Lister, Annette M Dekker, Elizabeth A Samuels, Paul C Adamson","doi":"10.1097/OLQ.0000000000002415","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002415","url":null,"abstract":"Bacterial sexually transmitted infections (STIs) remain a major public health challenge in the United States, and emergency departments are important sites for diagnosis and treatment among patients with limited access to routine sexual health care. This narrative review summarizes United States studies of emergency department interventions to improve testing, diagnosis, treatment, and follow-up for chlamydia, gonorrhea, and syphilis. We searched PubMed for English-language studies published from 1990 through 2025 that evaluated bacterial sexually transmitted infection interventions in emergency department settings. Twenty-two studies met inclusion criteria. Universal screening produced large increases in testing and case detection, electronic record prompts improved screening uptake, point-of-care testing improved same-day diagnosis and treatment while reducing unnecessary antibiotic use, and patient-directed tools produced modest gains. Bundled interventions addressing multiple steps in the care pathway appeared to have the largest overall impact, though there was heterogeneity in the interventions included making direct comparisons difficult. Future studies should further evaluate implementation feasibility, sustainability, equity, and cost-effectiveness of STI interventions across diverse emergency department settings.","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae among high-risk pregnant women in Thailand: implications for antenatal screening and perinatal outcomes. 泰国高危孕妇中沙眼衣原体和淋病奈瑟菌的流行：对产前筛查和围产期结局的影响

IF 1.9 4区医学

Sexually transmitted diseases Pub Date : 2026-09-15 DOI: 10.1097/OLQ.0000000000002407

Kidakarn Jiratkitiwong, Saifon Chawanpaiboon, Chenchit Pichailuck, Rossaphorn Kittiyaowamarn, Sakita Moungmaithong, Natnaree Girdthep, Aun Praoparotai

{"title":"Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae among high-risk pregnant women in Thailand: implications for antenatal screening and perinatal outcomes.","authors":"Kidakarn Jiratkitiwong, Saifon Chawanpaiboon, Chenchit Pichailuck, Rossaphorn Kittiyaowamarn, Sakita Moungmaithong, Natnaree Girdthep, Aun Praoparotai","doi":"10.1097/OLQ.0000000000002407","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002407","url":null,"abstract":"Background: Chlamydia trachomatis and Neisseria gonorrhoeae are common sexually transmitted infections linked to adverse pregnancy outcomes; however, routine antenatal screening is not performed. Pregnant women with syphilis, hepatitis B virus, or HIV are high risk, yet prevalence in this group is unclear.Objective: To determine the prevalence of C. trachomatis and N. gonorrhoeae among high-risk pregnant women and evaluate associated maternal and neonatal outcomes.Methods: This cross-sectional study was conducted at Siriraj Hospital, Bangkok, Thailand, from 2022 through 2025. Endocervical swabs underwent nucleic acid amplification testing for C. trachomatis and N. gonorrhoeae, and vaginal smears were examined for bacterial vaginosis. Maternal and neonatal outcomes were analyzed using logistic regression.Results: Among 119 women aged of 15-42 (24.8 ± 6.3) years (syphilis alone, 62.1%; hepatitis B virus, 22.7%; HIV, 7.6%; co-infection, 7.6%), prevalence was 18.5% for C. trachomatis, 3.4% for N. gonorrhoeae, and 13.4% for bacterial vaginosis. No independent maternal risk factors were identified. C. trachomatis was significantly associated with intrapartum fever (odds ratio 3.78; P = 0.045) and neonatal intensive care unit admission (odds ratio 7.50; P = 0.043).Conclusions: C. trachomatis was highly prevalent and significantly associated with adverse outcomes, supporting targeted screening in high-risk pregnancies.","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148971073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the Clinical Utility of Multiplex Sexually Transmitted Infection Assays: A Step Towards Etiological Diagnosis and Antimicrobial Stewardship. 扩大多重性传播感染检测的临床应用：迈向病原学诊断和抗菌药物管理的一步。

IF 1.9 4区医学

Sexually transmitted diseases Pub Date : 2026-09-01 Epub Date: 2026-05-12 DOI: 10.1097/OLQ.0000000000002342

Deepak Juyal, Shekhar Pal, Neha Dhawan, Benu Dhawan

引用次数: 0

Genital Herpes Diagnoses With Connecting Pharmacological Prescriptions Among Enrollees 18 Years and Older in a Large Employer-Based Healthcare Claims Data, United States, 2019-2023. 2019-2023年美国大型雇主医疗索赔数据中18岁及以上参保者的生殖器疱疹诊断与相关药理学处方

IF 1.9 4区医学

Sexually transmitted diseases Pub Date : 2026-09-01 Epub Date: 2026-05-07 DOI: 10.1097/OLQ.0000000000002346

Brian Emerson, Sancta B St Cyr, Guoyu Tao

{"title":"Genital Herpes Diagnoses With Connecting Pharmacological Prescriptions Among Enrollees 18 Years and Older in a Large Employer-Based Healthcare Claims Data, United States, 2019-2023.","authors":"Brian Emerson, Sancta B St Cyr, Guoyu Tao","doi":"10.1097/OLQ.0000000000002346","DOIUrl":"10.1097/OLQ.0000000000002346","url":null,"abstract":"Objectives: Genital herpes (GH) is caused by herpes simplex type 1 and type 2. GH affects 500 million people worldwide and is often managed with pharmaceutical therapies, counseling, and education. We examined diagnosed GH among individuals with employer-sponsored insurance in the United States from 2019 to 2023. Our analysis aims to describe: (1) demographics of employer-sponsored insurance enrollees diagnosed with GH between 2019 and 2023, and (2) prescription patterns for the treatment of GH and assess whether these prescriptions are aligned with the Centers for Disease Control and Prevention (CDC) Sexually Transmitted Infections Treatment Guidelines, 2015 and 2021.Methods: We analyzed 2019 to 2023 MarketScan database containing commercially insured healthcare claims to characterize the demographics, treatment patterns of prescribers, and alignment to national guidelines. Episodes of care were identified by GH International Classification of Diseases, Tenth Revision codes and national drug codes for drug therapy claims within 90 days of diagnosis date. Alignment with 2015/2021 CDC treatment guidelines was determined using antiviral name, dose, days' supply, and quantity dispensed.Results: A total of 178,531 in 27,319,749 enrollees with 202,666 episodes of diagnosed GH were identified in the 5-year span. Most of the diagnoses were in the South, and enrollees were aged 18 to 44 years. Among diagnosed GH episodes with available prescription data, 63.6% to 65.1% of the prescriptions were aligned with treatment guidelines. Valacyclovir was prescribed most often (76.3%-81.4%), with 64.5% to 68.5% of those aligned with the 2015/2021 CDC treatment guidelines.Conclusions: Claims data suggest GH morbidity is highest in 18-34-year-olds, valacyclovir was the most common drug prescribed, and most prescriptions aligned with CDC recommendations.","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"612-618"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective Alternative Treatment Regimens for People With Infectious Syphilis: A Systematic Review and Network Meta-Analysis. 传染性梅毒患者的有效替代治疗方案：系统综述和网络荟萃分析。

IF 1.9 4区医学

Sexually transmitted diseases Pub Date : 2026-09-01 Epub Date: 2026-05-07 DOI: 10.1097/OLQ.0000000000002341

Anna Cvetkovic, Laura Erdman, Rochelle Johnstone, Jessica J Bartoszko, Suzanne Turner, Dominik Mertz

{"title":"Effective Alternative Treatment Regimens for People With Infectious Syphilis: A Systematic Review and Network Meta-Analysis.","authors":"Anna Cvetkovic, Laura Erdman, Rochelle Johnstone, Jessica J Bartoszko, Suzanne Turner, Dominik Mertz","doi":"10.1097/OLQ.0000000000002341","DOIUrl":"10.1097/OLQ.0000000000002341","url":null,"abstract":"Background: Given increasing rates of syphilis and shortages of the first-line agent benzathine penicillin, alternative treatment options are needed. This systematic review examined the existing evidence for alternative treatment regimens for infectious syphilis.Methods: We searched MEDLINE and EMBASE from January 15, 2021 to January 15, 2025, including eligible studies from two previously published systematic reviews. A systematic review with network meta-analysis (NMA) of randomized controlled trials (RCTs) and a meta-analysis of observational studies was conducted when appropriate. RCTs, cohort studies, case-control studies, and cross-sectional studies published in English that included adult and adolescent participants with infectious syphilis comparing two or more treatment regimens for syphilis were eligible. Risk of bias was assessed using the Cochrane RoB2 tool and Newcastle-Ottawa Scale, and a GRADE assessment was performed.Results: Fourteen RCTs and 20 observational studies were identified. All studies defined cure based on serologic plus/minus clinical response. Thirteen RCTs were eligible for the NMA, representing 1623 participants and 10 treatments. Benzathine penicillin, followed by ceftriaxone, and then doxycycline was reported to be superior to benzathine penicillin alone. However, considering the low quality of the evidence and practicalities of this regimen, this should be interpreted with caution. All other comparisons did not show statistically significant differences in cure rates. However, the pooled point estimates were in favor of doxycycline compared with the standard of care in the NMA (OR of 6.88, lower CrI 0.14). The level of evidence was low for RCTs and very low for observational studies.Conclusions: Despite low-quality evidence, doxycycline is the best-supported alternative to benzathine penicillin for syphilis treatment.","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"626-636"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation, Feasibility, and Acceptability of Reflex Molecular Antibiotic Resistance Testing for Treatment Diversification of Neisseria gonorrhoeae in a Sexual Health Clinic. 反射性分子抗生素耐药检测在性健康诊所治疗淋病奈瑟菌多样化中的实施、可行性和可接受性。

IF 1.9 4区医学

Sexually transmitted diseases Pub Date : 2026-09-01 Epub Date: 2026-05-07 DOI: 10.1097/OLQ.0000000000002340

Stephanie E McLaughlin, Katherine Holzhauer, Matthew R Golden, Olusegun O Soge, Lindley A Barbee

{"title":"Implementation, Feasibility, and Acceptability of Reflex Molecular Antibiotic Resistance Testing for Treatment Diversification of Neisseria gonorrhoeae in a Sexual Health Clinic.","authors":"Stephanie E McLaughlin, Katherine Holzhauer, Matthew R Golden, Olusegun O Soge, Lindley A Barbee","doi":"10.1097/OLQ.0000000000002340","DOIUrl":"10.1097/OLQ.0000000000002340","url":null,"abstract":"Background: Resistance-guided treatment has the potential to expand treatment options for Neisseria gonorrhoeae (NG) and may be useful as an antimicrobial stewardship strategy.Methods: The study enrolled asymptomatic patients undergoing NG testing at a sexual health clinic in Seattle, WA, March 2022-July 2024. Specimens that tested positive for NG using the Aptima Combo 2 assay were then tested using the SpeeDx PlexPrime® GC+gyrA (RUO) assay, which detects gyrA S91 (wild type [WT]) and gyrA S91F (mutant). We offered patients with gyrA S91 NG treatment with ciprofloxacin and treated participants with the gyrA S91F mutation or indeterminate gyrA results with ceftriaxone. NG positive participants were asked to return for a test of cure 14 days (±2) following treatment.Results: Sixty-two (5%) of 1215 participants tested NG positive; 22 (36%) had gyrA WT (S91), 28 (45%) had the gyrA S91F mutation, and 12 (19%) were indeterminate. Sixteen (73%) of the 22 participants with gyrA WT (S91) received ciprofloxacin. All participants treated with ciprofloxacin had negative NG tests of cure. Mean time to reflexed gyrA test result was 2.8 days (SD = 0.9 days). Among 17 survey persons treated with ciprofloxacin, 78% indicated that waiting an extra day for test results was worth it to avoid an injection while the remaining respondents were neutral.Conclusion: Reflex molecular testing for quinolone susceptibility allowed 26% of patients with NG to be successfully treated with ciprofloxacin. Participants treated with ciprofloxacin believed that reflex testing was beneficial.","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"605-611"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expedited Partner Therapy Provision for Chlamydia at US College Health Centers, 2023. 2023年，美国大学健康中心为衣原体提供快速伴侣治疗。

IF 1.9 4区医学

Sexually transmitted diseases Pub Date : 2026-09-01 Epub Date: 2026-04-02 DOI: 10.1097/OLQ.0000000000002325

Alyssa M Lederer, Stacey B Griner, Samantha E Mundt, Sara B Oswalt

{"title":"Expedited Partner Therapy Provision for Chlamydia at US College Health Centers, 2023.","authors":"Alyssa M Lederer, Stacey B Griner, Samantha E Mundt, Sara B Oswalt","doi":"10.1097/OLQ.0000000000002325","DOIUrl":"10.1097/OLQ.0000000000002325","url":null,"abstract":"Background: Expedited partner therapy (EPT) is a critical strategy to treat and reduce the transmission of chlamydia. US college health centers (CHCs) serve students nationwide and are uniquely positioned to reach a major segment of young adults, a group at disproportionate risk for sexually transmitted infections. This study examined the provision of EPT at CHCs and if institutional characteristics are associated with EPT provision.Methods: We analyzed data from the 2023 American College Health Association Sexual Health Services Survey (N = 115 CHCs). We conducted descriptive analyses for EPT provision and investigated associations with institutional characteristics, including locale, enrollment number, geographic region, public/private, Carnegie classification, Minority Serving Institution status, and CHC chlamydia positivity rate. We also used conventional qualitative content analysis to identify themes from an open-ended question about challenges CHCs face with EPT provision.Results: Almost 70% of CHCs offered EPT in some capacity. EPT provision differed significantly by institutional type (private versus public) and chlamydia positivity rate. No other institutional characteristics were significant. Six qualitative themes were found regarding challenges to provision. Providing EPT for nonstudents and healthcare providers being required or preferring to interact with partners directly were most commonly endorsed.Conclusions: Although most responding CHCs offered EPT to some degree, EPT remains underutilized, with few differences based on institutional characteristics. Addressing the identified challenges could improve EPT uptake, benefiting young adults' sexual health outcomes.","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"637-642"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Vaginal Microbiota in Pig-Tailed Macaques and Colonization with Neisseria gonorrhoeae. 猪尾猕猴阴道微生物群与淋病奈瑟菌的定植。

IF 1.9 4区医学

Sexually transmitted diseases Pub Date : 2026-09-01 Epub Date: 2026-03-31 DOI: 10.1097/OLQ.0000000000002314

Sujatha Srinivasan, Matthew M Munch, Olusegun O Soge, Yvonne T Cosgrove Sweeney, Sean Proll, Noah G Hoffman, David N Fredricks, Dorothy L Patton

{"title":"The Vaginal Microbiota in Pig-Tailed Macaques and Colonization with Neisseria gonorrhoeae.","authors":"Sujatha Srinivasan, Matthew M Munch, Olusegun O Soge, Yvonne T Cosgrove Sweeney, Sean Proll, Noah G Hoffman, David N Fredricks, Dorothy L Patton","doi":"10.1097/OLQ.0000000000002314","DOIUrl":"10.1097/OLQ.0000000000002314","url":null,"abstract":"Background: Pig-tailed macaques ( Macaca nemestrina ) may serve as a useful animal model of Neisseria gonorrhoeae (GC) infection, but no such models are currently available. To aid in the development of a macaque model of gonorrhea, we characterized the macaque vaginal microbiota and evaluated the effect of streptomycin treatment on GC colonization.Methods: Six female pig-tailed macaques were observed for 96 days, with cervicovaginal samples collected every 2 to 3 days. Samples were taken for 1 month before streptomycin treatment to characterize the vaginal microbiota using 16S rRNA gene sequencing over a menstrual cycle. The animals were treated intramuscularly with streptomycin for 22 days. They were challenged twice, with a 2-week interval, with endocervical GC and once after cessation of antibiotics. GC colonization was assessed via 16S rRNA gene sequencing, nucleic acid amplification tests, and culture.Results: The macaque vaginal microbiota was diverse and heterogeneous, with several anaerobes typically noted in the human vagina, including Fannyhessea vaginae , Amygdalobacter indicium , and Parvimonas micra . Streptomycin treatment resulted in changes in the diversity and composition of the microbiota, but prolonged GC colonization was not achieved in any animal. Changes in the microbiota were noted during menses.Conclusions: Alternative approaches are needed to facilitate the establishment of GC infection in pig-tailed macaques.","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"596-604"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0