Sexually transmitted diseases最新文献

{"title":"The Association Between Depression and Sexually Transmitted Infections During Pregnancy Among Underserved Pregnant Patients.","authors":"Nikita Ghosh, Han-Yang Chen, Irene Stafford","doi":"10.1097/OLQ.0000000000002186","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002186","url":null,"abstract":"<p><strong>Background: </strong>Depression involves intertwining socio-economic, behavioral, and health factors, creating a complex landscape for providers to address during pregnancy. Its association with social determinants of health and immunologic inflammation complicates its relationship with sexually transmitted infections (STIs). This study aimed to assess the association between depression and STIs among underserved pregnant patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted of pregnant patients from February 2019 to May 2023 within a public health system. Medical records for patients undergoing pregnancy screening were reviewed. Demographic data, depression data, STI data, and obstetric outcomes were recorded. Patients with depression were identified through self-reports to providers and Edinburgh Postnatal Depression Scale (EPDS) scores of ten or higher. A multivariable logistic regression model with robust error variance was utilized for analysis.</p><p><strong>Results: </strong>Among the 20,111 singleton pregnant patients studied, 1,054 (5.24%) reported experiencing depression during pregnancy, and 3.2% were diagnosed with any STI. After multivariable adjustment, compared to patients without depression, those with depression had an increased odds of having any STI (aOR 1.54 95% CI 1.20-1.99). Patients with depression had higher odds (aOR 1.81, 95% CI 1.16-2.84) of having syphilis compared to those without.</p><p><strong>Conclusions: </strong>Our findings exemplify an elevated association of STI, particularly syphilis, among underserved pregnant patients with depression.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term Impact of Changes in Public Health Information Systems on Sexually Transmitted Infection Surveillance Data Quality.","authors":"John S Angles, Elizabeth A Torrone, Tracy Pondo, Melissa A Pagaoa, Erika G Martin","doi":"10.1097/OLQ.0000000000002180","DOIUrl":"10.1097/OLQ.0000000000002180","url":null,"abstract":"<p><strong>Abstract: </strong>Jurisdictional health departments use public health information systems (PHIS) to maintain and transmit their surveillance data for national surveillance. We investigated if changes to a PHIS had an impact on sexually transmitted infection case-based surveillance data and document short-term issues that resulted in decreased data quality.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consider Trichomonas vaginalis in the differential diagnosis for genital ulcers.","authors":"Samuel Ibáñez, Jorge Navarrete","doi":"10.1097/OLQ.0000000000002182","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002182","url":null,"abstract":"<p><strong>Abstract: </strong>A 21-year-old immunocompromised female (advanced HIV, CD4 count: 9 cells/μL) presented with painful genital ulcers. A multiplex PCR panel detected Trichomonas vaginalis in both vaginal and ulcer swabs, while tests for Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium were negative. The patient was treated with metronidazole, resulting in significant clinical improvement. This case underscores the importance of considering T. vaginalis in the differential diagnosis of genital ulcers, particularly in immunocompromised individuals, and highlights the utility of molecular testing in atypical presentations.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives of Doxycycline Postexposure Prophylaxis among Pediatric Providers.","authors":"John M Flores, Trenton Lam, Jose L Paredes Sosa, Sebastian Otero, Aniruddha Hazra","doi":"10.1097/OLQ.0000000000002181","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002181","url":null,"abstract":"<p><strong>Abstract: </strong>Doxycycline postexposure prophylaxis (doxyPEP) is a chemoprophylaxis that may reduce certain sexually transmitted infections in high-priority groups 18 years and older. This study utilized a cross-sectional survey among 167 pediatric providers in the USA, with ~40% reporting lacking comfort and familiarity with doxyPEP, and various barriers to use.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syphilis Screening and Treatment at a Large Urban Jail.","authors":"Zureyat Sola-Odeseye, Jana Kholy, Sophia Culp, Barry-Lewis Harris, Ank E Nijhawan","doi":"10.1097/OLQ.0000000000002178","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002178","url":null,"abstract":"<p><strong>Background: </strong>Syphilis cases have increased by 80% in the United States in the past five years, demanding new approaches to screening and treatment, particularly among key populations. This study aimed to assess the impact of syphilis screening in a large urban county jail, determining rates of new syphilis infections, identifying demographic groups most affected by syphilis, and assessing treatment completion rates.</p><p><strong>Methods: </strong>Electronic health records of individuals with positive rapid plasma reagin (RPR) results during incarceration in the Dallas County Jail between April 2023 and March 2024 were reviewed. New cases were defined by either a first positive RPR, a four-fold titer increase, or a positive result following a previously negative RPR. Data on demographics, HIV coinfection, and recent chlamydia or gonorrhea infection were collected. Treatment medication and completion (no, partial, or full) were recorded. Comparisons of proportions were performed using chi-square analysis and data analyses were conducted using SAS OnDemand for Academics (SAS 9.4 M8).</p><p><strong>Results: </strong>Out of 15,589 individuals tested for syphilis, 12,607 (80.9%) were male and 2,982 (19.1%) were female. Among these, there were 1816 (11.6%) cases of positive test results; 815 individuals (5.2%) were newly diagnosed with syphilis: 568 males (4.5%) and 247 females (8.3%). Among those newly diagnosed, the majority, (71.2%), were treated with doxycycline. Overall, 482 individuals (59.1%) completed treatment, 191 (23.4%) received partial treatment, and 142 (17.4%) were released prior to receiving any treatment.</p><p><strong>Conclusions: </strong>Syphilis screening in a large urban jail identified high rates of new infections and provided an opportunity for counseling, testing for other STIs and treatment. Females and African Americans had disproportionately high infection rates. Treatment completion was similar between doxycycline and intramuscular penicillin. Future studies should focus on increasing syphilis screening, treatment and prevention in jails and other high-incidence settings.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of monetary compensation on responsiveness to ecological momentary assessments: A pilot study of sexual minority men in one midwestern city.","authors":"Brittany Liebhard, Morgan Spahnie, JaNelle M Ricks, William C Miller, Abigail Norris Turner","doi":"10.1097/OLQ.0000000000002179","DOIUrl":"10.1097/OLQ.0000000000002179","url":null,"abstract":"<p><strong>Background: </strong>We conducted a pilot ecological momentary assessment (EMA) study in preparation for a prospective cohort study of the drivers of syphilis transmission among sexual minority men. Our objectives were: 1) evaluate the effect of monetary compensation (any versus no compensation and amount paid per survey) on participant responsiveness, and 2) evaluate acceptability and feasibility of the EMA smartphone app to capture sexual and other behaviors in the last 24 hours.</p><p><strong>Methods: </strong>We enrolled 40 men in the 4-week pilot and assigned them to one of two groups (higher versus lower compensation). Participants completed daily surveys by responding to push notifications or self-initiating in the app. Participants received $5, $3, or $0 per survey depending on compensation group, survey type, and study week. We evaluated response rates overall, by compensation group, and over time, and described responses to a follow-up survey assessing acceptability and feasibility.</p><p><strong>Results: </strong>The overall median completion rate was 60.7%. The higher compensation group had higher completion rates for self-initiated surveys, which only they were paid for (median 75% vs. 43%, p < 0.001). For study-initiated surveys, which both groups were paid for (but the higher compensation group slightly more), the lower compensation group had somewhat higher completion rates (median 94% vs. 75%, p = 0.13). Response rates among both groups decreased over time.</p><p><strong>Conclusions: </strong>Responsiveness to daily EMA surveys was higher when participants received compensation. The amount received per survey appeared to be less important. EMA may be a resource-effective supplement to traditional data collection methodologies in sexual health research.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How To Use Rapid Dual Treponemal and Lipoidal Tests in Clinical Practice.","authors":"Lao-Tzu Allan-Blitz, Jeffrey D Klausner","doi":"10.1097/OLQ.0000000000002176","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002176","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging Gaps in Congenital Syphilis Care: A Quality Improvement Initiative for Comprehensive Management at a Large Public Hospital in Los Angeles, California, USA.","authors":"Diana D Villarreal, Jessica Perez, Mikhaela D Cielo, James Homans, Susan M Butler-Wu, Cecilia Patino-Sutton, Jeffrey D Klausner","doi":"10.1097/OLQ.0000000000002175","DOIUrl":"10.1097/OLQ.0000000000002175","url":null,"abstract":"<p><strong>Background: </strong>Congenital syphilis rates are rising in the USA and globally, necessitating standardized care for infants born to birthing parents with syphilis. The Centers for Disease Control recommends comprehensive evaluation, treatment, and follow-up for these infants to ensure optimal outcomes.Local ProblemAt Los Angeles General Medical Center, a retrospective review of 97 infants (2022-2023) revealed gaps in adherence to national guidelines, particularly in risk stratification, treatment decisions, and outpatient follow-up planning. Among 15 syphilis-exposed infants (2 unknown-risk, 4 high-risk, 9 low-risk), some received abbreviated or potentially inadequate treatment without a full evaluation, while others had treatment deferred without ensuring appropriate outpatient follow-up. These inconsistencies in postnatal management highlighted the need for a structured, multidisciplinary approach to improve adherence to best practices.</p><p><strong>Methods: </strong>A quality improvement team developed the \"Congenital Syphilis Pathway\" to standardize care and improve adherence to the Centers for Disease Control guidelines. The intervention included recommended Pediatric Infectious Disease consultation to improve risk stratification and treatment decisions, targeted provider education to enhance guideline adherence, and systematic scheduling of outpatient follow-up to ensure appropriate postnatal monitoring. The pathway aimed to achieve 90% compliance with recommended evaluation, treatment, and follow-up practices between January and June 2024.InterventionsThe pathway recommended a Pediatric Infectious Disease consultation for all eligible infants during their hospital stay and included educational sessions on congenital syphilis management for key stakeholders at three points during implementation to reinforce protocol adherence.</p><p><strong>Results: </strong>The population included all infants born to birthing parents with syphilis at Los Angeles General Medical Center. Following pathway implementation in January 2024, Pediatric Infectious Disease consultation rates reached 100% by June 2024. Appropriate management improved from 85% at baseline to 100% in Q2 2024, while follow-up scheduling increased from 54% at baseline to 91% in Q2 2024.ConclusionA structured care pathway integrating standardized consultations, provider education, and systematic follow-up planning significantly improved adherence to congenital syphilis management guidelines. While direct pediatric infectious disease consultation may not be feasible in all settings, the core elements of this intervention - standardized evaluation pathways, provider education, and public health collaboration - can be adapted to improve care in diverse healthcare environments.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum Inhibitory Concentrations of Extended-Spectrum Cephalosporins: A Systematic Review and Meta-Analysis of Neisseria gonorrhoeae Treatment Failures.","authors":"Victoria F Miari, Jonna Messina Mosoff, R Matthew Chico","doi":"10.1097/OLQ.0000000000002116","DOIUrl":"10.1097/OLQ.0000000000002116","url":null,"abstract":"<p><strong>Background: </strong>Neisseria gonorrhoeae is one of the recognized global antimicrobial resistance priorities. Extended-spectrum cephalosporins, the last remaining reliable antimicrobial, increasingly fail to clear N. gonorrhoeae infections, especially pharyngeal gonorrhea, leading to limited future treatment options.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis of gonococcal treatment failures and compared the minimum inhibitory concentrations (MICs) of isolates from pharyngeal and extra-pharyngeal anatomical sites (PROSPERO registration: CRD42020189101).</p><p><strong>Results: </strong>The overall pooled mean MIC for cefixime was 0.17 mg/L (95% confidence interval [CI], 0.07-0.41 mg/L), and that for ceftriaxone was 0.10 mg/L (95% CI, 0.05-0.22 mg/L). For cefixime, the mean MIC estimates for pharyngeal and extrapharyngeal treatment failures were 0.05 mg/L (95% CI, 0.02-0.14 mg/L) and 0.29 mg/L (95% CI, 0.11-0.81 mg/L), and those for ceftriaxone were 0.09 mg/L (95% CI, 0.03-0.22 mg/L) and 0.14 mg/L (95% CI, 0.03-0.73 mg/L), respectively. The pooled mean MICs for pharyngeal isolates are below the phenotypic European Committee on Antimicrobial Susceptibility Testing resistance breakpoint for both antimicrobials (>0.125 mg/L).</p><p><strong>Conclusions: </strong>Our findings underscore the need to review the current resistance breakpoints used for pharyngeal infection, to establish international standards for MIC testing, and to advance efforts of the World Health Organization's global action plan to control the spread and impact of antimicrobial resistance in N. gonorrhoeae . Ongoing susceptibility testing of gonococcal isolates and surveillance of treatment failures are central to informing appropriate public health responses.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"279-284"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the Incidence of Antimicrobial-Resistant Neisseria gonorrhoeae in the United States Among Men and Women Aged 15 to 39 Years, 2008 to 2019.","authors":"Tracy Pondo, Karen E Nielsen, Matthew W Schmerer, Ian H Spicknall, Emily D Pollock, Kristen M Kreisel","doi":"10.1097/OLQ.0000000000002128","DOIUrl":"10.1097/OLQ.0000000000002128","url":null,"abstract":"<p><strong>Background: </strong>The Gonococcal Isolate Surveillance Project (GISP) was established to monitor antimicrobial resistance (AR) in Neisseria gonorrhoeae in the United States. Isolates collected in GISP undergo antimicrobial susceptibility testing allowing for estimates of resistance, based on exceeding minimum inhibitory concentrations (MICs), to be calculated.</p><p><strong>Methods: </strong>We estimated the annual number and proportion of gonococcal infections with antibiotic resistance or elevated MICs (AR/eMICs) against 6 antibiotics for men and women aged 15 to 39 years in the United States using male urethral specimens collected in GISP during 2008-2019. Although GISP only measured MICs for male gonococcal infections, this study estimated AR/eMICs in women using data from men with female sex partners. GISP data were weighted against national gonorrhea case report data based on 4 variables (age group, year of report, US Census region, and race/Hispanic ethnicity) to estimate annual, national proportions of gonococcal infections with AR/eMICs. These weighted proportions were then multiplied by national estimates of incident gonococcal infections to calculate the number of incident gonococcal infections with AR/eMICs nationally.</p><p><strong>Results: </strong>Women had a higher estimated number of cases with AR/eMICs compared with men (440,900 vs. 387,200 in 2019), although the estimated percentage of gonococcal infections with AR/eMICs was lower in women (50.7% vs. 54.4% in 2019). Elevated MICs to ceftriaxone remained below 1% throughout the study period.</p><p><strong>Conclusions: </strong>Our analysis indicates that there are more women with AR/eMICs gonorrhea than men. Although the proportion of cases that are resistant to any one antimicrobial is increasing, eMICs to ceftriaxone remains low.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"273-278"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}