Sexually transmitted diseases最新文献

{"title":"Promoting Pre-Exposure Prophylaxis to Gay, Bisexual, and Other Men Who Have Sex With Men in the US Deep South: A Qualitative Exploration of Promotion Perceptions and Preferences.","authors":"Ronnie M Gravett, Joseph D Tucker, Lynn T Matthews, Barbara Van Der Pol, Greer McCollum, Jason J Ong, Jeanne Marrazzo, Latesha Elopre","doi":"10.1097/OLQ.0000000000002146","DOIUrl":"10.1097/OLQ.0000000000002146","url":null,"abstract":"<p><strong>Background: </strong>Effective HIV pre-exposure prophylaxis (PrEP) promotion is critical to mitigate PrEP disparities, yet there are gaps in understanding how gay, bisexual, and other men who have sex with men respond to and prefer PrEP promotion. The Deep South of the United States, a region with high HIV rates and low PrEP uptake, has unique contextual factors that stifle effective PrEP provision and uptake, which could be overcome with effective PrEP promotional messaging.</p><p><strong>Methods: </strong>We conducted an exploratory qualitative study grounded in Andersen's Behavioral Model for Healthcare Utilization. We recruited HIV-negative gay, bisexual, and other men who have sex with men, aged 18 to 39 years, from social media, dating apps, and community outreach to complete semistructured interviews to explore perceptions of and preferences for PrEP promotion. Interview transcripts were inductively and deductively coded for thematic analysis.</p><p><strong>Results: </strong>Forty participants completed interviews (median age, 28 years; 68% Black; 48% current PrEP users). Three themes emerged: (1) the role of different identities with subthemes emphasizing diversity to reduce stigma and improve relatability; (2) interpersonal relationships, that is, friends, partners, and family, affect PrEP promotion; and (3) reduced emphasis on HIV risk in promotions.</p><p><strong>Conclusions: </strong>To see behavior change for seeking PrEP knowledge and PrEP uptake, PrEP promotions must evolve to improve diversity to foster relatability and reduce stigma, harness social networks to efficiently transmit messaging, and tactfully discuss risk behaviors without compounding stigma.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"488-494"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet Need for Human Papillomavirus Vaccination Among Men Who Have Sex With Men Living With and Without Human Immunodeficiency Virus, San Francisco, 2023.","authors":"Paloma L Ramirez, Antonio A M Moscatelli, Bow Suprasert, Moranda Tate, Erin C Wilson, Willi McFarland","doi":"10.1097/OLQ.0000000000002177","DOIUrl":"10.1097/OLQ.0000000000002177","url":null,"abstract":"<p><strong>Background: </strong>Men who have sex with men (MSM) are at high risk for human papillomavirus (HPV) infection and resulting anal cancer. Guidelines for HPV vaccination for MSM older than 26 years recommend shared clinical decision making. Our objectives were to measure history of HPV vaccination and identify disparities in vaccination in a community-recruited sample of MSM in 2023 in San Francisco.</p><p><strong>Methods: </strong>Data originated from National HIV Behavioral Surveillance. Time-location sampling recruited participants through outreach at venues where MSM congregate during randomly selected times. Face-to-face interviews collected demographics, risk and preventive behaviors, access to health care, and HIV status. Multivariable logistic regression analysis assessed factors associated with HPV vaccination.</p><p><strong>Results: </strong>Among 497 MSM respondents, 44.9% reported HPV vaccination. Human papillomavirus vaccination was more likely for MSM aged 18 to 29 years versus older (adjusted odds ratio [AOR], 4.84; 95% confidence interval [CI], 2.37-9.87), having a college degree versus less education (AOR, 1.74; 95% CI, 1.18-2.57), seeing a health care provider in the last 12 months (AOR, 3.60; 95% CI, 1.62-8.01), and diagnosed with an sexually transmitted disease (AOR, 1.97; 95% CI, 1.30-2.99). Among MSM not living with HIV, using preexposure prophylaxis in the last 12 months had an increased odds of HPV vaccination (AOR, 4.53; 95% CI, 2.69-7.63).</p><p><strong>Conclusions: </strong>Less than half of MSM in San Francisco reported HPV vaccination. We recommend health care providers verify vaccination history and more routinely offer HPV vaccine to unvaccinated MSM at any age. Men who have sex with men living with HIV should consider HPV vaccination given confirmed safety, strong immune response, and some data on efficacy, even while awaiting further clinical studies.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"482-487"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence of genetically related Neisseria gonorrhoeae strains causing Disseminated Gonococcal Infection (DGI) cases in southwestern Michigan during 2019 to 2023.","authors":"Sandeep J Joseph, Laura A S Quilter, Brian H Raphael, John C Cartee, Katherine Hebrank, Kim M Gernert, Matthew W Schmerer, Alison D Ridpath, Elizabeth Burgess, Leslie Dybas, Heather M Blankenship, Kelly Jones, James B Kent, Stephen Dietrich, Kyle T Bernstein, Ellen N Kersh","doi":"10.1097/OLQ.0000000000002211","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002211","url":null,"abstract":"<p><strong>Background: </strong>Disseminated gonococcal infection (DGI) is a rare complication of Neisseria gonorrhoeae (Ng) infection, historically affecting 0.5-3% of individuals. In 2019, a DGI genomic cluster associated with the ST-7822 strain was identified in southwest Michigan. This study retrospectively assessed the persistence of this strain.</p><p><strong>Methods: </strong>Ninety Ng isolates from disseminated sites of infection from Michigan (2019-2023) were sequenced; antimicrobial susceptibility testing (AST) was performed. Phylogenetic analysis was performed to assess genetic relatedness. Data from 370 ST-7822 urogenital and extragenital gonococcal infection (UGI) isolates were included in the phylogenetic analysis. The porB1A allele, a marker associated with DGI, and antimicrobial resistance markers were also analyzed.</p><p><strong>Results: </strong>Phylogenetic analysis identified seven DGI clades, with clade 7 (n = 26) containing the 2019 cluster (n = 11). Clade 7 isolates (mean SNP difference: 32) formed two sub-clusters from a single ancestor between 2019-2023 and clustered with local UGI isolates. All clade 7 DGI isolates and 82.7% of ST-7822 UGI isolates carried the porB1A allele. Among DGI isolates with AST data (n = 21), all were susceptible to ceftriaxone; no mosaic penA alleles were identified.</p><p><strong>Conclusions: </strong>The persistence of clade 7 associated with the 2019 Michigan DGI cluster suggests ongoing regional transmission of the ST-7822 strain type that has a high proportion with porB1A allele, which has been associated with invasive infection. The genetic similarity between DGI and UGI isolates suggests that DGI strains are not genetically distinct but derived from circulating strains causing mucosal infections. Continued genomic surveillance is essential to understand virulence factors contributing to disseminated infections.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study design matters: Using a rigorous analytic design to examine the association between rectal douching and incident rectal gonorrhea and chlamydia.","authors":"Emma Chrznowski, Lindley A Barbee, Lisa E Manhart, Christine M Khosropour","doi":"10.1097/OLQ.0000000000002226","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002226","url":null,"abstract":"<p><strong>Background: </strong>Prior studies have identified an association between rectal douching and prevalent rectal Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT), but few studies have examined associations with incident infections.</p><p><strong>Methods: </strong>We used data from ExGen, a 48-week cohort study conducted in Seattle, Washington, 2016-2018. Each week, participants completed a survey and self-collected rectal specimens, which were tested for CT/GC at the end of the study. Our primary analysis was a case-crossover analysis. We identified individuals with incident rectal GC or CT and included 1 case-week (the first week of the incident rectal infection) and 2 randomly-selected control-weeks (weeks where the participant tested negative for rectal GC/CT). We used multivariate conditional logistic regression to estimate the association between douching and rectal GC/CT. In an exploratory analysis, we created a \"synthetic\" cross-sectional study of the longitudinal data to mirror the design of other studies.</p><p><strong>Results: </strong>There were 140 individuals in ExGen. Our case-crossover sample comprised 17 GC case-weeks and 34 matched GC control-weeks, and 22 CT case-weeks and 44 matched CT control-weeks. Participants reported douching during 64.7% of GC case-weeks and 70.6% control-weeks (aOR = 0.47; 95% CI = 0.07-3.10). Douching was reported at a similar frequency among CT case-weeks (45.5%) versus control weeks (47.7%) (aOR = 1.16; 95% CI = 0.26-5.07). In our exploratory synthetic cross-sectional study, rectal douching was significantly associated with rectal GC but not CT.</p><p><strong>Conclusion: </strong>Douching was not associated with rectal GC/CT in this methodologically-rigorous analysis. A better understanding of the mechanisms of douching products and impact of long-term use may be warranted.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining Clinical Outcome Measures in a Therapeutic Trial for Late Latent Syphilis.","authors":"Khalil G Ghanem, Matthew Hamill","doi":"10.1097/OLQ.0000000000002225","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002225","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxycycline post-exposure prophylaxis is effective and highly acceptable in an urban public sexually transmitted disease clinic: Philadelphia, 2019-2023.","authors":"Felicia M T Lewis, Anna B Cope, Kelly Clark, Robbie Madera, Lenore Asbel, Daniel R Newman, Nicole L Davis","doi":"10.1097/OLQ.0000000000002224","DOIUrl":"10.1097/OLQ.0000000000002224","url":null,"abstract":"<p><strong>Background: </strong>We sought to determine real-world effectiveness of doxycycline post-exposure prophylaxis (doxy PEP) in reducing sexually transmitted infections (STI) among men who have sex with men attending an HIV pre-exposure prophylaxis (HIV PrEP) clinic in Philadelphia.</p><p><strong>Methods: </strong>Data from eligible HIV PrEP patients who did and did not receive doxy PEP from September 1, 2019-December 31, 2023 were analyzed. We used a cohort study design and Cox models to estimate associations between doxy PEP receipt and incident gonorrhea (GC), chlamydia (CT), and/or syphilis. We also used a crossover design and Poisson models to estimate incidence rate ratios (IRR) for any STI and each STI separately among individuals in the year before and after doxy PEP initiation.</p><p><strong>Results: </strong>Among the 508 eligible men, most were young men of color and 416 (82%) opted to receive doxy PEP. Receiving doxy PEP was associated with a reduction in any incident STI (hazard ratio [HR] 0.61, 95% confidence interval 0.40-0.93) and any incident CT (HR 0.40, 95% CI 0.21-0.78). Participants experienced a 62% relative reduction in STI rates while taking doxy PEP (IRR 0.38 (95% CI 0.29-0.50), including a reduction in CT (IRR 0.28, 95% CI 0.20-0.39) and GC (IRR 0.49, 95% CI 0.37-0.65).</p><p><strong>Conclusions: </strong>We observed a significant reduction in any STI and CT in both analytic arms, suggesting that doxy PEP is effective in real-world settings. Enhancing doxy PEP implementation would likely reduce community STI transmission.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Think Syphilis: Evaluating Testing and Treatment Services for Pregnant Women Attending Prenatal Care in Maricopa County, Arizona.","authors":"Layla Gabir, Jonathan Bell, Aisha Praag, Margarita Rios, Stephanie Devlin, Renuka Khurana, Melanie Taylor","doi":"10.1097/OLQ.0000000000002223","DOIUrl":"10.1097/OLQ.0000000000002223","url":null,"abstract":"<p><strong>Background: </strong>Arizona has led the nation for rates of congenital syphilis. The purpose of this study was to evaluate compliance with mandated three timepoint syphilis testing for pregnant women attending prenatal care, describe access to benzathine penicillin G (BPG) treatment, and assess receipt and use of Think Syphilis campaign materials in Maricopa County, AZ.</p><p><strong>Methods: </strong>A facility-level cross-sectional survey was performed among prenatal care providers and clinical staff in 2022-2023. Responses from individual participants were applied to their facilities, including respective satellite offices within their corporations.</p><p><strong>Results: </strong>Responses from 42 distinct healthcare facilities were included, representing 104 outpatient obstetrician-gynecologist (Ob/Gyn) clinical settings. These facilities represented 232 delivering providers accounting for 33,196 live births, approximately 68% of all reported live births in Maricopa County for 2021. 97.6% (41/42) reported use of syphilis screening policies for pregnant women. Reported compliance with performing prenatal syphilis testing was 78.6% (33/42) for syphilis at first prenatal care visit and 73.8% (31/42) during the third trimester. Among providers with first-hand knowledge of hospital-based screening practices, 76.5% (13/17) reported syphilis screening at delivery. Only 11.9% (5/42) reported on-site clinic-based administration of BPG; 71.4% (30/42) reported referring syphilis patients to an external site for treatment with BPG. Barriers to on-site treatment included cost and perception of syphilis as rare. The Maricopa County STI Clinic was the most reported treatment referral site by 90.5% (19/21) of respondents. Regarding the Think Syphilis campaign, 21.4% (9/42) confirmed receipt of campaign materials, and of these 77.8% (7/9) shared materials with office staff.</p><p><strong>Conclusions: </strong>Reported performance of mandated syphilis testing for pregnant women attending prenatal care in Maricopa County is substantial. However, clinic-based barriers to on-site BPG administration exist. This survey afforded an opportunity to educate providers and clinic staff on maternal syphilis testing and treatment using the Think Syphilis campaign.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visit types and linkage to HIV prevention among individuals seeking mpox vaccination in an urban specialized sexual health clinic.","authors":"Palak Shah, Christine Germain, Kevin L Ard, Robert A Parker, Ingrid V Bassett, Jana Jarolimova","doi":"10.1097/OLQ.0000000000002222","DOIUrl":"10.1097/OLQ.0000000000002222","url":null,"abstract":"<p><strong>Abstract: </strong>Individuals attending mpox vaccine-only visits at an STI clinic were more likely to be new patients with high socioeconomic status and identify as White than those vaccinated during non-mpox related visits. A small number received HIV PrEP or testing following vaccination; this may represent a missed opportunity for HIV prevention.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review of Urine-Based Human Papillomavirus Screening: Performance, Challenges, and Opportunities to Expand Access in the United States.","authors":"Lily Yang, Chibuzor Babalola, Jeffrey D Klausner","doi":"10.1097/OLQ.0000000000002221","DOIUrl":"10.1097/OLQ.0000000000002221","url":null,"abstract":"<p><strong>Summary: </strong>A narrative review of urine-based HPV screening tests found that urine testing is a decently accurate and acceptable method for HPV screening in the United States.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participants and Recipients in Social Network Distribution of HIV Self-Testing Kits Among Men Who Have Sex With Men in China.","authors":"Rongyan Li, Yi Zhou, Ye Zhang, Dan Wu, Xinyuan Zhang, Fengshi Jing, Jie Fan, Xi He, Joseph D Tucker, Weiming Tang","doi":"10.1097/OLQ.0000000000002216","DOIUrl":"10.1097/OLQ.0000000000002216","url":null,"abstract":"<p><strong>Background: </strong>Secondary distribution of HIV self-testing (HIVST) kits offers a promising strategy to expand testing among marginalized MSM. We compared characteristics of kit distributors (index participants) and recipients, and identified predictors of HIV testing and kit distribution.</p><p><strong>Methods: </strong>We analyzed data from a randomized controlled trial among MSM in Zhuhai, China (2019-2020). Regression models identified predictors of HIV testing and kit distribution.</p><p><strong>Results: </strong>A total of 303 index participants and 264 recipients were included. Index participants were more likely than recipients to have previously tested for HIV (84.5% vs. 62.5%), report recent (past 3 months) male-male anal intercourse (83.2% vs. 60.6%), and have multiple male partners (52.8% vs. 40.6%). Among index participants, HIV testing was associated with older age (per year increase, aOR = 1.14; 95% CI: 1.05-1.24), higher education (college vs. high school or below, aOR = 4.71; 95% CI: 1.94-11.6), and condomless sex (aOR = 3.90; 95% CI: 1.37-12.9). Among recipients, higher income ($451-750, aOR = 2.58; 95% CI: 1.11-6.00; $751-1200, aOR = 2.35; 95% CI: 1.04-5.36, vs. <$450) was linked to prior testing. Approximately 45% of index participants distributed HIVST kits to recipients. Distribution was positively associated with older age (IRR = 1.03; 95% CI: 1.00-1.07), graduate education (vs. high school or below, IRR = 2.18; 95% CI: 1.05-4.54), and number of sexual partners (IRR = 1.09; 95% CI: 1.02-1.17).</p><p><strong>Conclusions: </strong>Tailored HIVST interventions using social network-based distribution can enhance HIV testing coverage among MSM. This strategy may improve testing uptake in low- and middle-income countries but requires further investigation.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}