Sexually transmitted diseases最新文献

{"title":"\"It's been a very liberating experience\": doxycycline post-exposure prophylaxis (doxy-PEP) for STI prevention and experiences with sexual pleasure by men who have sex with men (MSM).","authors":"Rodney Perkins, Rob J Fredericksen, Katerina A Christopoulos, Kristin Beima-Sofie, Stephanie E Cohen, Julia C Dombrowski, Aurnell Dright, Saraniesha Gardner, Pamela Kohler, Anne F Luetkemeyer, Jillian Pintye, Connie Celum","doi":"10.1097/OLQ.0000000000002220","DOIUrl":"10.1097/OLQ.0000000000002220","url":null,"abstract":"<p><strong>Background: </strong>Pleasure is a key component in sexual decision-making. Doxycycline postexposure prophylaxis (doxy-PEP) is a novel intervention for STI prevention for MSM that may influence sexual experiences. Using the Sexual Health Model, we assessed whether doxy-PEP use influences intimacy and sexual pleasure among MSM.</p><p><strong>Methods: </strong>From November 2021 through December 2022, we conducted individual interviews with MSM living with and without HIV enrolled in a clinical trial of doxy-PEP (NCT03980223). Participants were purposively sampled to capture a range of doxy-PEP use frequency. Interviews explored how doxy-PEP influenced sexual health and decision-making, pleasure, intimacy, and relationships. Interview transcripts and debrief reports were thematically analyzed.</p><p><strong>Results: </strong>We interviewed 43 DoxyPEP trial participants, of whom the median age was 38 years (IQR 34-46), 63% identified as white, 18% as Black, and 38% as Hispanic. Nineteen (44%) were living with HIV. Participants reported that doxy-PEP use improved their quality of life by providing peace of mind and resulted in more enjoyable sex experiences and increased intimacy. Participants felt doxy-PEP provided freedom to choose about condom use and selection of partners, and supported communication with sexual partners about STI prevention. These positive experiences with doxy-PEP were similar in men living with and without HIV.</p><p><strong>Conclusion: </strong>MSM reported that doxy-PEP use improved their sexual pleasure and intimacy with partners. Recognizing these positive aspects of doxy-PEP is essential for tailoring messaging and counseling about doxy-PEP and could motivate doxy-PEP use.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incentivized community-based syphilis screening: uptake, yield, and cost.","authors":"Meghan Curry O'Connell, Tinka Duran, Sarah Shewbrooks, Cheng Wang, Tyler Broghammer, Emily Good Weasel, Melanie M Taylor, Tipi Means","doi":"10.1097/OLQ.0000000000002219","DOIUrl":"10.1097/OLQ.0000000000002219","url":null,"abstract":"<p><strong>Background: </strong>High and increasing syphilis rates among American Indian/Alaska Native (AI/AN) communities and particularly among AI/AN women and infants call for immediate interventions to reach and offer syphilis testing to sexually active populations paired with timely treatment.</p><p><strong>Methods: </strong>The Great Plains Tribal Epidemiology Center within the Great Plains Tribal Leaders Health Board (GPTLHB) partnered with a local non-tribal healthcare facility to offer free community-based syphilis testing in Rapid City, South Dakota, starting in December 2022 through June 2024. Participants received cash incentive cards for undergoing testing for syphilis, human immunodeficiency virus (HIV) and hepatitis C (HCV).</p><p><strong>Results: </strong>Fifteen community testing events were conducted. Laboratory-based syphilis testing was performed on 1434 unique individuals, average age 38.8 years. Seventy-six (76) people were diagnosed with syphilis that had previously not been identified (prevalence 5.3% (76/1434); 51 (67.1%) were female. Treatment was provided to 80.3% of people with syphilis (61/76) within an average of 36 days. In total, the 15 events cost $158,019 ($75,000 administrative staff time + $5,100 laboratory staff time + $24,009 lab tests + $ 53,910 incentives) or $88 per test performed ($158,019/1797). The cost to identify a previously unidentified case was $$2,079 ($158,019/76 newly identified infected persons).</p><p><strong>Conclusions: </strong>This community-based screening event revealed high prevalence of undiagnosed syphilis. Incentives supported community members to access screening services. Collaborations between clinical, tribal, and public health entities to bring diagnosis and treatment services to patients using a community-based approach have clear benefits but need ongoing supportive resources to be maintained.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Systems to Support Status-Neutral HIV Care in the Emergency Department.","authors":"Leah Benrubi, Leo K Westgard, Taisuke Sato, Kyle Zollo-Venecek, Brien Barnewolt, Laura Kogelman, Alysse G Wurcel","doi":"10.1097/OLQ.0000000000002217","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002217","url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of the implementation of an electronic medical record (EMR)-based sexually transmitted infection (STI) order set on Human Immunodeficiency Virus (HIV) testing rates and the acceptability of Status-Neutral HIV Care in the emergency department (ED).</p><p><strong>Methods: </strong>We developed and implemented an STI order set integrated into the EMR to streamline HIV testing and Status-Neutral Care. The cohort included ED encounters from April 2022 to December 2023 in which patients were tested for chlamydia or gonorrhea. We measured the adoption and acceptability of the order set among clinicians through surveys and analyzed the impact on rates of HIV testing and referral to Infectious Diseases using regression models.</p><p><strong>Results: </strong>Out of 3,922 ED encounters, 1,161 (29.6%) included an HIV test. The introduction of the STI order set in February 2023 correlated with increased testing rates for all STIs, including a significant rise in HIV testing (p < 0.001). Survey data indicated that the majority of attending ED physicians were aware of and had used the order set Despite low overall usage (6.8%), the order set was perceived to improve efficiency. Male gender and Black/African American race were significantly associated with increased HIV testing.</p><p><strong>Conclusions: </strong>The implementation of an EMR-based STI order set was associated with improved HIV testing rates in the ED and was well-received by clinicians, though its low usage suggests a need for further promotion and training. The study highlights the potential of systems-based interventions to enhance Status-Neutral Care and reduce missed opportunities for HIV diagnosis.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk-Based Versus Universal Screening Practices for Hepatitis C Virus at a Sexually Transmitted Infection Clinic.","authors":"Harrison Martin, Natalie Fenn, Amanda Maguire-Wilkerson, Alexi Almonte, Amy Nunn, Philip A Chan","doi":"10.1097/OLQ.0000000000002107","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002107","url":null,"abstract":"<p><strong>Abstract: </strong>We evaluated hepatitis C virus (HCV) screening practices at a sexually transmitted infection clinic in Rhode Island. Risk-based HCV screening generated fewer tests than universal screening but may have missed infections in men who have sex with men. Injection drug use was most strongly associated with positive HCV antibody test results.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":"52 7","pages":"436-440"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Syphilis Case Rates Among Women of Reproductive Age-United States, 2013 to 2022.","authors":"Priyanka Anand, Laura A S Quilter, Emily R Learner, Lindley A Barbee, David A Jackson","doi":"10.1097/OLQ.0000000000002127","DOIUrl":"10.1097/OLQ.0000000000002127","url":null,"abstract":"<p><strong>Abstract: </strong>We analyzed syphilis case notifications in reproductive-aged women during 2013-2022. Late/unknown duration syphilis grew faster after 2020 (45.8% vs. 17.9% annual growth pre-2020). Increased screening, inaccurate staging, delayed diagnosis, or increased incidence following clinical and partner services gaps during 2020 may contribute to rises in late/unknown duration cases.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"392-394"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Preoperative Syphilis Screening on the Detection of Syphilis at a Tertiary Care Center: A Retrospective Cohort Study.","authors":"Shogo Hanai, Yohei Doi, Hitoshi Honda","doi":"10.1097/OLQ.0000000000002144","DOIUrl":"10.1097/OLQ.0000000000002144","url":null,"abstract":"<p><strong>Background: </strong>The incidence of syphilis has been rising globally, but effective screening strategies are lacking. Preoperative syphilis screening is commonly performed at Japanese hospitals for infection prevention purposes. However, its effectiveness in improving subsequent management is unclear.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted to assess the effectiveness of universal preoperative syphilis screening testing implemented at a Japanese tertiary care hospital from April 2017 to March 2023. The annual prevalence of positive preoperative treponemal tests was tracked, and subsequent clinical management for patients with a positive test result was investigated. Attributes of patients with a positive result who were more likely to receive further evaluation were also elucidated.</p><p><strong>Results: </strong>In total, 82,439 patients underwent surgery during the study period. Preoperative treponemal testing was performed in 94.8% (78,170 of 82,439) of the patients. A positive test result was recorded in 544 (0.70%), with an annual positivity rate ranging from 0.61% to 0.83%, whereas the proportion of presumed active syphilis ranged from 0.02% to 0.08%. A total of 85 patients with a positive syphilis screening test result, a nontreponemal test with a positive titer, and without history of syphilis were identified. Of those, only 45 patients (52.9%) received further evaluation.</p><p><strong>Conclusions: </strong>The positivity of preoperative treponemal testing was low despite the rising incidence of syphilis in Japan, and the prevalence of presumed active syphilis identified during the preoperative period was even smaller. Routine treponemal testing in the preoperative setting had limited utility in effectively identifying patients with active syphilis.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"402-406"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Doxycycline for STI Post-Exposure Prophylaxis in People Assigned Female at Birth in the United States.","authors":"Aniruddha Hazra, Chase Cannon, Jason Bena, Oliver Bacon, Jason Lee, Hyman Scott, Stephanie E Cohen","doi":"10.1097/OLQ.0000000000002215","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002215","url":null,"abstract":"<p><strong>Abstract: </strong>This multi-center case series examines real-world use of doxycycline post-exposure prophylaxis (doxy-PEP) among persons assigned female at birth (AFAB) at four U.S. sexual health clinics. Most cases were transgender men highly vulnerable to STI acquisition. Findings highlight early implementation patterns, safety considerations, and underscore the urgent need for doxy-PEP efficacy data in AFAB populations.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144544925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk perception, intended sexual behaviours and potential associated risks for sexually transmissible infections acquisition among Australian travellers: A cross-sectional study.","authors":"Wondimeneh Shiferaw, Deborah Mills, Kenneth Koh, Judith A Dean, Stanley Khoo, David Rutherford, Michael Tooth, Jenny Visser, Colleen Lau, Luis Furuya-Kanamori","doi":"10.1097/OLQ.0000000000002214","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002214","url":null,"abstract":"<p><strong>Background: </strong>Changes in travellers' sexual behaviours, driven by opportunities during travel, contribute to the acquisition of sexually transmissible infections (STIs). However, research on travellers' risk perception, intentions regarding new sexual partners, and engagement in behaviours that may place them at potential risk of STI acquisition remains limited. This study aims to assess the risk perception and intended sexual behaviours associated with STI acquisition among Australian travellers.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted from July 2023 to August 2024 among Australian residents (aged ≥18 years) planning to travel overseas within six months. The survey was distributed in five Travel Medicine Alliance (TMA) clinics and at the Gladstone Road Medical Centre (GRMC) clinic. Socio-demographics, travel plans, sexual intentions, STI risk perception, and patterns of intended sexual behaviours were collected. Subgroup analysis was performed on participants travelling without a partner to estimate their intention to engage in new sexual encounters.</p><p><strong>Results: </strong>Of the 205 respondents, 172 (83.9%) attended the TMA clinics and 33 (16.1%) the GRMC clinic. The median age was 42.5 years (interquartile range 28-56 years), 51% (n = 105) were female. Nearly a quarter (22.7%, n = 29) intended to engage in sexual activity with new partners while travelling. Among these, 72.4% perceived their risk of contracting STIs as low, despite reporting intended sexual behaviours linked to STI acquisition risk such as no intention to use condoms (28.0%), intention to engage in sexual relationships with sex workers (24.1%), and plans to undergo post-travel STI testing (34.6%). Nearly half (41.4%), identified a need for better STI-related pre-travel information.</p><p><strong>Conclusions: </strong>A substantial proportion of surveyed travellers intended to engage in sexual activity with a new sexual partner while travelling, with many underestimating their STI risk and demonstrating intended sexual behaviours that increase their likelihood of STI acquisition. These findings underscore the need for comprehensive sexual health counselling during pre-travel consultations, with a focus on STI risk awareness, preventive strategies, and post-travel STI screening.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144544924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Papillomavirus-Related Cancer Prevention Among People Experiencing Housing Instability: A Systematic Review.","authors":"Annalynn M Galvin, Idara N Akpan, Ashvita Garg, Paula M Cuccaro, Erika L Thompson, Diane M Santa Maria","doi":"10.1097/OLQ.0000000000002159","DOIUrl":"10.1097/OLQ.0000000000002159","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV)-related cancer is highly preventable through HPV vaccination and cancer screening, but people experiencing homelessness or housing instability (PEH) may not engage in these behaviors due to conflicting priorities. This systematic review synthesized and estimated HPV-related cancer prevention behaviors among PEH.</p><p><strong>Methods: </strong>Using PRISMA guidelines, articles published before 2023 were located via PubMed, Ovid/Medline, CINAHL, and Embase. Full-text, peer-reviewed studies that measured HPV-related cancer prevention in any sample of people experiencing homelessness were included. Two researchers abstracted data independently, with high interrater reliability (>90%). Results were narratively summarized with consensus, and proportions were compared using preventive behavior.</p><p><strong>Results: </strong>After reviewing 405 articles, we included 18 articles from the United States from 1998 to 2022. There were 6674 people (e.g., women, youth, men who have sex with men) experiencing homelessness assessed for HPV-related cancer prevention behaviors. Pooled prevalence was approximately 59.8% (±6%) for cervical cancer screening in the last 3 years and 42.9% (±4.7%) for HPV vaccination initiation. Other factors related to housing instability and HPV-related cancer prevention included gender, sexual trauma, and procedural pain, with mixed results for housing status and HPV knowledge.</p><p><strong>Conclusions: </strong>Findings demonstrate the varied adherence to HPV-related cancer prevention, with rates consistently below recommended World Health Organization guidelines. Future studies should adjust for specific risk factors in modeling that may be associated with or modified by the effects of homelessness and evaluate upstream prevention (e.g., vaccination) and other types of HPV-related cancer (e.g., anal cancer).</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"381-391"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Doxycycline and Other Antibiotics as Bacterial Sexually Transmitted Infection Prophylaxis in a US Sample of Primarily Gay and Bisexual Men.","authors":"Hafsa Salim, Hussain Ramzan","doi":"10.1097/OLQ.0000000000002145","DOIUrl":"10.1097/OLQ.0000000000002145","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"e30"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}