Sexually transmitted diseases最新文献

{"title":"LIMIT Trial: Lidocaine With Intramuscular Injection of Benzathine Penicillin G for Treponema pallidum Treatment.","authors":"Joseph Cherabie, Germysha Weatherall, Patrick Kojima, Caleb Bender, Donald Hong, Lauren Karpman, Andrew Brand, Aditi Ramakrishnan, Rachel Presti, Hilary Reno","doi":"10.1097/OLQ.0000000000002400","DOIUrl":"10.1097/OLQ.0000000000002400","url":null,"abstract":"<p><strong>Background: </strong>Studies have shown that intramuscular benzathine penicillin G (BPG) or bicillin injections cause severe pain in many patients, which may reduce adherence. Local anesthetics mixed with BPG may reduce injection pain without affecting drug effectiveness. The objective of this study was to examine if there is any benefit of adding 0.5 mL 1% lidocaine to prepackaged BPG, with respect to pain, compared with standard of care, in the treatment of Treponema pallidum infections, both 10 min and 24 h after injection.</p><p><strong>Methods: </strong>This study is a double-blinded randomized placebo-controlled trial of the effect on pain of the addition of 0.5 mL 1% lidocaine solution to a prepackaged BPG injection, compared with the addition of 0.5 mL normal saline solution, in adults being treated for syphilis ( T. pallidum ) infections, within the Infectious Diseases Clinic at Washington University in St. Louis, MO.</p><p><strong>Results: </strong>Preliminary analysis included 15 participants. A Wilcoxon signed-rank test indicated a statistically significant reduction in pain 10 min after lidocaine injection compared with the saline injection ( z = -2.65, P = 0.008). The mean pain score following administration, after 10 min, of the lidocaine solution was 3, compared with 6.73 for the saline solution. Overall, 87% of participants reported at least a 2-point reduction in pain scores after 10 min with lidocaine relative to saline. However, no significant difference in pain scores was observed between the 2 solutions at the 24-h follow-up.</p><p><strong>Conclusion: </strong>This trial demonstrates that lidocaine can help reduce the pain associated with intramuscular injections of BPG.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"814-817"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male Partner Treatment for Bacterial Vaginosis: A Systematic Review and Meta-Analysis of Randomized Trials.","authors":"Zainab Aliyu Attahir, Surasith Chaithongwongwatthana, Alhassan Ibrahim, Bukola Lawal","doi":"10.1097/OLQ.0000000000002368","DOIUrl":"10.1097/OLQ.0000000000002368","url":null,"abstract":"<p><p>Bacterial vaginosis (BV) is the commonest vaginal infection globally, resulting from a shift from Lactobacillus-dominant microbiota to an overgrowth of anaerobes. Although standard antibiotic therapy achieves short-term cure, recurrence remains high. Recent evidence suggests that male genital microbiota is a potential reservoir for BV-associated bacteria (BVAB), prompting investigation into the role of concurrent male partner treatment (MPT). We conducted a systematic review and meta-analysis of randomized controlled trials to assess the effect of MPT on BV recurrence and cure. The study followed Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines and was registered in PROSPERO (CRD420251132582). Embase, Scopus, Google Scholar, and PubMed databases were searched independently, from 1980 to September 2025. Pooled risk ratios (RR) and 95% confidence intervals (CI) were calculated using random-effects models. Risk of bias and certainty of evidence were assessed using RoB 2 and GRADE. Eight randomized controlled trials were included. MPT showed no significant effect on BV recurrence (RR 0.92; 95% CI 0.69-1.23; I2 = 64%) or cure rate (RR 1.01; 95% CI 0.94-1.07; I2 = 46%). Adverse events were mild and similar across groups (RD 0.04; 95% CI 0.02-0.11). However, lower recurrence was observed among fully adherent couples, particularly in a recent trial using combined oral and topical therapy. While the overall pooled effect of routine partner treatment is neutral, a benefit may exist among fully adherent couples receiving intensive regimens. Targeted approaches that optimize regimen intensity and adherence warrant further investigation.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":"53 11","pages":"846-852"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory Intersectional Analysis of Lifetime Syphilis Prevalence Among People Who Inject Drugs in Montreal, Canada.","authors":"Brendan L Harney, Julie Bruneau, Valérie Martel-Laferrière, Sarah Larney","doi":"10.1097/OLQ.0000000000002329","DOIUrl":"10.1097/OLQ.0000000000002329","url":null,"abstract":"<p><strong>Background: </strong>Syphilis cases have increased among women and heterosexual men in Canada and people who inject drugs (PWID) are an emerging group at risk of infection. We aimed to examine syphilis prevalence among PWID stratified by men and women, and differences according to intersecting population groups, socio-structural factors and sexual and substance use behaviors.</p><p><strong>Methods: </strong>Data were from Hepatitis C Cohort, a community-based cohort study of PWID in Montreal. We tested for syphilis (lifetime and active) via treponemal testing reflexed to nontreponemal testing if positive. Odds ratios were estimated using bivariable exact logistic regression to examine differences in the prevalence of lifetime syphilis infection.</p><p><strong>Results: </strong>From November 2022 to March 2024, 386 people (16.1% women) had a syphilis test. Thirty-three people (8.6%, 95% CI 6.1,11.8) had evidence of lifetime syphilis infection, of whom 2 had active syphilis. Lifetime prevalence was significantly higher among men identifying as gay or bisexual, men with HIV, and those who reported recent sex work, condom-less sex, 2 or more sex partners and amphetamine injecting. Among women, prevalence was higher among those who reported recent sex work, recent unstable housing and amphetamine injecting; however, there was no statistically significant difference.</p><p><strong>Conclusion: </strong>Active syphilis infection was uncommon among this cohort of PWID; however, lifetime syphilis infection was almost 9%. Among men in this cohort, evidence indicates that syphilis intersects with other key population group characteristics. More data are needed to better understand syphilis among women who inject drugs. Periodic syphilis testing among PWID may be justified alongside testing for other sexually transmissible and blood borne infections.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"853-858"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexually Transmitted Infections and Associated Factors Among Immigrants in Lima, Peru.","authors":"Nadiesda D Mamani, Danny G Perez, Tatiana M Galvez, Lourdes B Ramos, Jerome T Galea, Juan A Flores, Segundo R Leon","doi":"10.1097/OLQ.0000000000002401","DOIUrl":"10.1097/OLQ.0000000000002401","url":null,"abstract":"<p><strong>Background: </strong>International migration is increasing substantially in recent years, raising concerns about immigrant health in low- and middle-income countries. In Perú, the large influx of Venezuelan immigrants has increased demands on the health system, while data on sexually transmitted infections and HIV (STI/HIV) in this population remain limited. This study aimed to estimate the prevalence of laboratory-confirmed STI/HIV and identify factors associated with prevalent STI/HIV among Venezuelan immigrants in Lima, Peru.</p><p><strong>Methods: </strong>A cross-sectional analytic study was conducted among 325 Venezuelan immigrants in Metropolitan Lima and Callao, Peru, using peer-referral sampling supported by a Venezuelan community recruiter. Participants completed a structured epidemiological questionnaire and provided biological samples for laboratory-confirmed diagnoses of STI/HIV. The primary outcome was a binary composite measure of laboratory-confirmed STI/HIV, defined by the presence of at least 1 of 4 infections. Data were analyzed using descriptive statistics, bivariate analyses, and multivariable logistic regression in Stata 18. In the adjusted analysis, LGBTQ+ sexual identity (adjusted odds ratio [aOR] 3.45, 95% confidence interval [CI] 2.04-5.84) and previous self-reported STI history (aOR 3.68, 95% CI 2.15-6.30) remained independently associated with laboratory-confirmed STI/HIV. Variables with P < 0.200 in bivariate analysis were included in the multivariate model.</p><p><strong>Results: </strong>The prevalence of any laboratory-confirmed STI/HIV was 11.1%. In bivariate analyses, STI/HIV prevalence was higher among men, participants identifying as LGBTQ+, those reporting drug use, individuals with a previous self-reported STI/HIV diagnosis, and those reporting 2 or more sexual partners during the previous 3 months. In a multivariable logistic regression model, previous self-reported STI/HIV diagnosis and drug use remained independently associated with prevalent STI/HIV.</p><p><strong>Conclusions: </strong>STI/HIV positivity among Venezuelan immigrants in Lima was associated with previous STI/HIV diagnosis and sexual identity after multivariable adjustment. These findings support the need to strengthen equitable access to culturally appropriate STI/HIV prevention, testing, linkage to care, and health promotion services for Venezuelan immigrant communities in Perú.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"865-870"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Determinants of Sexually Transmitted Infections Among Thai Men Who Have Sex With Men Enrolled in National PrEP Program: A Real-World Cross-Sectional Study.","authors":"Chadaporn Inta, Sirinya Teeraananchai, Suthat Chottanapund, Sawaporn Hinsheranan, Ratchadaporn Ungcharoen, Win Min Han","doi":"10.1097/OLQ.0000000000002389","DOIUrl":"10.1097/OLQ.0000000000002389","url":null,"abstract":"<p><strong>Background: </strong>Sexually transmitted infections (STIs) remain a major public health concern among men who have sex with men (MSM). This study estimated STI prevalence and associated factors among MSM enrolled in Thailand's national PrEP registry under the Universal Health Coverage program.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of MSM aged 15-49 y who underwent STI testing between January 2020 and August 2024 at enrollment in the PrEP registry program. STIs included syphilis, gonorrhea, chlamydia, and chancroids. Multivariable logistic regression was used to identify factors associated with STI and syphilis.</p><p><strong>Results: </strong>Among 24,606 MSM, 1974 (8.0%) were diagnosed with any STI, predominantly syphilis (n = 1911; 7.7%). STI prevalence was highest among MSM aged 20-24 y (8.6%), followed by 35-49 y (8.7%). STI prevalence was higher among those with prior PrEP use (9.7%) than among nonusers (7.7%) and was markedly elevated among Hepatitis C virus-positive MSM (24.0%). In multivariable models, higher odds of STI diagnosis were observed among MSM aged 20-24 y (adjusted odds ratio [aOR] 1.21; 95% confidence interval [CI] 1.08-1.36) and 35-49 y (aOR 1.14; 95% CI 1.01-1.29), those with prior PrEP use (aOR 1.26; 95% CI 1.11-1.45), and those with hepatitis C virus infection (aOR 3.17; 95% CI 1.95-5.13).</p><p><strong>Conclusions: </strong>STIs, particularly syphilis, remain common among MSM enrolled in the Thai national PrEP program. These findings highlight the need to integrate STI and hepatitis screening into PrEP services and to strengthen targeted prevention strategies for MSM at increased risk.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"787-795"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Diagnostic Codes for Identifying Chlamydial Infections From TriNetX Electronic Health Record Data in the United States.","authors":"Lin Li, Kexin Zhu, Hosn Nabaa, Konstantin Kozmenko, Valerie Bosch Castells, Delphine Saragoussi, Sandra S Chaves","doi":"10.1097/OLQ.0000000000002378","DOIUrl":"10.1097/OLQ.0000000000002378","url":null,"abstract":"<p><strong>Background: </strong>The accuracy of diagnostic codes for chlamydial infections in electronic health records is understudied. TriNetX, a global federated database, provides real-time access to patient-level electronic health records, but its suitability for studying chlamydial infections is unknown. This study aimed to validate ICD-10-CM diagnostic codes for chlamydial infections in TriNetX USA data.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using the TriNetX USA Network from 2016 to 2024. Patients aged 14 to 44 years with chlamydia diagnosis codes (including Chlamydia trachomatis , Chlamydia psittaci , and Chlamydia pneumoniae ) or known nucleic acid amplification test results were included. All eligible patients were categorized into four mutually exclusive groups based on the presence of diagnosis code (yes or no) and nucleic acid amplification test results (gold standard, positive, or negative): true positive, false positive, false negative, and true negative. Positive predictive value (PPV), negative predictive value (NPV), sensitivity, and specificity, and their 95% confidence intervals (CIs) were calculated for chlamydia diagnosis, including stratified analyses by age, sex, race, ICD codes, and calendar year.</p><p><strong>Results: </strong>Among 4,501,240 eligible patients (75.9% female), chlamydial infection diagnosis codes showed: PPV: 84.3% (95% CI: 84.2%-84.5%); NPV: 95.5% (95% CI: 95.5%-95.5%); sensitivity: 42.8% (95% CI: 42.6%-42.9%); specificity: 99.3% (95% CI: 99.3%-99.4%). Stratified analyses revealed PPV: 80.9%-87.1%, NPV: 91.7%-97.3%, specificity: 99.1%-99.9%, and sensitivity: 10.4%-49.7%, with the lowest sensitivity observed in C. trachomatis code analysis.</p><p><strong>Conclusions: </strong>Most diagnostic codes can accurately identify chlamydial infections in the TriNetX USA Network. However, low sensitivity suggests that many cases could be missed without laboratory test results.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"e89-e96"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance Consequences of the Use of Doxycycline for Prevention of Bacterial Sexually Transmitted Infections: A Systematic Review.","authors":"Mary-Theresa Usuanlele, Conrad Kabali, Lawrence Mbuagbaw, Mark Loeb, Dominik Mertz","doi":"10.1097/OLQ.0000000000002309","DOIUrl":"10.1097/OLQ.0000000000002309","url":null,"abstract":"<p><strong>Background: </strong>Canada has experienced rising rates of bacterial sexually transmitted infections (STIs)-notably syphilis, chlamydia, and gonorrhea-over the past 2 decades, especially among gay, bisexual, and other men who have sex with men. Doxycycline pre- and postexposure prophylaxis has emerged as a potential prevention strategy. However, concerns about antimicrobial resistance have prompted further investigation.</p><p><strong>Methods: </strong>We conducted a systematic review of English-language studies (2013-2023) using PubMed, Embase, Cochrane, and MedRxiv. We included randomized controlled trials, cohort, case-control, ecological studies, and systematic reviews that reported on prolonged or recurrent doxycycline use for any indication across all populations. Data were summarized descriptively due to heterogeneity, and risk of bias and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) assessments were conducted to rate the level of evidence.</p><p><strong>Results: </strong>Sixteen studies across 17 publications met the inclusion criteria. Included studies comprised 2 systematic reviews, 8 randomized controlled trials, 3 cohort studies, 2 cross-sectional studies, and 1 modeling study. Seven studies assessed tetracycline/doxycycline resistance in STI pathogens and 12 focused on non-STI organisms. Findings were mixed, with some studies reporting increased resistance, others minimal or no change. Neisseria gonorrhoeae showed high baseline doxycycline resistance. Evidence on resistance in skin and gut flora was limited and inconsistent, and no clear pattern of co-resistance to other antimicrobials was found. Overall, the quality of evidence was low to very low.</p><p><strong>Conclusion: </strong>Evidence on antimicrobial resistance risks from doxycycline pre- and postexposure prophylaxis published up to 2023 was limited and uncertain. Findings are inconsistent and underpowered, and emerging evidence could change these conclusions.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"838-845"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147780952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Study Identifying Behavioral Science Communication Strategies to Improve Client Engagement and HIV Prevention by Disease Interventionists.","authors":"Carly Wolfer, Maria Sobrino, Elijah R Castle, Lila Starbuck, Chi-Chi N Udeagu, Sarit A Golub","doi":"10.1097/OLQ.0000000000002388","DOIUrl":"10.1097/OLQ.0000000000002388","url":null,"abstract":"<p><strong>Background: </strong>Disease intervention specialists (DIS), essential implementers of HIV prevention efforts, have increasingly relied on learned empathy, rather than evidence-based strategies for client engagement. Given the mismatch between DIS demands and training, as well as demonstrated reductions in both client engagement and front-line implementer well-being, research is needed to identify and evaluate the communication strategies and skills that DIS currently employ, those they overlook, and those they would need additional support to utilize effectively.</p><p><strong>Methods: </strong>With 18 semi-structured interviews, we identified the range of strategies currently used by DIS to engage clients in HIV prevention at a city health department. We also considered how strategies correspond to established behavioral science theory and research.</p><p><strong>Results: </strong>We identified 26 distinct strategies within 4 clusters: empathy, emotion regulation, persuasion, and partnership. The most commonly reported strategies were cognitive and compassionate empathy and logistical support/help, while the least utilized were change talk and seeking collaboration. Overall, we observed a disproportionate reliance on empathy and emotion-based strategies, but a relative underutilization of persuasion and partnership-based communication strategies with evidence-based impacts on client engagement and motivation for health behavior change.</p><p><strong>Conclusions: </strong>Staff underutilized client engagement approaches with strong empirical support (e.g., motivational interviewing), while overutilizing emotionally demanding strategies often linked to provider burnout. Although empathy-based communication is foundational to public health care, overreliance may compromise staff wellbeing and miss opportunities to optimize client behavior change. Systematically training DIS in evidence-based communication strategies represents a promising path to improve both client engagement and provider sustainability.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"871-876"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends in Anal HPV Infection Among Men Who Have Sex With Men Attending Sexual Health Clinics in Three United States Cities, 2018-2024.","authors":"Carla L DeSisto, Troy D Querec, Rachel L Winer, Preeti Pathela, Lenore Asbel, Robbie Madera, Jennifer Tang, John Lin, Lauri E Markowitz","doi":"10.1097/OLQ.0000000000002362","DOIUrl":"10.1097/OLQ.0000000000002362","url":null,"abstract":"<p><strong>Background: </strong>We assessed temporal trends in prevalent anal human papillomavirus (HPV) infection among men who have sex with men (MSM) without HIV who attended sexual health clinics in 3 US cities from 2018 to 2024.</p><p><strong>Methods: </strong>Residual anal specimens from MSM without HIV, aged 18 to 45 years, were tested for 28 HPV genotypes. Demographic information was obtained from clinic records. Trends in quadrivalent vaccine (4vHPV)-type prevalence and nonvaccine-type HPV prevalence were evaluated using Joinpoint regression, stratified by age group (18-26 and 27-45 years). Nonvaccine-type HPV prevalence was used as a measure of sexual exposure; these HPV types are not targeted by any available vaccine. Joinpoint regression fits a series of joined straight lines on a logarithmic scale to the trends in prevalence; trends were reported as annual percent change (APC).</p><p><strong>Results: </strong>Among persons aged 18 to 26 years, 4vHPV-type prevalence declined from 23.7% in 2018 to 2019 to 13.4% in 2023 to 2024 (APC = -13.4%), while nonvaccine-type HPV prevalence had a slight but nonsignificant decline. Among persons aged 27 to 45 years, 4vHPV-type prevalence declined from 37.2% in 2018 to 2019 to 28.2% in 2023 to 2024 (APC = -5.6%), while nonvaccine-type HPV prevalence remained stable.</p><p><strong>Conclusions: </strong>Among MSM aged 18 to 26 and 27 to 45 years, there was a decline in 4vHPV-type prevalent anal infections from 2018 to 2024. There was little to no decline in nonvaccine-type HPV prevalence during the same time period, suggestive of unchanging sexual exposure to HPV. These data demonstrate the impact of HPV vaccine on anal HPV infections in MSM.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"801-806"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13271034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of ParC -and GyrA- Mutations to Fluoroquinolone Treatment Failures in Mycoplasma genitalium : A Systematized Review.","authors":"Miguel Fernández-Huerta, Zaira Moure, Miriam Torrecillas, Berta Fidalgo, Ignacio Fernández, Eduardo Lagarejos, Jesús Trejo-Zahínos, Luis Piñeiro, Judit Serra-Pladevall, Naokatsu Ando, Gerald L Murray, Mateu Espasa-Soley","doi":"10.1097/OLQ.0000000000002370","DOIUrl":"10.1097/OLQ.0000000000002370","url":null,"abstract":"<p><p>While macrolide resistance in Mycoplasma genitalium is consistently associated with mutations in the 23S rRNA gene, enabling macrolide resistance-guided therapies, the correlation between genotype and fluoroquinolone resistance is less definitive. We aim to estimate the contribution of ParC and GyrA mutations in M. genitalium to fluoroquinolone resistance through a systematized review of the scientific literature. In May 2025, a Boolean search was performed in PubMed for manuscripts reporting fourth-generation fluoroquinolone-based treatment outcomes in M. genitalium infections harboring ParC mutations at S83 and/or D87. Concurrent GyrA mutations were also recorded. Sixteen studies were included in the review, accounting for 376 M. genitalium infections. Most treatment failures were associated with the S83I variant in ParC, where 43% of cases receiving fluoroquinolones failed. While the rate of treatment failure estimated among S83R variants was slightly higher (50%), this mutation was much less frequently identified. On the other hand, no treatment failures were identified associated with mutations S83N, D87G, and D87H. Concomitant GyrA mutation M95I or variations affecting D99 significantly increased the rate of treatment failure up to 3-fold. Sitafloxacin was significantly more effective than moxifloxacin in the presence of resistance mutations. This descriptive review provides compiled and preliminary data regarding the contribution of parC and gyrA mutations to fluoroquinolone resistance, to be considered in diagnostic assay designs. This may ultimately lead to therapeutic decision-making guidance.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"818-831"},"PeriodicalIF":1.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148303165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}