Sexually transmitted diseases最新文献

{"title":"Short-Term Impact of Changes in Public Health Information Systems on Sexually Transmitted Infection Surveillance Data Quality.","authors":"John S Angles, Elizabeth A Torrone, Tracy Pondo, Melissa A Pagaoa, Erika G Martin","doi":"10.1097/OLQ.0000000000002180","DOIUrl":"10.1097/OLQ.0000000000002180","url":null,"abstract":"<p><strong>Abstract: </strong>Jurisdictional health departments use public health information systems to maintain and transmit their surveillance data for national surveillance. We investigated if changes to a public health information systems had an impact on sexually transmitted infection case-based surveillance data and document short-term issues that resulted in decreased data quality.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"e77-e79"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferences and Acceptability Related to Self-Administered and At-Home Testing Among Clients at Chicago Department of Public Health STI Specialty Clinics.","authors":"Michael Wasz, Jeremy Grey, Grace Kadubeck, Van Quach, David Kern, Tammy Rutledge, Irina Tabidze, Supriya D Mehta","doi":"10.1097/OLQ.0000000000002200","DOIUrl":"10.1097/OLQ.0000000000002200","url":null,"abstract":"<p><strong>Background: </strong>Chicago has high rates of sexually transmitted infections (STIs), disproportionately affecting vulnerable populations. Self-administered at-home testing (SAAHT) may improve access to STI testing. Before SAAHT services are made available at Chicago Department of Public Health (CDPH) STI clinics, understanding characteristics of persons who might be less likely to use SAAHT can help CDPH anticipate where extra effort might be needed to improve service utilization.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted from July to September 2023 at CDPH STI Specialty Clinics in Lakeview and South Austin. Participants (≥18 years of age) completed surveys on SAAHT acceptability. Factor analysis and modified Poisson regression identified factors associated with the likelihood of not using SAAHT.</p><p><strong>Results: </strong>Reported unlikelihood of using SAAHT methods was more prevalent among person who were male, heterosexual, and non-Hispanic Black/African American, and those unemployed or without postsecondary education. Being unlikely to use SAAHT methods was inversely related to perceptions of SAAHT convenience, result trustworthiness, and self-confidence in using SAAHT methods.</p><p><strong>Discussion: </strong>Findings indicate a general acceptability of SAAHT among CDPH clients, with respondents reporting being at least somewhat likely to use SAAHT regardless of the procedures involved. Unlikelihood of using SAAHT methods was related to demographic characteristics and perceptions of SAAHT, and associations differed according to method of collection, logistics of returning test kits, and mode of receiving results. Addressing method-specific concerns, providing culturally relevant education, and offering alternative sampling techniques could improve acceptability. Future efforts should explore preferences to better tailor interventions, ultimately enhancing SAAHT uptake and STI testing access in urban settings.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"676-683"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Approach to HIV Cluster Detection and Response: The Role of Partner Services.","authors":"Emily J Holman, Alexandra M Oster, Karen Schlanger","doi":"10.1097/OLQ.0000000000002201","DOIUrl":"10.1097/OLQ.0000000000002201","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"e74-e76"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Youth-Friendly Sexual Health Services and Peer Support for Improved Sexual and Reproductive Health Outcomes Among Adolescents and Young Adults in South Africa: Results of a Factorial Randomized Controlled Trial.","authors":"Jana Jarolimova, Jacob Busang, Natsayi Chimbindi, Nonhlanhla Okesola, Theresa Smit, Guy Harling, Nuala McGrath, Andrew Copas, Janet Seeley, Kathy Baisley, Maryam Shahmanesh","doi":"10.1097/OLQ.0000000000002203","DOIUrl":"10.1097/OLQ.0000000000002203","url":null,"abstract":"<p><strong>Background: </strong>Adolescents and young adults in South Africa have high burdens of sexually transmitted infections (STIs) and unintended pregnancy. We evaluated the impact of peer support and/or expanded sexual and reproductive health (SRH) services on STIs, contraception, and pregnancy in rural KwaZulu-Natal, South Africa.</p><p><strong>Methods: </strong>We analyzed secondary outcomes from a 2 × 2 factorial randomized controlled trial conducted from March 2020 to August 2022 among 16- to 29-year-olds, comparing (1) enhanced standard of care (SoC), access to mobile youth-friendly HIV prevention (AYFS); (2) SRH, self-collected STI testing and referral to AYFS with expanded SRH services; (3) peer support, peer navigator facilitation of AYFS attendance; (4) SRH + peer support. At 12 months, all participants were offered STI testing; female participants self-reported contraceptive use and pregnancy.</p><p><strong>Results: </strong>Among 1743 trial participants (51% female), 927 (53%) had 12-month STI results; 209 (22.5%) tested positive: 163 (17.6%) chlamydia, 54 (5.8%) gonorrhea, and 44 (4.8%) trichomoniasis. The prevalence of STI was somewhat lower among those exposed to peer support (adjusted odds ratio [aOR] adjusted for sex, age, location, 0.77; 95% confidence interval, 0.56-1.06) or SRH (aOR, 0.74; 0.56-1.06) and, compared with SoC, was reduced in those exposed to both (aOR, 0.59; 0.38-0.94). In SRH arms, 64 of 469 (13.6%) had a new STI at 12 months, with no difference by peer support ( P = 0.97). Among females, 336 of 634 (53.0%) reported using contraception and 47 of 667 (7.1%) reported pregnancy, with little difference by study arm.</p><p><strong>Conclusions: </strong>Peer support and STI testing with expanded SRH each had no more than small effects on STIs, contraception, or pregnancy. Combined or more intensive interventions, for example, repeat screening, enhanced partner notification, and deeper understanding of structural drivers, are needed.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"659-667"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between High-Risk Human Papillomavirus Prevalence and Circumcision Status Among Sexually Experienced Adult Men, 2013 to 2016, United States.","authors":"Rayleen M Lewis, Sarah K Brewer, Julia W Gargano, Troy D Querec, Elizabeth R Unger, Lauri E Markowitz","doi":"10.1097/OLQ.0000000000002207","DOIUrl":"10.1097/OLQ.0000000000002207","url":null,"abstract":"<p><strong>Background: </strong>Randomized control trials in sub-Saharan countries found that male circumcision may prevent high-risk human papillomavirus (HR-HPV) acquisition. Using 2013-2016 National Health and Nutrition Examination Survey data, we explored the association between circumcision and HR-HPV among sexually experienced 18- to 59-year-old men.</p><p><strong>Methods: </strong>Self-collected penile specimens were tested for HPV DNA. We estimated weighted HR-HPV prevalence (positivity to ≥1 HR type: HPV-16/18/31/33/35/39/45/51/52/56/58/59/66/68) by circumcision status. The association between circumcision and HR-HPV was assessed using multivariable logistic regression models. Effect modification by circumcision on the association between number of lifetime sex partners and HR-HPV was explored.</p><p><strong>Results: </strong>Overall, 77.7% of men reported being circumcised, with large variation by race/ethnicity and country of birth. High-risk HPV prevalence was significantly higher among circumcised (25.7%) than uncircumcised (20.4%) men; this was attenuated after adjustment for lifetime and new past-year sex partners (adjusted prevalence ratio, 1.10; 95% confidence interval, 0.92-1.32). There was evidence that circumcision modified the association between lifetime partners and HR-HPV, but HR-HPV prevalence increased with increasing number of partners in circumcised and uncircumcised men.</p><p><strong>Conclusions: </strong>Our observed lack of statistical association between circumcision and HR-HPV may differ from randomized trial results because of the differences between circumcised and uncircumcised men or differences in anatomic site sampled or timing of circumcision.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"699-705"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Accuracy of Empiric Treatment Among Patients With Vaginitis Symptoms in the United States.","authors":"Jenny Tse, Justin Chen, Liucheng Shi, Mindy M Cheng, Rebecca Lillis, Aimee M Near","doi":"10.1097/OLQ.0000000000002197","DOIUrl":"10.1097/OLQ.0000000000002197","url":null,"abstract":"<p><strong>Background: </strong>Evidence suggests low diagnostic test utilization and high empiric prescribing rates for vaginitis symptoms. This study retrospectively assessed real-world bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomoniasis (TV) treatment patterns in the United States relative to test results and their timing.</p><p><strong>Methods: </strong>Patients with vaginitis or related symptom diagnosis were identified between 2018 and 2023 in an ambulatory electronic medical record database linked to prescription and outpatient medical claims databases. Pregnant and nonpregnant subgroups were stratified by test type (nucleic acid amplification test [NAAT] panel [BV, VVC, and TV], direct probe, or traditional methods) up to first diagnosis date +2 days. Treatment claims before (empiric) and up to 7 days after (informed) the test result date were assessed.</p><p><strong>Results: </strong>There were 1465 pregnant and 13,447 nonpregnant patients meeting selection criteria; 31.7%, 26.3%, and 2.0% of pregnant and 26.6%, 16.1%, and 2.0% of nonpregnant cohorts had positive results for BV, VVC, and TV, respectively. Empiric treatment was common across treated pregnant subgroups tested with laboratory NAAT panel (55.0%), direct probe (35.5%), and traditional methods (66.7%), and nonpregnant subgroups (55.7%, 52.2%, 74.2%, respectively). Many empiric treatments were not aligned to positive test results, including coinfections (e.g., 6.5%-8.2% of pregnant and 11.7%-13.0% of nonpregnant patients who tested BV positive by NAAT panel or direct probe were empirically treated with antifungal agents for VVC).</p><p><strong>Conclusions: </strong>High empiric treatment rates and evidence of inappropriate treatment highlight the potential utility for rapid, accurate tests to diagnose common vaginal infections, to inform clinical decision making and results-guided prescribing at the point of care.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"690-698"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consider Trichomonas vaginalis in the Differential Diagnosis for Genital Ulcers.","authors":"Samuel Ibáñez, Jorge Navarrete","doi":"10.1097/OLQ.0000000000002182","DOIUrl":"10.1097/OLQ.0000000000002182","url":null,"abstract":"<p><strong>Abstract: </strong>A 21-year-old immunocompromised female (advanced HIV, CD4 count: 9 cells/μL) presented with painful genital ulcers. A multiplex PCR panel detected Trichomonas vaginalis in both vaginal and ulcer swabs, while tests for Neisseria gonorrhoeae , Chlamydia trachomatis , and Mycoplasma genitalium were negative. The patient was treated with metronidazole, resulting in significant clinical improvement. This case underscores the importance of considering Trichomonas vaginalis in the differential diagnosis of genital ulcers, particularly in immunocompromised individuals, and highlights the utility of molecular testing in atypical presentations.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"e80-e81"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversing a Tragic National Loss: The Elimination of the Centers for Disease Control and Prevention's Sexually Transmitted Disease Laboratory Reference and Research Branch.","authors":"Stephen A Morse, Arlene C Seña, Ronald C Ballard","doi":"10.1097/OLQ.0000000000002218","DOIUrl":"10.1097/OLQ.0000000000002218","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"649-653"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of Condom Failure in Men Who Have Sex With Men in Kenya, Malawi, and South Africa: Findings From the HIV Prevention Trials Network 075 Study.","authors":"Theo G M Sandfort, Charlotte E Rinnooy Kan, Thomas Corbeil, Victor Mudhune, Erica L Hamilton, Sufia Dadabhai, Caitlin Laughney, Ravindre Panchia, Doerieyah Reynolds","doi":"10.1097/OLQ.0000000000002208","DOIUrl":"10.1097/OLQ.0000000000002208","url":null,"abstract":"<p><strong>Background: </strong>Research on condom failure among African men who have sex with men (MSM) is rare; therefore, we sought to identify multilevel correlates of condom failure.</p><p><strong>Methods: </strong>Using logistic regression, we identified the associations of various participant, partnership, and sexual interaction characteristics with condom slippage and breakage among African MSM participating in HIV Prevention Trials Network (HPTN) 075, a 1-year, multinational, prospective cohort study (2015-2017).</p><p><strong>Results: </strong>Of 401 participants, 387 (96.5%) reported at least one sexual interaction in which condoms were used. Condom slippage was reported in 194 (10.2%) of the 1908 sexual interactions reported by participants and breakage in 223 (11.7%) interactions. Both slippage and breakage were reported less frequently by participants in ongoing intimate relationships compared with those who were not (odds ratio [OR], 0.52; 95% confidence interval [CI], 0.29-0.95; OR, 0.57; 95% CI, 0.34-0.93). Slippage and breakage occurred more frequently when sex happened under the influence of substances (OR, 1.67; 95% CI, 1.13-2.46; OR, 2.08; 95% CI, 1.48-2.93) or when sex was forced (OR, 3.18; 95% CI, 1.68-6.02; OR, 2.39; 95% CI, 1.41-4.04). Having experienced homophobia was also associated with slippage and breakage (OR, 1.32; 95% CI, 1.04-1.68; OR, 1.35; 95% CI, 1.10-1.65).</p><p><strong>Conclusions: </strong>Ongoing condom failures suggest the importance of continued condom education of African MSM, addressing circumstances that promote or hinder optimal use, and increasing their control in sexual interactions. Experienced homophobia might as a distal factor also contribute to condom failure.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"668-675"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12327758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Antibody Confirmation Assays for Hepatitis C Virus Testing in Patients With HIV.","authors":"Fien Vanroye, Kimcheng Choun, Els Genbrugge, Koen Vercauteren, Dorien Van den Bossche","doi":"10.1097/OLQ.0000000000002205","DOIUrl":"10.1097/OLQ.0000000000002205","url":null,"abstract":"<p><strong>Background: </strong>The World Health Organisation recommends testing populations most affected by hepatitis C virus (HCV) infection, like people living with HIV. After screening with an Ab test, HCV RNA testing is required to identify active (viremic) infections. One could focus the HCV RNA testing capacity on true positive serological test results, by implementing serological HCV confirmation assays. Our goal was to evaluate the performance of 3 HCV confirmation assays in people living with HIV.</p><p><strong>Methods: </strong>A total of 415 frozen plasma specimens collected in Cambodia (Sihanouk Hospital Center of HOPE) and Belgium (Institute of Tropical Medicine) were tested with Geenius HCV supplemental Assay (Bio-Rad, Marne la Coquette, France), HCV Blot 3.0 (MP Biomedical, Irvine, CA), and INNO-LIA HCV Score (Fujirebio, Ghent, Belgium). Results were compared against HCV RNA results and/or a composite reference standard.</p><p><strong>Results: </strong>Overall, INNO-LIA had the highest sensitivity (97.0%; 95% confidence interval [CI], 94.0%-98.5%) and Geenius the highest specificity (98.2%; 95% CI, 93.7%-99.5%). In a subset of patients with active infection (n = 177), all 3 assays showed comparable sensitivity (99.0%; 95% CI, 96.0%-100.0%). Both for INNO-LIA (8.7% [36 of 415]) and HCV Blot (7.0% [29 of 415]), the indeterminate results were mostly negative and/or indeterminate (80.6% [29 of 36] and 93.1% [27 of 29], respectively) on the composite reference standard compared with only 26.3% (10 of 38) on Geenius.</p><p><strong>Conclusions: </strong>All 3 antibody confirmation assays show comparable and high sensitivity in active HCV infections. Geenius potentially offers some advantages in ease of use, low turnaround time, and ruling out past infections. The added value of HCV antibody confirmation assays needs to be established in larger cost-effectiveness studies and is influenced by decreasing HCV prevalence and HCV RNA capacity.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"706-711"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}