Sexually transmitted diseases最新文献

{"title":"Lymphogranuloma Venereum Detection in Chlamydia trachomatis Positive Self-Collected Mail-in Male Rectal Samples in Maryland, United States.","authors":"Justin Hardick, Madison Conte, Mattlyn Young, Nisha Ramdeep, Yukari C Manabe, Matthew M Hamill","doi":"10.1097/OLQ.0000000000002133","DOIUrl":"10.1097/OLQ.0000000000002133","url":null,"abstract":"<p><strong>Background: </strong>Infection with Chlamydia trachomatis (CT) can have distinct clinical presentations, such as trachoma, or lymphogranuloma venereum (LGV). Certain populations are at greater risk for LGV acquisition and transmission, which may require a longer duration of therapy than other urogenital CT sexually transmitted infections (STIs). Commercial assays are not available in the United States to distinguish LGV from non-LGV genovars.</p><p><strong>Methods: </strong>Lymphogranuloma venereum real-time polymerase chain reaction was performed on rectal CT-positive samples (N = 93) obtained from men (N = 80) who ordered from a mail-in self-collection STI service between April 2021 and February 2024. pmpH gene sequencing was performed on all samples to confirm LGV versus non-LGV, and multilocus sequence typing was performed on LGV-positive samples (n = 7) for additional confirmation.</p><p><strong>Results: </strong>Lymphogranuloma venereum was detected in 7.5% (7 of 93) of samples by real-time polymerase chain reaction, with pmpH sequencing and multilocus sequence typing confirming 100% (7 of 7) of these results. Overall, pmpH sequencing data were obtained for 92% (86 of 93) of samples with the following genovar distribution based on BLAST analysis: 54% (47 of 86) J, 28% (24 of 86) F, 9% (8 of 86) E, and 8% (7 of 86) L. No individual had more than 1 LGV-positive sample. No statistically significant associations with demographic factors were identified.</p><p><strong>Conclusions: </strong>Lymphogranuloma venereum was detected in CT-positive rectal swabs from users of an online, mail-in, self-collect STI testing platform in Maryland. These data suggest that increased LGV reflexive testing may be warranted to better understand the cotemporary epidemiology of LGV. These data also illustrate that mail-in programs for routine STI testing may be leveraged for public health surveillance purposes.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"333-337"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, Attitudes, and Interest in Doxycycline Postexposure Prophylaxis as Bacterial Prophylaxis Against Sexually Transmitted Infections-New York City Sexual Health Clinics, June to August 2023.","authors":"Ciarra Leocadio, Gabriela Betancourt, Jennifer Tang, Zachary Heth, Preeti Pathela","doi":"10.1097/OLQ.0000000000002138","DOIUrl":"10.1097/OLQ.0000000000002138","url":null,"abstract":"<p><strong>Background: </strong>Increased incidence of bacterial sexually transmitted infections including chlamydia, gonorrhea, and syphilis dictates the need for novel prevention strategies. One such strategy, doxycycline prescribed prophylactically, has proven to be effective at reducing transmission among men who have sex with men and transgender women. We assessed awareness, attitudes, and interest in doxycycline preexposure/postexposure prophylaxis (doxyPrEP/doxyPEP) among New York City sexual health clinic patients, including men who have sex with men, other cisgender men, women, transgender persons, and patients identifying as gender nonconforming or nonbinary.</p><p><strong>Methods: </strong>A self-administered survey was completed by 280 patients from 5 New York City sexual health clinics between June and August 2023 that collected information assessing their knowledge, concerns, and willingness to use doxyPrEP and doxyPEP. We used Poisson regression models to examine factors associated with willingness to use doxyPEP.</p><p><strong>Results: </strong>Of the 280 patients, 73% (205) and 55% (153) reported that they would take doxyPEP and doxyPrEP, respectively, if offered by their provider. Willingness to use doxyPEP was observed across gender groups and significantly associated with history or current use of HIV preexposure prophylaxis (adjusted risk ratio [aRR], 1.17; 95% confidence interval [CI], 1.07-1.27). Compared with non-Hispanic White participants, Hispanic (aRR, 1.27; 95% CI, 1.07-1.52) and non-Hispanic other (Alaskan Native, American Indian, Native Hawaiian, Pacific Islander, multiracial) group (aRR, 1.28; 95% CI, 1.06-1.56) participants were more likely to report willingness to use doxyPEP. Possible antibiotic resistance was of highest concern.</p><p><strong>Conclusions: </strong>If offered by a provider, doxyPEP would likely be accepted by patients of all gender groups. Additional research on acceptability in other settings would help guide widespread implementation.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"364-369"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intentions of Telehealth Appointments and Associations between Barriers and Likelihood of Telehealth Appointments Among Clients at Chicago Department of Public Health STI Specialty Clinics.","authors":"Casey Morgan Luc, Michael Wasz, Grace Kadubek, Van Quach, Colleen M Leonard, David Kern, Tammy Rutledge, Irina Tabidze, Supriya D Mehta","doi":"10.1097/OLQ.0000000000002188","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002188","url":null,"abstract":"<p><strong>Background: </strong>With the COVID-19 pandemic, telehealth services emerged as an effective care-delivery tool to increase equitable access to care. The Chicago Department of Public Health's (CDPH) sexually transmitted infections (STI) specialty clinics provide comprehensive, no-cost care for STIs and HIV. Telehealth services may facilitate expanded services, but the acceptability to patients is unknown.</p><p><strong>Methods: </strong>We analyzed data collected from participants seeking care at one of two CDPH STI specialty clinics from July 6 to September 12, 2023. Modified Poisson regression was used to assess factors associated with 1) using any telehealth services in the past 12 months, and 2) likelihood of not using future telehealth services at STI specialty clinics.</p><p><strong>Results: </strong>Of 251 respondents, most were 18-29 years old (56%), 36% non-Hispanic (NH) White, 28% NH Black, and 71% male. Nearly half (46%) had used past telehealth services and 33% reported being unlikely to use telehealth services at specialty clinics. In adjusted analyses, compared to NH White, NH Black participants were more likely to report no intention to use future telehealth services (aPR: 1.55, 95% CI: 1.02, 2.35). Among those who did not previously use telehealth services, choosing CDPH STI specialty clinics for privacy concerns/confidentiality was significantly associated with a lower likelihood of using future telehealth services.</p><p><strong>Conclusions: </strong>A reported moderate-high acceptance of telehealth services at CDPH STI specialty clinics may suggest telehealth implementation could have successful uptake. Next steps toward implementing a telehealth program will need to consider which services to include, provider training and needs, and system factors, such as integration with electronic medical records and establishment of a patient portal.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrameatal condyloma acuminata.","authors":"Vinayak Viswanath","doi":"10.1097/OLQ.0000000000002183","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002183","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Chlamydia trachomatis Infection and Depression.","authors":"Nathan Steffens, Caroline Doyle, Phillip F Bressoud, Holly A Swain Ewald, Paul W Ewald","doi":"10.1097/OLQ.0000000000002185","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002185","url":null,"abstract":"<p><strong>Background: </strong>This study investigated associations between Chlamydia trachomatis and depression in subjects with and without urogenital symptoms, in males and females, and across different severities of depression.</p><p><strong>Methods: </strong>We reviewed electronic medical records from the University of Louisville Campus Health Services. Data on mood, Chlamydia trachomatis and Neisseria gonorrhoeae infection statuses, symptoms, age, sex, and the use of alcohol, cigarettes, and illicit drugs were analyzed.</p><p><strong>Results: </strong>Across the entire study cohort (n = 839), C. trachomatis infection was associated with an increased likelihood of reporting depression (aOR = 1.79, 95%CI [1.19, 2.69]). The odds of reporting depression remained elevated when the analysis was restricted to infected patients without urogenital symptoms (aOR = 1.75, 95%CI [1.07, 2.80]). In a sex-stratified analysis, C. trachomatis infection was associated with a statistically significant increased odds of reporting depression in females (aOR = 2.09, 95%CI [1.25, 3.45]) but not in males. When subjects were categorized according to an ordered scale of depression, C. trachomatis infection was associated with an increased odds of falling into a more severe category (OR = 1.83, 95%CI [1.251, 2.694]). Finally, using a within-subject design, patients were more likely to report depression when infected at the time of the appointment compared with when the same patients were uninfected (OR = 3.17, 95%CI [1.22, 9.69]).</p><p><strong>Conclusions: </strong>Our results are consistent with C. trachomatis contributing to the spectrum of depression independent of urogenital symptoms. We propose that these depression findings may result from an immune system response that lowers serotonin availability.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in syphilis prevalence by race and ethnicity among people who are pregnant in the United States 2016-2023.","authors":"Yizhi Liang, Nicolas A Menzies, Minttu M Rönn","doi":"10.1097/OLQ.0000000000002187","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002187","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to estimate syphilis prevalence among people who were pregnant and delivered live births by race and ethnicity 2016-2023.</p><p><strong>Methods: </strong>We analyzed data on syphilis infection from U.S. birth certificates using a Bayesian mathematical model, adjusting for test sensitivity, specificity, and screening coverage. We calibrated the model under two scenarios: (1) assuming screening coverage is as estimated in Medicaid claims data and (2) assuming higher screening coverage than observed in Medicaid claims data. We also compared the prevalence estimates to stillbirths attributable to syphilis reported through routine surveillance. We examined racial and ethnic disparities using the index of disparity.</p><p><strong>Results: </strong>In Scenario 1, syphilis prevalence among people who were pregnant and delivered live births increased from 101.1 (95% uncertainty interval [UI]: 87.5-120.5) per 100,000 live births in 2016 to 533.4 (95%UI: 496.6-581.0) per 100,000 live births in 2023. In Scenario 2, prevalence increased from 73.9 (95%UI: 51.2-130.0) per 100,000 live births to 378.1 (95%UI: 295.5-592.0) per 100,000 live births over the same period. With rising prevalence, relative racial and ethnic disparities narrowed over time. Prevalence was estimated to be higher among women with stillbirths compared to women with live births.</p><p><strong>Conclusions: </strong>In the United States, syphilis prevalence among pregnant women has increased in all race and ethnicity groups. Improved estimates of screening coverage are needed to understand the gaps in congenital syphilis prevention and to inform estimates of syphilis prevalence among pregnant persons.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial vaginosis incidence following a single hyperosmolal vaginal lubricant exposure: A comparison of two observational cohorts.","authors":"Sarah E Brown, Xin He, Laurence Magder, Elizabeth D Johnston, Daniel Morgan, Jacques Ravel, Katrina Mark, Khalil G Ghanem, Rebecca M Brotman","doi":"10.1097/OLQ.0000000000002184","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002184","url":null,"abstract":"<p><strong>Background: </strong>Hyperosmolal lubricants may negatively affect the vaginal microenvironment, increasing the risk for bacterial vaginosis (BV). We compared the incidence of Amsel-defined BV in reproductive-age women exposed to hyperosmolal lubricant during transvaginal ultrasound to those without recent lubricant exposure.</p><p><strong>Methods: </strong>We analyzed two observational cohorts over 10 weeks: 58 lubricant-exposed women from the Gynecology and Lubricants Effects study and 59 lubricant-unexposed women from a University of Alabama Birmingham cohort linked to the University of Maryland Human Microbiome Project. BV was diagnosed using Amsel criteria at baseline, mid-study (lubricant-exposed: week 2, lubricant-unexposed: week 5), and final visit (week 10), and categorized by symptomatology. Risks for incident BV and Amsel criteria were assessed using modified Poisson regression with robust standard errors. An additional outcome of new-onset/newly-symptomatic BV included those with baseline asymptomatic BV. A secondary analysis focused on Black participants (N = 73) due to an observed higher BV incidence.</p><p><strong>Results: </strong>Baseline demographics and behaviors were similar between the cohorts. Among all participants, lubricant was not associated with new-onset BV (adjusted relative risk (aRR):1.32, 95% CI:0.58-3.01). 88% (23/26) of all new-onset/newly-symptomatic BV cases occurred in Black participants. Among Black participants, exposure to lubricant doubled the risk of developing new-onset BV (aRR:2.18, 95% CI:1.16-4.11) and new-onset/newly-symptomatic BV (aRR:1.91, 95% CI: 1.04-3.51), and increased the risk for new-onset clue cells (aRR:2.18, 95% CI:1.17 - 4.06) versus no lubricant exposure.</p><p><strong>Conclusion: </strong>Hyperosmolal lubricants was associated with BV incidence in Black women. Factors contributing to this elevated risk require further research.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Depression and Sexually Transmitted Infections During Pregnancy Among Underserved Pregnant Patients.","authors":"Nikita Ghosh, Han-Yang Chen, Irene Stafford","doi":"10.1097/OLQ.0000000000002186","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002186","url":null,"abstract":"<p><strong>Background: </strong>Depression involves intertwining socio-economic, behavioral, and health factors, creating a complex landscape for providers to address during pregnancy. Its association with social determinants of health and immunologic inflammation complicates its relationship with sexually transmitted infections (STIs). This study aimed to assess the association between depression and STIs among underserved pregnant patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted of pregnant patients from February 2019 to May 2023 within a public health system. Medical records for patients undergoing pregnancy screening were reviewed. Demographic data, depression data, STI data, and obstetric outcomes were recorded. Patients with depression were identified through self-reports to providers and Edinburgh Postnatal Depression Scale (EPDS) scores of ten or higher. A multivariable logistic regression model with robust error variance was utilized for analysis.</p><p><strong>Results: </strong>Among the 20,111 singleton pregnant patients studied, 1,054 (5.24%) reported experiencing depression during pregnancy, and 3.2% were diagnosed with any STI. After multivariable adjustment, compared to patients without depression, those with depression had an increased odds of having any STI (aOR 1.54 95% CI 1.20-1.99). Patients with depression had higher odds (aOR 1.81, 95% CI 1.16-2.84) of having syphilis compared to those without.</p><p><strong>Conclusions: </strong>Our findings exemplify an elevated association of STI, particularly syphilis, among underserved pregnant patients with depression.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term Impact of Changes in Public Health Information Systems on Sexually Transmitted Infection Surveillance Data Quality.","authors":"John S Angles, Elizabeth A Torrone, Tracy Pondo, Melissa A Pagaoa, Erika G Martin","doi":"10.1097/OLQ.0000000000002180","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002180","url":null,"abstract":"<p><strong>Abstract: </strong>Jurisdictional health departments use public health information systems (PHIS) to maintain and transmit their surveillance data for national surveillance. We investigated if changes to a PHIS had an impact on sexually transmitted infection case-based surveillance data and document short-term issues that resulted in decreased data quality.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consider Trichomonas vaginalis in the differential diagnosis for genital ulcers.","authors":"Samuel Ibáñez, Jorge Navarrete","doi":"10.1097/OLQ.0000000000002182","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002182","url":null,"abstract":"<p><strong>Abstract: </strong>A 21-year-old immunocompromised female (advanced HIV, CD4 count: 9 cells/μL) presented with painful genital ulcers. A multiplex PCR panel detected Trichomonas vaginalis in both vaginal and ulcer swabs, while tests for Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium were negative. The patient was treated with metronidazole, resulting in significant clinical improvement. This case underscores the importance of considering T. vaginalis in the differential diagnosis of genital ulcers, particularly in immunocompromised individuals, and highlights the utility of molecular testing in atypical presentations.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}