Sexually transmitted diseases最新文献

{"title":"The Occurrence of Single-Site Pharyngeal Neisseria gonorrhoeae Among Female Sex Workers in the Netherlands.","authors":"Ymke J Evers, Charlotte M M Peters, Petra F G Wolffs, Dieuwertje L Horsten, Chantal Weijzen, Nicole H T M Dukers-Muijrers, Christian J P A Hoebe","doi":"10.1097/OLQ.0000000000002104","DOIUrl":"10.1097/OLQ.0000000000002104","url":null,"abstract":"<p><strong>Background: </strong>Female sex workers (FSWs) have a higher burden of sexually transmitted infections (STI), including Neisseria gonorrhoeae (NG), than the non-sex worker population, mainly due to social vulnerability and work-related factors. This large study evaluated the anatomical site distribution of NG, and specifically the occurrence of single-site pharyngeal NG, among FSWs visiting Dutch STI clinics in the Netherlands.</p><p><strong>Methods: </strong>Coded STI clinic consultations from FSW attending any Dutch STI clinic between 2016 and 2021, in which tests were performed on all 3 anatomical sites, according to the Dutch testing policy for FSW, were included in analyses (n = 22,304). To compare the anatomical site distribution of NG among FSWs with women in general, 15,494 consultations from women who were tested on 3 anatomical sites in clinics that performed standard testing at 3 anatomical sites were used. Descriptive statistics were used to compare the anatomical site distribution of NG and occurrence of single-site pharyngeal NG among FSW and universally tested women.</p><p><strong>Results: </strong>NG was diagnosed among 3.5% (782 of 22,034) among FSWs and 1.7% (271 of 15,494) among universally tested women ( P < 0.001). Pharyngeal NG was diagnosed among 2.3% of FSWs versus 0.8% of universally tested women ( P < 0.001). Single-site pharyngeal NG was diagnosed in 19.9% (156 of 782) of all NG infections, compared with 14.8% (40 of 271) of NG infections among universally tested women.</p><p><strong>Conclusion: </strong>The substantial proportion pharyngeal NG and single-site pharyngeal NG among FSW confirms the relevance of pharyngeal testing among this key population for optimal patient management, also in the context of the potential role of pharyngeal NG in antimicrobial resistance.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"255-258"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASTDA Position Paper: Alternatives to Benzathine Penicillin G for the Treatment of Syphilis During Pregnancy.","authors":"Teresa Batteiger, Elaine Liu, Jeanne Sheffield, Hilary Reno, Zoon Wangu, Khalil G Ghanem, Susan Tuddenham","doi":"10.1097/OLQ.0000000000002108","DOIUrl":"10.1097/OLQ.0000000000002108","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"195-200"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review of Congenital Syphilis in the United States: Innovative Perspectives on a Complex Public Health and Medical Disease.","authors":"Alice Lehman, Nehemiah Olson, Jill Foster, Stephen Contag","doi":"10.1097/OLQ.0000000000002093","DOIUrl":"10.1097/OLQ.0000000000002093","url":null,"abstract":"<p><strong>Abstract: </strong>Over the past 2 decades, congenital syphilis cases have risen 11-fold in the United States. Although disparities across geography, race, and ethnicity exist, lack of timely screening or treatment is identified in 88% of cases nationally. Congenital syphilis is a public health and medical problem rooted in systematic and societal structural determinants of health and health care limitations. Early syphilis in pregnancy leads to congenital syphilis if untreated in 50% to 70% of cases, with risk for fetal demise, and among survivors, congenital anomalies, organ damage, and central nervous system disease. Prevention of congenital syphilis lies in early detection and treatment in pregnant persons. In this narrative review, we describe the evolving epidemiology of syphilis and congenital syphilis, highlighting unique aspects among women. We explore the role of novel screening and treatment strategies, public health policy, and medical considerations in terms of congenital syphilis prevention. Readers of this review will understand congenital syphilis as a complex public health and medical disease that can be prevented through innovative and coordinated strategies in public health policy, expanded screening, and research opportunities.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"217-224"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Study of Doxycycline Postexposure Prophylaxis Knowledge, Attitudes, and Practices Among Health Care Providers in New York City.","authors":"Paul A D'Avanzo, Joan Bosco, Caroline Carnevale, Jason Zucker","doi":"10.1097/OLQ.0000000000002103","DOIUrl":"10.1097/OLQ.0000000000002103","url":null,"abstract":"<p><strong>Background: </strong>Three randomized controlled trials have demonstrated the efficacy of doxycycline for bacterial sexually transmitted infection postexposure prophylaxis (Doxy PEP). Few studies have assessed provider knowledge, attitudes, and practices (KAP) regarding Doxy PEP implementation. Between July of 2023 and January 2024, this study qualitatively assessed KAP and intention to prescribe Doxy PEP among health care providers in the New York City area.</p><p><strong>Methods: </strong>In-depth, semistructured individual interviews were conducted with 18 health care provider key informants including physicians, nurse practitioners, and physician assistants from various practice settings. Transcripts were analyzed using inductive KAP codes, with additional deductive coding used to identify emergent subthemes.</p><p><strong>Results: </strong>The following themes were identified: (1) STI Disparities, (2) Doxy PEP Experience, (3) Doxy PEP Benefits, (4) Doxy PEP Concerns, and (5) Doxy PEP Implementation. Doxy PEP knowledge was high, with all providers being aware and most (78%) having prescribed it to at least one patient at the time of interview. Providers were knowledgeable of factors contributing to high rates of STIs. Benefits included reducing STI anxiety. Concerns included contributing to antimicrobial resistance and impacts on microbiota. Practice implications included challenges getting Doxy PEP approved by the pharmacy. These factors were shown to affect Doxy PEP's perceived acceptability.</p><p><strong>Conclusions: </strong>To ensure that Doxy PEP is implemented safely and equitably, KAP factors that may influence provider decision making should be examined. Understanding providers' KAP and how they affect intention to prescribe Doxy PEP, and to what patients, has important implications for successful implementation.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":"52 4","pages":"233-241"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of the National Institute of Allergy and Infectious Diseases Workshop on Alternative Therapies to Penicillin for the Treatment of Syphilis.","authors":"Krista Cato, Eleanore Chuang, Kristie L Connolly, Carolyn Deal, Thomas Hiltke","doi":"10.1097/OLQ.0000000000002113","DOIUrl":"10.1097/OLQ.0000000000002113","url":null,"abstract":"<p><strong>Abstract: </strong>The dramatic increase in syphilis cases in the United States in recent years is a serious public health concern. Periodic shortages of benzathine penicillin G (BPG), the mainstay of syphilis treatment, create challenges for management of syphilis in the United States and worldwide. The National Institute of Allergy and Infectious Diseases convened working groups of experts to assess the landscape of syphilis treatments for uncomplicated adult syphilis, syphilis in pregnant women, congenital syphilis, and neurosyphilis. The working groups came together at a workshop entitled \"Alternative Therapies to Penicillin for the Treatment of Syphilis\" on February 13 to 14, 2024, to share their findings regarding promising alternative treatments, research gaps, and challenges. Discussions focused on using existing antibiotics, with a preference for those with favorable safety profiles and demonstrated success against syphilis or other infectious diseases. Clinical research on alternative treatments is complicated by the high effectiveness of penicillin and by differences in clinical, physiological, cultural, and socioeconomic considerations across different patient populations and geographic settings. In addition, current diagnostic tests and tests-of-cure create challenges for clinical trial design. Various potential trial designs were discussed, focusing on subjects with different types and stages of disease. This summary of the workshop is presented to inform plans for future research, including clinical trials on alternatives to penicillin for the treatment of syphilis.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"201-210"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Evaluation of Syphilis Partner Services Among Gay, Bisexual, and Other Men Who Have Sex With Men With Early Syphilis in King County, WA.","authors":"Roxanne P Kerani, Alene Chang, Anna Berzkalns, Juan Palacios-Moreno, Meena Ramchandani, Matthew R Golden","doi":"10.1097/OLQ.0000000000002132","DOIUrl":"10.1097/OLQ.0000000000002132","url":null,"abstract":"<p><strong>Background: </strong>Partner services (PS) have been integral to syphilis control in the United States since the early 20th century but have not been evaluated in a controlled study.</p><p><strong>Methods: </strong>We compared PS outcomes among gay, bisexual, and other men who have sex with men (GBMSM) diagnosed with syphilis from May 2020 to June 2021 for whom health department staff initiated PS efforts (PS group) and a randomly selected control group for whom no PS efforts were initiated. We interviewed participants about partner outcomes and used χ2 tests and Poisson regression to test for differences in outcomes between groups.</p><p><strong>Results: </strong>We attempted to contact 350 GBMSM and offered participation to 184 men, of whom 92 (51%) participated, including 41 men in the PS group and 51 controls. The percentage of participants who reported notifying ≥1 sex partner after diagnosis was similar in the PS and control groups (83% vs. 80%, P = 0.80). Mean number of partners notified or tested did not differ between PS and control groups (notified mean [range], 2.5 [0-10] vs. 3.3 [0-20], P = 0.16; tested mean [range]: 1.2 [0-8] vs. 1 [0-10], P = 0.66); multivariate results were similar. Among those contacted for PS, approximately half (48%) reported PS staff helped them with medical care for syphilis, and 31% said that PS staff connected them to preexposure prophylaxis.</p><p><strong>Conclusions: </strong>This small, controlled evaluation suggests that syphilis PS may have no impact on partner treatment among GBMSM, although most men support the intervention. A randomized trial is needed to definitively define the contemporary effectiveness of syphilis PS among GBMSM.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"225-232"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Syphilis in the US: A Narrative Review.","authors":"Mahmoud M Azqul, Stacey B Griner, Casey N Pinto","doi":"10.1097/OLQ.0000000000002094","DOIUrl":"10.1097/OLQ.0000000000002094","url":null,"abstract":"<p><strong>Abstract: </strong>Congenital syphilis (CS) continues to pose a significant global challenge. There has been a marked increase in reported cases in the United States, with 102.5 cases per 100,000 live births in 2022 compared with 11.6 cases per 100,000 live births in 2014. Congenital syphilis can lead to a range of severe complications, including premature birth, intrauterine growth restriction, miscarriage, perinatal death, stillbirth, and postnatal complications that may persist into later life. Maternal/parental factors such as age, race/ethnicity, occupation, income level, access to health care services, and incarceration have been linked to higher rates of CS. In addition, pregnant individuals who engage in high-risk behaviors such as sex work, having multiple sexual partners, or substance use are at a higher risk of exposure and subsequent infection. Routine screening for syphilis during pregnancy is crucial for its detection, timely management, and prevention of CS. The asymptomatic nature of the latent stage of syphilis further underscores the importance of prenatal syphilis screening. Studies in various countries have shown that early or first antenatal care visit screening for CS is cost-effective. This review article critically evaluates the current knowledge of CS in the United States, including its prevalence, social determinants of health, prevention efforts, challenges, the significance of screening, and the call to action to address the rising trend. (See Graphical Abstract).</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"211-216"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing STI and HIV Preventive Behaviors and Addressing Community-Prioritized Social Determinants of Health Among Young GBQMSM and Transgender Women of Color: Piloting a Bilingual Multilevel Intervention.","authors":"Scott D Rhodes, Lilli Mann-Jackson, Jorge Alonzo, Eunyoung Y Song, Manuel Garcia, José A Robles Arvizu, Jonathan Bell, Scott Trent, Sandy K Aguilar-Palma, Lucero Refugio Aviles, Benjamin D Smart","doi":"10.1097/OLQ.0000000000002106","DOIUrl":"10.1097/OLQ.0000000000002106","url":null,"abstract":"<p><strong>Background: </strong>Sexually transmitted infections (STIs) and HIV disproportionately affect young people; gay, bisexual, queer, and other men who have sex with men (GBQMSM); transgender women; and persons of color. Our community-based participatory research partnership developed and implemented Impact Triad, a bilingual multilevel intervention harnessing peer navigation and mHealth to increase STI/HIV preventive behaviors and address 4 community-prioritized social determinants of health-education, employment, social support, and discrimination-among young African American/Black and Latine GBQMSM and transgender women.</p><p><strong>Methods: </strong>Fifteen community-based peer navigators were trained to work within their social networks for 12 months. Each navigator engaged 5 social network members who completed baseline and immediate post-intervention assessments (retention rate, 97.3%). Regression modeling was used to assess changes in outcomes between baseline and follow-up.</p><p><strong>Results: </strong>Among 74 enrolled social network members, the average age was 27.8 years; 61% identified as African American/Black, 31% as Latine, and 8% as multiracial/multiethnic. The majority self-identified as cisgender men and 8% as transgender women; 78% identified as gay. About half reported monthly income below $1000.Compared with baseline, at follow-up, social network members increased: STI screening (P = 0.001), HIV testing (P = 0.001), condom use (P = 0.03), and preexposure prophylaxis use (P = 0.02). Knowledge of preexposure prophylaxis (P < 0.0001) and of community-based educational (P = 0.047), job-training (P = 0.002), and job-finding resources (P = 0.02) also increased. Social support increased (P < 0.0001) and perceived discrimination decreased (P < 0.01).</p><p><strong>Conclusions: </strong>Pilot findings suggest that Impact Triad is promising in increasing STI/HIV protective behaviors and addressing social determinants of health among young GBQMSM and transgender women of color; further testing is warranted.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":"52 4","pages":"248-254"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STI TESTING AND RATES OF STI DIAGNOSES BEFORE AND DURING COVID-19 PANDEMIC IN A U.S. HIV COHORT.","authors":"Gina M Simoncini, Carl Armon, Kate Buchacz, Jonathan Mahnken, Qingjiang Hou, Kalliope Chagaris, Jack Fuhrer, Cynthia Mayer, Cynthia Firnhaber, Marcus D Durham, Alexander C Ewing, Kimberly Carlson, Jun Li","doi":"10.1097/OLQ.0000000000002124","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002124","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic affected sexually transmitted infection (STI) testing and diagnosis rates in the United States (U.S.), but these patterns have not been well characterized among people with HIV (PWH).</p><p><strong>Methods: </strong>We analyzed medical records data of HIV Outpatient Study (HOPS) participants seen for HIV care from January 2019-March 2021, with ≥1 CD4+ cell count and viral load test results recorded. We used Poisson regression models to estimate rate ratio (RR) and 95% confidence interval (CI) to compare STI testing and diagnoses rates on/after vs before March 1, 2020 (early COVID-19 pandemic (pandemic) vs. pre-pandemic).</p><p><strong>Results: </strong>Of 2,311 eligible patients, STI tests (STI cases, primarily defined as tests that were positive) were as follows during the analysis timeframe: 4,991 gonorrhea (157), 4,978 chlamydia (135), and 4,216 syphilis (114). Comparing pandemic vs. pre-pandemic periods, STI testing RRs were 0.78 for both gonorrhea (CI: 0.73-0.82) and chlamydia (CI: 0.73-0.83), and 0.93 for syphilis (CI: 0.88-0.99); diagnosis rates were not statistically different. Multivariable models showed reduced testing for gonorrhea (adjusted RR 0.79, CI: 0.72-0.87) and chlamydia (adjusted RR 0.78, CI: 0.71-0.86) for men who have sex with men, but not for other HIV transmission groups.</p><p><strong>Conclusions: </strong>The fallout of the COVID-19 pandemic on sexual health may not be seen for some time. Despite reduced STI testing, rates of STI diagnoses did not decrease. It will take a return to more routine screening and improved access to sexual health care to uncover the true impact of undetected or untreated STIs.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Amsel-defined bacterial vaginosis before and after transvaginal ultrasound with lubricant application.","authors":"Sarah E Brown, Xin He, Laurence Magder, Christina A Stennett, Sarah J Robbins, Daniel Morgan, Elizabeth Johnston, Jacques Ravel, Katrina Mark, Khalil G Ghanem, Rebecca M Brotman","doi":"10.1097/OLQ.0000000000002158","DOIUrl":"10.1097/OLQ.0000000000002158","url":null,"abstract":"<p><strong>Abstract: </strong>Emerging evidence suggests a link between hyperosmolal vaginal lubricants and bacterial vaginosis (BV). In 80 patients undergoing transvaginal ultrasound (TVUS) with a standardized lubricant, we observed a significant increase in Amsel-defined BV 1-13 days post-TVUS compared to baseline, likely driven by heightened amine odor (OR: 5.88; 95% CI: 1.22-28.23).</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}