Sexually transmitted diseases最新文献

{"title":"Oral High-Risk Human Papillomavirus Infection Among Women Reporting Same-Sex Sexual Contact: A Propensity Score-Matched Analysis of the National Health and Nutrition Examination Survey 2009-2016.","authors":"Nir Meller, Noam Rothman, Micha Baum","doi":"10.1097/OLQ.0000000000002435","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002435","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the prevalence of oral high-risk human papillomavirus (HR-HPV) infection between women reporting any lifetime sexual contact with a female partner (WSW) and women reporting exclusively male partners (WSM) in a nationally representative U.S. sample, and to assess how much of the difference is explained by lifetime partner count.</p><p><strong>Methods: </strong>Cross-sectional analysis of women aged 18-69 in the National Health and Nutrition Examination Survey 2009-2016 with evaluated oral HPV genotyping and sexual behavior data. Survey-weighted prevalence was estimated in the full sample. WSW were matched 1:2 to WSM by propensity score on age, smoking, race/ethnicity, and poverty income ratio. Logistic regression in the matched sample additionally adjusted for lifetime partner count (≥10, and four categories).</p><p><strong>Results: </strong>Of 7,943 women, 751 were WSW; 724 (96.4%) of them also reported male partners. Weighted oral HR-HPV prevalence was 2.84% (95% CI 1.57-4.69%) among WSW and 1.04% (0.78-1.35%) among WSM. After matching, WSW had higher odds of infection (OR 2.05, 95% CI 1.15-3.64). WSW reported more lifetime partners (median 12 vs 5), including more male partners (median 10 vs 5). Adjustment for partner count attenuated the association below statistical significance (≥10 partners: OR 1.46, 0.79-2.72).</p><p><strong>Conclusions: </strong>WSW, nearly all of whom also reported male partners, had higher odds of oral HR-HPV infection than demographically matched WSM; lifetime partner count explained part of this difference. A history of female partners should not be taken to imply lower oral HPV risk, and HPV vaccination should be offered according to current recommendations.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syphilitic Leukoplakia with Epithelial Dysplasia: A Diagnostic Challenge Highlighted by a Case Report and PRISMA-Compliant Systematic Review.","authors":"Betul İlhan, Gaye Bölükbaşi, Ayça Dilşad Çağlayan, Pelin Güneri, Ali Veral, Sevgi Akarsu","doi":"10.1097/OLQ.0000000000002429","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002429","url":null,"abstract":"<p><p>Oral syphilis may present as a non-scrapable white lesion that clinically mimics oral leukoplakia. This combined case report and systematic review aimed to characterize syphilis-associated oral lesions with a white component and to evaluate separately cases classified as syphilitic leukoplakia. PubMed, Scopus, Web of Science, and Embase were searched through December 2025. Eligible English-language reports described a confirmed diagnosis of syphilis and an oral lesion with a white component. Two reviewers independently screened records, data were synthesized descriptively, and the included publications were appraised using the corresponding JBI tools. Sixteen publications met the inclusion criteria; together with the present case, they yielded 28 patients. Most patients were male (85.7%), and the tongue was the most frequently involved site (57.1%). Extraoral or systemic findings were documented in 39.3%, explicitly absent in 25.0%, and unreported in 35.7%. Five cases, including the present case, were classified as syphilitic leukoplakia. All five underwent biopsy, and epithelial dysplasia was identified in three. Among the 18 patients with reported outcomes, complete or near-complete resolution occurred in 17 and partial remission in one after antimicrobial therapy. Syphilis should be considered in the differential diagnosis of unexplained oral white lesions, particularly those resembling leukoplakia, to ensure appropriate serologic testing, histopathological assessment, and treatment.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiology of Symptomatic Male Urethritis in the Brazilian Amazon and Agreement Between Two Molecular Testing Workflows.","authors":"Silvana Paiva da Costa, Carolina Talhari, Susan Smith Doria, Ana Claudia Chaves Camillo, Celília de Lima Borges, José Carlos Sardinha, André Luiz Leturiondo, Camila Gurgel Dos Santos Silva, Cynthia de Oliveira Ferreira, Angelica Espinosa Miranda, Sinesio Talhari, Maria das Graças Vale Barbosa Guerra","doi":"10.1097/OLQ.0000000000002434","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002434","url":null,"abstract":"<p><p>Among 117 men with symptomatic urethritis in the Brazilian Amazon, Neisseria gonorrhoeae was most frequent (53.0 to 56.4%, across the two molecular workflows), followed by Chlamydia trachomatis (14.5 to 15.4%), Mycoplasma genitalium (6.8%), and Trichomonas vaginalis (1.7%). Overall molecular workflow agreement was 92.3% for CT and 82.9% for NG.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and prevalence of Gonorrhea and Chlamydia in inner-city Johannesburg: Findings from recruitment for a clinical trial on a novel antibiotic.","authors":"Dorothy C Nyemba, Danielle Travill, Lucky Molefe, Audrey Dhlamini, Lerato Lunika, Sinead Delany-Moretlwe","doi":"10.1097/OLQ.0000000000002430","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002430","url":null,"abstract":"<p><p>Sexually transmitted infections are endemic in South Africa, partly because of the limitations of syndromic management as the standard approach. In recruitment initiative for a novel gonorrhea antibiotic trial, 8189 adults aged ≥18 years were reached and 3381 tested for Chlamydia and Gonorrhea, revealing high prevalence, especially among young people.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Chlamydia and Gonorrhea Testing into a Community-Based Cohort of Latine Young Adults: Patterns and Predictors of Uptake.","authors":"Alexandra M Minnis, Erica N Browne, Mary-Kate Shapley-Quinn, Alondra Jaime-Aguilar, Marie Stoner, Miranda Diaz, Sue Napierala, Paula S Nordstrom Miranda, Nivedita Bhushan, Marissa Raymond-Flesch","doi":"10.1097/OLQ.0000000000002433","DOIUrl":"10.1097/OLQ.0000000000002433","url":null,"abstract":"<p><strong>Background: </strong>We examined STI testing behaviors in a community-based study that removed access and cost barriers by offering in-person and mail-in testing.</p><p><strong>Methods: </strong>A Crecer is a prospective cohort study of adolescents and young adults in an agricultural, majority Latine community (2015-2025). STI testing was offered at three annual visits in emerging adulthood (2022-2025). Participants provided biospecimens for chlamydia/gonorrhea testing, either in-person or via mailed self-collection kit, and completed questionnaires. We examined associations between individual, relationship, and environmental factors and STI testing using Poisson regression with generalized estimating equations.</p><p><strong>Results: </strong>Participants (N=389, 56% female sex at birth, 95% Latine) had a mean age of 20 (range 18-22). Sixty-three percent tested at the first visit in early adulthood, decreasing to 44% and 33% in subsequent annual visits. Initial uptake was higher among those completing in-person versus remote visits (84% vs. 25%). Chlamydia prevalence was 8% at the first visit in early adulthood, and positivity was 5% and 2% at subsequent visits. Testing did not vary by sex. In multivariable analysis, uptake was higher among those experiencing intimate partner violence (adjusted Relative Risk (aRR): 1.3; 95% CI: 1.1, 1.4, p<0.001), and among those reporting sex without a condom in the prior 12 months (aRR: 1.2; CI: 1.0, 1.4, p=0.03). Receipt of sexual health services outside the study was not associated with testing uptake.</p><p><strong>Conclusions: </strong>While many tested based on perceived STI risk, uptake fell short of public health recommendations. Low uptake of mail-in testing highlights the need for testing models that better align with Latine young adults' preferences and circumstances. Findings underscore the importance of understanding testing barriers and normalizing STI screening as routine preventive care.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and clinical factors associated with Syphilis treatment initiation in a tribal health system: a retrospective cohort study.","authors":"Andrea Blair, Ashley Comiford, Molly Feder, Jorge Mera","doi":"10.1097/OLQ.0000000000002436","DOIUrl":"10.1097/OLQ.0000000000002436","url":null,"abstract":"<p><strong>Background: </strong>American Indian/Alaska Native (AI/AN) individuals are disproportionately burdened by syphilis compared with other racial and ethnic groups. Early syphilis treatment is important to reduce transmission and prevent negative health outcomes. Understanding the characteristics of individuals who test positive and the factors associated with initiating treatment will support syphilis prevention and treatment efforts.</p><p><strong>Methods: </strong>Cherokee Nation conducted a retrospective cohort study of individuals who tested positive for syphilis between 2016 and 2023. Data were collected from electronic health records and analyzed descriptively using counts and percentages and inferentially using Chi-square tests and multivariable logistic regression.</p><p><strong>Results: </strong>Overall, 356 individuals tested positive for syphilis and 314 (88.2%) initiated treatment. Most individuals who tested positive were ≤ 34 years (60.7%), single (83.4%), diagnosed during the COVID-19 pandemic (75.8%), residing in a county with a Cherokee Nation clinic (84.3%), and had a non-emergency healthcare visit within one year (70.5%). Approximately half (52.0%) had documented substance use and 31.2% had an STI co-infection within one year. Individuals diagnosed outside of an emergency department or urgent care setting had higher odds of initiating treatment compared with those diagnosed in an emergency department or urgent care setting (aOR=2.01, 95% CI: 1.02-3.97). Individuals with an STI co-infection had higher odds of initiating treatment compared with those without an STI co-infection (aOR=2.96, 95% CI: 1.19-7.33).</p><p><strong>Conclusions: </strong>This study suggests that focusing public health and clinical syphilis treatment efforts on emergency department and urgent care providers and patients may increase syphilis treatment initiation.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Trichomonas vaginalis infection in women at an STI clinic: low yield, target testing.","authors":"Ana Ferreirinha, Rita Corte-Real, Mafalda Pestana, José Miguel Neves, Cândida Fernandes","doi":"10.1097/OLQ.0000000000002426","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002426","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Burden Matters: The Case for Testing for Trichomoniasis.","authors":"Olivia T Van Gerwen","doi":"10.1097/OLQ.0000000000002427","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002427","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Detection and Codetection of Lower Genital Tract Microorganisms among Women Attending an STI Referral Service in the Brazilian Amazon.","authors":"Ana Claudia Chaves Camilo, Sinesio Talhari, Susan Smith Doria, Silvana Paiva da Costa, Celília de Lima Borges, José Carlos Sardinha, André Luiz Leturiondo, Camila Gurgel Dos Santos Silva, Cynthia de Oliveira Ferreira, Angelica Espinosa Miranda, Maria das Graças Vale Barbosa Guerra, Carolina Talhari","doi":"10.1097/OLQ.0000000000002425","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002425","url":null,"abstract":"<p><p>Among 133 women attending an STI referral service in the Brazilian Amazon, multiplex real-time PCR identified a heterogeneous microbiological profile, including STI pathogens, bacterial vaginosis-associated microorganisms, Candida species, and frequent codetection. Clinical and epidemiological characteristics showed variable associations, while self-reported vaginal discharge had limited ability to distinguish specific molecular findings.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment variability among people assigned male at birth with repeat positive Mycoplasma genitalium tests: a case series.","authors":"Chase A Cannon, Timothy W Menza, Christina S Thibault, Gwendolyn E Wood, Lisa E Manhart","doi":"10.1097/OLQ.0000000000002424","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002424","url":null,"abstract":"<p><strong>Background: </strong>Mycoplasma genitalium (MG) can cause nongonococcal urethritis (NGU) and symptomatic proctitis. Rising antimicrobial resistance and lack of clinically available molecular resistance assays make MG treatment challenging. This study adds systematic data on the effectiveness of alternative MG regimens.</p><p><strong>Methods: </strong>Adult natal male patients who attended a public Sexual Health Clinic (SHC) and had ≥2 positive MG nucleic acid amplification tests within any 6-month period from January 2023-September 2025 were included. We classified cases as persistent infection or reinfection using clinical, demographic and self-reported behavioral data. For each patient, we summarized total number of visits, number, duration and components of each antibiotic regimen, and outcomes by MG clinical syndrome and infection status (persistence vs reinfection).</p><p><strong>Results: </strong>Among 3,009 SHC patients, 400 (13%) had incident MG and 19 (4.8%) met inclusion criteria for repeat MG infection across 61 clinic visits. Nongonococcal urethritis (n=14/19 patients, 74%) and proctitis (n=2/19 patients, 10%) were the most prevalent syndromes. Suspected reinfection was common (40%). All 19 patients achieved cure, including 10 (53%) with microbiologic and 9 (47%) with presumed clinical cure, after treatment for a mean of 18-49 days with between 1-9 antibiotic regimens. Eight (53%) patients were cured with doxycycline plus moxifloxacin, two (100%) with doxycycline plus pristinamycin, three (75%) with minocycline alone, and three (75%) with prolonged minocycline plus tinidazole treatment.</p><p><strong>Conclusions: </strong>Despite frequent reinfection, most repeat positive tests represented persistent MG infections. All cases achieved cure after initial treatment failure, but many required multiple regimens over several weeks.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}