Sexually transmitted diseases最新文献

{"title":"Chlamydia and Gonorrhea Infections in Genital and Extragenital Samples Among Men and Women.","authors":"Kristal J Aaron, Charlotte A Gaydos, Edward W Hook, Max Chernesky, Jeanne Moncada, Stephanie N Taylor, Harold C Wiesenfeld, Kenneth H Mayer, Matthew R Golden, Alexander Boutwell, Barbara Van Der Pol","doi":"10.1097/OLQ.0000000000002154","DOIUrl":"10.1097/OLQ.0000000000002154","url":null,"abstract":"<p><strong>Background: </strong>For people who have anal and/or oral sex, many programs recommend genital and extragenital (defined here as anorectal and oropharyngeal) screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) to identify all potential sites of infection.</p><p><strong>Methods: </strong>We assessed genital and extragenital CT and NG prevalence among people reporting extragenital sexual exposure.</p><p><strong>Results: </strong>Among 343 gay and bisexual men who reported sex with men (GBMSM), 42 (12.2%) had CT with positivity of 3.5%, 9.3%, and 1.8% in the genital, anal, and oral samples, respectively. In this same group, 55 (16.0%) had NG with positivity of 5.2%, 8.5%, and 7.6% in the genital, anal, and oral samples, respectively. If only genital screening had been performed, 71.4% of CT infections and 67.3% of NG infections in GBMSM would have gone undetected. Among 96 men who only have sex with women (MSW), 10 (10.4%) had chlamydial infection-all detected in genital samples with no extragenital infections detected. Nine gonococcal infections (9.4%) were detected in MSW, with positivity of 6.3%, 2.1%, and 3.1% in the genital, anal, and oral samples, respectively. If only genital testing had been performed, no CT infections would have been missed among MSW; however, 33.3% of NG infections would have been missed. Among 329 cisgender women, 35 (10.6%) had CT with positivity of 7.9%, 6.1%, and 1.8% in the genital, anal, and oral samples, respectively. In the same group, 17 (5.2%) had NG with positivity of 4.0%, 2.1%, and 2.4% in the genital, anal, and oral samples, respectively. Among these women, 25.7% and 23.5% of CT and NG infections, respectively, would not have been detected.</p><p><strong>Conclusions: </strong>The increased case finding when including extragenital testing for GBMSM and women was confirmed in this analysis. However, the benefit-cost ratio and the clinical or public health value of extragenital screening in these different populations require further study.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":"597-602"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-exposure prophylaxis (PrEP) uptake among female sex workers in northern Nigeria: A qualitative study of barriers and facilitators.","authors":"Abubakar S Abubakar, Zubairu Iliyasu, Shaheeda L Farouk, Nafisat T Abdullahi, Bilkisu Z Iliyasu, Mary M Arrowsmith, Hamisu M Salihu, Muktar H Aliyu","doi":"10.1097/OLQ.0000000000002247","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002247","url":null,"abstract":"<p><strong>Background: </strong>Female sex workers (FSWs) in sub-Saharan Africa, including Nigeria, face disproportionately high risks of HIV acquisition. While oral pre-exposure prophylaxis (PrEP) is highly effective, its uptake among FSWs remains low, especially in conservative, high-stigma settings like northern Nigeria. This study explored the multilevel barriers and enablers influencing PrEP uptake among this key population.</p><p><strong>Methods: </strong>We conducted 13 semi-structured interviews, including 10 in-depth interviews with brothel-based and non-brothel-based FSWs and 3 key informant interviews with PrEP program implementers from One-Stop Shop clinics. Participants were purposively sampled across Kano metropolis. Using reflexive thematic analysis, guided by the Social Ecological Model, we examined individual, interpersonal, community, and structural factors influencing PrEP decision-making.</p><p><strong>Results: </strong>Barriers to PrEP uptake included limited awareness, misconceptions regarding antiretroviral therapy, concerns about side effects, partner stigma, and service access constraints. The visual similarity between PrEP and ART packaging reinforced stigma and fears of partner violence or rejection. Facilitators included peer-led sensitization, provider rapport, transport stipends, and decentralized community-based delivery. FSWs and implementers emphasized the need for discreet, long-acting PrEP options and identified brothel managers, intimate partners, and community health workers as key gatekeepers.</p><p><strong>Conclusions: </strong>PrEP uptake among FSWs in Nigeria is influenced by interconnected individual, social, and structural barriers. Enhancing uptake requires multi-level interventions, such as differentiated service delivery, stigma-sensitive packaging, and peer- and partner-engaged outreach. Integrating PrEP into trusted, accessible services tailored to the realities of FSWs' lives can improve equity and ensure the sustainability of HIV prevention efforts in similar high-burden settings.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to STD-2025-175: Letter to the Editor.","authors":"Keonte J Graves, Jan Novak, Hemant Tiwari, W Evan Secor, Peter Augostini, Christina A Muzny","doi":"10.1097/OLQ.0000000000002246","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002246","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rates of Follow-up Testing for Chlamydia Trachomatis and Neisseria Gonorrhoeae Among Active-Duty Service Members.","authors":"James J Marsh, David M Aleman-Reyes, Joseph E Marcus","doi":"10.1097/OLQ.0000000000002248","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002248","url":null,"abstract":"<p><strong>Background: </strong>Patients who test positive for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) should get retested to evaluate for reinfection. The United States military has previously been reported to have high rates of CT and GC, but follow-up rates are unknown. This study evaluates factors associated with follow-up CT or GC testing in active-duty service members (ADSM).</p><p><strong>Methods: </strong>Positive cases of CT and GC among ADSM who were stationed at Joint Base San Antonio between January and June 2023 were evaluated in a retrospective chart review. A patient had follow-up testing if they had a repeat test within 3-12 months after their initial positive test. Follow-up rates were compared among groups based on demographics, clinical setting of testing, and presence of symptoms.</p><p><strong>Results: </strong>Of the 200 ADSM who tested positive for CT or GC during the study period, 101 (51%) were men, and the median age was 23 [IQR: 20-26]. 140 (70%) were junior enlisted (E1-E4). Women received follow-up testing at a higher rate than men (71% vs. 51%; p = 0.003), without significant difference in follow-up testing by clinic, race, service, or organism. Women who were symptomatic at time of initial test had a significantly higher rate of follow-up testing than symptomatic men (76% vs. 49%; p = 0.003).</p><p><strong>Conclusions: </strong>Despite standardized follow-up testing recommendations, there were significantly lower follow-up testing rates in men, with the greatest difference in testing in patients who were symptomatic at presentation. Future work should standardize follow-up testing of CT or GC infections in men.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical performance of the CTGCTV2 assay for the BD COR™ system for detection of Chlamydia trachomatis and Neisseria gonorrhoeae from extragenital specimens.","authors":"Barbara Van Der Pol, Jordan Ippolito, Rachel Gao, Courtney Passow, Katherine Christensen","doi":"10.1097/OLQ.0000000000002244","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002244","url":null,"abstract":"<p><strong>Background: </strong>Extragenital (oropharyngeal and anorectal) Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (or gonococci [GC]) infections are underdiagnosed. Here we report sensitivity and specificity estimates that were obtained from the multiplex, PCR-based BD CTGCTV2 (CTGCTV2) assay, which simultaneously detects CT and GC from extragenital specimens on the high-throughput BD COR™ (COR) system.</p><p><strong>Methods: </strong>Testing on the index assay utilized remnant (collected during a predicate, registrational trial) oropharyngeal (n = 2,318) or anorectal (n = 2,292) specimens, stored in PreservCyt ThinPrep liquid-based cytology media, from sexually active individuals (≥15 years of age). A composite comparator algorithm (CCA) was utilized to define infectious status in the predicate study, which consisted of a two out of three agreement from FDA-cleared CT/GC molecular assays for a reference-positive or -negative result. Results obtained from the CT/GC assay on the COR were compared to the predefined CCA.</p><p><strong>Results: </strong>Testing for CT on COR had an estimated sensitivity of 100% [95% CI: 86.2, 100] and 97.7% [93.5, 99.2] from oropharyngeal and anorectal specimens, respectively. GC testing on COR resulted in sensitivity estimates of 92.8% [85.8, 96.5] and 95.8% [89.7, 98.4] from oropharyngeal and anorectal specimens, respectively. Specificity estimates for CT were 99.8% [99.5, 99.9] and 99.4% [99.0, 99.7], respectively. For GC, specificity estimates were 99.5% [99.1, 99.7] and 99.8% [99.5, 99.9] for oropharyngeal and anorectal specimens, respectively.</p><p><strong>Conclusions: </strong>CTGCTV2 performance on COR was accurate when testing oropharyngeal and anorectal specimens.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the need for creating ICD-10 codes to enhance monitoring of doxycycline postexposure prophylaxis prescriptions in the United States.","authors":"Guoyu Tao, Larry He, Chirag Patel, John Papp, Lindley A Barbee","doi":"10.1097/OLQ.0000000000002245","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002245","url":null,"abstract":"<p><strong>Background: </strong>In 2024, the Centers for Disease Control and Prevention (CDC) recommended postexposure prophylaxis with doxycycline (doxy PEP) within 72 hours after sex for men who have sex with men (MSM) and other selected populations diagnosed with one or more bacterial sexually transmitted infections (STIs) within the past 12 months. To determine if doxy PEP prescriptions can be identified using existing International Classification of Diseases, Tenth Revision (ICD-10) codes, we assessed utilization of several ICD-10 codes that document sexual behaviors and doxycycline prescriptions using a large electronic health record (EHR) dataset.</p><p><strong>Methods: </strong>We used 2018-2023 Truveta EHR data to analyze encounters indicating increased risk for HIV/ STI (ICD-10 codes: Z72.53 [high-risk bisexual behavior], Z72.52 [high-risk homosexual behavior], Z20.6 [exposure to HIV], Z20.2 [exposure to infections with a predominantly sexual mode of transmission], and Z29.81 [encounter for HIV preexposure prophylaxis]) among men aged 15-60 years and stratified by doxycycline prescription within 14 days of the encounter.</p><p><strong>Results: </strong>Among 428,023 encounters coded for increased risk of HIV/STI among men aged 15-60 years, 78.2% were coded as Z20.2, followed by 10.4% as Z20.6, 9.9% as Z72.52, 1.2% as Z72.53, and 0.3% as Z29.81. The proportion of those encounters with doxycycline prescriptions was 16.1%. Among 68,891 encounters with doxycycline prescriptions, top five ICD-10 codes associated an STI syndrome were: symptoms of genitourinary system (R30-R39, 28.7%), diseases of urinary system (N30-N39, 9.9%), chlamydia (A74.9, 2.6%), gonorrhea (A54.9, 1.5%), syphilis (A53.9, 1.2%), and top one with a non-STI syndrome was asthma (J45, 5.9%).</p><p><strong>Conclusion: </strong>Before CDC recommendations for doxy PEP, most encounters for potentially eligible patients were not explicitly among MSM, and doxycycline was prescribed broadly for various indications. A new ICD-10 code is needed for monitoring doxy PEP prescriptions with administrative data.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Serum Cytokine Levels Before and after Treatment.","authors":"Silver K Vargas, Kelika A Konda, E Michael Reyes-Diaz, Jazmin Qquellon, Francesca Vasquez, Carlos F Caceres, Jeffrey D Klausner","doi":"10.1097/OLQ.0000000000002243","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002243","url":null,"abstract":"<p><strong>Abstract: </strong>We analyzed cytokines pre-and-post treatment among syphilis patients to assess cure after treatment. HIV-status was associated with changes in Eotaxin and IL1RA levels. We found no relationship between cytokine levels and syphilis stage. Other molecules need to be assessed as potential early markers of treatment response.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unpacking DoxyPEP Safety.","authors":"Giancarlo Ceccarelli, Luca Bortolani, Valentina Bleve, Letizia Santinelli, Gabriella d'Ettorre","doi":"10.1097/OLQ.0000000000002238","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002238","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxycycline Post-Exposure Prophylaxis Update at CDPH STI Specialty Clinics, 2024.","authors":"Casey Morgan Luc, Michael Wasz, Reed Wagner, Nairobi Williamson, Msn Van Quach, David Kern, Tammy Rutledge, Irina Tabidze","doi":"10.1097/OLQ.0000000000002239","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002239","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Self-Reported Human Papillomavirus (HPV) Vaccination Uptake Among Patients at Chicago Sexually Transmitted Infections Specialty Clinics.","authors":"Grace Kadubek, Michael Wasz, Casey M Luc, Jaclyn Shallat, Msn Van Quach, David Kern, Tammy Rutledge, Irina Tabidze, Supriya D Mehta","doi":"10.1097/OLQ.0000000000002240","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002240","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) is a leading cause of six cancers. Despite effective vaccines, HPV vaccination rates remain suboptimal, standing at 26% of females and 9% of males, nationally in 2018. This study assessed factors associated with HPV vaccination uptake among patients at Chicago Department of Public Health (CDPH) STI Specialty Clinics.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted at two CDPH STI Clinics. Of 332 surveys collected, 246 were analyzed after excluding individuals missing HPV vaccination data or under 18 years of age. Bivariate and multivariable analyses were used to examine associations between HPV vaccination and sociodemographic factors, adjusting for sex, age, education, and sexual orientation.</p><p><strong>Results: </strong>HPV vaccination prevalence was higher among individuals assigned female-at-birth (65%) than male (46%). Male participants had a 36% lower prevalence of HPV vaccination compared to female at participants (adjusted PR: 0.64, 95% CI: 0.47-0.86). Age was inversely associated with HPV vaccination as the proportion of vaccination decreased with older age groups. Individuals with a high school education or less had a 37% lower prevalence of vaccination compared to individuals with a college degree or higher (aPR: 0.63 (0.40-0.99)). Individuals identifying as bisexual had a 18% higher and those identifying as gay or lesbian had a 51% higher prevalence of vaccination compared to heterosexual individuals ( aPR: 1.18(0.84-1.66), 1.51(1.07-2.12)).</p><p><strong>Conclusion: </strong>CDPH should prioritize HPV vaccination among individuals assigned male at-birth, aged 25 and older, with high school education or less, and reduce the coverage gap between heterosexual patients and those of a sexual minority.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}