Stamford Journal of Pharmaceutical Sciences最新文献_第6页

Social Life, Economic Status and Health care Delivery Practices of the People of Bede Community of Bangladesh: A Case Study 孟加拉国比德社区人民的社会生活、经济地位和保健服务实践:个案研究

Stamford Journal of Pharmaceutical Sciences Pub Date : 2010-08-12 DOI: 10.3329/SJPS.V2I2.5823

M. T. Hossain, M. H. Miazi, A. Ghani

{"title":"Social Life, Economic Status and Health care Delivery Practices of the People of Bede Community of Bangladesh: A Case Study","authors":"M. T. Hossain, M. H. Miazi, A. Ghani","doi":"10.3329/SJPS.V2I2.5823","DOIUrl":"https://doi.org/10.3329/SJPS.V2I2.5823","url":null,"abstract":"This study was conducted to observe the socio-economical status, living standard and health management practices of the people of the Bede community of Bangladesh. Bedes living in the Savar area of Dhaka district was selected for a case study. To conduct the study, data were obtained through a questionnairebased survey of 700 respondents about their social and economical status, professional practices, standard of living and literacy status, health management and treatment methods used. It has been observed that these mostly nomadic people of the Bede community have a weak socio-economic condition, large family size {(9-16 member family (58.22%); 17-24 member family (22.20%)}, intense smoking habit and a low level of literacy (80.00% people are illiterate). They practice ethno-medicine and snake-charming as their main professional business to earn a living. In offering health care services to people, they use medicaments prepared from various plant and animal parts and minerals and apply various ethno-treatment techniques, like spiritual, physical, mystical and psychological techniques to treat various ailments. Although they practice their age-old traditional system of medicine as their profession to treat others, they have been found to depend largely on Allopathic, Homeopathic and modern Traditional medicines for treating their own illness, particularly when they suffer from diarrhoea, dysentery, small pox, orthopedic problems, and even snake-bite, which is supposed to be their own specialty. Bedes live below the poverty line. Key words: Bede community; Social life; Health practices; Economic status DOI: 10.3329/sjps.v2i2.5823 Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 42-47","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"41 1","pages":"48-52"},"PeriodicalIF":0.0,"publicationDate":"2010-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75174044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxicity and Antifungal Activities of Root Bark of Calotropis gigantea 巨角牛蒡根皮的细胞毒性及抗真菌活性研究

Stamford Journal of Pharmaceutical Sciences Pub Date : 2010-08-12 DOI: 10.3329/SJPS.V2I2.2187

M. R. Habib, M. Alam, M. Haque, Farjana Nikkon, M. R. Karim

{"title":"Cytotoxicity and Antifungal Activities of Root Bark of Calotropis gigantea","authors":"M. R. Habib, M. Alam, M. Haque, Farjana Nikkon, M. R. Karim","doi":"10.3329/SJPS.V2I2.2187","DOIUrl":"https://doi.org/10.3329/SJPS.V2I2.2187","url":null,"abstract":"In this study, methanol extract from the root bark of Calotropis gigantea L. and its petroleum ether (40°C- 60°C), chloroform and ethyl acetate soluble fractions were tested for their cytotoxic activity against brine shrimp nauplii ( Artemia salina , Leach) and for antifungal activity against Aspergillus flavus , Aspergillus niger , Penicillium sp and Trichoderma harzianum . Thin layer chromatography (TLC) screening showed that methanol extract and its different fractions contained different type compounds such as steroid, terpene, glycoside, heterocyclic and flavonoid. In brine shrimp lethality bioassay, it was found that chloroform fraction was highly cytotoxic (LD 50 14.72 μg/ml) among the tested samples. Though methanol extract and ethyl acetate fraction have no activity against all the tested fungi but petroleum ether and chloroform fractions showed potent activity against Aspergillus niger , Penicillium sp, Trichoderma harzianum and Aspergillus niger , Trichoderma harzianum , respectively, in antifungal activity test. Key words: Calotropis gigantea ; Methanol extract; Antifungal activity; Cytotoxicty. DOI: 10.3329/sjps.v2i2.2187 Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 38-41","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"16 1","pages":"38-41"},"PeriodicalIF":0.0,"publicationDate":"2010-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75797055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effects of coating on the release profile of drug combination from hydrophilic matrix pellets 包衣对亲水性基质微丸联合用药释放特性的影响

Stamford Journal of Pharmaceutical Sciences Pub Date : 2010-08-12 DOI: 10.3329/SJPS.V2I2.5824

Muhammad Shahidul Islam, Md. Moniruzzaman, R. Rony, T. Haque

{"title":"Effects of coating on the release profile of drug combination from hydrophilic matrix pellets","authors":"Muhammad Shahidul Islam, Md. Moniruzzaman, R. Rony, T. Haque","doi":"10.3329/SJPS.V2I2.5824","DOIUrl":"https://doi.org/10.3329/SJPS.V2I2.5824","url":null,"abstract":"In this work zinc sulfate, ferrous sulfate and ascorbic acid was formulated on the same pellet by combination pelletization technique and their and in vitro dissolution studies were performed by using United States Pharmacopoeia (USP) apparatus type II. In addition, effect of different types of polymers, formulation variables and variations in coating composition on the release of drug were studied. The desired release profile for ferrous sulfate was 35% for 1st hour, 45-75% for 2nd hour and 60-85% for third hour and not less than 85% for 4th hour. The release rate controlling polymer used was various concentrations of Methoccel K15M CR with different concentrations of Microcrystalline cellulose (Avicel PH 101). The maximum release percentage of Ferrous Sulphate was obtained from 2.5 % of Methocel K15M CR and 30 % Avicel PH 101 containing pellets (F-4) and it was 92.32%. And the minimum release percentage of Ferrous Sulphate was obtained from 10 % of Methocel K15M CR and 35.7% Avicel PH 101 containing pellets (F-1) and it was 86.36%. The release profile from other formulations containing 35.4% Methocel K 15M CR & 7.5% Avicel (F-2) and 32% Methocel K 15M CR & 4% Avicel (F-3) were also within desired range. The effect of Eudragit coating (enteric) and the presence of PEG and HPMC in the film coating composition on the drug release were also investigated. Hydrophobic matrix pellets prepared using lower concentrations of Methocel K15M CR were found to be best suited for modulating the delivery of the ferrous sulphate from the combination. Key words: Non Pariel Seeds (NPS); Pan Coater; Ascorbic acid; Methocel K15M CR; Pelletization; PEG; Avicel PH 101; Xanthan gum. DOI: 10.3329/sjps.v2i2.5824 Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 53-58","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"4 5","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2010-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91547375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Development and Validation of Rapid and Sensitive HPLC Method for the Determination of Methotrexate in Human Serum 高效液相色谱法测定人血清中甲氨蝶呤的快速、灵敏方法的建立与验证

Stamford Journal of Pharmaceutical Sciences Pub Date : 2010-08-12 DOI: 10.3329/SJPS.V2I1.1693

M. Nagulu, V. Kiran, Y. N. Reddy, D. Krishna

{"title":"Development and Validation of Rapid and Sensitive HPLC Method for the Determination of Methotrexate in Human Serum","authors":"M. Nagulu, V. Kiran, Y. N. Reddy, D. Krishna","doi":"10.3329/SJPS.V2I1.1693","DOIUrl":"https://doi.org/10.3329/SJPS.V2I1.1693","url":null,"abstract":"Methotrexate competitively inhibits dihydrofolic acid reductase and thereby inhibits DNA synthesis and cellular replication.This study describes a simple and fast high-performance liquid chromatography method for the determination of methotrexate [MTX] in serum.samples were collected from adult cancer patients receiving high dose MTX at Mahathma Gandhi Memorial hospital (Warangal,AP.India) at various time intervals after the end of each infusion. Serum was deproteinized with trichloroacetic acid and the supernatant was injected into a 250×4.6 mm octadecylsilane column. Mobile phase was made of TRIS-phosphate buffer (pH 5.7): methanol: acetonitrile (70:20:10) with a flow rate of 1ml/min. Ultraviolet detection was done at 313 nm and at ambient temperature. Para aminoacetophenone was used as internal standard. Methotrexate and internal standard retention times were 4.6 and 9.5 minutes, respectively. Results showed that reproducibility (precision) of method within a day was 2.6 to 6 percent and between days was 5.5 to 9.5 percent. The recovery of the method was between 61.5 and 72.7 percent. The quantitation limit of the method for methotrexate was 0.1μM. This method is suitable for quantitation of methotrexate after infusion of high doses of this drug and has good accuracy, precision and quantitation limit. Key Words: Methotrexate; HPLC; Serum Concentration. DOI: 10.3329/sjps.v2i1.1693 Stamford Journal of Pharmaceutical Sciences Vol.2(1) 2009: 8-13","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"20 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2010-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87380862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Estimation of Manganese, Zinc and Copper in Multimineral Preparation Containing Vitamins: A Complexometric Approach 含维生素的复合矿物质制剂中锰、锌和铜的络合测定方法

Stamford Journal of Pharmaceutical Sciences Pub Date : 2010-08-12 DOI: 10.3329/SJPS.V2I2.5820

M. Basher, R. Banoo, S. Haque

引用次数: 1

Infrared spectroscopic characterization, free radical scavenging and cytotoxic evaluation of chitosan extracted from Penaeus monodon shells 单对虾壳聚糖的红外光谱表征、自由基清除及细胞毒性评价

Stamford Journal of Pharmaceutical Sciences Pub Date : 2010-08-12 DOI: 10.3329/SJPS.V2I2.5821

S. Chowdhury, Md Al-Amin, M. Jamila, Samiul Haque, Taksim Ahmed, Mohammed Ehsanul Hoque Mazumder

{"title":"Infrared spectroscopic characterization, free radical scavenging and cytotoxic evaluation of chitosan extracted from Penaeus monodon shells","authors":"S. Chowdhury, Md Al-Amin, M. Jamila, Samiul Haque, Taksim Ahmed, Mohammed Ehsanul Hoque Mazumder","doi":"10.3329/SJPS.V2I2.5821","DOIUrl":"https://doi.org/10.3329/SJPS.V2I2.5821","url":null,"abstract":"Chitosans are naturally occurring biologically safe and non-toxic polymer of polysaccharides. In the present study, Chitosan [(1-4) 2-amino-2-deoxy-β-D-glucan] was extracted from the exoskeleton of Black Tiger ( Penaeus monodon ) shrimp shells by alkaline deacetylation of chitin. Three different chitosan extracts, coded as Chito A (3.33% w/w), Chito B (4.01% w/w) and Chito C (3.45% w/w) were extracted using 3%, 4% and 5% w/v concentrations of HCl as decalcifiers respectively. Physicochemical properties such as appearance, odor, insolubility and pH of all the extracts were found to comply with the compendial specifications of pharmaceutical grade chitosan. Qualitative identification of the samples was carried out using Infrared (IR) spectroscopy. Major peaks of the extracts matched with reference IR spectrum of standard chitosan. Extracted chitosans were found lacking cytotoxicity in brine shrimp lethality bioassay. All the extracts showed strong antioxidant activity in DPPH free radical scavenging assay and the IC 50 values were found to be 37 ± 2 μg/mL (Chito A), 35 ± 1 μg/mL (Chito B) and 30 ± 2 μg/mL (Chito C) while the standard antioxidant Quercetin showed an IC 50 value of 15 ± 2 μg/mL. Key words: Chitosan; Black Tiger ( Penaeus monodon ) shrimp shells; deacetylation of chitin; IR spectroscopy; cytotoxicity; DPPH; free radical scavenging. DOI: 10.3329/sjps.v2i2.5821 Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 27-30","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"1 1","pages":"27-30"},"PeriodicalIF":0.0,"publicationDate":"2010-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89125558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Synthesis, anticonvulsant activity and in silico study of some novel amino acids incorporated bicyclo compounds 一些新型氨基酸结合双环化合物的合成、抗惊厥活性及硅研究

Stamford Journal of Pharmaceutical Sciences Pub Date : 2010-08-12 DOI: 10.3329/SJPS.V2I2.2607

C. Sharma, R. Nema, V. Sharma

引用次数: 12

In-vitro Cytotoxicity and Antioxidant Studies of Elaeocarpus serratus 锯柏的体外细胞毒性和抗氧化研究

Stamford Journal of Pharmaceutical Sciences Pub Date : 2010-08-12 DOI: 10.3329/SJPS.V2I2.5829

Most. Nazma Parvin, Shammy Sarwar, S. Chowdhury, H. Zakaria, N. Huda

{"title":"In-vitro Cytotoxicity and Antioxidant Studies of Elaeocarpus serratus","authors":"Most. Nazma Parvin, Shammy Sarwar, S. Chowdhury, H. Zakaria, N. Huda","doi":"10.3329/SJPS.V2I2.5829","DOIUrl":"https://doi.org/10.3329/SJPS.V2I2.5829","url":null,"abstract":"The pet-ether soluble fraction (PEF), Carbon tetrachloride soluble fraction (CTSF) and Chloroform soluble fraction (CFSF) of the methanolic extract of stem bark of Elaeocarpus serratus were investigated for cytotoxic activity using brine shrimp lethality bioassay .The methanolic extract was also evaluated for possible antioxidant activity using nitric oxide scavenging activity and reducing power assays. In Elaeocarpus serratus , the LC 50 value were found to be 14.94, 0.831 & 3.288 μg/mL in pet-ether soluble fraction (PEF), Carbon tetrachloride soluble fraction (CTSF) and Chloroform soluble fraction (CFSF) of the methanolic extract respectively. The extract showed significant antioxidant activity in nitric oxide scavenging activity and reducing power assay. In nitric oxide scavenging activity, the IC 50 value of Elaeocarpus serratus extract was 89.325μg/mL while the IC 50 value of ascorbic acid was 47.684μg/mL. It was found that scavenging of nitric oxide by the extract was concentration dependent. Key words: Elaeocarpus serratus ; Cytotoxicity; Antioxidant; Reducing power. DOI: 10.3329/sjps.v2i2.5829 Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 86-90","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"1 1","pages":"86-90"},"PeriodicalIF":0.0,"publicationDate":"2010-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81983630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Evaluation of analgesic and neuropharmacological properties of the aerial part of Tinospora cordifolia Miers. in mice 堇青花地上部镇痛及神经药理作用的评价。在老鼠身上

Stamford Journal of Pharmaceutical Sciences Pub Date : 2010-08-12 DOI: 10.3329/SJPS.V2I2.5822

Mokarram Hossain, S. Hasan, R. Akter, Md Nurul Islam, Md Jahidur Rashid, M. Saha, Md. Ehsanul Hoque Mazumder, S. Rana

{"title":"Evaluation of analgesic and neuropharmacological properties of the aerial part of Tinospora cordifolia Miers. in mice","authors":"Mokarram Hossain, S. Hasan, R. Akter, Md Nurul Islam, Md Jahidur Rashid, M. Saha, Md. Ehsanul Hoque Mazumder, S. Rana","doi":"10.3329/SJPS.V2I2.5822","DOIUrl":"https://doi.org/10.3329/SJPS.V2I2.5822","url":null,"abstract":"Tinospora cordifolia Miers. is used in the Ayurvedic system of medicine for the treatment of jaundice, diabetes, and rheumatoid arthritis, and is also used as memory enhancer. But still there is no report of analgesic and neuropharmacological activities of the plant. For this reason, the present study was designed to evaluate analgesic and neuropharmacological activities of methanol extract of the aerial parts of Tinospora cordifolia . Analgesic activity of the crude extract at the dose of 200 and 400 mg/kg b.w. was evaluated for its central and peripheral pharmacological actions using hotplate and tail flick tests and acetic acid-induced writhing test respectively in mice. The extract produced a significant (p < 0.05-0.001) increase in pain threshold in hotplate and tail flick tests in a dose dependent manner. In acetic acid-induced writhing test the extract at both doses produced significant (p < 0.001) inhibition of writhing reaction but maximum inhibition (65.01%) of writhing was found at 400 mg/kg dose compared to the reference drug Diclofenac-Na at the dose of 10 mg/kg b.w. (77.07%). Neuropharmacological activity of the extract was also evaluated using rodent behabioural models; hole cross to evaluate motor activity, open field to evaluate exploratory behaviour and thiopental sodium-induced sleeping time to evaluate sedative potential of the extract. The extract significantly (p < 0.05-0.001) decreased motor activity and exploratory behavior of mice in hole cross and open field test respectively. The extract also produced rapid onset and maximized the duration of sleeping time when administered with thiopental sodium. Results of this study suggest that the aerial part of T. cordifolia possesses significant analgesic and CNS depressant activity. Key words: Tinospora cordifolia ; Menispermaceae; Analgesic; Neuropharmacological. DOI: 10.3329/sjps.v2i2.5822 Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 31-37","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"16 1","pages":"31-37"},"PeriodicalIF":0.0,"publicationDate":"2010-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89081058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

In-vitro Antioxidant and Cytotoxicity Studies of Annona squamosa Linn. 番荔枝体外抗氧化及细胞毒性研究。

Stamford Journal of Pharmaceutical Sciences Pub Date : 2010-08-12 DOI: 10.3329/SJPS.V2I1.5813

I. J. Biva, M. Vhuiyan, M. Saha, M. Islam, Shammy Sarwar

引用次数: 5