{"title":"一些新型氨基酸结合双环化合物的合成、抗惊厥活性及硅研究","authors":"C. Sharma, R. Nema, V. Sharma","doi":"10.3329/SJPS.V2I2.2607","DOIUrl":null,"url":null,"abstract":"In the present study, some novel amino acids incorporated bicyclo compounds have been synthesized and their structure was confirmed by physico-chemical and spectral data. The title compounds were evaluated for in silico toxicity study and anticonvulsant activity by maximal electric shock method. The results showed that substitution with cysteine and glutamic acid moiety was found to increase the activity. In silico toxicity study results showed that the compounds are free of toxicity in neurotoxicity, irritability, sensitivity, immunotoxicity and oncogenecity Key words: Maximal electrical shock method; anticonvulsant activity; in silico toxicity. DOI: 10.3329/sjps.v2i2.2607 Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 42-47","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"11 1","pages":"42-47"},"PeriodicalIF":0.0000,"publicationDate":"2010-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":"{\"title\":\"Synthesis, anticonvulsant activity and in silico study of some novel amino acids incorporated bicyclo compounds\",\"authors\":\"C. Sharma, R. Nema, V. Sharma\",\"doi\":\"10.3329/SJPS.V2I2.2607\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In the present study, some novel amino acids incorporated bicyclo compounds have been synthesized and their structure was confirmed by physico-chemical and spectral data. The title compounds were evaluated for in silico toxicity study and anticonvulsant activity by maximal electric shock method. The results showed that substitution with cysteine and glutamic acid moiety was found to increase the activity. In silico toxicity study results showed that the compounds are free of toxicity in neurotoxicity, irritability, sensitivity, immunotoxicity and oncogenecity Key words: Maximal electrical shock method; anticonvulsant activity; in silico toxicity. DOI: 10.3329/sjps.v2i2.2607 Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 42-47\",\"PeriodicalId\":21823,\"journal\":{\"name\":\"Stamford Journal of Pharmaceutical Sciences\",\"volume\":\"11 1\",\"pages\":\"42-47\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Stamford Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3329/SJPS.V2I2.2607\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stamford Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/SJPS.V2I2.2607","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis, anticonvulsant activity and in silico study of some novel amino acids incorporated bicyclo compounds
In the present study, some novel amino acids incorporated bicyclo compounds have been synthesized and their structure was confirmed by physico-chemical and spectral data. The title compounds were evaluated for in silico toxicity study and anticonvulsant activity by maximal electric shock method. The results showed that substitution with cysteine and glutamic acid moiety was found to increase the activity. In silico toxicity study results showed that the compounds are free of toxicity in neurotoxicity, irritability, sensitivity, immunotoxicity and oncogenecity Key words: Maximal electrical shock method; anticonvulsant activity; in silico toxicity. DOI: 10.3329/sjps.v2i2.2607 Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 42-47
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