Stamford Journal of Pharmaceutical Sciences最新文献_第5页

Comparative Antioxidant Potential of Different Extracts of Celastrus paniculatus Willd. Seed 茴香不同提取物抗氧化活性的比较。种子

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-01-10 DOI: 10.3329/SJPS.V3I1.6802

Fatema Tuz Zohera, R. Habib, M. Z. Imam, Ehsanul Hoque Mazumder, S. Rana

{"title":"Comparative Antioxidant Potential of Different Extracts of Celastrus paniculatus Willd. Seed","authors":"Fatema Tuz Zohera, R. Habib, M. Z. Imam, Ehsanul Hoque Mazumder, S. Rana","doi":"10.3329/SJPS.V3I1.6802","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.6802","url":null,"abstract":"The objective of the present study was to evaluate the comparative antioxidant potential of methanol, ethyl acetate, pet ether and water extracts of Celastrus paniculatus seed. Antioxidant activity was evaluated by using total phenol and flavonoid content determination assays, total antioxidant capacity, 1,1-diphenyl-2- picryl-hydrazil (DPPH) free radical assay, Reducing power assessment, Nitric oxide (NO) scavenging assay and Cupric ion reducing capacity assay (CUPRAC method). The extracts showed moderate antioxidant activity in a dose dependent manner. The extracts were found to contain phenolics and flavonoid compounds. In DPPH radical scavenging assay, ethyl acetate extract had the lowest IC 50 value (585.58μg/ml) compared to ascorbic acid. In nitric oxide scavenging assay IC 50 value was found to be 122.99μg/ml, 320.54μg/ml, 601.81μg/ml and 206.37μg/ml respectively for the Water, Methanol, Ethyl Acetate and Pet Ether extracts compared to 6.83μg/ml which was the IC 50 value for the reference ascorbic acid. The extracts also showed good reducing power. The results of the present study indicate that the extracts possesses significant antioxidant potential of which ethyl acetate extract is the most promising one and possess highest antioxidant potential. Key Words: Celastrus paniculatus ; antioxidant; DPPH; NO scavenging; CUPRAC; ROS. DOI: 10.3329/sjps.v3i1.6802 S. J. Pharm. Sci. 3(1): 68-74","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"1 1","pages":"68-74"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89290702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Antioxidant, Antimicrobial and Cytotoxic Activities of Samanea saman (Jacq.) Merr. 沙曼草抗氧化、抗菌和细胞毒活性研究稳定。

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-01-10 DOI: 10.3329/SJPS.V3I1.6792

A. Ferdous, M. Z. Imam, Tajnin Ahmed

{"title":"Antioxidant, Antimicrobial and Cytotoxic Activities of Samanea saman (Jacq.) Merr.","authors":"A. Ferdous, M. Z. Imam, Tajnin Ahmed","doi":"10.3329/SJPS.V3I1.6792","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.6792","url":null,"abstract":"In the present investigation the n-hexane, carbon tetrachloride and choloroform soluble fractions of crude methanolic extract of Samanea saman bark were tested for antioxidant, antimicrobial and cytotoxic potential. Antioxidant activity of the extracts was evaluated by DPPH radical scavenging assay and total antioxidant activity test. Antimicrobial activity was tested using disc diffusion method against thirteen bacteria and three fungi and cytotoxicity was tested by brine shrimp lethality bioassay. Chloroform and hexane soluble fraction showed IC 50 value of 12μg/ml and 14μg/ml respectively in scavenging DPPH radical while the reference Butylated hydroxytoluene showed an IC 50 value of 10μg/ml. The carbon tetrachloride fraction showed the highest total antioxidant capacity. The carbon tetrachloride fraction was also found to possess mild to moderate microbial growth inhibitory capacity. In the brine shrimp lethality bioassay, the n-hexane, carbon tetrachloride, chloroform soluble fractions showed LC 50 value of 14.94μg/ml, 0.831μg/ml and 3.288μg/ml respectively. The results suggest good antioxidant and cytotoxic potential of chloroform and hexane soluble fractions and antimicrobial activity of carbon tetrachloride fraction of Samanea saman bark extract. Key Words: Samanea saman ; Leguminoseae; Cytotoxicity; Antimicrobial; Antioxidant; Total antioxidant capacity. DOI: 10.3329/sjps.v3i1.6792 S. J. Pharm. Sci. 3(1): 11-17","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"18 1","pages":"11-17"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78063165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Patients' Knowledge and Awareness towards Use of Antibiotics in Bangladesh: A Cross-sectional Study Conducted in Three Tertiary Healthcare Centers in Bangladesh 孟加拉国患者对抗生素使用的知识和意识:在孟加拉国三个三级医疗保健中心进行的横断面研究

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-01-10 DOI: 10.3329/SJPS.V3I1.6799

M. Saha, Shammy Sarwar, M. Shill, M. Shahriar

{"title":"Patients' Knowledge and Awareness towards Use of Antibiotics in Bangladesh: A Cross-sectional Study Conducted in Three Tertiary Healthcare Centers in Bangladesh","authors":"M. Saha, Shammy Sarwar, M. Shill, M. Shahriar","doi":"10.3329/SJPS.V3I1.6799","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.6799","url":null,"abstract":"This study is aimed to estimate general knowledge and awareness of patients regarding use of antibiotics to find out possible reasons of irrational use of antibiotics in Bangladesh. It was a questionnaire based crosssectional health survey conducted on 350 subjects aged 18 or over who came to get service at three tertiary healthcare centers named Dhaka Medical College (DMC) Hospital, Sir Salimullah Medical College (SSMC) Mitford Hospital and Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital of Dhaka, Bangladesh. It was found from the study that the general knowledge of the patients about the indication of antibiotics was very poor. Majority of the patients did not know the appropriate use of antibiotics. Only 26% respondents answered correctly that antibiotics are indicated for bacterial infections. In addition, 38.97% of them also did not know that an antibiotic is a prescription drug and should not be used without doctor’s prescription. The awareness about the patients towards use of antibiotics was also poor. A very high percentage of the patients (51.71%) answered that they do not complete the full course of therapy. Surprisingly, 39.14% of the patients replied that they stop antibiotics when the symptoms disappear and remarkably 14.29% just make the dose double if they forget to take due dose. On the other hand, 28.86% of the patients said that they do not maintain dosing schedule during the course of therapy. Moreover, prevalence of self-medication with antibiotics in cold and fever was also extremely high (60.86%). This study indicates that there is an urgent need of health education for the community to increase knowledge and awareness about use of antibiotics to decrease the self-medication and inappropriate use of antibiotics. Key words: Antibiotics; General Knowledge; Awareness; Tertiary Healthcare Center; Health Education DOI: 10.3329/sjps.v3i1.6799 S. J. Pharm. Sci. 3(1): 54-58","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"1 1","pages":"54-58"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73210964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Chemical Constituents and Pharmacological Properties of Capsule Gurmar - A New Anti-diabetic Formulation of Hamdard Laboratories (Waqf) Bangladesh Gurmar胶囊的化学成分和药理特性-孟加拉国Hamdard实验室(Waqf)的一种新型抗糖尿病制剂

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-01-10 DOI: 10.3329/SJPS.V3I1.6794

M. Afroze, Mridul Kabiraz, R. Islam, A. Ghani

引用次数: 2

Biological Investigations of Dried Fruit of Solanum nigrum Linn. 龙葵干果的生物学研究。

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-01-10 DOI: 10.3329/SJPS.V3I1.6796

U. Karmakar, Uttam Kumar Tarafder, S. K. Sadhu, N. N. Biswas, M. Shill

{"title":"Biological Investigations of Dried Fruit of Solanum nigrum Linn.","authors":"U. Karmakar, Uttam Kumar Tarafder, S. K. Sadhu, N. N. Biswas, M. Shill","doi":"10.3329/SJPS.V3I1.6796","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.6796","url":null,"abstract":"The ethanolic extract of the dried fruit of Solanum nigrum Linn. (Family: Solanaceae) was assessed for its possible analgesic, antidiarrhoeal, antimicrobial, antioxidant and cytotoxic activity. Phytochemical screening of the ethanolic extract revealed the presence of carbohydrate, alkaloids, tannins, saponins, steroids, glycosides, and gums. In acetic acid induced writhing in mice, the ethanolic extract (250 and 500mg/kg) exhibited significant (p<0.05 & p<0.01) inhibition of writhing reflex 51.39% and 66.67% respectively compared to standard diclofenac sodium. The fruit extract showed a significant (P<0.01 and P<0.001) antidiarrhoeal activity against castor oil induce diarrhoea in mice in which it decreased the frequency of defecation and increased the mean latent period at the dose of 250mg/kg and 500mg/kg body weight. The ethanolic extract showed moderate antibacterial activity against both gram-positive and gram-negative bacteria. In the qualitative antioxidant assay using DPPH (1, 1-diphenyl-2-picryl hydrazyl) the extract showed free radical scavenging properties. In the brine shrimp lethality test, the extract showed cytotoxicity significantly with LC 50 = 63.10μg/ml and LC 90 = 160μg/ml. All the results tend to justify the traditional uses of the plant and require further investigation to identify the chemicals responsible for these effects. Key words: Solanum nigrum Linn; analgesic activity; antidiarrheal activity; antimicrobial activity; antioxidant activity; cytotoxic activity. DOI: 10.3329/sjps.v3i1.6796 S. J. Pharm. Sci. 3(1): 38-45","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"7 1","pages":"38-45"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89657992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

RP-HPLC Method for Simultaneous Estimation of Amlodipine Besylate and Hydrochlorothiazide in Combined Dosage Forms 反相高效液相色谱法同时测定苯磺酸氨氯地平和氢氯噻嗪复方剂型的含量

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-01-10 DOI: 10.3329/SJPS.V3I1.6798

G. Patel, Sanjay Patel, Dharmesh Prajapati, R. Mehta, South Jordan

{"title":"RP-HPLC Method for Simultaneous Estimation of Amlodipine Besylate and Hydrochlorothiazide in Combined Dosage Forms","authors":"G. Patel, Sanjay Patel, Dharmesh Prajapati, R. Mehta, South Jordan","doi":"10.3329/SJPS.V3I1.6798","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.6798","url":null,"abstract":"A reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous estimation of Amlodipine Besylate and Hydrochlorothiazide in combine dosage form. Amlodipine Besylate (AML) is a long acting calcium channel blocker and in the treatment of CVS disorder. Hydrochlorothiazide (HCT) is a diuretic and antihypertensive. The mobile phase used was a combination of Water: Methanol (70:30). The detection of the combined dosage form was carried out at 245nm and a flow rate employd was 0.5ml/min. The retention time for Amlodipine Besylate and Hydrochlorothiazide was found to be 6.95 and 2.65 min respectively. Linearity was obtained in the concentration range of 6 to 18μg/ml of Amlodipine Besylate and 6 to 18μg/ml of Hydrochlorothiazide with a correlation coefficient of 0.997 and 0.9974. Detector consists of photodiode array detector; the reversed phase column used was RP-C 18 (5 μm size, 250mm, 4.6mm i.d.) at ambient temperature. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method is precise, selective and rapid for simultaneous estimation of Amlodipine Besylate and Hydrochlorothiazide in routine analysis. Key Words: Simultaneous Estimation; Amlodipine Besylate; Hydrochlorothiazide; HPLC. DOI: 10.3329/sjps.v3i1.6798 S. J. Pharm. Sci. 3(1): 49-53","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"128 1","pages":"49-53"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88198176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Assessment of Dissolution Profile of Aceclofenac Tablets Available in Bangladesh 孟加拉市售乙酰氯芬酸片溶出度评估

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-01-10 DOI: 10.3329/SJPS.V3I1.6790

Tajnin Ahmed, A. Ferdous, S. Biswas, F. Sharif

引用次数: 3

Simultaneous Spectrophotometric Estimation and Validation of Domperidone, Tramadol Hydrochloride and Acetaminophen in Tablet Dosage Form 片剂剂型中多潘立酮、盐酸曲马多和对乙酰氨基酚的同时分光光度法测定与验证

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-01-10 DOI: 10.3329/SJPS.V3I1.2655

Vikas Jain, Rajesh Sharma

{"title":"Simultaneous Spectrophotometric Estimation and Validation of Domperidone, Tramadol Hydrochloride and Acetaminophen in Tablet Dosage Form","authors":"Vikas Jain, Rajesh Sharma","doi":"10.3329/SJPS.V3I1.2655","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.2655","url":null,"abstract":"Simultaneous estimation of active ingredients in multi-component pharmaceutical products normally requires the use of separation techniques, such as HPLC, HPTLC or GC, followed by their quantitation. Presented here are two spectrophotometric methods that do not require prior separation for simultaneous estimation of three drugs; acetaminophen, tramadol hydrochloride and domperidone in a tablet formulation. Shimadzu UV 1700 capable of multi-component analysis was used for quantitation. Method A is based on the simultaneous equation and method B on the multi-component analysis. The absorption maxima of the drugs found to be at 244nm, 271.5nm and 284.5nm respectively for acetaminophen, tramadol hydrochloride and domperidone in methanol/0.1 N HCl (1:2) solvent mixture. Acetaminophen, tramadol hydrochloride and domperidone obeyed Beer's law in the concentration range of 2-22 μg/ml, 10-55 μg/ml and 30-300 μg/ml respectively. The simultaneous equation method is based on the additivity of absorbances and multi-component analysis involves recording of absorbances of standard solutions at 244nm, 250nm, 271.5nm and 284.5nm. These were processed by means of statistical calculations and results of sample solution were obtained. Result of analysis for both methods were tested and validated for various parameters according to ICH guidelines. Key Words: simultaneous equation method; multicomponent analysis; acetaminophen; tramadol hydrochloride; domperidone. DOI: 10.3329/sjps.v3i1.2655 S. J. Pharm. Sci. 3(1): 28-33","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"1 1","pages":"28-33"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86395450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Current Status of Antimicrobial Sensitivity Pattern of Streptococcus pneumonia Strains Collected from Clinical Sources in Dhaka, Bangladesh 孟加拉国达卡临床来源肺炎链球菌的抗菌药物敏感性模式现状

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-01-10 DOI: 10.3329/SJPS.V3I1.6800

M. Shahriar, Manasi Madak, A. Haque, Shaila Kabir, M. Saha

{"title":"Current Status of Antimicrobial Sensitivity Pattern of Streptococcus pneumonia Strains Collected from Clinical Sources in Dhaka, Bangladesh","authors":"M. Shahriar, Manasi Madak, A. Haque, Shaila Kabir, M. Saha","doi":"10.3329/SJPS.V3I1.6800","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.6800","url":null,"abstract":"A study of antimicrobial sensitivity of Streptococcus pneumoniae strains from clinical specimens was carried out to facilitate the preference of antimicrobial drugs in the management of S. pneumoniae induced infections. The duration of the study was about 12 months starting from March 2009 to March 2010. The results of the study show that tetracycline and chloramphenicol had a low sensitivity (20% and 22%, respectively) to S. pneumoniae while a moderate sensitivity was found for azithromycin (50%), erythromycin (54%), cotrimoxazole (58%), cefuroxime (62%), and cefaclor (62%). However, the highest sensitivity was observed for ceftriaxone (92%) followed by levofloxacin (74%) and ceftazidime (70%). This study reveals the growing antimicrobial resistance in Bangladesh and refers not to use the antimicrobial drugs that show insufficient sensitivity against S. pneumoniae to prevent resistance and associated treatment failure. Key words: Streptococcus pneumoniae ; antimicrobial sensitivity; clinical isolates. DOI: 10.3329/sjps.v3i1.6800 S. J. Pharm. Sci. 3(1): 59-62","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"40 1","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86333027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Development of UV Spectroscopic Method for Nefopam and Escitalopram as INN Drugs in Tablet Dosage Form 奈福泮和艾司西酞普兰片剂的紫外光谱分析方法的建立

Stamford Journal of Pharmaceutical Sciences Pub Date : 2011-01-10 DOI: 10.3329/SJPS.V3I1.6791

K. Fatema, Zakiur Rahman, S. Biswas, S. Akter

{"title":"Development of UV Spectroscopic Method for Nefopam and Escitalopram as INN Drugs in Tablet Dosage Form","authors":"K. Fatema, Zakiur Rahman, S. Biswas, S. Akter","doi":"10.3329/SJPS.V3I1.6791","DOIUrl":"https://doi.org/10.3329/SJPS.V3I1.6791","url":null,"abstract":"Nefopam and Escitalopram are INN drugs and as such it has not been yet included in the BP or USP. The objective of this work is to develop a simple, sensitive, accurate, precise and reproducible UVSpectrophotometric method for quantitative estimation of Nefopam and Escitalopram in tablet dosage forms. Various solvents were used to find out the medium for maximum solubility of each drug. The χ max of Nefopam and Escitalopram was 266nm and 284nm in water respectively. Both drugs obey Beer- Lambert’s law in the range of 50-400μg/ml for Nefopam and 25-200μg/ml for Escitalopram. The correlation coefficients of std. curves were 0.998 and 0.995. The values of SD were 0.131 and 0.081 respectively. %RSD (Relative standard deviation) of interday absorbance of Nefopam was 0.766 and Escitalopram was 0.854. The LOD (Limit of Detection) were 0.393 and 0.243 and LOQ (Limit of Quantification) were 1.310 and 0.810 respectively. The percent potencies were 92.16 and 102.06 for Nefopam and Escitalopram. The potency of these tablets complied with their claimed quantity (±10%). So, based on these data, it may be concluded that these proposed method are simple, sensitive, precise, reproducible and accurate for the analysis of these drugs in tablet dosage form. Key Words: INN drugs; correlation coefficients; LOD; LOQ; Nefopam; Escitalopram. DOI: 10.3329/sjps.v3i1.6791 S. J. Pharm. Sci. 3(1): 4-10","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"72 1","pages":"4-10"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87843653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9