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引用次数: 3
摘要
本研究的目的是通过对已上市的乙酰氯芬酸片剂配方的溶出度数据应用概况比较方法来找出品牌间的差异。采用USP标准溶出度仪对市售5个品牌的乙酰氯芬酸片在pH 6.8的模拟肠道介质中60分钟的时间进行研究。4个样品符合USP体外释放度标准(60分钟溶出不少于乙酰氯芬酸标记量的80%)。1个品牌(代码:S1)不符合标准;规定时限内释药率为66.85%。关键词:孟加拉国;体外溶出度;市场准备工作;aceclofenac;平板电脑。DOI: 10.3329/sjps.v3i1.6790 S. J. Pharm。科学3(1):1-3
Assessment of Dissolution Profile of Aceclofenac Tablets Available in Bangladesh
The objective of this work is to find out brand-to-brand variation by applying profile comparison approaches to the dissolution data of marketed aceclofenac tablet formulations. Commercially available five brands of aceclofenac tablets were studied in simulated intestinal medium (pH 6.8) for 60 minutes time period using USP reference dissolution apparatus. Four samples complied with the USP in vitro dissolution specifications for drug release (not less than 80% of the labeled amount of Aceclofenac should be dissolved in 60 minutes). One brand (Code: S1) failed to meet the criteria; drug release was 66.85% within the specified time period. Key words: Bangladesh; In vitro dissolution; market preparations; aceclofenac; tablet. DOI: 10.3329/sjps.v3i1.6790 S. J. Pharm. Sci. 3(1): 1-3
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