Seminars in perinatology最新文献_第6页

Infections during pregnancy: An ongoing threat 妊娠期感染：持续威胁。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-06-01 DOI: 10.1016/j.semperi.2025.152075

Claudia Fernandes Lorea , Katherine Pressman , Lavinia Schuler-Faccini

{"title":"Infections during pregnancy: An ongoing threat","authors":"Claudia Fernandes Lorea , Katherine Pressman , Lavinia Schuler-Faccini","doi":"10.1016/j.semperi.2025.152075","DOIUrl":"10.1016/j.semperi.2025.152075","url":null,"abstract":"<div><div>Congenital infections are an ongoing relevant cause of congenital and perinatal abnormalities since effective vaccination is not available for many diseases. Moreover, climate change, mutational evolution of pathogens, or their vectors associated with intense human traveling predispose to outbreaks and modification of the geographic distribution of traditionally limited infectious diseases. Here, we review the so-called TORCH infections (toxoplasmosis, others, rubella, cytomegalovirus, herpes) with a special emphasis on the arboviral infections (zika, dengue, chikungunya, oropouche). Although respiratory viruses are rarely transmitted through the placenta, the maternal condition itself can cause adverse effects on the developing embryo/fetus (COVID-19, influenza). Some perinatal-acquired infections will also be briefly discussed due to their relevance in the child's development. The majority of teratogenic congenital and some perinatal-acquired infections have effects on the central nervous system or sensory organs with long-lasting disabilities. Vaccines are unavailable for several teratogenic or perinatal infections, and treatment options are still limited, particularly for arboviral and other emergent diseases. Social inequalities are associated with the prevalence, fetal outcomes and long-term disabilities of these diseases. The One Health approach could be an essential way to reduce the burden of these diseases in the population.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 4","pages":"Article 152075"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pain medication use during pregnancy 怀孕期间使用止痛药。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-06-01 DOI: 10.1016/j.semperi.2025.152074

Rebecca A. Nunge , Anthony M. Kendle , Sura Alwan

引用次数: 0

Drugs in Lactation 哺乳期药物。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-06-01 DOI: 10.1016/j.semperi.2025.152077

Margarita A.P. Berwick , Anika J. Heuberger , Joimishael V. Martin , Thomas W. Hale , Adetola F. Louis-Jacques

引用次数: 0

Review of pharmacology of medications during pregnancy 妊娠期药物的药理学研究综述。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-06-01 DOI: 10.1016/j.semperi.2025.152073

Christy L. Pratt , Nicole M. Hahn

引用次数: 0

Thyroid disease as a teratogen 甲状腺疾病作为致畸物。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-06-01 DOI: 10.1016/j.semperi.2025.152083

Devabhaktuni A, Han CS

{"title":"Thyroid disease as a teratogen","authors":"Devabhaktuni A, Han CS","doi":"10.1016/j.semperi.2025.152083","DOIUrl":"10.1016/j.semperi.2025.152083","url":null,"abstract":"<div><div>Maternal thyroid hormones are critical for normal fetal development, particularly brain development. The increase in metabolic demand of pregnancy results in critical physiologic thyroid changes which ultimately lead to an increase in thyroid hormone production. Placental iodothyronine deiodinases tightly regulate the transfer of thyroid hormone to the fetus. As such, too little or excess thyroid hormone can have a teratogenic effect. Therefore, diagnosis and management of thyroid disorders in pregnancy is necessary to prevent adverse maternal, fetal, and neonatal outcomes; however, it remains challenging, in part due to population-, laboratory-, and trimester-specific thyroid hormone reference ranges. Furthermore, certain areas of study remain controversial including whether treatment of subclinical hypothyroidism and isolated thyroid autoimmunity is warranted and consideration of the implementation of universal thyroid screening. This review summarizes the current literature on thyroid physiology and thyroid dysfunction in pregnancy including overt and subclinical hypothyroidism, hyperthyroidism, thyroid autoimmunity, thyroid storm, postpartum thyroiditis, and thyroid cancer.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 4","pages":"Article 152083"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evolution of teratology: Historical perspectives and lessons learned 畸形学的演变：历史观点和经验教训。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-06-01 DOI: 10.1016/j.semperi.2025.152025

Sarah Običan, Nevena Krstić

{"title":"The evolution of teratology: Historical perspectives and lessons learned","authors":"Sarah Običan, Nevena Krstić","doi":"10.1016/j.semperi.2025.152025","DOIUrl":"10.1016/j.semperi.2025.152025","url":null,"abstract":"<div><div>Teratology, the study of congenital anomalies caused by environmental, chemical, and biological factors, derives from the Greek \"teratos,\" meaning monster, reflecting historical intrigue with birth defects. While the field is relatively modern, curiosity about anomalies spans millennia, as seen in ancient art and mythology. Over time, societal views shifted from curiosity to fear, recognizing birth defects as potential social, economic, and spiritual burdens. The 20th century brought pivotal advances. Discoveries such as the rubella-birth defect link, ionizing radiation effects, and the thalidomide disaster reshaped understanding and regulations. Wilson's \"Six Principles of Teratology\" established guidelines for how teratogens impact development, focusing on timing, dose-response relationships, and genetic susceptibility. Despite progress, birth defects still affect millions worldwide, underscoring the importance of education and counseling on teratogenic risks. Resources like TERIS, Reprotox, and MotherToBaby now provide healthcare professionals with evidence-based guidance, aiding informed decision-making and improving pregnancy outcomes. The ever-evolving field of teratology emphasizes the need for ongoing research and effective communication to manage and prevent birth defects.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 4","pages":"Article 152025"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When pregnancy termination fails: A tale of two teratogens: methotrexate and misoprostol – A narrative mini-review 当终止妊娠失败：甲氨蝶呤和米索前列醇两种致畸物的故事-一个叙事的小回顾。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-06-01 DOI: 10.1016/j.semperi.2025.152078

Orna Diav-Citrin , Corinna Weber-Schoendorfer

引用次数: 0

Teratogenic risks of treated and untreated maternal obesity 治疗和未经治疗的产妇肥胖的致畸风险。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-06-01 DOI: 10.1016/j.semperi.2025.152081

Robert E. Jones , Chloe A. Zera

{"title":"Teratogenic risks of treated and untreated maternal obesity","authors":"Robert E. Jones , Chloe A. Zera","doi":"10.1016/j.semperi.2025.152081","DOIUrl":"10.1016/j.semperi.2025.152081","url":null,"abstract":"<div><div>Untreated obesity in pregnancy is associated with adverse fetal and neonatal outcomes that influence the long-term offspring health trajectory, propagating obesity and cardiometabolic disease from one generation to the next. The current efforts to reduce the risk of these negative outcomes through preconception weight loss remain largely ineffective. Anti-obesity medications (AOMs) are an understudied option for this indication, likely due to the potential for teratogenicity with accidental exposure during pregnancy. However, the current recommendation to discontinue all AOMs prior to conception fails to frame obesity within the chronic disease paradigm typically used for preconception counseling. Evolving evidence suggests that glucagon-like peptide 1 receptor agonists (GLP-1 RAs), the newest and most effective AOM class, may be safe in early pregnancy. Although further research is needed, counseling about GLP-1 RAs during pregnancy should include the potential for both risk and benefit. This review summarizes the known risks that obesity in pregnancy poses to the offspring and discusses the benefits and limitations of current treatment strategies. While there remain several barriers to optimal preconception and prenatal care for people with obesity, this review aims to arm providers with the knowledge needed for patient-centered counseling prior to and during pregnancy.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 4","pages":"Article 152081"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perinatal psychiatry: balancing maternal-fetal exposures to mental disorders and drug treatments 围产期精神病学：平衡母胎接触精神障碍和药物治疗。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-06-01 DOI: 10.1016/j.semperi.2025.152076

Anne M. Nielsen , Catherine S. Stika , Katherine L. Wisner

{"title":"Perinatal psychiatry: balancing maternal-fetal exposures to mental disorders and drug treatments","authors":"Anne M. Nielsen , Catherine S. Stika , Katherine L. Wisner","doi":"10.1016/j.semperi.2025.152076","DOIUrl":"10.1016/j.semperi.2025.152076","url":null,"abstract":"<div><h3>Introduction</h3><div>The potential effects of psychotropic medications during pregnancy must be balanced against those of untreated maternal mental illness, which has been under-appreciated as an exposure that impacts development.</div></div><div><h3>Methods</h3><div>This is an expert, non-systematic literature review of the effect of maternal stress and psychotropic medication on fetal development.</div></div><div><h3>Results</h3><div>Studies on the outcomes of pregnancy and child development following exposures to stress, mental disorders and psychotropic medications during pregnancy are reviewed. Alterations in pharmacokinetics due to the physiology of pregnancy may change the efficacy of drug treatment. The impact of stress and mental health conditions in pregnancy is difficult to separate from other exposures; however, these exposures have adverse effects on fetal and child development independent from medication treatment. A focus on optimal treatment to reduce psychiatric symptoms, which is the justification for use of the drug, is critical. Building healthy fetal brains through adequate maternal essential nutrient intake holds promise to support reduction of the risk for adverse neurodevelopmental outcomes.</div></div><div><h3>Conclusion</h3><div>Untreated maternal mental illness is an exposure that impacts outcomes, the course of comorbid medical disorders, and offspring development. The current knowledge base dictates that treatment of psychiatric disorders be prioritized in the benefit-harm decision process.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 4","pages":"Article 152076"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ethical imperative to pursue neonatal health equity and justice 追求新生儿健康公平和正义的道德要求。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-05-29 DOI: 10.1016/j.semperi.2025.152096

Yarden S. Fraiman , Alejandra Barrero-Castillero , Renee D. Boss

引用次数: 0