{"title":"Pain medication use during pregnancy.","authors":"Rebecca A Nunge, Anthony M Kendle, Sura Alwan","doi":"10.1016/j.semperi.2025.152074","DOIUrl":null,"url":null,"abstract":"<p><p>Pain management during pregnancy is a frequently encountered issue in clinical practice. It is important to balance treatment of maternal pain with the potential risks of medication exposure on fetal development. This review examines the safety and risks associated with various pain medications, including nonsteroidal anti-inflammatory drugs, acetaminophen, steroids, opioids, gabapentinoids, and muscle relaxants. While many analgesic medications have demonstrated benefits for treatment of acute or chronic pain in pregnancy, others carry risks such as congenital anomalies, neonatal withdrawal syndrome, and adverse pregnancy outcomes. Data on long-term neurodevelopmental effects remain inconclusive for many medications. Given the limitations of available research, healthcare providers must weigh the benefits and risks of pain management strategies through informed, shared decision-making with patients. This review provides an evidence-based resource to guide clinicians in optimizing pain treatment during pregnancy while minimizing fetal and neonatal risks.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152074"},"PeriodicalIF":3.2000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in perinatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.semperi.2025.152074","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pain management during pregnancy is a frequently encountered issue in clinical practice. It is important to balance treatment of maternal pain with the potential risks of medication exposure on fetal development. This review examines the safety and risks associated with various pain medications, including nonsteroidal anti-inflammatory drugs, acetaminophen, steroids, opioids, gabapentinoids, and muscle relaxants. While many analgesic medications have demonstrated benefits for treatment of acute or chronic pain in pregnancy, others carry risks such as congenital anomalies, neonatal withdrawal syndrome, and adverse pregnancy outcomes. Data on long-term neurodevelopmental effects remain inconclusive for many medications. Given the limitations of available research, healthcare providers must weigh the benefits and risks of pain management strategies through informed, shared decision-making with patients. This review provides an evidence-based resource to guide clinicians in optimizing pain treatment during pregnancy while minimizing fetal and neonatal risks.
期刊介绍：
The purpose of each issue of Seminars in Perinatology is to provide authoritative and comprehensive reviews of a single topic of interest to professionals who care for the mother, the fetus, and the newborn. The journal''s readership includes perinatologists, obstetricians, pediatricians, epidemiologists, students in these fields, and others. Each issue offers a comprehensive review of an individual topic, with emphasis on new developments that will have a direct impact on their practice.
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