Margarita A P Berwick, Anika J Heuberger, Joimishael V Martin, Thomas W Hale, Adetola F Louis-Jacques
{"title":"哺乳期药物。","authors":"Margarita A P Berwick, Anika J Heuberger, Joimishael V Martin, Thomas W Hale, Adetola F Louis-Jacques","doi":"10.1016/j.semperi.2025.152077","DOIUrl":null,"url":null,"abstract":"<p><p>Medication management in lactation is a challenging topic for healthcare practitioners around the world. In contrast to traditional advice, very few medications are now thought to be absolutely contraindicated in breastfeeding. As data from case reports, quantitative studies of medication transfer to milk, and lactation physiology accumulate, fact-based guidance for use of medications can be increasingly provided. This review presents the strengths and weaknesses of current scientific knowledge underlying recommendations for use of medications during breastfeeding, describes key pharmacokinetic factors influencing infant drug exposure in breastmilk, and provides a practical algorithm and case study on use of clinical resources as well as pharmacologic data to help in development of a management plan for lactating individuals with various medication needs.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152077"},"PeriodicalIF":3.2000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Drugs in Lactation.\",\"authors\":\"Margarita A P Berwick, Anika J Heuberger, Joimishael V Martin, Thomas W Hale, Adetola F Louis-Jacques\",\"doi\":\"10.1016/j.semperi.2025.152077\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Medication management in lactation is a challenging topic for healthcare practitioners around the world. In contrast to traditional advice, very few medications are now thought to be absolutely contraindicated in breastfeeding. As data from case reports, quantitative studies of medication transfer to milk, and lactation physiology accumulate, fact-based guidance for use of medications can be increasingly provided. This review presents the strengths and weaknesses of current scientific knowledge underlying recommendations for use of medications during breastfeeding, describes key pharmacokinetic factors influencing infant drug exposure in breastmilk, and provides a practical algorithm and case study on use of clinical resources as well as pharmacologic data to help in development of a management plan for lactating individuals with various medication needs.</p>\",\"PeriodicalId\":21761,\"journal\":{\"name\":\"Seminars in perinatology\",\"volume\":\" \",\"pages\":\"152077\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in perinatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.semperi.2025.152077\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in perinatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.semperi.2025.152077","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Medication management in lactation is a challenging topic for healthcare practitioners around the world. In contrast to traditional advice, very few medications are now thought to be absolutely contraindicated in breastfeeding. As data from case reports, quantitative studies of medication transfer to milk, and lactation physiology accumulate, fact-based guidance for use of medications can be increasingly provided. This review presents the strengths and weaknesses of current scientific knowledge underlying recommendations for use of medications during breastfeeding, describes key pharmacokinetic factors influencing infant drug exposure in breastmilk, and provides a practical algorithm and case study on use of clinical resources as well as pharmacologic data to help in development of a management plan for lactating individuals with various medication needs.
期刊介绍：
The purpose of each issue of Seminars in Perinatology is to provide authoritative and comprehensive reviews of a single topic of interest to professionals who care for the mother, the fetus, and the newborn. The journal''s readership includes perinatologists, obstetricians, pediatricians, epidemiologists, students in these fields, and others. Each issue offers a comprehensive review of an individual topic, with emphasis on new developments that will have a direct impact on their practice.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
