Skin Pharmacology and Physiology最新文献_第6页

IF 2.7 4区医学

Skin Pharmacology and Physiology Pub Date : 2022-07-01 DOI: 10.1159/000525826

Rudolf Brenneisen Bern

引用次数: 0

Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A Case-Control Study 雄激素性脱发中信号转导因子和转录激活因子-3的表达:一项病例对照研究

IF 2.7 4区医学

Skin Pharmacology and Physiology Pub Date : 2022-06-16 DOI: 10.1159/000525532

A. Hassan, Mohammad Qassim Al-Dhoun, O. Shaker, Aya M. AlOrbani

{"title":"Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A Case-Control Study","authors":"A. Hassan, Mohammad Qassim Al-Dhoun, O. Shaker, Aya M. AlOrbani","doi":"10.1159/000525532","DOIUrl":"https://doi.org/10.1159/000525532","url":null,"abstract":"Background: Signal transducer and activator of transcription (STAT)-3 belongs to a group of latent transcription factors phosphorylated and activated by several protein tyrosine kinases, including members of Janus kinases (JAKs) family. It has been implicated that the JAK-STAT pathway activation could promote quiescence in the hair cycle, and topical treatment of mouse and human skin with JAK inhibitors was shown to result in rapid hair growth. Objective: Our aim was to assess the tissue expression of STAT3 in patients with androgenetic alopecia and correlate it with disease severity and clinical parameters. Methods: Twenty-five androgenetic alopecia patients who served as both cases and controls were included in this study. Full clinical examination was done and tissue STAT3 gene expression was then measured by real-time polymerase chain reaction. Results: Scalp tissue affected by androgenetic alopecia shows significantly higher STAT3 gene expression levels compared to unaffected (androgen independent) areas (p < 0.001), but no statistically significant relation was found between tissue STAT3 expression level and severity of hair loss (p = 0.660). Limitations: Limited sample size. Conclusion: This study demonstrated an upregulation in STAT3 gene expression in androgenetic alopecia. Further studies are needed to assess the possible role of the JAK-STAT pathway in the pathogenesis of androgenetic alopecia.","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"35 1","pages":"278 - 281"},"PeriodicalIF":2.7,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44743014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of an Efficient and Skin-Adherent Semisolid Sunscreen Nanoformulation 一种高效皮肤粘附型半固体防晒纳米配方的评价

IF 2.7 4区医学

Skin Pharmacology and Physiology Pub Date : 2022-06-15 DOI: 10.1159/000525176

L. Frank, R. P. Gazzi, A. Pohlmann, S. Guterres, R. V. Contri

{"title":"Evaluation of an Efficient and Skin-Adherent Semisolid Sunscreen Nanoformulation","authors":"L. Frank, R. P. Gazzi, A. Pohlmann, S. Guterres, R. V. Contri","doi":"10.1159/000525176","DOIUrl":"https://doi.org/10.1159/000525176","url":null,"abstract":"Introduction: Sunscreens are substances applied on the skin surface to protect the skin from the harmful effects of UV light. Nanoparticles can increase the retention time of the sunscreen on the skin surface and its efficacy, by acting as physical barriers. The present investigation aimed to evaluate the influence of the chitosan coating of benzophenone-3-loaded lipid-core nanocapsules (CH-LCN) on the skin adhesion and photoprotective effect of the sunscreen. Methods: CH-LNC were obtained by the interfacial deposition of preformed polymer. A suitable semisolid formulation was obtained by using hydroxyethyl cellulose as the gel-forming polymer. Skin adhesion experiments were performed in vitro by applying the formulation on porcine skin and keeping it under water at 32 °C for up to 60 min. Photoprotective effect was analyzed in vitro by the capacity of the formulations to protect a photo unstable substance (resveratrol) from degradation under UV light. Results: CH-LNC presented size of around 150 nm, with low polydispersity, positive zeta potential, due to chitosan, and benzophenone-3 encapsulation efficiency of close to 100% (3 mg/mL). The proposed gel presented suitable consistence and pH for skin application and benzophenone-3 concentration of around 3 mg/g. Although coated and uncoated lipid-core nanocapsules increased benzophenone-3 skin adhesion after 10 min of water immersion, only the nanoparticles coated with chitosan were able to do so after 60 min. The chitosan coating of the nanocapsules increased the photoprotection of the sunscreen under UVA and UVB light after 60 min of exposure, probably due to the film-forming properties of chitosan. Conclusion: The chitosan coating of CH-LCN increased the skin adhesion and the photoprotective effect of the sunscreen.","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"35 1","pages":"291 - 298"},"PeriodicalIF":2.7,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46919295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparison of Lipid Foam Cream and Basic Cream on Epidermal Reconstruction in Mild Atopic Eczema 脂质泡沫霜与基础霜在轻度特应性湿疹表皮重建中的比较

IF 2.7 4区医学

Skin Pharmacology and Physiology Pub Date : 2022-06-15 DOI: 10.1159/000525283

D. Dähnhardt, S. Dähnhardt-Pfeiffer, Judith Schulte-Walter, Eckhard Hanisch, Thomas Neubourg, R. Fölster-Holst

{"title":"Comparison of Lipid Foam Cream and Basic Cream on Epidermal Reconstruction in Mild Atopic Eczema","authors":"D. Dähnhardt, S. Dähnhardt-Pfeiffer, Judith Schulte-Walter, Eckhard Hanisch, Thomas Neubourg, R. Fölster-Holst","doi":"10.1159/000525283","DOIUrl":"https://doi.org/10.1159/000525283","url":null,"abstract":"Introduction: Basic therapy is of central importance in the treatment of atopic eczema. Using electron microscopic images, the morphology of epidermal skin barrier and its lipids was investigated after application of a lipid foam cream and basic cream. Methods: Patients with two contralateral comparable atopic eczema (local SCORAD 1–10) on the forearms were tested. Eczema was treated with a lipid foam cream or basic cream twice daily for 28 days. At the beginning, after 14 days, and at the end of application, the local SCORAD, trans-epidermal water loss (TEWL), skin hydration, intercellular lipid length in the intercellular space of the stratum corneum (SC), and skin lipids were determined. Results: After application of the foam cream, the epidermal skin barrier could be completely restored and corresponded to healthy skin, while the epidermal skin barrier could not reach this state after care with the basic cream. The content of lipids in the SC increases significantly by 31% after basic cream treatment, whereas they are significantly increased by 85% after application of the lipid foam cream. The local SCORAD improved for both treatments to about the same extent, and no significant results could be shown for TEWL and skin hydration. Conclusion: In subjects with mild atopic eczema, the lipid foam cream leads to a measurable recovery of the skin barrier which is much more pronounced in comparison to the basic cream.","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"35 1","pages":"282 - 290"},"PeriodicalIF":2.7,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49104682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes 疤痕管理的新兴治疗靶点:遗传和表观遗传景观

IF 2.7 4区医学

Skin Pharmacology and Physiology Pub Date : 2022-06-13 DOI: 10.1159/000524990

Sara Amjadian, S. Moradi, P. Mohammadi

{"title":"The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes","authors":"Sara Amjadian, S. Moradi, P. Mohammadi","doi":"10.1159/000524990","DOIUrl":"https://doi.org/10.1159/000524990","url":null,"abstract":"Background: Wound healing is a complex process including hemostasis, inflammation, proliferation, and remodeling during which an orchestrated array of biological and molecular events occurs to promote skin regeneration. Abnormalities in each step of the wound healing process lead to reparative rather than regenerative responses, thereby driving the formation of cutaneous scar. Patients suffering from scars represent serious health problems such as contractures, functional and esthetic concerns as well as painful, thick, and itchy complications, which generally decrease the quality of life and impose high medical costs. Therefore, therapies reducing cutaneous scarring are necessary to improve patients’ rehabilitation. Summary: Current approaches to remove scars, including surgical and nonsurgical methods, are not efficient enough, which is in principle due to our limited knowledge about underlying mechanisms of pathological as well as the physiological wound healing process. Thus, therapeutic interventions focused on basic science including genetic and epigenetic knowledge are recently taken into consideration as promising approaches for scar management since they have the potential to provide targeted therapies and improve the conventional treatments as well as present opportunities for combination therapy. In this review, we highlight the recent advances in skin regenerative medicine through genetic and epigenetic approaches to achieve novel insights for the development of safe, efficient, and reproducible therapies and discuss promising approaches for scar management. Key Message: Genetic and epigenetic regulatory switches are promising targets for scar management, provided the associated challenges are to be addressed.","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"35 1","pages":"247 - 265"},"PeriodicalIF":2.7,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45156988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells 合成糖皮质激素地塞米松诱导人真皮乳头细胞雄激素受体活性的研究

IF 2.7 4区医学

Skin Pharmacology and Physiology Pub Date : 2022-05-13 DOI: 10.1159/000525067

M. Kwack, O. Ben Hamida, M. Kim, Jung Chul Kim, Y. Sung

{"title":"Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells","authors":"M. Kwack, O. Ben Hamida, M. Kim, Jung Chul Kim, Y. Sung","doi":"10.1159/000525067","DOIUrl":"https://doi.org/10.1159/000525067","url":null,"abstract":"Psychosocial stress stimulates the secretion of glucocorticoids (GCs), which are stress-related neurohormones. GCs are secreted from hair follicles and promote hair follicle regression by inducing cellular apoptosis. Moreover, the androgen receptor (AR) is abundant in the balding scalp, and androgens suppress hair growth by binding to AR in androgenetic alopecia. First, by using immunofluorescence, we investigated whether the treatment of dermal papilla (DP) cells with dexamethasone (DEX), a synthetic GC, causes the translocation of the glucocorticoid receptor (GR) into the nucleus. DEX treatment causes the translocation of the GR into the nucleus. Next, we investigated whether stress-induced GCs affect the AR, a key factor in male pattern baldness. In this study, we first assessed that DEX increases the expression of AR mRNA in non-balding DP cells, which rarely express AR without androgen. RU486, a GR antagonist, attenuated DEX-inducible AR mRNA expression and AR activation in human non-balding DP cells. In addition, AR translocated into the nucleus after DEX treatment. Furthermore, we indeed showed that the expression of AR was induced in the nucleus by DEX in DP cells of human and mouse hair follicles. Our results first suggest that stress-associated hair loss may be due to increased AR expression and activity induced by DEX. These results demonstrate that hair loss occurs in non-balding scalps with low AR expression.","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"35 1","pages":"299 - 304"},"PeriodicalIF":2.7,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43536931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Front & Back Matter 正面和背面

IF 2.7 4区医学

Skin Pharmacology and Physiology Pub Date : 2022-05-01 DOI: 10.1159/000524836

J. Fluhr, M. Lane

引用次数: 0

A Composite of Hepatocyte Growth Factor- and 5α-Dihydrotestosterone-Gelatin Microspheres with Adipose-Derived Stem Cells Enhances Wound Healing 肝细胞生长因子-和5α-二氢睾酮明胶微球与脂肪来源干细胞的复合物增强伤口愈合

IF 2.7 4区医学

Skin Pharmacology and Physiology Pub Date : 2022-04-19 DOI: 10.1159/000524188

K. Tao, X. Bai, P. Ji, Yue Zhang, Tao Cao, F. Han, Zhi Zhang, Hao Guan, D. Hu

{"title":"A Composite of Hepatocyte Growth Factor- and 5α-Dihydrotestosterone-Gelatin Microspheres with Adipose-Derived Stem Cells Enhances Wound Healing","authors":"K. Tao, X. Bai, P. Ji, Yue Zhang, Tao Cao, F. Han, Zhi Zhang, Hao Guan, D. Hu","doi":"10.1159/000524188","DOIUrl":"https://doi.org/10.1159/000524188","url":null,"abstract":"Introduction: Reconstructing sebaceous glands is one goal of functionally healing patients who have suffered severe burns, instead of the simple pursuit of wound closure. Effective regeneration of skin appendages remains a challenge in skin wound management and research. Objective: The aim of this study was to evaluate the differentiation of adipose-derived stem cells (ADSCs) into sebaceous glands and clarified the involvement of hepatocyte growth factor (HGF) and 5α-dihydrotestosterone (5α-DHT) in this process. Methods: This study used HGF- and 5α-DHT-gelatin microspheres to treat human ADSCs and investigated the reconstruction of sebaceous glands. HGF- and 5α-DHT-gelatin microspheres were constructed using microcapsule slow-release technology. A mice full-thickness skin-wound model was established to evaluate wound healing, and hematoxylin-eosin staining was utilized to determine the skin structure. Results: In vitro analyses found that HGF- and 5α-DHT-gelatin microspheres promoted migration of and tube formation by ADSCs. Furthermore, AKT/ERK signaling, which is related to sebocyte and sweat gland epithelial-cell growth, was activated after HGF and 5α-DHT treatment. An in vivo wound healing model demonstrated that ADSCs primed with amnion-loaded HGF- and 5α-DHT-gelatin microspheres promoted wound healing and increased sebaceous gland formation compared to the control group. Conclusions: This study confirms the efficacy of ADSCs treated with amnion and HGF- and 5α-DHT-gelatin microspheres in accelerating wound healing and effectively restoring sebaceous glands. This engineered tissue provides insight into and a novel therapeutic material for burns and full-thickness skin wounds.","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"35 1","pages":"206 - 214"},"PeriodicalIF":2.7,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44572427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Induction of Radiodermatitis in Nude Mouse Model Using Gamma Irradiator IBL 637 γ辐照剂ibl637诱导裸鼠放射性皮炎

IF 2.7 4区医学

Skin Pharmacology and Physiology Pub Date : 2022-04-13 DOI: 10.1159/000524596

T. Bernhardt, S. Kriesen, K. Manda, Christin Schlie, R. Panzer, G. Hildebrandt, B. Vollmar, S. Emmert, L. Boeckmann

{"title":"Induction of Radiodermatitis in Nude Mouse Model Using Gamma Irradiator IBL 637","authors":"T. Bernhardt, S. Kriesen, K. Manda, Christin Schlie, R. Panzer, G. Hildebrandt, B. Vollmar, S. Emmert, L. Boeckmann","doi":"10.1159/000524596","DOIUrl":"https://doi.org/10.1159/000524596","url":null,"abstract":"Introduction: Acute radiodermatitis is a common, though severe, side effect of radiotherapy against cancer that may lead to an interruption or even abortion of the radiotherapy. Mouse models provide an excellent tool to study pathomechanisms of a radiation-induced dermatitis as well as to test and develop novel innovative treatment strategies. Objective: The aim of this study was to provide an overview of different mouse models and irradiation devices that have been used so far and to describe the process of the induction of a radiation dermatitis in an immune proficient nude mouse model (SKH1-Hrhr) using a IBL 637 cesium-137γ-ray machine. Methods: This process includes the construction of a radiation shielding chamber, restricting the radiation to the right hind leg of the mouse, a dosimetry, and a dose finding study to identify the appropriate irradiation dose to induce a moderate radiation dermatitis. Results: A radiation shielding chamber was successfully constructed allowing selective irradiation of the right hind leg. A moderate radiodermatitis is induced with irradiation doses in the range of 60–70 Gy under the here described conditions. Symptoms peak about 8 days after irradiation and decrease relatively quickly thereafter. Histological analyses confirmed typical signs of inflammation. Conclusion: This study describes for the first time a protocol to induce a moderate radiodermatitis in the nude mouse model SKH1-Hrhr using a IBL 637 gamma irradiator. This protocol will allow researchers to study novel treatment strategies to alleviate the burden of a radiodermatitis as a side effect of cancer treatment.","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"35 1","pages":"224 - 234"},"PeriodicalIF":2.7,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46015270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Correlation of Body Mass Index with Epidermal Biophysical Properties Varies with Gender in Chinese 中国人体重指数与表皮生物物理特性的相关性因性别而异

IF 2.7 4区医学

Skin Pharmacology and Physiology Pub Date : 2022-04-04 DOI: 10.1159/000524295

L. Ye, Q. Lai, S. Wen, Xiaohua Wang, Bin Yang, M. Man

{"title":"Correlation of Body Mass Index with Epidermal Biophysical Properties Varies with Gender in Chinese","authors":"L. Ye, Q. Lai, S. Wen, Xiaohua Wang, Bin Yang, M. Man","doi":"10.1159/000524295","DOIUrl":"https://doi.org/10.1159/000524295","url":null,"abstract":"Background: Epidermal function is associated with diabetes and renal disease. Whether obesity can reflect the changes in epidermal function is not clear yet. Objective: We assessed here the correlation of epidermal functions with body mass index (BMI) in a large Chinese cohort. Methods and Subjects: A total of 1,405 Chinese aged 21–98 years old were enrolled in this study. Epidermal functions, including transepidermal water loss (TEWL), stratum corneum hydration, and skin surface pH, were measured on the flexor forearm and the shin. Subjects’ height and body weight were also measured. Results: Age positively correlated with both TEWL and skin surface pH, while it negatively correlated with stratum corneum hydration on both the forearm and the shin of females. Similarly, age positively correlated with skin surface pH, while negatively correlating with stratum corneum hydration on both the forearm and the shin of males. In females, BMI positively correlated with skin surface pH, while it negatively correlated with stratum corneum hydration on both the forearm and the shin. However, BMI correlated neither with skin surface pH on both the forearm and the shin nor with stratum corneum hydration on the shin of males. Conclusion: These results demonstrate that correlations of BMI with age and epidermal functions vary with gender.","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"35 1","pages":"215 - 223"},"PeriodicalIF":2.7,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48688830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8