Soonjin Hong, Prithwiraj Maitra, Audrey Nguyen, Kuniko Kadoya, Rahul C Mehta, Elizabeth SelwanLewis
{"title":"开发一种体外功能试验来评估保湿剂对干燥皮肤的封闭特性。","authors":"Soonjin Hong, Prithwiraj Maitra, Audrey Nguyen, Kuniko Kadoya, Rahul C Mehta, Elizabeth SelwanLewis","doi":"10.1159/000529630","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Dry skin is a hallmark of impaired skin barrier function. Moisturizers are a mainstay of treatment to help the skin retain moisture, and there is a high consumer demand for effective products. However, the development and optimization of new formulations are hampered due to lack of reliable efficacy measures using in vitro models.</p><p><strong>Methods: </strong>In this study, a microscopy-based barrier functional assay was developed using an in vitro skin model of chemically induced barrier damage to evaluate the occlusive activity of moisturizers.</p><p><strong>Results: </strong>The assay was validated by demonstrating the different effects on barrier function between humectant (glycerol) and occlusive (petrolatum). Significant changes in barrier function were observed upon tissue disruption, which was ameliorated by commercial moisturizing products.</p><p><strong>Conclusion: </strong>This newly developed experimental method may be helpful to develop new and improved occlusive moisturizers for the treatment of dry skin conditions.</p>","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":"36 3","pages":"140-148"},"PeriodicalIF":2.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Development of an in vitro Functional Assay to Evaluate the Occlusive Properties of Moisturizers on Dry Skin.\",\"authors\":\"Soonjin Hong, Prithwiraj Maitra, Audrey Nguyen, Kuniko Kadoya, Rahul C Mehta, Elizabeth SelwanLewis\",\"doi\":\"10.1159/000529630\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Dry skin is a hallmark of impaired skin barrier function. Moisturizers are a mainstay of treatment to help the skin retain moisture, and there is a high consumer demand for effective products. However, the development and optimization of new formulations are hampered due to lack of reliable efficacy measures using in vitro models.</p><p><strong>Methods: </strong>In this study, a microscopy-based barrier functional assay was developed using an in vitro skin model of chemically induced barrier damage to evaluate the occlusive activity of moisturizers.</p><p><strong>Results: </strong>The assay was validated by demonstrating the different effects on barrier function between humectant (glycerol) and occlusive (petrolatum). Significant changes in barrier function were observed upon tissue disruption, which was ameliorated by commercial moisturizing products.</p><p><strong>Conclusion: </strong>This newly developed experimental method may be helpful to develop new and improved occlusive moisturizers for the treatment of dry skin conditions.</p>\",\"PeriodicalId\":21748,\"journal\":{\"name\":\"Skin Pharmacology and Physiology\",\"volume\":\"36 3\",\"pages\":\"140-148\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Skin Pharmacology and Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000529630\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Skin Pharmacology and Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000529630","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Development of an in vitro Functional Assay to Evaluate the Occlusive Properties of Moisturizers on Dry Skin.
Introduction: Dry skin is a hallmark of impaired skin barrier function. Moisturizers are a mainstay of treatment to help the skin retain moisture, and there is a high consumer demand for effective products. However, the development and optimization of new formulations are hampered due to lack of reliable efficacy measures using in vitro models.
Methods: In this study, a microscopy-based barrier functional assay was developed using an in vitro skin model of chemically induced barrier damage to evaluate the occlusive activity of moisturizers.
Results: The assay was validated by demonstrating the different effects on barrier function between humectant (glycerol) and occlusive (petrolatum). Significant changes in barrier function were observed upon tissue disruption, which was ameliorated by commercial moisturizing products.
Conclusion: This newly developed experimental method may be helpful to develop new and improved occlusive moisturizers for the treatment of dry skin conditions.
期刊介绍：
In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
