Seminars in cell & developmental biology最新文献_第7页

Viral manipulation of host cell gene expression 宿主细胞基因表达的病毒操纵

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2023.02.011

Mandy Muller

引用次数: 0

Viral miRNA regulation of host gene expression 病毒miRNA调控宿主基因表达

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2022.11.007

Nicole L. Diggins, Meaghan H. Hancock

{"title":"Viral miRNA regulation of host gene expression","authors":"Nicole L. Diggins, Meaghan H. Hancock","doi":"10.1016/j.semcdb.2022.11.007","DOIUrl":"10.1016/j.semcdb.2022.11.007","url":null,"abstract":"<div><p><span>Viruses have evolved a multitude of mechanisms to combat barriers to productive infection in the host cell. Virally-encoded miRNAs are one such means to regulate host gene expression in ways that benefit the virus lifecycle. miRNAs are small non-coding RNAs that regulate </span>protein expression<span> but do not trigger the adaptive immune response, making them powerful tools encoded by viruses to regulate cellular processes. Diverse viruses encode for miRNAs but little sequence homology exists between miRNAs of different viral species. Despite this, common cellular pathways are targeted for regulation, including apoptosis, immune evasion, cell growth and differentiation. Herein we will highlight the viruses that encode miRNAs and provide mechanistic insight into how viral miRNAs aid in lytic and latent infection by targeting common cellular processes. We also highlight how viral miRNAs can mimic host cell miRNAs as well as how viral miRNAs have evolved to regulate host miRNA expression. These studies dispel the myth that viral miRNAs are subtle regulators of gene expression, and highlight the critical importance of viral miRNAs to the virus lifecycle.</span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"146 ","pages":"Pages 2-19"},"PeriodicalIF":7.3,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9319716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Control of coronary vascular cell fate in development and regeneration 冠状血管细胞发育和再生过程中命运的控制。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-14 DOI: 10.1016/j.semcdb.2023.08.005

Ian R. McCracken, Nicola Smart

{"title":"Control of coronary vascular cell fate in development and regeneration","authors":"Ian R. McCracken, Nicola Smart","doi":"10.1016/j.semcdb.2023.08.005","DOIUrl":"10.1016/j.semcdb.2023.08.005","url":null,"abstract":"<div><p>The coronary vasculature consists of a complex hierarchal network of arteries, veins, and capillaries which collectively function to perfuse the myocardium. However, the pathways controlling the temporally and spatially restricted mechanisms underlying the formation of this vascular network remain poorly understood. In recent years, the increasing use and refinement of transgenic mouse models has played an instrumental role in offering new insights into the cellular origins of the coronary vasculature, as well as identifying a continuum of transitioning cell states preceding the full maturation of the coronary vasculature. Coupled with the emergence of single cell RNA sequencing platforms, these technologies have begun to uncover the key regulatory factors mediating the convergence of distinct cellular origins to ensure the formation of a collectively functional, yet phenotypically diverse, vascular network. Furthermore, improved understanding of the key regulatory factors governing coronary vessel formation in the embryo may provide crucial clues into future therapeutic strategies to reactivate these developmentally functional mechanisms to drive the revascularisation of the ischaemic adult heart.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"155 ","pages":"Pages 50-61"},"PeriodicalIF":7.3,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10265619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Calvin Benson Bassham cycle 卡尔文·本森·巴萨姆周期。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-14 DOI: 10.1016/j.semcdb.2023.09.002

Christine A. Raines, Amanda P. Cavanagh

引用次数: 0

New insights into the role of thrombospondin-1 in glioblastoma development 血小板反应蛋白-1在胶质母细胞瘤发展中的作用的新见解。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-09 DOI: 10.1016/j.semcdb.2023.09.001

Andreas Bikfalvi , Joris Guyon , Thomas Daubon

引用次数: 1

Epigenetic regulation of inflammation 炎症的表观遗传学调控。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-07 DOI: 10.1016/j.semcdb.2023.08.004

Aamir Ahmad

引用次数: 2

A journey through translational control 通过平移控制的旅程。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-01 DOI: 10.1016/j.semcdb.2023.08.003

Huili Guo

引用次数: 0

Plasma membrane repair empowers the necrotic survivors as innate immune modulators 质膜修复使坏死幸存者成为先天免疫调节剂

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-08-28 DOI: 10.1016/j.semcdb.2023.08.001

Shiqi Xu , Tyler J. Yang , Suhong Xu , Yi-Nan Gong

引用次数: 2

Selective induction of programmed cell death using synthetic biology tools 利用合成生物学工具选择性诱导程序性细胞死亡

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-08-17 DOI: 10.1016/j.semcdb.2023.07.012

Kateryna Shkarina , Petr Broz

{"title":"Selective induction of programmed cell death using synthetic biology tools","authors":"Kateryna Shkarina , Petr Broz","doi":"10.1016/j.semcdb.2023.07.012","DOIUrl":"10.1016/j.semcdb.2023.07.012","url":null,"abstract":"<div><p>Regulated cell death (RCD) controls the removal of dispensable, infected or malignant cells, and is thus essential for development, homeostasis and immunity of multicellular organisms. Over the last years different forms of RCD have been described (among them apoptosis, necroptosis, pyroptosis and ferroptosis), and the cellular signaling pathways that control their induction and execution have been characterized at the molecular level. It has also become apparent that different forms of RCD differ in their capacity to elicit inflammation or an immune response, and that RCD pathways show a remarkable plasticity. Biochemical and genetic studies revealed that inhibition of a given pathway often results in the activation of back-up cell death mechanisms, highlighting close interconnectivity based on shared signaling components and the assembly of multivalent signaling platforms that can initiate different forms of RCD. Due to this interconnectivity and the pleiotropic effects of ‘classical’ cell death inducers, it is challenging to study RCD pathways in isolation. This has led to the development of tools based on synthetic biology that allow the targeted induction of RCD using chemogenetic or optogenetic methods. Here we discuss recent advances in the development of such toolset, highlighting their advantages and limitations, and their application for the study of RCD in cells and animals.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 74-92"},"PeriodicalIF":7.3,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1084952123001507/pdfft?md5=e3301e41e4693bd0e37e41f30005f7df&pid=1-s2.0-S1084952123001507-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10025090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

C. elegans as a model for health and disease 秀丽隐杆线虫作为健康和疾病的典范。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-08-09 DOI: 10.1016/j.semcdb.2023.07.006

Steven Zuryn

引用次数: 0