Seminars in cell & developmental biology最新文献_第7页

Thrombospondin proteins – Versatile extracellular proteins with multiple biological functions 血小板反应蛋白-具有多种生物学功能的多功能细胞外蛋白。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-18 DOI: 10.1016/j.semcdb.2023.09.003

Kenneth W. Adolph

引用次数: 0

Editorial on “Vascular cell fate in health and disease” 关于“血管细胞在健康和疾病中的命运”的社论。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-18 DOI: 10.1016/j.semcdb.2023.09.004

Christine Cheung

引用次数: 0

Better late than never: A unique strategy for late gene transcription in the beta- and gammaherpesviruses 迟做总比不做好:在β和γ疱疹病毒中晚期基因转录的独特策略

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2022.12.001

Sarah E. Dremel , Allison L. Didychuk

{"title":"Better late than never: A unique strategy for late gene transcription in the beta- and gammaherpesviruses","authors":"Sarah E. Dremel , Allison L. Didychuk","doi":"10.1016/j.semcdb.2022.12.001","DOIUrl":"10.1016/j.semcdb.2022.12.001","url":null,"abstract":"<div><p>During lytic replication, herpesviruses<span><span> express their genes in a temporal cascade culminating in expression of “late” genes. Two subfamilies of herpesviruses, the beta- and gammaherpesviruses (including human herpesviruses cytomegalovirus, Epstein-Barr virus, and Kaposi’s sarcoma-associated herpesvirus), use a unique strategy to facilitate transcription of late genes. They encode six essential viral </span>transcriptional activators<span><span> (vTAs) that form a complex at a subset of late gene promoters. One of these vTAs is a viral mimic of host TATA-binding protein (vTBP) that recognizes a strikingly minimal cis-acting element consisting of a modified TATA box with a TATTWAA consensus sequence. vTBP is also responsible for recruitment of cellular </span>RNA polymerase II<span> (Pol II). Despite extensive work in the beta/gammaherpesviruses, the function of the other five vTAs remains largely unknown. The vTA complex and Pol II assemble on the promoter into a viral preinitiation complex (vPIC) to facilitate late gene transcription. Here, we review the properties of the vTAs and the promoters on which they act.</span></span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"146 ","pages":"Pages 57-69"},"PeriodicalIF":7.3,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9675825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

“Transfer” of power: The intersection of DNA virus infection and tRNA biology 权力的“转移”:DNA病毒感染与tRNA生物学的交叉

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2023.01.011

Sarah E. Dremel , Ariana R. Jimenez , Jessica M. Tucker

引用次数: 1

Good cop, bad cop: Polyamines play both sides in host immunity and viral replication 好警察，坏警察:多胺在宿主免疫和病毒复制中扮演两面角色

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2022.12.004

Yazmin E. Cruz-Pulido , Bryan C. Mounce

引用次数: 0

All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict 剪接方面的所有差异:宿主选择性剪接改变了病毒-宿主冲突的格局

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2023.01.013

Joshua T. Mann , Brent A. Riley , Steven F. Baker

{"title":"All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict","authors":"Joshua T. Mann , Brent A. Riley , Steven F. Baker","doi":"10.1016/j.semcdb.2023.01.013","DOIUrl":"10.1016/j.semcdb.2023.01.013","url":null,"abstract":"<div><p><span>Alternative RNA splicing is a co-transcriptional process that richly increases proteome diversity, and is dynamically regulated based on cell species, lineage, and activation state. Virus infection in vertebrate hosts results in rapid host transcriptome-wide changes, and regulation of alternative splicing can direct a combinatorial effect on the host </span>transcriptome. There has been a recent increase in genome-wide studies evaluating host alternative splicing during viral infection, which integrates well with prior knowledge on viral interactions with host splicing proteins. A critical challenge remains in linking how these individual events direct global changes, and whether alternative splicing is an overall favorable pathway for fending off or supporting viral infection. Here, we introduce the process of alternative splicing, discuss how to analyze splice regulation, and detail studies on genome-wide and splice factor changes during viral infection. We seek to highlight where the field can focus on moving forward, and how incorporation of a virus-host co-evolutionary perspective can benefit this burgeoning subject.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"146 ","pages":"Pages 40-56"},"PeriodicalIF":7.3,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9676319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Shaping the host cell environment with viral noncoding RNAs 利用病毒非编码rna塑造宿主细胞环境

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2022.12.008

Carlos Gorbea, Abdalla Elhakiem, Demián Cazalla

引用次数: 0

Viral manipulation of host cell gene expression 宿主细胞基因表达的病毒操纵

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2023.02.011

Mandy Muller

引用次数: 0

Viral miRNA regulation of host gene expression 病毒miRNA调控宿主基因表达

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2022.11.007

Nicole L. Diggins, Meaghan H. Hancock

{"title":"Viral miRNA regulation of host gene expression","authors":"Nicole L. Diggins, Meaghan H. Hancock","doi":"10.1016/j.semcdb.2022.11.007","DOIUrl":"10.1016/j.semcdb.2022.11.007","url":null,"abstract":"<div><p><span>Viruses have evolved a multitude of mechanisms to combat barriers to productive infection in the host cell. Virally-encoded miRNAs are one such means to regulate host gene expression in ways that benefit the virus lifecycle. miRNAs are small non-coding RNAs that regulate </span>protein expression<span> but do not trigger the adaptive immune response, making them powerful tools encoded by viruses to regulate cellular processes. Diverse viruses encode for miRNAs but little sequence homology exists between miRNAs of different viral species. Despite this, common cellular pathways are targeted for regulation, including apoptosis, immune evasion, cell growth and differentiation. Herein we will highlight the viruses that encode miRNAs and provide mechanistic insight into how viral miRNAs aid in lytic and latent infection by targeting common cellular processes. We also highlight how viral miRNAs can mimic host cell miRNAs as well as how viral miRNAs have evolved to regulate host miRNA expression. These studies dispel the myth that viral miRNAs are subtle regulators of gene expression, and highlight the critical importance of viral miRNAs to the virus lifecycle.</span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"146 ","pages":"Pages 2-19"},"PeriodicalIF":7.3,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9319716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Control of coronary vascular cell fate in development and regeneration 冠状血管细胞发育和再生过程中命运的控制。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-14 DOI: 10.1016/j.semcdb.2023.08.005

Ian R. McCracken, Nicola Smart

{"title":"Control of coronary vascular cell fate in development and regeneration","authors":"Ian R. McCracken, Nicola Smart","doi":"10.1016/j.semcdb.2023.08.005","DOIUrl":"10.1016/j.semcdb.2023.08.005","url":null,"abstract":"<div><p>The coronary vasculature consists of a complex hierarchal network of arteries, veins, and capillaries which collectively function to perfuse the myocardium. However, the pathways controlling the temporally and spatially restricted mechanisms underlying the formation of this vascular network remain poorly understood. In recent years, the increasing use and refinement of transgenic mouse models has played an instrumental role in offering new insights into the cellular origins of the coronary vasculature, as well as identifying a continuum of transitioning cell states preceding the full maturation of the coronary vasculature. Coupled with the emergence of single cell RNA sequencing platforms, these technologies have begun to uncover the key regulatory factors mediating the convergence of distinct cellular origins to ensure the formation of a collectively functional, yet phenotypically diverse, vascular network. Furthermore, improved understanding of the key regulatory factors governing coronary vessel formation in the embryo may provide crucial clues into future therapeutic strategies to reactivate these developmentally functional mechanisms to drive the revascularisation of the ischaemic adult heart.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"155 ","pages":"Pages 50-61"},"PeriodicalIF":7.3,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10265619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0