Seminars in cell & developmental biology最新文献_第6页

Why some hearts heal and others don’t: The phylogenetic landscape of cardiac regenerative capacity 为什么有些心脏能愈合而有些不能：心脏再生能力的系统发育图景

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-11 DOI: 10.1016/j.semcdb.2025.103609

Makoto Nakamura , Guo N. Huang

{"title":"Why some hearts heal and others don’t: The phylogenetic landscape of cardiac regenerative capacity","authors":"Makoto Nakamura , Guo N. Huang","doi":"10.1016/j.semcdb.2025.103609","DOIUrl":"10.1016/j.semcdb.2025.103609","url":null,"abstract":"<div><div>The limited ability of adult humans to replenish lost heart muscle cells after a heart attack has attracted scientists to explore natural heart regeneration capabilities in the animal kingdom. In particular, research has accelerated since the landmark discovery more than twenty years ago that zebrafish can completely regrow myocardial tissue. In this review, we survey heart regeneration studies in diverse model and non-model animals, aiming to gain insights into both the evolutionary trends in cardiac regenerative potential and the variations among closely related species. Differences in cardiomyogenesis, vasculature formation, and the communication between cardiovascular cells and other players have been investigated to understand the cellular basis, although the precise molecular and genetic causes underlying the stark differences in cardiac regenerative potential among certain close cousins remain largely unknown. By studying cardiovascular regeneration and repair in diverse organisms, we may uncover distinct mechanisms, offering new perspectives for advancing regenerative medicine.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"170 ","pages":"Article 103609"},"PeriodicalIF":6.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac enhancers: Gateway to the regulatory mechanisms of heart regeneration 心脏增强剂：心脏再生调控机制的门户

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-10 DOI: 10.1016/j.semcdb.2025.103610

Ian J. Begeman, Megan E. Guyer, Junsu Kang

引用次数: 0

Geometric factors for cell arrangement: How do cells determine their position in vivo? 细胞排列的几何因素：细胞如何决定它们在体内的位置？

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-05 DOI: 10.1016/j.semcdb.2025.103604

Sungrim Seirin-Lee , Akatsuki Kimura

{"title":"Geometric factors for cell arrangement: How do cells determine their position in vivo?","authors":"Sungrim Seirin-Lee , Akatsuki Kimura","doi":"10.1016/j.semcdb.2025.103604","DOIUrl":"10.1016/j.semcdb.2025.103604","url":null,"abstract":"<div><div>The spatial arrangement of cells plays a crucial role in ensuring robust development of organisms, directing cells to their specific fates in the right place and at the right time. In early embryogenesis, the cell arrangement is determined by several factors such as the cell division axis, cell-cell interactions, and surrounding geometric constraints. While many species utilize similar principles to determine the cell arrangement, the precise dynamics of cell arrangement differ among species, even at early stages. In particular, geometric constraints significantly impact cell arrangement. Nematode species exhibit diverse cell arrangement dynamics due to their rigid eggshells, which intensively confine the internal cells. In this paper, we review the mechanisms of cell arrangement with a focus on geometric constraints, drawing from interdisciplinary perspectives. We also review mathematical models developed to enhance our understanding of these mechanisms and discuss future directions for theoretical approaches in exploring geometric effects on cell arrangement in various tissues of various species.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"169 ","pages":"Article 103604"},"PeriodicalIF":6.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cilia and flagella – Current understanding and recent advances in divergent experimental systems 纤毛和鞭毛——目前对不同实验系统的理解和最新进展

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-04-03 DOI: 10.1016/j.semcdb.2025.103606

Junmin Pan

引用次数: 0

The ever-diversifying landscape of intra-genomic conflict 不断多样化的基因组内部冲突

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-03-26 DOI: 10.1016/j.semcdb.2025.103603

Mia T. Levine, Sarah E. Zanders

引用次数: 0

Cell death in regeneration and cell turnover: Lessons from planarians and Drosophila 再生和细胞更新中的细胞死亡：来自涡虫和果蝇的教训

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-03-25 DOI: 10.1016/j.semcdb.2025.103605

Teresa Adell, Francesc Cebrià, Josep F. Abril, Sofia J. Araújo, Montserrat Corominas, Marta Morey, Florenci Serras, Cristina González-Estévez

{"title":"Cell death in regeneration and cell turnover: Lessons from planarians and Drosophila","authors":"Teresa Adell, Francesc Cebrià, Josep F. Abril, Sofia J. Araújo, Montserrat Corominas, Marta Morey, Florenci Serras, Cristina González-Estévez","doi":"10.1016/j.semcdb.2025.103605","DOIUrl":"10.1016/j.semcdb.2025.103605","url":null,"abstract":"<div><div>Programmed cell death plays a crucial role during tissue turnover in all animal species, and it is also essential during regeneration, serving as a key signalling mechanism to promote tissue repair and regrowth. In freshwater planarians, remarkable regenerative abilities are supported by neoblasts, a population of adult stem cells, which enable high somatic cell turnover. Cell death in planarians occurs continuously during regeneration and adult homeostasis, underscoring its critical role in tissue remodeling and repair. However, the exact mechanisms regulating cell death in these organisms remain elusive. In contrast, <em>Drosophila melanogaster</em> serves as a powerful model for studying programmed cell death in development, metamorphosis, and adult tissue maintenance, leveraging advanced genetic tools and visualization techniques. In <em>Drosophila</em>, cell death sculpts tissues, eliminates larval structures during metamorphosis, and supports homeostasis in adulthood. Despite limited regenerative capacity compared to planarians, <em>Drosophila</em> provides unique insights into cell death's regulatory mechanisms. Comparative analysis of these two systems highlights both conserved and divergent roles of programmed cell death in tissue renewal and regeneration. This review synthesizes the latest knowledge of programmed cell death in planarians and <em>Drosophila</em>, aiming to illuminate shared principles and system-specific adaptations, with relevance to tissue repair across biological systems.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"169 ","pages":"Article 103605"},"PeriodicalIF":6.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Death fuels growth: Emerging players bridging apoptosis and cell proliferation in Drosophila and beyond 死亡促进生长：在果蝇和其他物种中连接细胞凋亡和细胞增殖的新兴参与者

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-03-12 DOI: 10.1016/j.semcdb.2025.103602

Caitlin Hounsell, Yun Fan

引用次数: 0

Epithelial apoptosis: A back-and-forth mechanical interplay between the dying cell and its surroundings 上皮细胞凋亡：濒死细胞与周围环境之间来回的机械相互作用

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-02-21 DOI: 10.1016/j.semcdb.2025.02.001

Stéphanie Arnould , Corinne Benassayag , Tatiana Merle , Bruno Monier , Marianne Montemurro , Magali Suzanne

引用次数: 0

Zebrafish tailfin as an in vivo model for capturing tissue-scale cell dynamics 斑马鱼尾鳍作为捕获组织尺度细胞动力学的体内模型。

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.005

Yue Rong Tan, Hsiao-Yuh Roan, Chen-Hui Chen

{"title":"Zebrafish tailfin as an in vivo model for capturing tissue-scale cell dynamics","authors":"Yue Rong Tan, Hsiao-Yuh Roan, Chen-Hui Chen","doi":"10.1016/j.semcdb.2024.12.005","DOIUrl":"10.1016/j.semcdb.2024.12.005","url":null,"abstract":"<div><div>The intricate control of collective cell dynamics is crucial for enabling organismic development and tissue regeneration. Despite the availability of various <em>in vitro</em> and <em>in vivo</em> models, studies on tissue-scale cell dynamics and associated emergent properties in living systems remain methodically challenging. Here, we describe key advantages of using the adult zebrafish tailfin (caudal fin) as a robust <em>in vivo</em> model for dissecting millimeter-scale collective cell dynamics during regeneration and wound healing in a complex tissue. For researchers considering this model system, we briefly introduce the tailfin anatomy, as well as available transgenic reporter tools and live-imaging setups that may be utilized to study epidermal cell behaviors. To highlight the unique strengths of the zebrafish tailfin model, we present an example project that was made possible by techniques for tracking cell dynamics at a millimeter scale with single-cell resolution in live animals. Finally, we discuss the research directions at the interface of collective cell dynamics and regenerative biology that most excite us and can be examined using the tailfin model.</div></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"166 ","pages":"Pages 29-35"},"PeriodicalIF":6.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advancement in the spatial immuno-oncology 空间免疫肿瘤学的最新进展。

IF 6.2 2区生物学

Seminars in cell & developmental biology Pub Date : 2025-02-01 DOI: 10.1016/j.semcdb.2024.12.003

Alex To , Zou Yu , Ryohichi Sugimura

引用次数: 0