Seminars in cell & developmental biology最新文献_第6页

Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook 毒理学测试策略的备选肺细胞模型系统:目前的知识和未来展望

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-30 DOI: 10.1016/j.semcdb.2022.12.006

Joana A. Moura , Kirsty Meldrum , Shareen H. Doak, Martin J.D. Clift

{"title":"Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook","authors":"Joana A. Moura , Kirsty Meldrum , Shareen H. Doak, Martin J.D. Clift","doi":"10.1016/j.semcdb.2022.12.006","DOIUrl":"10.1016/j.semcdb.2022.12.006","url":null,"abstract":"<div><p>Due to the current relevance of pulmonary toxicology (with focus upon air pollution and the inhalation of hazardous materials), it is important to further develop and implement physiologically relevant models of the entire respiratory tract. Lung model development has the aim to create human relevant systems that may replace animal use whilst balancing cost, laborious nature and regulatory ambition. There is an imperative need to move away from rodent models and implement models that mimic the holistic characteristics important in lung function. The purpose of this review is therefore, to describe and identify the various alternative models that are being applied towards assessing the pulmonary toxicology of inhaled substances, as well as the current and potential developments of various advanced models and how they may be applied towards toxicology testing strategies. These models aim to mimic various regions of the lung, as well as implementing different exposure methods with the addition of various physiologically relevent conditions (such as fluid-flow and dynamic movement). There is further progress in the type of models used with focus on the development of lung-on-a-chip technologies and bioprinting, as well as and the optimization of such models to fill current knowledge gaps within toxicology.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"147 ","pages":"Pages 70-82"},"PeriodicalIF":7.3,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9342246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Orchestration of tissue shape changes and gene expression patterns in development 发育过程中组织形状变化和基因表达模式的协调

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-30 DOI: 10.1016/j.semcdb.2022.12.009

Koichiro Uriu , Luis G. Morelli

引用次数: 2

Proteotoxic stress and the ubiquitin proteasome system 蛋白毒性应激和泛素-蛋白酶体系统。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-19 DOI: 10.1016/j.semcdb.2023.08.002

Rachel Kandel , Jasmine Jung , Sonya Neal

{"title":"Proteotoxic stress and the ubiquitin proteasome system","authors":"Rachel Kandel , Jasmine Jung , Sonya Neal","doi":"10.1016/j.semcdb.2023.08.002","DOIUrl":"10.1016/j.semcdb.2023.08.002","url":null,"abstract":"<div><p>The ubiquitin proteasome system maintains protein homeostasis by regulating the breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The efficient elimination is vital for preventing damage to the cell by misfolded proteins, known as proteotoxic stress. Proteotoxic stress can lead to the collapse of protein homeostasis and can alter the function of the ubiquitin proteasome system. Conversely, impairment of the ubiquitin proteasome system can also cause proteotoxic stress and disrupt protein homeostasis. This review examines two impacts of proteotoxic stress, 1) disruptions to ubiquitin homeostasis (ubiquitin stress) and 2) disruptions to proteasome homeostasis (proteasome stress). Here, we provide a mechanistic description of the relationship between proteotoxic stress and the ubiquitin proteasome system. This relationship is illustrated by findings from several protein misfolding diseases, mainly neurodegenerative diseases, as well as from basic biology discoveries from yeast to mammals. In addition, we explore the importance of the ubiquitin proteasome system in endoplasmic reticulum quality control, and how proteotoxic stress at this organelle is alleviated. Finally, we highlight how cells utilize the ubiquitin proteasome system to adapt to proteotoxic stress and how the ubiquitin proteasome system can be genetically and pharmacologically manipulated to maintain protein homeostasis.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"156 ","pages":"Pages 107-120"},"PeriodicalIF":7.3,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1084952123001611/pdfft?md5=45f7454982f2f991e629c7dc9990a43c&pid=1-s2.0-S1084952123001611-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41135275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Thrombospondin proteins – Versatile extracellular proteins with multiple biological functions 血小板反应蛋白-具有多种生物学功能的多功能细胞外蛋白。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-18 DOI: 10.1016/j.semcdb.2023.09.003

Kenneth W. Adolph

引用次数: 0

Editorial on “Vascular cell fate in health and disease” 关于“血管细胞在健康和疾病中的命运”的社论。

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-18 DOI: 10.1016/j.semcdb.2023.09.004

Christine Cheung

引用次数: 0

Better late than never: A unique strategy for late gene transcription in the beta- and gammaherpesviruses 迟做总比不做好:在β和γ疱疹病毒中晚期基因转录的独特策略

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2022.12.001

Sarah E. Dremel , Allison L. Didychuk

{"title":"Better late than never: A unique strategy for late gene transcription in the beta- and gammaherpesviruses","authors":"Sarah E. Dremel , Allison L. Didychuk","doi":"10.1016/j.semcdb.2022.12.001","DOIUrl":"10.1016/j.semcdb.2022.12.001","url":null,"abstract":"<div><p>During lytic replication, herpesviruses<span><span> express their genes in a temporal cascade culminating in expression of “late” genes. Two subfamilies of herpesviruses, the beta- and gammaherpesviruses (including human herpesviruses cytomegalovirus, Epstein-Barr virus, and Kaposi’s sarcoma-associated herpesvirus), use a unique strategy to facilitate transcription of late genes. They encode six essential viral </span>transcriptional activators<span><span> (vTAs) that form a complex at a subset of late gene promoters. One of these vTAs is a viral mimic of host TATA-binding protein (vTBP) that recognizes a strikingly minimal cis-acting element consisting of a modified TATA box with a TATTWAA consensus sequence. vTBP is also responsible for recruitment of cellular </span>RNA polymerase II<span> (Pol II). Despite extensive work in the beta/gammaherpesviruses, the function of the other five vTAs remains largely unknown. The vTA complex and Pol II assemble on the promoter into a viral preinitiation complex (vPIC) to facilitate late gene transcription. Here, we review the properties of the vTAs and the promoters on which they act.</span></span></span></p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"146 ","pages":"Pages 57-69"},"PeriodicalIF":7.3,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9675825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

“Transfer” of power: The intersection of DNA virus infection and tRNA biology 权力的“转移”:DNA病毒感染与tRNA生物学的交叉

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2023.01.011

Sarah E. Dremel , Ariana R. Jimenez , Jessica M. Tucker

引用次数: 1

Good cop, bad cop: Polyamines play both sides in host immunity and viral replication 好警察，坏警察:多胺在宿主免疫和病毒复制中扮演两面角色

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2022.12.004

Yazmin E. Cruz-Pulido , Bryan C. Mounce

引用次数: 0

All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict 剪接方面的所有差异:宿主选择性剪接改变了病毒-宿主冲突的格局

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2023.01.013

Joshua T. Mann , Brent A. Riley , Steven F. Baker

{"title":"All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict","authors":"Joshua T. Mann , Brent A. Riley , Steven F. Baker","doi":"10.1016/j.semcdb.2023.01.013","DOIUrl":"10.1016/j.semcdb.2023.01.013","url":null,"abstract":"<div><p><span>Alternative RNA splicing is a co-transcriptional process that richly increases proteome diversity, and is dynamically regulated based on cell species, lineage, and activation state. Virus infection in vertebrate hosts results in rapid host transcriptome-wide changes, and regulation of alternative splicing can direct a combinatorial effect on the host </span>transcriptome. There has been a recent increase in genome-wide studies evaluating host alternative splicing during viral infection, which integrates well with prior knowledge on viral interactions with host splicing proteins. A critical challenge remains in linking how these individual events direct global changes, and whether alternative splicing is an overall favorable pathway for fending off or supporting viral infection. Here, we introduce the process of alternative splicing, discuss how to analyze splice regulation, and detail studies on genome-wide and splice factor changes during viral infection. We seek to highlight where the field can focus on moving forward, and how incorporation of a virus-host co-evolutionary perspective can benefit this burgeoning subject.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":"146 ","pages":"Pages 40-56"},"PeriodicalIF":7.3,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9676319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Shaping the host cell environment with viral noncoding RNAs 利用病毒非编码rna塑造宿主细胞环境

IF 7.3 2区生物学

Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI: 10.1016/j.semcdb.2022.12.008

Carlos Gorbea, Abdalla Elhakiem, Demián Cazalla

引用次数: 0