Seminars in respiratory and critical care medicine最新文献_第7页

Developing Interventions for Chronic Obstructive Pulmonary Disease. 制定慢性阻塞性肺病干预措施。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-10-01 Epub Date: 2024-07-05 DOI: 10.1055/s-0044-1787875

Audra J Schwalk, Niral M Patel, Nagendra Y Madisi

{"title":"Developing Interventions for Chronic Obstructive Pulmonary Disease.","authors":"Audra J Schwalk, Niral M Patel, Nagendra Y Madisi","doi":"10.1055/s-0044-1787875","DOIUrl":"10.1055/s-0044-1787875","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is an incurable, progressive respiratory disease that may have a significant negative impact on the morbidity and mortality of affected patients. A substantial portion of the world's population is affected by COPD, and despite optimal medical management with medications, supplemental oxygen, and pulmonary rehabilitation, many patients are left debilitated because of this disease. Bronchoscopic treatment modalities offer a less-invasive method for the treatment of refractory COPD compared to surgical interventions and have expanded the potential therapeutic options for these patients. Bronchoscopic lung volume reduction is aimed at decreasing the hyperinflation and air trapping that occur in emphysema, and the most studied and successful intervention is endobronchial valve placement. Endobronchial coils, polymeric sealants, and thermal ablation are other researched alternatives. Additional interventional procedures are being investigated for the treatment of the mucus hypersecretion and cough that are associated with the chronic bronchitis phenotype of COPD and include targeted lung denervation, metered dose spray cryotherapy, deobstruction balloon, and bronchial rheoplasty. This review summarizes the most recent evidence pertaining to available therapies for the management of COPD, including chronic bronchitis, with a particular focus on bronchoscopic interventions.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"582-592"},"PeriodicalIF":2.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recovery from Sepsis: Management beyond Acute Care. 败血症后的康复：急性期护理之外的管理。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-05 DOI: 10.1055/s-0044-1787993

Sarah K Andersen, Margaret S Herridge, Kirsten M Fiest

引用次数: 0

Sepsis from Science to Social Perspective. 从科学到社会视角看败血症。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-08-29 DOI: 10.1055/s-0044-1789249

Djillali Annane, Ricard Ferrer

引用次数: 0

Definition and Epidemiology of Sepsis. 败血症的定义和流行病学。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-05 DOI: 10.1055/s-0044-1787990

Pietro Arina, Daniel A Hofmaenner, Mervyn Singer

引用次数: 0

How to Survive Sepsis: Patient Testimonial. 如何度过败血症：患者感言。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-11 DOI: 10.1055/s-0044-1787874

Krista Bracke

{"title":"How to Survive Sepsis: Patient Testimonial.","authors":"Krista Bracke","doi":"10.1055/s-0044-1787874","DOIUrl":"10.1055/s-0044-1787874","url":null,"abstract":"Leaving university I started working for the Belgian National Radio as a journalist. I used to travel a lot and produce radio features about life abroad and how people all over the world dealt with the different challenges in society. A privileged job that I enjoyed doing for many years. In the meantime, I got married and became a mother of two sons. Nothing to worry about, so it seemed, until January 30, 2009. I had been fighting the symptoms of flu for some days. Instead of recovering, I began to feel worse and worse: I had a high fever, was asleep most of the time, could barely eat or drink, and had to cough a lot. The general practitioner sent me to hospital. A few hours later, I had to be reanimated. It was a close call: I was infected by the Streptococcus pyogenes bacteria. My blood started thickening, my organs stopped functioning, and I went into a septic shock, followed by a cardiac arrest. I was successfully reanimated, but still not stable. For 10 days, I was fighting to survive at the intensive care unit (ICU), with several cardiac arrests and reanimations, some of which were long-lasting. The Head of the ICU informed my husband that there was less than 5% chance to survive and if so, he could not predict what kind of damage there would be: the amount of drugs that I had been given, including noradrenaline, was so extremely high, that it became very unclear how my body would respond to it. And if, as by miracle, I would survive: what kind of damage would there be? Physical? Mental? Physical and mental? No specialist could answer those questions. But both the health care professionals and my family fought to keep me alive.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"533-540"},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Diagnosis of Sepsis: The Role of Biomarkers and Rapid Microbiological Tests. 败血症的早期诊断：生物标志物和快速微生物检验的作用。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1055/s-0044-1787270

Erika P Plata-Menchaca, Juan Carlos Ruiz-Rodríguez, Ricard Ferrer

引用次数: 0

Management of Sepsis in the First 24 Hours: Bundles of Care and Individualized Approach. 败血症最初 24 小时的管理：一揽子护理和个性化方法。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-08-29 DOI: 10.1055/s-0044-1789185

Irene Coloretti, Martina Tosi, Emanuela Biagioni, Stefano Busani, Massimo Girardis

{"title":"Management of Sepsis in the First 24 Hours: Bundles of Care and Individualized Approach.","authors":"Irene Coloretti, Martina Tosi, Emanuela Biagioni, Stefano Busani, Massimo Girardis","doi":"10.1055/s-0044-1789185","DOIUrl":"https://doi.org/10.1055/s-0044-1789185","url":null,"abstract":"Early diagnosis and prompt management are essential to enhance the outcomes of patients with sepsis and septic shock. Over the past two decades, evidence-based guidelines have guided appropriate treatment and recommended the implementation of a bundle strategy to deliver fundamental treatments within the initial hours of care. Shortly after its introduction, the implementation of a bundle strategy has led to a substantial decrease in mortality rates across various health care settings. The primary advantage of these bundles is their universality, making them applicable to all patients with sepsis. However, this same quality also represents their primary disadvantage as it fails to account for the significant heterogeneity within the septic patient population. Recently, the individualization of treatments included in the bundle has been suggested as a potential strategy for further improving the prognosis of patients with sepsis. New strategies for the early identification of microorganisms and their resistance patterns, advanced knowledge of antibiotic kinetics in critically ill patients, more conservative fluid therapy in specific patient populations, and early use of alternative vasopressors to catecholamines, as well as tailored source control based on patient conditions and site of infection, are potential approaches to personalize initial care for specific subgroups of patients. These innovative methodologies have the potential to improve the management of septic shock. However, their implementation in clinical practice should be guided by solid evidence. Therefore, it is imperative that future research evaluate the safety, efficacy, and cost-effectiveness of these strategies.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":"45 4","pages":"503-509"},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulation of Host-Pathogen Interactions in Sepsis: Host-Related Factors. 败血症中宿主与病原体相互作用的失调：与宿主相关的因素。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1055/s-0044-1787554

Sebastiaan C M Joosten, Willem J Wiersinga, Tom van der Poll

引用次数: 0

Informative Subtyping of Patients with Sepsis. 对败血症患者进行信息亚型分类。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-08 DOI: 10.1055/s-0044-1787992

John Cafferkey, Manu Shankar-Hari

引用次数: 0

Acute Management of Sepsis beyond 24 Hours. 败血症 24 小时后的急性处理。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-05 DOI: 10.1055/s-0044-1787991

Antoine Premachandra, Nicholas Heming

{"title":"Acute Management of Sepsis beyond 24 Hours.","authors":"Antoine Premachandra, Nicholas Heming","doi":"10.1055/s-0044-1787991","DOIUrl":"10.1055/s-0044-1787991","url":null,"abstract":"Sepsis manifests as a dysregulated immune response to an infection, leading to tissue damage, organ failure, and potentially death or long-term health issues. Sepsis remains a major health challenge globally, causing approximately 50 million cases and 11 million deaths annually. Early management of sepsis focuses on source control, antimicrobial treatment, and supporting vital organ function. Subsequent care includes metabolic, nutritional, and immune therapies to address the complex needs of septic patients. Metabolic management is based on obtaining moderate glucose targets. Nutritional support aims to mitigate hypercatabolism and muscle wasting, but aggressive early nutrition does not improve outcomes and could even be harmful. Immune modulation is crucial due to the dual nature of sepsis-induced immune responses. Corticosteroids have shown benefits in shock and organ dysfunction reversal and in mortality reduction with current guidelines recommending them in vasopressor therapy-dependent patients. In conclusion, sepsis management beyond the initial hours requires a multifaceted approach, focusing on metabolic, nutritional, and immune system support tailored to individual patient needs to enhance survival and recovery.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"510-515"},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0