Early Diagnosis of Sepsis: The Role of Biomarkers and Rapid Microbiological Tests.

IF 2.3 3区 医学 Q2 CRITICAL CARE MEDICINE
Erika P Plata-Menchaca, Juan Carlos Ruiz-Rodríguez, Ricard Ferrer
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引用次数: 0

Abstract

Sepsis is a medical emergency resulting from a dysregulated response to an infection, causing preventable deaths and a high burden of morbidity. Protocolized and accurate interventions in sepsis are time-critical. Therefore, earlier recognition of cases allows for preventive interventions, early treatment, and improved outcomes. Clinical diagnosis of sepsis by clinical scores cannot be considered an early diagnosis, given that underlying molecular pathophysiological mechanisms have been activated in the preceding hour or days. There is a lack of a widely available tool enhancing preclinical diagnosis of sepsis. Sophisticated technologies for sepsis prediction have several limitations, including high costs. Novel technologies for fast molecular and microbiological diagnosis are focusing on bedside point-of-care combined testing to reach most settings where sepsis represents a challenge.

败血症的早期诊断:生物标志物和快速微生物检验的作用。
败血症是一种因对感染的反应失调而导致的医疗紧急情况,会造成可预防的死亡和高发病率。对败血症进行规范和准确的干预时间紧迫。因此,更早地识别病例有助于预防性干预、早期治疗和改善预后。通过临床评分对败血症进行临床诊断不能被视为早期诊断,因为潜在的分子病理生理机制已在前一小时或前几天被激活。目前还缺乏一种可广泛使用的工具来加强败血症的临床前诊断。用于败血症预测的先进技术存在一些局限性,包括成本高昂。用于快速分子诊断和微生物诊断的新技术侧重于床旁护理点联合检测,以便在脓毒症构成挑战的大多数情况下使用。
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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
87
审稿时长
6-12 weeks
期刊介绍: The journal focuses on new diagnostic and therapeutic procedures, laboratory studies, genetic breakthroughs, pathology, clinical features and management as related to such areas as asthma and other lung diseases, critical care management, cystic fibrosis, lung and heart transplantation, pulmonary pathogens, and pleural disease as well as many other related disorders.The journal focuses on new diagnostic and therapeutic procedures, laboratory studies, genetic breakthroughs, pathology, clinical features and management as related to such areas as asthma and other lung diseases, critical care management, cystic fibrosis, lung and heart transplantation, pulmonary pathogens, and pleural disease as well as many other related disorders.
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