Seminars in respiratory and critical care medicine最新文献_第6页

Sleep and Respiratory Infections. 睡眠和呼吸道感染。

IF 2.7 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2025-04-01 Epub Date: 2025-02-03 DOI: 10.1055/a-2531-1018

Ignacio Boira, Eusebi Chiner

{"title":"Sleep and Respiratory Infections.","authors":"Ignacio Boira, Eusebi Chiner","doi":"10.1055/a-2531-1018","DOIUrl":"10.1055/a-2531-1018","url":null,"abstract":"Sleep disorders that involve circadian rhythm disruption and sleep-disordered breathing (SDB) such as obstructive sleep apnea (OSA) are closely linked to respiratory infections. SDB leads to a proinflammatory state due to intermittent hypoxia, sleep fragmentation, increased oxidative stress, and elevation of inflammatory mediators such as tumor necrosis factor (TNF), interleukin-6 (IL-6), and C-reactive protein (CRP). Furthermore, inflammatory mediator levels correlate with SDB severity, especially in people with OSA. Nocturnal microaspiration, gastroesophageal reflux, and associated comorbidities (e.g., obesity) increase the risk of community-acquired pneumonia, viral infections such as SARS-CoV-2, respiratory complications, and death. OSA has been associated with post-COVID syndrome. It also increases the risk of postoperative complications in both adults and children. Circadian rhythm disorders such as insomnia predispose to immune disorders and increase the risk of infection. Chronic conditions such as bronchiectasis, with or without concomitant cystic fibrosis, can lead to structural sleep changes and increase the risk of OSA due to chronic cough, arousals, aspirations, hypoxia, upper airway edema, and overexpression of proinflammatory cytokines. The protective effect of treatment for sleep disorders against respiratory infection is currently unknown. However, in people presenting with respiratory infection, it is important to test for SDB to prevent complications.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"170-178"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Critical Role of Sleep in Enhancing Pulmonary Rehabilitation Outcomes. 睡眠在增强肺部康复结果中的关键作用。

IF 2.7 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2025-04-01 Epub Date: 2025-03-31 DOI: 10.1055/a-2557-8463

Mario Henríquez-Beltrán, Jessica González, Gonzalo Labarca, Adriano D S Targa

{"title":"The Critical Role of Sleep in Enhancing Pulmonary Rehabilitation Outcomes.","authors":"Mario Henríquez-Beltrán, Jessica González, Gonzalo Labarca, Adriano D S Targa","doi":"10.1055/a-2557-8463","DOIUrl":"10.1055/a-2557-8463","url":null,"abstract":"Pulmonary rehabilitation is a comprehensive, interdisciplinary intervention that aims to enhance the physical and psychological well-being of individuals with chronic respiratory diseases. This approach entails the implementation of tailored therapies, including exercise training, education, and behavioral modification. Sleep plays a crucial role in numerous physiological processes, including the regulation of inflammation and tissue repair, both of which are fundamental to the efficacy of rehabilitation. A paucity of optimal sleep health has been associated with deleterious effects on pivotal factors that are indispensable for favorable outcomes in pulmonary rehabilitation, including mental and physical health and immune function. This, in turn, may increase susceptibility to impaired pulmonary function. The integration of pulmonary rehabilitation protocols with healthy sleep practices is expected to yield significant improvements in lung function and overall health, which will, in turn, promote long-term adherence to rehabilitative behaviors. This study aims to examine the relationship between sleep health and pulmonary rehabilitation outcomes.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"149-157"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision Medicine to Guide Obstructive Sleep Apnea Treatment Beyond the Continuous Positive Airway Pressure. 精准医学指导阻塞性睡眠呼吸暂停治疗超越持续气道正压。

IF 2.7 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2025-04-01 Epub Date: 2025-05-23 DOI: 10.1055/a-2591-5502

Gonzalo Labarca, Mario Henríquez-Beltrán, Daniel Solomons

引用次数: 0

What Is Next for COVID-19 Vaccination? COVID-19疫苗接种的下一步是什么？

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2025-02-01 Epub Date: 2025-03-31 DOI: 10.1055/a-2531-1211

Antoni Trilla, Guillem Trilla, Marta Aldea, Anna Vilella

{"title":"What Is Next for COVID-19 Vaccination?","authors":"Antoni Trilla, Guillem Trilla, Marta Aldea, Anna Vilella","doi":"10.1055/a-2531-1211","DOIUrl":"10.1055/a-2531-1211","url":null,"abstract":"Whenever a new COVID-19 vaccination season starts, we must face new challenges, including which vaccines to use, the update of the high-risk groups to be vaccinated, and especially the type and amount of information to be communicated to people in order to promote vaccination. COVID-19 vaccination recommendations should fit these specific conditions. The use of effective vaccines against the predominant SARS-CoV-2 virus variants and the extent of the immune response (waning immunity) are key aspects to try to protect better the high-risk populations. Updated vaccines are currently swiftly available. However, the number of people vaccinated with any additional booster dose is declining. Improved health information and training for health care professionals, together with the use of better tools to make simpler vaccination recommendations, can encourage higher vaccination rates. Addressing these challenges is essential to improve vaccination coverage and ensure adequate protection in the face of evolving COVID-19 threats. The SARS-CoV-2 virus has become a constant presence in our society. The virus changes but is neither endemic nor seasonal so far. The Omicron variant prevailed for nearly 2 years and now several of its subvariants like JN.1, KP.2, or XEC are or can be the dominant ones. In the face of this moving situation, the main message must be the same: COVID-19 vaccines are safe and effective. The role of current COVID-19 vaccination efforts is to mitigate the severity of the disease and reduce the risk of complications and death, instead of preventing most SARS-CoV-2 infections. New vaccines against COVID-19 are now at different stages of clinical research.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"82-94"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety, Efficacy, and Effectiveness of Maternal Vaccination against Respiratory Infections in Young Infants. 母亲接种疫苗预防婴幼儿呼吸道感染的安全性、有效性和有效性。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2025-02-01 Epub Date: 2024-12-21 DOI: 10.1055/a-2471-6906

Nisha Makan-Murphy, Shabir A Madhi, Ziyaad Dangor

引用次数: 0

Vaccination against Respiratory Infections in the Immunosenescent Older Adult Population: Challenges and Opportunities. 免疫衰老老年人预防呼吸道感染的疫苗接种：挑战与机遇。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1055/a-2500-2121

Fiona Ecarnot, Stefania Maggi

引用次数: 0

State of the Art and Emerging Technologies in Vaccine Design for Respiratory Pathogens. 呼吸道病原体疫苗设计的最新技术和新兴技术。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2025-02-01 Epub Date: 2025-01-27 DOI: 10.1055/a-2500-1878

Matteo Ridelfi, Giulio Pierleoni, Vittoria Zucconi Galli Fonseca, Giampiero Batani, Rino Rappuoli, Claudia Sala

{"title":"State of the Art and Emerging Technologies in Vaccine Design for Respiratory Pathogens.","authors":"Matteo Ridelfi, Giulio Pierleoni, Vittoria Zucconi Galli Fonseca, Giampiero Batani, Rino Rappuoli, Claudia Sala","doi":"10.1055/a-2500-1878","DOIUrl":"10.1055/a-2500-1878","url":null,"abstract":"In this review, we present the efforts made so far in developing effective solutions to prevent infections caused by seven major respiratory pathogens: influenza virus, respiratory syncytial virus (RSV), the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Bordetella pertussis, Streptococcus pneumoniae (pneumococcus), Mycobacterium tuberculosis, and Pseudomonas aeruginosa. Advancements driven by the recent coronavirus disease 2019 (COVID-19) crisis have largely focused on viruses, but effective prophylactic solutions for bacterial pathogens are also needed, especially in light of the antimicrobial resistance (AMR) phenomenon. Here, we discuss various innovative key technologies that can help address this critical need, such as (a) the development of Lung-on-Chip ex vivo models to gain a better understanding of the pathogenesis process and the host-microbe interactions; (b) a more thorough investigation of the mechanisms behind mucosal immunity as the first line of defense against pathogens; (c) the identification of correlates of protection (CoPs) which, in conjunction with the Reverse Vaccinology 2.0 approach, can push a more rational and targeted design of vaccines. By focusing on these critical areas, we expect substantial progress in the development of new vaccines against respiratory bacterial pathogens, thereby enhancing global health protection in the framework of the increasingly concerning AMR emergence.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"63-81"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory Syncytial Virus Prevention in the Adult Population: State of the Art. 成人呼吸道合胞病毒预防：最新进展

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2025-02-01 Epub Date: 2025-06-06 DOI: 10.1055/a-2586-3974

Tommaso Bigoni, Franco Alfano, Francesca Aloe, Federico Baraldi, Francesco Paolo Caggiano, Olga Dell'Adami de Tarczal, Alberto Papi

{"title":"Respiratory Syncytial Virus Prevention in the Adult Population: State of the Art.","authors":"Tommaso Bigoni, Franco Alfano, Francesca Aloe, Federico Baraldi, Francesco Paolo Caggiano, Olga Dell'Adami de Tarczal, Alberto Papi","doi":"10.1055/a-2586-3974","DOIUrl":"https://doi.org/10.1055/a-2586-3974","url":null,"abstract":"Respiratory syncytial virus (RSV) is a common respiratory virus associated with acute respiratory infections (ARIs) in infants and older adults. RSV-related ARIs significantly affect the relevant clinical outcomes, including hospitalization and mortality, in older adults. Elderly individuals and those with chronic diseases are at a higher risk of infections with severe morbidity because of clinical frailty and deficiencies in immune responses. Prevention of respiratory viral infections in the adult population can be achieved through hygiene measures and active immunization. Several vaccination strategies have been developed, including nucleic acid, subunit, chimeric, live-attenuated, particle-based, and recombinant vaccines, with varying results. Subunit vaccines involving the RSV-fusion protein F in its prefusional (pre-F) conformation, with or without adjuvants, have demonstrated significant protection in older adults, reducing the rate of total and severe RSV-related lower tract respiratory diseases (LRTDs). Similarly, an mRNA vaccine encoding for the stabilized pre-F conformation showed a significantly reduced RSV-associated LRTDs in older adults. This evidence led to recent approval of two subunit vaccines (Arexvy and Abrysvo) and one nucleic acid-based vaccine (mResvia) by regulatory authorities. Currently, several vaccines are recommended for adults, resulting in crowded schedules. Therefore, covaccination is a potential strategy for improving vaccine adherence. The coadministration of approved RSV vaccines with seasonal influenza vaccines has been proven to be non-inferior to the immune response from sequential administration. Other vaccines coadministered against different pathogens are currently under investigation.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":"46 1","pages":"41-52"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-Generation Pneumococcal Vaccines for Children and Adults. 下一代儿童和成人肺炎球菌疫苗。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2025-02-01 Epub Date: 2025-04-16 DOI: 10.1055/a-2588-6965

Rosario Menéndez, María Garces-Sanchez

引用次数: 0

Early Experience on Universal Prophylaxis in Infants against Respiratory Syncytial Virus: Facts and Expectations. 婴儿 RSV 普遍预防的早期经验：事实与期望。

IF 2.3 3区医学

Seminars in respiratory and critical care medicine Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1055/a-2531-0968

Antoni Soriano-Arandes, Anna Creus-Costa, Aida Perramon-Malavez, Cristina Andrés, Jorgina Vila, Anna Gatell, Maria Piñana, Pepe Serrano, Alejandra González-Sánchez, Ramon Capdevila, Clara Prats, Pere Soler-Palacin, Andrés Antón

{"title":"Early Experience on Universal Prophylaxis in Infants against Respiratory Syncytial Virus: Facts and Expectations.","authors":"Antoni Soriano-Arandes, Anna Creus-Costa, Aida Perramon-Malavez, Cristina Andrés, Jorgina Vila, Anna Gatell, Maria Piñana, Pepe Serrano, Alejandra González-Sánchez, Ramon Capdevila, Clara Prats, Pere Soler-Palacin, Andrés Antón","doi":"10.1055/a-2531-0968","DOIUrl":"10.1055/a-2531-0968","url":null,"abstract":"During the 2023/24 season, nirsevimab significantly reduced the risk of bronchiolitis and confirmed respiratory syncytial virus (RSV) infections in primary care, hospital, and pediatric intensive care unit admissions among infants aged 0 to 11 months, even in a season with a high community RSV burden, particularly for older infants. These findings are very useful for public health authorities to continue to implement immunization campaigns against RSV in the coming seasons. Moreover, universal immunization against RSV represents a transformative step toward reducing the burden of RSV in infants. With promising evidence from recently published studies, the expectations for a reduction of RSV-associated hospitalizations, alongside the improvement of public health outcomes and equitable access to these measures, are high. However, achieving these goals will require addressing challenges related to vaccine uptake, funding, and RSV surveillance to prompt detect resistances due to mutations of the virus. These interventions need to be integrated into public health strategies because they hold the potential to make a significant impact on infant's health worldwide.","PeriodicalId":21727,"journal":{"name":"Seminars in respiratory and critical care medicine","volume":" ","pages":"31-40"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0