Dysregulation of Host-Pathogen Interactions in Sepsis: Host-Related Factors.

IF 2.3 3区医学 Q2 CRITICAL CARE MEDICINE

Seminars in respiratory and critical care medicine Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI:10.1055/s-0044-1787554

Sebastiaan C M Joosten, Willem J Wiersinga, Tom van der Poll

引用次数: 0

Abstract

Sepsis stands as a prominent contributor to sickness and death on a global scale. The most current consensus definition characterizes sepsis as a life-threatening organ dysfunction stemming from an imbalanced host response to infection. This definition does not capture the intricate array of immune processes at play in sepsis, marked by simultaneous states of heightened inflammation and immune suppression. This overview delves into the immune-related processes of sepsis, elaborating about mechanisms involved in hyperinflammation and immune suppression. Moreover, we discuss stratification of patients with sepsis based on their immune profiles and how this could impact future sepsis management.

查看原文本刊更多论文

败血症中宿主与病原体相互作用的失调：与宿主相关的因素。

败血症是全球范围内导致疾病和死亡的一个主要因素。目前最一致的定义是，败血症是由于宿主对感染的反应失衡而导致的危及生命的器官功能障碍。这一定义并没有涵盖败血症中错综复杂的免疫过程，其特点是炎症加剧和免疫抑制同时存在。本综述深入探讨了败血症的免疫相关过程，详细阐述了过度炎症和免疫抑制的相关机制。此外，我们还讨论了根据败血症患者的免疫特征对其进行分层，以及这将如何影响未来的败血症管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Seminars in respiratory and critical care medicine 医学-呼吸系统

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal focuses on new diagnostic and therapeutic procedures, laboratory studies, genetic breakthroughs, pathology, clinical features and management as related to such areas as asthma and other lung diseases, critical care management, cystic fibrosis, lung and heart transplantation, pulmonary pathogens, and pleural disease as well as many other related disorders.The journal focuses on new diagnostic and therapeutic procedures, laboratory studies, genetic breakthroughs, pathology, clinical features and management as related to such areas as asthma and other lung diseases, critical care management, cystic fibrosis, lung and heart transplantation, pulmonary pathogens, and pleural disease as well as many other related disorders.