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Seminars in reproductive medicine最新文献

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Only the Best of the Bunch-Sperm Preparation Is Not Just about Numbers. 优中选优--精子制备不仅仅是数字问题。
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2023-12-19 DOI: 10.1055/s-0043-1777756
Meurig T Gallagher, Ingrida Krasauskaite, Jackson C Kirkman-Brown
{"title":"Only the Best of the Bunch-Sperm Preparation Is Not Just about Numbers.","authors":"Meurig T Gallagher, Ingrida Krasauskaite, Jackson C Kirkman-Brown","doi":"10.1055/s-0043-1777756","DOIUrl":"10.1055/s-0043-1777756","url":null,"abstract":"<p><p>In this <i>Seminar</i>, we present an overview of the current and emerging methods and technologies for optimizing the man and the sperm sample for fertility treatment. We argue that sperms are the secret to success, and that there are many avenues for improving both treatment and basic understanding of their role in outcomes. These outcomes encompass not just whether treatment is successful or not, but the wider intergenerational health of the offspring. We discuss outstanding challenges and opportunities of new technologies such as microfluidics and artificial intelligence, including potential pitfalls and advantages. This article aims to provide a comprehensive overview of the importance of sperm in fertility treatment and suggests future directions for research and innovation.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"273-278"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Andrology: The Male Factor. 男性学：男性因素
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-03-18 DOI: 10.1055/s-0044-1779744
Antti Perheentupa
{"title":"Andrology: The Male Factor.","authors":"Antti Perheentupa","doi":"10.1055/s-0044-1779744","DOIUrl":"10.1055/s-0044-1779744","url":null,"abstract":"","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"41 6","pages":"211-212"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deteriorating Semen Quality: The Role of the Environment. 精液质量下降：环境的作用
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-03-18 DOI: 10.1055/s-0044-1782151
Helena E Virtanen, Wiwat Rodprasert, Jorma Toppari
{"title":"Deteriorating Semen Quality: The Role of the Environment.","authors":"Helena E Virtanen, Wiwat Rodprasert, Jorma Toppari","doi":"10.1055/s-0044-1782151","DOIUrl":"10.1055/s-0044-1782151","url":null,"abstract":"<p><p>Since the end of the last century, several reports have suggested that semen quality is declining, especially in Western countries. Furthermore, cross-sectional studies using similar protocols have suggested regional differences in semen quality of young and fertile men. Reasons for these regional differences and local adverse trends in semen quality are unknown, but environmental factors are suspected to have a role. Besides adulthood environmental exposures, those occurring during testicular development may also affect semen quality. Longitudinal follow-up studies and mixture risk analyses are needed to study the effect of fetal, childhood, and adult life environment on semen quality.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"41 6","pages":"226-240"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microdissection Testicular Sperm Extraction. 显微切割睾丸精子提取术
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-01-23 DOI: 10.1055/s-0043-1777833
Aaron Brant, Peter N Schlegel
{"title":"Microdissection Testicular Sperm Extraction.","authors":"Aaron Brant, Peter N Schlegel","doi":"10.1055/s-0043-1777833","DOIUrl":"10.1055/s-0043-1777833","url":null,"abstract":"<p><p>Nonobstructive azoospermia (NOA) is among the most common causes of male infertility. For men with NOA seeking fertility treatment, microdissection testicular sperm extraction (microTESE) is the best option for retrieving sperm, which can be used with in vitro fertilization-intracytoplasmic sperm injection to achieve pregnancy in their partner. With the aid of the operating microscope, microTESE allows for thorough evaluation of the testis tissue and selection of seminiferous tubules that appear most capable of sperm production. Rates of success with microTESE vary depending on the underlying cause of NOA and the center at which the procedure is performed. Not all patients are candidates for microTESE, and those who are candidates should be counseled on the likelihood of sperm retrieval and the potential for changes in postoperative testis function.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"267-272"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small Non-Coding RNAs in Male Reproduction. 男性生殖中的小非编码 RNA。
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-02-12 DOI: 10.1055/s-0044-1779726
Opeyemi Olotu, Ammar Ahmedani, Noora Kotaja
{"title":"Small Non-Coding RNAs in Male Reproduction.","authors":"Opeyemi Olotu, Ammar Ahmedani, Noora Kotaja","doi":"10.1055/s-0044-1779726","DOIUrl":"10.1055/s-0044-1779726","url":null,"abstract":"<p><p>Male reproductive functions are strictly regulated in order to maintain sperm production and fertility. All processes are controlled by precise regulation of gene expression, which creates specific gene expression programs for different developmental stages and cell types, and forms the functional basis for the reproductive system. Small non-coding RNAs (sncRNAs) are involved in gene regulation by targeting mRNAs for translational repression and degradation through complementary base pairing to recognize their targets. This review article summarizes the current knowledge on the function of different classes of sncRNAs, in particular microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), during male germ cell differentiation, with the focus on sncRNAs expressed in the germline. Although transcriptionally inactive, mature spermatozoa contain a complex population of sncRNAs, and we also discuss the recently identified role of sperm sncRNAs in the intergenerational transmission of epigenetic information on father's environmental and lifestyle exposures to offspring. Finally, we summarize the current information on the utility of sncRNAs as potential biomarkers of infertility that may aid in the diagnosis and prediction of outcomes of medically assisted reproduction.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"213-225"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Andrology. Andrology.
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-03-18 DOI: 10.1055/s-0044-1779590
Kathleen M Hoeger, Terhi Piltonen
{"title":"Andrology.","authors":"Kathleen M Hoeger, Terhi Piltonen","doi":"10.1055/s-0044-1779590","DOIUrl":"10.1055/s-0044-1779590","url":null,"abstract":"","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"41 6","pages":"209-210"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Male Contraception. 男性避孕。
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2023-12-19 DOI: 10.1055/s-0043-1777757
John K Amory
{"title":"Male Contraception.","authors":"John K Amory","doi":"10.1055/s-0043-1777757","DOIUrl":"10.1055/s-0043-1777757","url":null,"abstract":"<p><p>Approximately 40 to 50% of pregnancies are unintended. Contraceptive use significantly reduces the risk of unintended pregnancy. Approximately 70% of couples' contraceptive use is female and 30% is male, attributable to the reliance on condoms and vasectomies. Unfortunately, many women cannot use currently available contraceptives due to medical contraindications or side effects. At the same time, men want additional safe and effective contraceptive methods. Because of this, work to develop novel, safe, and effective male contraceptives is underway. This review will briefly discuss the pros and cons of condoms and vasectomies, and then describe research into the development of novel methods of male contraception, by the mechanism of action of the contraceptive. First, we will discuss male contraceptives that block sperm transmission. Next, we will discuss male contraceptives that impair sperm production. Lastly, we will discuss male contraceptives that impair sperm function.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"279-286"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Microbiome in Human Reproductive Tract: High-Throughput Methods for the Taxonomic Characterization of Microorganisms. 探索人类生殖道微生物组：微生物分类特征的高通量方法。
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-02-06 DOI: 10.1055/s-0044-1779025
Eduardo Salas-Espejo, Laura C Terrón-Camero, José L Ruiz, Nerea M Molina, Eduardo Andrés-León
{"title":"Exploring the Microbiome in Human Reproductive Tract: High-Throughput Methods for the Taxonomic Characterization of Microorganisms.","authors":"Eduardo Salas-Espejo, Laura C Terrón-Camero, José L Ruiz, Nerea M Molina, Eduardo Andrés-León","doi":"10.1055/s-0044-1779025","DOIUrl":"10.1055/s-0044-1779025","url":null,"abstract":"<p><p>Microorganisms are important due to their widespread presence and multifaceted roles across various domains of life, ecology, and industries. In humans, they underlie the proper functioning of multiple systems crucial to well-being, including immunological and metabolic functions. Emerging research addressing the presence and roles of microorganisms within human reproduction is increasingly relevant. Studies implementing new methodologies (e.g., to investigate vaginal, uterine, and semen microenvironments) can now provide relevant insights into fertility, reproductive health, or pregnancy outcomes. In that sense, cutting-edge sequencing techniques, as well as others such as meta-metabolomics, culturomics, and meta-proteomics, are becoming more popular and accessible worldwide, allowing the characterization of microbiomes at unprecedented resolution. However, they frequently involve rather complex laboratory protocols and bioinformatics analyses, for which researchers may lack the required expertise. A suitable pipeline would successfully enable both taxonomic classification and functional profiling of the microbiome, providing easy-to-understand biological interpretations. However, the selection of an appropriate methodology would be crucial, as it directly impacts the reproducibility, accuracy, and quality of the results and observations. This review focuses on the different current microbiome-related techniques in the context of human reproduction, encompassing niches like vagina, endometrium, and seminal fluid. The most standard and reliable methods are 16S rRNA gene sequencing, metagenomics, and meta-transcriptomics, together with complementary approaches including meta-proteomics, meta-metabolomics, and culturomics. Finally, we also offer case examples and general recommendations about the most appropriate methods and workflows and discuss strengths and shortcomings for each technique.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"41 5","pages":"125-143"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiome in Reproduction: Analysis Methods, Novel Techniques, and State-of-the-Art in Female Reproductive Health. 生殖中的微生物组：女性生殖健康的分析方法、新技术和最新技术。
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-02-06 DOI: 10.1055/s-0043-1778655
Signe Altmäe
{"title":"Microbiome in Reproduction: Analysis Methods, Novel Techniques, and State-of-the-Art in Female Reproductive Health.","authors":"Signe Altmäe","doi":"10.1055/s-0043-1778655","DOIUrl":"10.1055/s-0043-1778655","url":null,"abstract":"","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"41 5","pages":"121-124"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Upper Reproductive System Microbiome: Evidence beyond the Uterus. 上生殖系统微生物组：子宫之外的证据
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-02-06 DOI: 10.1055/s-0043-1778056
Analuce Canha-Gouveia, Valentina Di Nisio, Andres Salumets, Pauliina Damdimopoulou, Pilar Coy, Signe Altmäe, Alberto Sola-Leyva
{"title":"The Upper Reproductive System Microbiome: Evidence beyond the Uterus.","authors":"Analuce Canha-Gouveia, Valentina Di Nisio, Andres Salumets, Pauliina Damdimopoulou, Pilar Coy, Signe Altmäe, Alberto Sola-Leyva","doi":"10.1055/s-0043-1778056","DOIUrl":"10.1055/s-0043-1778056","url":null,"abstract":"<p><p>The microbiome of the female upper reproductive system has garnered increasing recognition and has become an area of interest in the study of women's health. This intricate ecosystem encompasses a diverse consortium of microorganisms (i.e., microbiota) and their genomes (i.e., microbiome) residing in the female upper reproductive system, including the uterus, the fallopian tubes, and ovaries. In recent years, remarkable advancements have been witnessed in sequencing technologies and microbiome research, indicating the potential importance of the microbial composition within these anatomical sites and its impact in women's reproductive health and overall well-being. Understanding the composition, dynamics, and functions of the microbiome of the female upper reproductive system opens up exciting avenues for improving fertility, treating gynecological conditions, and advancing our comprehension of the intricate interplay between the microbiome and the female reproductive system. The aim of this study is to compile currently available information on the microbial composition of the female upper reproductive system in humans, with a focus beyond the uterus, which has received more attention in recent microbiome studies compared with the fallopian tubes and ovaries. In conclusion, this review underscores the potential role of this microbiome in women's physiology, both in health and disease.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"41 5","pages":"190-199"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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