Small Non-Coding RNAs in Male Reproduction.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-01 Epub Date: 2024-02-12 DOI:10.1055/s-0044-1779726

Opeyemi Olotu, Ammar Ahmedani, Noora Kotaja

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引用次数: 0

Abstract

Male reproductive functions are strictly regulated in order to maintain sperm production and fertility. All processes are controlled by precise regulation of gene expression, which creates specific gene expression programs for different developmental stages and cell types, and forms the functional basis for the reproductive system. Small non-coding RNAs (sncRNAs) are involved in gene regulation by targeting mRNAs for translational repression and degradation through complementary base pairing to recognize their targets. This review article summarizes the current knowledge on the function of different classes of sncRNAs, in particular microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), during male germ cell differentiation, with the focus on sncRNAs expressed in the germline. Although transcriptionally inactive, mature spermatozoa contain a complex population of sncRNAs, and we also discuss the recently identified role of sperm sncRNAs in the intergenerational transmission of epigenetic information on father's environmental and lifestyle exposures to offspring. Finally, we summarize the current information on the utility of sncRNAs as potential biomarkers of infertility that may aid in the diagnosis and prediction of outcomes of medically assisted reproduction.

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男性生殖中的小非编码 RNA。

男性的生殖功能受到严格调控，以保持精子的生成和生育能力。所有过程都由基因表达的精确调控控制，从而为不同发育阶段和细胞类型创建特定的基因表达程序，并构成生殖系统的功能基础。小非编码 RNA（sncRNA）通过互补碱基配对识别靶标，靶向 mRNA 进行翻译抑制和降解，从而参与基因调控。这篇综述文章总结了目前关于不同类别的sncRNAs，特别是microRNAs（miRNAs）和PIWI-interacting RNAs（piRNAs）在男性生殖细胞分化过程中的功能的知识，重点是在生殖细胞中表达的sncRNAs。我们还讨论了最近发现的精子 sncRNA 在将父亲的环境和生活方式暴露的表观遗传信息代际传递给后代方面的作用。最后，我们总结了目前有关 sncRNA 作为不孕症潜在生物标志物的实用性的信息，这些标志物可能有助于诊断和预测医学辅助生殖的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.