Seminars in reproductive medicine最新文献

Environmental Hazards and Male Fertility: Why Don't We Know More?

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2025-02-10 DOI: 10.1055/s-0044-1801746

Makiko Mitsunami, Jaime E Hart, Jorge E Chavarro

引用次数: 0

Environmental Exposures and Polycystic Ovary Syndrome: A Review.

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2025-02-05 DOI: 10.1055/s-0044-1801405

Elizabeth Peebles, Shruthi Mahalingaiah

{"title":"Environmental Exposures and Polycystic Ovary Syndrome: A Review.","authors":"Elizabeth Peebles, Shruthi Mahalingaiah","doi":"10.1055/s-0044-1801405","DOIUrl":"https://doi.org/10.1055/s-0044-1801405","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder in women of reproductive age, affecting around 5 to 10% of women and up to 21% depending on the applied diagnostic criteria and study population. People with PCOS may experience oligomenorrhea, androgen excess, and polycystic ovary morphology. The etiology of the disease is not completely understood, with genetics, epigenetics, endocrine, metabolic, lifestyle, and environmental factors contributing to its development and severity. Environmental exposures are an important, burgeoning field in menstrual research, as they potentially link to menstrual cycle disruption and the risk of reproductive disorders such as PCOS. This review examines the recent research investigating environmental exposures-air pollution, micro- and nanoplastics, heavy metals, and endocrine-disrupting chemicals-and PCOS in human and animal models, concluding with potential mechanisms, limitations, and considerations for future work. Overall, research on environmental exposures and PCOS is limited and yields heterogeneous results across studies. Specifically, exposures such as air pollutants, micro- and nanoplastics, persistent organic pollutants, and parabens have noticeably limited research. Future research can help fill the gap in understanding how environmental exposures, particularly across gestational, childhood, and reproductive adult life stages, may impact PCOS.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine-Disrupting Chemicals and Female Reproductive Aging.

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2025-01-29 DOI: 10.1055/s-0044-1801388

Jiaxin Wu, Siobán D Harlow, John F Randolph, Ellen B Gold, Sung Kyun Park

{"title":"Endocrine-Disrupting Chemicals and Female Reproductive Aging.","authors":"Jiaxin Wu, Siobán D Harlow, John F Randolph, Ellen B Gold, Sung Kyun Park","doi":"10.1055/s-0044-1801388","DOIUrl":"https://doi.org/10.1055/s-0044-1801388","url":null,"abstract":"Female reproductive aging often affects women's emotional, physical, and physiological well-being. Ovarian aging is characterized by fluctuations in reproductive hormones and determines the age at which menopause occurs. Understanding potentially modifiable factors that influence this process is essential for addressing health disparities, improving quality of life, and informing relevant public health strategies. This review synthesizes in vivo, in vitro, and epidemiological findings about the effects of endocrine-disrupting chemicals (EDCs), specifically heavy metals and perfluoroalkyl and polyfluoroalkyl substances (PFAS) on female reproductive aging. Most in vivo and in vitro studies have demonstrated that heavy metals alter ovarian morphology, folliculogenesis, and steroidogenesis. Evidence regarding the effects of PFAS is limited and inconsistent. Epidemiological studies have consistently shown that heavy metals are associated with a higher risk of diminished ovarian reserve (indicated by decreased anti-Müllerian hormone) and earlier menopause, with limited findings regarding reproductive hormone changes. PFAS exposure has been associated with decreased estradiol and earlier menopause but not significantly with ovarian reserve. Gaps in the literature require more comprehensive epidemiological research on the effects of EDCs on female reproductive aging, including ovarian reserve, age at menopause, and vasomotor symptoms, to inform future interventions to reduce hazardous exposures and improve women's health.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics. PFAS暴露与男性生殖健康：对精子表观遗传学的影响。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2025-01-09 DOI: 10.1055/s-0044-1801363

DruAnne L Maxwell, Michael C Petriello, J Richard Pilsner

{"title":"PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics.","authors":"DruAnne L Maxwell, Michael C Petriello, J Richard Pilsner","doi":"10.1055/s-0044-1801363","DOIUrl":"10.1055/s-0044-1801363","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants found in human tissues and persist in the environment, posing significant risks to reproductive health. This review examines the impact of PFAS exposure on male reproductive health, with a focus on sperm epigenetics. PFASs disrupt endocrine function by altering key reproductive hormones and impairing sperm motility, quality, and viability. Epidemiologic and animal studies highlight inconsistent yet concerning associations between PFAS exposure and semen parameters, as well as altered gene expression and DNA methylation patterns. Moreover, PFAS exposure during critical windows of development has been linked to differential impacts on male versus female pubertal development, cognitive outcomes, and reproductive physiology, emphasizing the complexity of PFAS interactions. This comprehensive analysis highlights the need for continued research into the mechanisms by which PFASs influence reproductive health and development with potential implications for sperm epigenetics. The review emphasizes the importance of understanding the epigenetic mechanisms behind these disruptions, particularly DNA methylation and its role in heritable changes. Investigating the epigenetic modifications driven by PFAS exposure is crucial for elucidating the mechanisms by which these chemicals influence reproductive health. Future research should focus on understanding these epigenetic changes in both immediate fertility outcomes and transgenerational health risks.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Endocrine-Disrupting Chemicals, Climate, and Air Pollution on Pregnancy Outcomes: A Scoping Review. 内分泌干扰物、气候和空气污染对妊娠结局的影响：范围综述。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-18 DOI: 10.1055/s-0044-1800961

Shaun R Wesley, Mary Gallo, Tejumola Apata, Jane van Dis, Stefanie J Hollenbach

{"title":"Impact of Endocrine-Disrupting Chemicals, Climate, and Air Pollution on Pregnancy Outcomes: A Scoping Review.","authors":"Shaun R Wesley, Mary Gallo, Tejumola Apata, Jane van Dis, Stefanie J Hollenbach","doi":"10.1055/s-0044-1800961","DOIUrl":"https://doi.org/10.1055/s-0044-1800961","url":null,"abstract":"Environmental pollutants, including endocrine-disrupting chemicals (EDCs), air pollution, and climate change, are increasingly recognized for their potential impact on pregnancy outcomes. EDCs, found in pesticides, industrial chemicals, and personal care products, are associated with preterm birth and fetal growth restriction, primarily through hormonal interference. Air pollution, notably PM2.5, NO2, and O3, has been linked to increased rates of preterm birth, low birth weight, and stillbirth. Climate factors, such as extreme heat, elevate risks of pregnancy loss and preterm birth, with significant impacts on vulnerable populations across diverse socioeconomic and geographic regions. These exposures contribute to adverse pregnancy outcomes through mechanisms involving oxidative stress, inflammation, and endocrine disruption. The interplay among these environmental factors underscores the need for integrated, longitudinal studies to understand their combined effects on pregnancy outcomes better. Future research should focus on region-specific impacts, cumulative exposure, and policy-driven interventions to mitigate these environmental risks, especially in vulnerable populations disproportionately affected by these hazards. This scoping review synthesizes recent findings from 2019 to 2024 to highlight these associations and identify research gaps.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Antiphospholipid Syndrome on Reproductive Outcomes: Current Insights and Management Approaches. 抗磷脂综合征对生殖结果的影响：目前的见解和管理方法。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-09-01 Epub Date: 2024-10-24 DOI: 10.1055/s-0044-1790225

Lauren He, Catherine Sims

{"title":"Impact of Antiphospholipid Syndrome on Reproductive Outcomes: Current Insights and Management Approaches.","authors":"Lauren He, Catherine Sims","doi":"10.1055/s-0044-1790225","DOIUrl":"10.1055/s-0044-1790225","url":null,"abstract":"Antiphospholipid syndrome (APS) is a disease characterized by the presence of antiphospholipid (aPL) antibodies, thrombosis, and obstetric complications. While patients with APS can have successful pregnancies, many important considerations exist. APS can also cooccur with other systemic autoimmune diseases which can affect pregnancy, particularly systemic lupus erythematosus. This article reviews specific considerations for pregnancy and reproductive health in patients with APS. Similar to other autoimmune diseases, stable or quiescent disease and planning with a rheumatologist and obstetrician prior to conception are vital components of a successful pregnancy. Pregnancy management for patients with aPL antibodies or diagnosis of APS with aspirin and/or anticoagulation depending on disease profile is discussed, as well as the effects of physiologic changes during pregnancy in maternal and fetal outcomes for this population. Given the reproductive span lasts beyond conception through delivery, we include discussions on safe contraception options, the use of assistive reproductive technology, pregnancy termination, menopause, and male fertility. While APS is a relatively rare condition, the effects this disease can have on maternal and fetal outcomes even with available therapies demonstrates the need for more high-quality, evidence-based research.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"197-208"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Autoimmune Thyroid Diseases and Their Complex Interplay with Female Fertility. 自身免疫性甲状腺疾病及其与女性生育力的复杂相互作用综述。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-09-01 Epub Date: 2024-12-12 DOI: 10.1055/s-0044-1795160

Lindsay Carafone, Alex J Knutson, Benjamin J Gigliotti

{"title":"A Review of Autoimmune Thyroid Diseases and Their Complex Interplay with Female Fertility.","authors":"Lindsay Carafone, Alex J Knutson, Benjamin J Gigliotti","doi":"10.1055/s-0044-1795160","DOIUrl":"https://doi.org/10.1055/s-0044-1795160","url":null,"abstract":"Hashimoto thyroiditis and Graves' disease are autoimmune thyroid disorders that are common in women of reproductive age and have a complex relationship with female fertility and health of the maternal-fetal dyad. Both hyperthyroidism and hypothyroidism, whether subclinical or overt in severity, directly or indirectly affect nearly every level of the hypothalamic-pituitary-ovary axis, uterine and ovarian function, as well as fetal development from implantation through delivery. Autoimmunity itself also appears to negatively impact both spontaneous and assisted fertility, as well as miscarriage risk, although the mechanism remains unclear, and the presence and magnitude of risk is variable in published literature. While treatment of overt hyperthyroidism and hypothyroidism is unequivocally recommended by professional societies, the impact of treatment on fertility outcomes, and the role of treatment in subclinical thyroid disease is more controversial. Unfortunately, levothyroxine has not been shown to abrogate the risk of subfertility and miscarriage observed in euthyroid thyroid autoantibody positive women.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"42 3","pages":"178-192"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmunity in Reproduction. 生殖中的自身免疫

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-09-01 Epub Date: 2024-12-12 DOI: 10.1055/s-0044-1793830

Erin M Masaba

引用次数: 0

Impact of Systemic Lupus Erythematosus on Conception: Insights into Infertility, Fertility Preservation, Assisted Reproductive Technology, and Pregnancy Outcomes. 系统性红斑狼疮对受孕的影响：对不孕症、生育能力保存、辅助生殖技术和妊娠结局的见解。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-09-01 Epub Date: 2024-12-12 DOI: 10.1055/s-0044-1793827

Amanda Moyer, Cuoghi Edens

引用次数: 0

A Review of Celiac Disease and Its Implications on Fertility and Pregnancy. 乳糜泻及其对生育和怀孕的影响综述。