Seminars in reproductive medicine最新文献

The Safety of Hormone Replacement Therapy in Gynecological Cancer Survivors.

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2025-03-18 DOI: 10.1055/s-0045-1802985

Victoria Dodhia, Ying Cheong

{"title":"The Safety of Hormone Replacement Therapy in Gynecological Cancer Survivors.","authors":"Victoria Dodhia, Ying Cheong","doi":"10.1055/s-0045-1802985","DOIUrl":"10.1055/s-0045-1802985","url":null,"abstract":"Treatment of gynecological cancers often induces a premature menopause. Plus advancing treatments mean more gynecological cancer survivors are living to physiological menopause. Hormone replacement therapy (HRT) has proven substantial long-term benefits in physiological menopause and premature menopause particularly. We aimed to evaluate the current evidence on the safety of HRT in gynecological cancer survivors to help clinicians counsel these patients. HRT is not contraindicated in most gynecological cancer survivors, as evidence available often shows safety or even benefit with HRT use. However, HRT is contraindicated in a few cancers-in low-grade serous ovarian carcinoma, high-risk endometrial carcinoma, and some uterine sarcomas. Caution is advised in high-grade serous, late-stage endometrioid, and granulosa ovarian carcinomas when there is substandard evidence demonstrating safety, but also a theoretical harm present. Due to deficient large randomized controlled trials and methodological biases being present in most studies, HRT use needs to be individualized in most cancers-ovarian carcinomas, endometrial carcinomas, and cervical adenocarcinomas. Justification for HRT use is strong, and HRT is not contraindicated in most gynecological cancers due to largely reassuring evidence. More robust long-term data are needed for further reliable guidance for clinicians and patients.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Hazards and Male Fertility: Why Don't We Know More?

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-02-10 DOI: 10.1055/s-0044-1801746

Makiko Mitsunami, Jaime E Hart, Jorge E Chavarro

引用次数: 0

Environment and Reproduction.

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-03-10 DOI: 10.1055/s-0044-1800828

Audrey J Gaskins, Lidia Minguez-Alarcon

引用次数: 0

The Environment and Reproduction.

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-03-10 DOI: 10.1055/s-0044-1801397

Kathleen M Hoeger, Terhi T Piltonen

引用次数: 0

PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics. PFAS暴露与男性生殖健康：对精子表观遗传学的影响。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-01-09 DOI: 10.1055/s-0044-1801363

DruAnne L Maxwell, Michael C Petriello, J Richard Pilsner

{"title":"PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics.","authors":"DruAnne L Maxwell, Michael C Petriello, J Richard Pilsner","doi":"10.1055/s-0044-1801363","DOIUrl":"10.1055/s-0044-1801363","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants found in human tissues and persist in the environment, posing significant risks to reproductive health. This review examines the impact of PFAS exposure on male reproductive health, with a focus on sperm epigenetics. PFASs disrupt endocrine function by altering key reproductive hormones and impairing sperm motility, quality, and viability. Epidemiologic and animal studies highlight inconsistent yet concerning associations between PFAS exposure and semen parameters, as well as altered gene expression and DNA methylation patterns. Moreover, PFAS exposure during critical windows of development has been linked to differential impacts on male versus female pubertal development, cognitive outcomes, and reproductive physiology, emphasizing the complexity of PFAS interactions. This comprehensive analysis highlights the need for continued research into the mechanisms by which PFASs influence reproductive health and development with potential implications for sperm epigenetics. The review emphasizes the importance of understanding the epigenetic mechanisms behind these disruptions, particularly DNA methylation and its role in heritable changes. Investigating the epigenetic modifications driven by PFAS exposure is crucial for elucidating the mechanisms by which these chemicals influence reproductive health. Future research should focus on understanding these epigenetic changes in both immediate fertility outcomes and transgenerational health risks.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"288-301"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the Impact of Environmental Non-Persistent Compounds: Phthalates, BPA, and Benzophenone on Endometriosis.

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-03-10 DOI: 10.1055/s-0045-1802986

Maggie K Fuzak, Anna Z Pollack

{"title":"Examining the Impact of Environmental Non-Persistent Compounds: Phthalates, BPA, and Benzophenone on Endometriosis.","authors":"Maggie K Fuzak, Anna Z Pollack","doi":"10.1055/s-0045-1802986","DOIUrl":"https://doi.org/10.1055/s-0045-1802986","url":null,"abstract":"Endometriosis is a debilitating condition characterized by the growth of endometrial-like tissue outside the uterus, leading to chronic pain and inflammation. While its etiology remains complex, emerging evidence implicates environmental contaminants as potential contributors. This review explores the roles of endocrine-disrupting chemicals such as phthalates, bisphenol A (BPA), and benzophenone-like ultraviolet (UV) filters in the development and progression of endometriosis. These chemicals, commonly found in everyday products such as plastics, personal care items, and sunscreen, can mimic or interfere with hormonal functions, disrupting the hormonal balance essential for reproductive health. This review included 18 peer-reviewed studies on phthalates, BPA, and UV filters from 2003 to 2023. Evidence for UV filters was inconclusive, with only two studies available. BPA was positively associated with endometriosis in four out of seven studies. Phthalates were associated with a greater odds of endometriosis in five studies, and with a reduced odds in one study, while three studies found no association with endometriosis. This underscores the need for further research with improved timing of exposure measurement. Understanding the role of phthalates, BPA, and UV filters on endometriosis is crucial for developing effective prevention strategies, potentially reducing the burden of endometriosis.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"42 4","pages":"274-287"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine-Disrupting Chemicals and Female Reproductive Aging.

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-01-29 DOI: 10.1055/s-0044-1801388

Jiaxin Wu, Siobán D Harlow, John F Randolph, Ellen B Gold, Sung Kyun Park

{"title":"Endocrine-Disrupting Chemicals and Female Reproductive Aging.","authors":"Jiaxin Wu, Siobán D Harlow, John F Randolph, Ellen B Gold, Sung Kyun Park","doi":"10.1055/s-0044-1801388","DOIUrl":"10.1055/s-0044-1801388","url":null,"abstract":"Female reproductive aging often affects women's emotional, physical, and physiological well-being. Ovarian aging is characterized by fluctuations in reproductive hormones and determines the age at which menopause occurs. Understanding potentially modifiable factors that influence this process is essential for addressing health disparities, improving quality of life, and informing relevant public health strategies. This review synthesizes in vivo, in vitro, and epidemiological findings about the effects of endocrine-disrupting chemicals (EDCs), specifically heavy metals and perfluoroalkyl and polyfluoroalkyl substances (PFAS) on female reproductive aging. Most in vivo and in vitro studies have demonstrated that heavy metals alter ovarian morphology, folliculogenesis, and steroidogenesis. Evidence regarding the effects of PFAS is limited and inconsistent. Epidemiological studies have consistently shown that heavy metals are associated with a higher risk of diminished ovarian reserve (indicated by decreased anti-Müllerian hormone) and earlier menopause, with limited findings regarding reproductive hormone changes. PFAS exposure has been associated with decreased estradiol and earlier menopause but not significantly with ovarian reserve. Gaps in the literature require more comprehensive epidemiological research on the effects of EDCs on female reproductive aging, including ovarian reserve, age at menopause, and vasomotor symptoms, to inform future interventions to reduce hazardous exposures and improve women's health.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"330-360"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Endocrine-Disrupting Chemicals, Climate, and Air Pollution on Pregnancy Outcomes: A Scoping Review. 内分泌干扰物、气候和空气污染对妊娠结局的影响：范围综述。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2024-12-18 DOI: 10.1055/s-0044-1800961

Shaun R Wesley, Mary Gallo, Tejumola Apata, Jane van Dis, Stefanie J Hollenbach

{"title":"Impact of Endocrine-Disrupting Chemicals, Climate, and Air Pollution on Pregnancy Outcomes: A Scoping Review.","authors":"Shaun R Wesley, Mary Gallo, Tejumola Apata, Jane van Dis, Stefanie J Hollenbach","doi":"10.1055/s-0044-1800961","DOIUrl":"10.1055/s-0044-1800961","url":null,"abstract":"Environmental pollutants, including endocrine-disrupting chemicals (EDCs), air pollution, and climate change, are increasingly recognized for their potential impact on pregnancy outcomes. EDCs, found in pesticides, industrial chemicals, and personal care products, are associated with preterm birth and fetal growth restriction, primarily through hormonal interference. Air pollution, notably PM2.5, NO2, and O3, has been linked to increased rates of preterm birth, low birth weight, and stillbirth. Climate factors, such as extreme heat, elevate risks of pregnancy loss and preterm birth, with significant impacts on vulnerable populations across diverse socioeconomic and geographic regions. These exposures contribute to adverse pregnancy outcomes through mechanisms involving oxidative stress, inflammation, and endocrine disruption. The interplay among these environmental factors underscores the need for integrated, longitudinal studies to understand their combined effects on pregnancy outcomes better. Future research should focus on region-specific impacts, cumulative exposure, and policy-driven interventions to mitigate these environmental risks, especially in vulnerable populations disproportionately affected by these hazards. This scoping review synthesizes recent findings from 2019 to 2024 to highlight these associations and identify research gaps.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"312-329"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Exposures and Polycystic Ovary Syndrome: A Review.

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-02-05 DOI: 10.1055/s-0044-1801405

Elizabeth Peebles, Shruthi Mahalingaiah

{"title":"Environmental Exposures and Polycystic Ovary Syndrome: A Review.","authors":"Elizabeth Peebles, Shruthi Mahalingaiah","doi":"10.1055/s-0044-1801405","DOIUrl":"10.1055/s-0044-1801405","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder in women of reproductive age, affecting around 5 to 10% of women and up to 21% depending on the applied diagnostic criteria and study population. People with PCOS may experience oligomenorrhea, androgen excess, and polycystic ovary morphology. The etiology of the disease is not completely understood, with genetics, epigenetics, endocrine, metabolic, lifestyle, and environmental factors contributing to its development and severity. Environmental exposures are an important, burgeoning field in menstrual research, as they potentially link to menstrual cycle disruption and the risk of reproductive disorders such as PCOS. This review examines the recent research investigating environmental exposures-air pollution, micro- and nanoplastics, heavy metals, and endocrine-disrupting chemicals-and PCOS in human and animal models, concluding with potential mechanisms, limitations, and considerations for future work. Overall, research on environmental exposures and PCOS is limited and yields heterogeneous results across studies. Specifically, exposures such as air pollutants, micro- and nanoplastics, persistent organic pollutants, and parabens have noticeably limited research. Future research can help fill the gap in understanding how environmental exposures, particularly across gestational, childhood, and reproductive adult life stages, may impact PCOS.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"253-273"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Antiphospholipid Syndrome on Reproductive Outcomes: Current Insights and Management Approaches. 抗磷脂综合征对生殖结果的影响：目前的见解和管理方法。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-09-01 Epub Date: 2024-10-24 DOI: 10.1055/s-0044-1790225

Lauren He, Catherine Sims

{"title":"Impact of Antiphospholipid Syndrome on Reproductive Outcomes: Current Insights and Management Approaches.","authors":"Lauren He, Catherine Sims","doi":"10.1055/s-0044-1790225","DOIUrl":"10.1055/s-0044-1790225","url":null,"abstract":"Antiphospholipid syndrome (APS) is a disease characterized by the presence of antiphospholipid (aPL) antibodies, thrombosis, and obstetric complications. While patients with APS can have successful pregnancies, many important considerations exist. APS can also cooccur with other systemic autoimmune diseases which can affect pregnancy, particularly systemic lupus erythematosus. This article reviews specific considerations for pregnancy and reproductive health in patients with APS. Similar to other autoimmune diseases, stable or quiescent disease and planning with a rheumatologist and obstetrician prior to conception are vital components of a successful pregnancy. Pregnancy management for patients with aPL antibodies or diagnosis of APS with aspirin and/or anticoagulation depending on disease profile is discussed, as well as the effects of physiologic changes during pregnancy in maternal and fetal outcomes for this population. Given the reproductive span lasts beyond conception through delivery, we include discussions on safe contraception options, the use of assistive reproductive technology, pregnancy termination, menopause, and male fertility. While APS is a relatively rare condition, the effects this disease can have on maternal and fetal outcomes even with available therapies demonstrates the need for more high-quality, evidence-based research.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"197-208"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0