Seminars in reproductive medicine最新文献_第10页

Polycystic Ovary Syndrome Models of Care: A Review and Qualitative Evaluation of a Guideline-Recommended Integrated Care. 多囊卵巢综合征的护理模式:指南推荐综合护理的回顾和定性评价。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2021-07-01 Epub Date: 2021-06-29 DOI: 10.1055/s-0041-1727191

Chau Thien Tay, Stephanie Pirotta, Helena J Teede, Lisa J Moran, Tracy Robinson, Helen Skouteris, Anju E Joham, Siew S Lim

{"title":"Polycystic Ovary Syndrome Models of Care: A Review and Qualitative Evaluation of a Guideline-Recommended Integrated Care.","authors":"Chau Thien Tay, Stephanie Pirotta, Helena J Teede, Lisa J Moran, Tracy Robinson, Helen Skouteris, Anju E Joham, Siew S Lim","doi":"10.1055/s-0041-1727191","DOIUrl":"https://doi.org/10.1055/s-0041-1727191","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a heterogeneous disorder and many women are dissatisfied with their healthcare under the current fragmented health services. Here, we review existing literature on PCOS healthcare services and qualitatively evaluate an integrated PCOS service based on experiences of women with PCOS. Limited prior PCOS-dedicated services have been studied and their quantitative and efficacy-focused evaluations are summarized. Here, we also provide a broader PCOS service evaluation via semistructured interviews and surveys, with thematic analysis based on a predetermined evaluation framework. Fifteen women completed interviews and surveys. Overall the integrated, evidence-based PCOS service was well-received and women were generally satisfied with appropriateness, effectiveness, and reported positive health impact resulting from the service. Integrated care, tailored treatments, education, lifestyle support, and laser therapy were highly valued. Patients reported improvements on symptoms, understanding and confidence in managing PCOS, and emotional well-being. Elements of efficiency in the initial stages, awareness and communication, and the need for service expansion and tensions between evidence-based treatments and patient preferences were also captured to guide improvement. Further research into models of care is recommended to meet the needs of women with PCOS.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"39 3-04","pages":"133-142"},"PeriodicalIF":2.7,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39039180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Natural History of Polycystic Ovary Syndrome and New Advances in the Epidemiology. 多囊卵巢综合征的自然发病及流行病学研究新进展。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2021-07-01 Epub Date: 2021-08-31 DOI: 10.1055/s-0041-1735211

Terhi T Piltonen, Riikka K Arffman, Anju E Joham

{"title":"Natural History of Polycystic Ovary Syndrome and New Advances in the Epidemiology.","authors":"Terhi T Piltonen, Riikka K Arffman, Anju E Joham","doi":"10.1055/s-0041-1735211","DOIUrl":"https://doi.org/10.1055/s-0041-1735211","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women, affecting up to 15% of the female population. The natural history of the syndrome is complex, including both androgen exposure in early life and adiposity-driven dysfunction involving also dysregulated, also involving altered hypothalamus-ovarian crosstalk. The manifestations can arise as early as childhood or puberty onward, suggesting that genetic susceptibility is an important etiological factor. In adulthood, women with PCOS present with reproductive, metabolic, and psychological health issues at a population-based level. Epidemiological studies on large datasets offer an excellent opportunity to evaluate health effects and costs related to the syndrome. Hospital or insurance-based datasets are also available; however, the results are not representative of the female population in the community. More longitudinal studies spanning from early childhood to late adulthood are needed to assess the long-term health impact and early manifestations of PCOS. Moreover, the identification of women with PCOS from large datasets can be expensive. Self-reported symptoms or PCOS diagnosis may offer a feasible approach.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"39 3-04","pages":"94-101"},"PeriodicalIF":2.7,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39370869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Comprehensive PCOS Research and Guideline Translation Program to Improve Practice. 综合多囊卵巢综合征研究和指南翻译计划，以提高实践。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2021-07-01 Epub Date: 2021-09-16 DOI: 10.1055/s-0041-1733916

Vijayanand A Ramasamy, Rhonda M Garad, Jacqueline A Boyle

{"title":"A Comprehensive PCOS Research and Guideline Translation Program to Improve Practice.","authors":"Vijayanand A Ramasamy, Rhonda M Garad, Jacqueline A Boyle","doi":"10.1055/s-0041-1733916","DOIUrl":"https://doi.org/10.1055/s-0041-1733916","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy affecting reproductive-age women with a reported prevalence of 8 to 13%. To address the knowledge, practice, consumer satisfaction, and research gaps, an international research collaboration was formed to develop the first \"International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome (2018).\" This article describes an effective research translation program to disseminate the guideline internationally to women and health providers. To date, this had led to 75,197 views and almost 36,000 downloads of the PCOS guideline, and 43,000 views and 10,600 downloads of a suite of PCOS resources. AskPCOS app, the first freely accessible, evidence-based PCOS app, has 9,910 users (between 400 and 800 users per month), 23,447 sessions, and 87,801 screen viewings. Fifty-four percent of returning users are from across 137 countries, with the most users in Australia, the United States, the United Kingdom, the Netherlands, and India. Extensive global uptake of the PCOS guideline and compendium of resources was augmented by extensive formative consumer and health professional consultation, end-user engagement across the evidence-creation spectrum, co-design, and quality improvement.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"39 3-04","pages":"161-166"},"PeriodicalIF":2.7,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39442896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Need to Reassess the Diagnosis of Polycystic Ovary Syndrome (PCOS): A Review of Diagnostic Recommendations from the International Evidence-Based Guideline for the Assessment and Management of PCOS. 重新评估多囊卵巢综合征(PCOS)诊断的必要性:国际多囊卵巢综合征评估和管理循证指南诊断建议综述

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2021-07-01 Epub Date: 2021-08-17 DOI: 10.1055/s-0041-1735259

Sylvia Kiconco, Helena J Teede, Ricardo Azziz, Robert J Norman, Anju E Joham

{"title":"The Need to Reassess the Diagnosis of Polycystic Ovary Syndrome (PCOS): A Review of Diagnostic Recommendations from the International Evidence-Based Guideline for the Assessment and Management of PCOS.","authors":"Sylvia Kiconco, Helena J Teede, Ricardo Azziz, Robert J Norman, Anju E Joham","doi":"10.1055/s-0041-1735259","DOIUrl":"https://doi.org/10.1055/s-0041-1735259","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a common endocrine disorder that is associated with negative metabolic, reproductive, endocrine, and psychological consequences among women of reproductive age. The diagnosis of PCOS remains challenging due to limited and conflicting evidence regarding definitions for each of the diagnostic features. This review of the recommended PCOS assessment criteria from the international evidence-based guideline highlights the crucial need to reassess, redefine, and optimize the diagnosis of PCOS. Notably, normal values and cut-offs need to be defined for each diagnostic feature across the lifespan and diverse ethnic groups. Understanding how these features cluster together and relate to short- and long-term health outcomes in PCOS is also vital. Ultimately, greater knowledge of the natural history of PCOS is needed through well-characterized, community-based longitudinal studies, which will inform future PCOS diagnosis guidelines and optimize women's health in reproductive life.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"39 3-04","pages":"71-77"},"PeriodicalIF":2.7,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39320530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Metabolomic Biomarkers in Polycystic Ovary Syndrome: A Review of the Evidence. 多囊卵巢综合征的代谢组学生物标志物:证据综述

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2021-07-01 Epub Date: 2021-05-04 DOI: 10.1055/s-0041-1729841

Simon Alesi, Drishti Ghelani, Aya Mousa

{"title":"Metabolomic Biomarkers in Polycystic Ovary Syndrome: A Review of the Evidence.","authors":"Simon Alesi, Drishti Ghelani, Aya Mousa","doi":"10.1055/s-0041-1729841","DOIUrl":"https://doi.org/10.1055/s-0041-1729841","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is an endocrinologic condition affecting one in five women of reproductive age. PCOS is often characterized by disruptions to the menstrual cycle, development of male-pattern hair growth (hirsutism), and polycystic ovary morphology. Recently, PCOS has been linked to metabolic dysfunction, with 40 to 80% of women characterized as overweight or obese. Despite these well-known negative health effects of PCOS, 75% of sufferers remain undiagnosed. This is most likely due to the variability in symptom presentation and the lack of a definitive test for the condition. Metabolomics, which is a platform used to analyze and characterize a large number of metabolites, has recently been proposed as a potential tool for investigating the metabolic pathways that could be involved in the pathophysiology of PCOS. In doing so, novel biomarkers could be identified to improve diagnosis and treatment of PCOS. This review aims to summarize the findings of recent metabolomic studies that highlight metabolic-specific molecules which are deranged in PCOS, to identify potential biomarkers for the condition. Current limitations for metabolomic studies are discussed, as well as future directions to progress the field toward further validation and integration into clinical practice.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"39 3-04","pages":"102-110"},"PeriodicalIF":2.7,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38947985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Informing a PCOS Lifestyle Program: Mapping Behavior Change Techniques to Barriers and Enablers to Behavior Change Using the Theoretical Domains Framework. 告知多囊卵巢综合征生活方式计划:使用理论领域框架将行为改变技术映射到行为改变的障碍和推动因素。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2021-07-01 Epub Date: 2021-08-25 DOI: 10.1055/s-0041-1735456

Stephanie Pirotta, A E Joham, L J Moran, H Skouteris, S S Lim

{"title":"Informing a PCOS Lifestyle Program: Mapping Behavior Change Techniques to Barriers and Enablers to Behavior Change Using the Theoretical Domains Framework.","authors":"Stephanie Pirotta, A E Joham, L J Moran, H Skouteris, S S Lim","doi":"10.1055/s-0041-1735456","DOIUrl":"https://doi.org/10.1055/s-0041-1735456","url":null,"abstract":"This article aimed to identify the behavior change techniques (BCTs) based on facilitators and barriers to lifestyle management in women with polycystic ovary syndrome (PCOS) according to the behavior change wheel (BCW). This qualitative study design using inductive thematic analysis following semistructured interviews (n = 20) identified barriers and enablers to lifestyle management. These were then mapped to Capability, Opportunity, Motivation-Behavioral Model (COM-B) constructs and the corresponding Theoretical Domains Framework (TDF) domains. This study included women with PCOS residing in Australia. Main outcome measures include intervention functions, policy categories, and BCTs described in the BCW. Twenty-three BCTs were recognized to influence behavior change in women with PCOS. Factors were categorized into the subcomponents of the COM-B: psychological capability (e.g., lack of credible information), physical capability (e.g., managing multiple health conditions), physical opportunity (e.g., limited access to resources), social opportunity (e.g., adequate social support), reflective motivation (e.g., positive health expectancies following behavior change), and automatic motivation (e.g., emotional eating). Future research should use this work to guide PCOS lifestyle intervention development and then test intervention effectiveness through an experimental phase to provide empirical evidence for wider use and implementation of tailored, theory-informed PCOS lifestyle programs as part of evidence-based PCOS management.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"39 3-04","pages":"143-152"},"PeriodicalIF":2.7,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39343162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An Analysis on the Implementation of the Evidence-based PCOS Lifestyle Guideline: Recommendations from Women with PCOS. 循证PCOS生活方式指南的实施分析:PCOS女性的建议。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2021-07-01 Epub Date: 2021-08-30 DOI: 10.1055/s-0041-1735575

Siew Lim, Breanna Wright, Melissa Savaglio, Denise Goodwin, Stephanie Pirotta, Lisa Moran

{"title":"An Analysis on the Implementation of the Evidence-based PCOS Lifestyle Guideline: Recommendations from Women with PCOS.","authors":"Siew Lim, Breanna Wright, Melissa Savaglio, Denise Goodwin, Stephanie Pirotta, Lisa Moran","doi":"10.1055/s-0041-1735575","DOIUrl":"https://doi.org/10.1055/s-0041-1735575","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder affecting women of reproductive age, affecting 8-13% in this group. Women with PCOS are more likely to have excess BMI, which in turn exacerbates the symptoms of PCOS in these women. The latest evidence-based guideline recommends lifestyle management as the first-line treatment for PCOS. However, the implementation of this recommendation through health services faces a significant challenge. As part of the mapping of the implementation plan for lifestyle management in PCOS, citizen panels and semi-structured interviews were conducted to capture the voices of consumers. Women with PCOS expressed the need for multidisciplinary, integrated care as a recurrent theme. Other important considerations included health professionals who listen and are open to learning about PCOS, the empowerment of women to self-manage PCOS and the provision of peer support. Women with PCOS also expressed the key recommendation of focusing on practical skills when providing lifestyle advice. Within that, both individual and group lifestyle sessions were valued for privacy and peer support respectively and delivery by a dietitian is preferred. These recommendations by women with PCOS should be considered when developing the implementation plan for the PCOS lifestyle guideline.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"39 3-04","pages":"153-160"},"PeriodicalIF":2.7,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39370478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Pathophysiology of Hypercoagulability and Infertility. 高凝性与不孕症的病理生理。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2021-03-01 Epub Date: 2021-05-17 DOI: 10.1055/s-0041-1729763

Ann Kinga Malinowski

引用次数: 4

Preimplantation Genetic Testing for Aneuploidy: Current Perspectives. 非整倍体的植入前基因检测:当前的观点。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2021-03-01 Epub Date: 2021-07-08 DOI: 10.1055/s-0041-1731828

Ariadne L'Heveder, Benjamin P Jones, Roy Naja, Paul Serhal, Jara Ben Nagi

{"title":"Preimplantation Genetic Testing for Aneuploidy: Current Perspectives.","authors":"Ariadne L'Heveder, Benjamin P Jones, Roy Naja, Paul Serhal, Jara Ben Nagi","doi":"10.1055/s-0041-1731828","DOIUrl":"https://doi.org/10.1055/s-0041-1731828","url":null,"abstract":"Despite improvements in assisted reproduction techniques (ARTs), live birth rates remain suboptimal, particularly in women with advanced maternal age (AMA). The leading cause of poor reproductive outcomes demonstrated in women with AMA, as well as women with recurrent miscarriage and repetitive implantation failure, is thought to be due to high rates of embryonic aneuploidy. Preimplantation genetic testing for aneuploidies (PGT-A) aims to select an euploid embryo for transfer and therefore improve ART outcomes. Early PGT-A studies using fluorescent in situ hybridization on mainly cleavage-stage biopsies failed to show improved delivery rates and, in certain cases, were even found to be harmful. However, the development of comprehensive chromosome screening, as well as improvements in culture media and vitrification techniques, has resulted in an emerging body of evidence in favor of PGT-A, demonstrating higher implantation, pregnancy, and live birth rates. While there are concerns regarding the potential harm of invasive biopsy and the cost implications of PGT-A, the introduction of noninvasive techniques and the development of new high-throughput methods which lower costs are tackling these issues. This review aims to assess the evidence for PGT-A, address possible concerns regarding PGT-A, and also explore the future direction of this technology.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"39 1-02","pages":"1-12"},"PeriodicalIF":2.7,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1731828","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39164922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Endometrial Receptivity Testing and Therapy in Assisted Reproductive Treatment. 辅助生殖治疗中的子宫内膜容受性检测与治疗。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2021-03-01 Epub Date: 2021-08-14 DOI: 10.1055/s-0041-1730421

Lukasz Tadeusz Polanski, Miriam Baumgarten

引用次数: 3