Seminars in reproductive medicine最新文献_第2页

Current Ovulation and Luteal Phase Tracking Methods and Technologies for Fertility and Family Planning: A Review. 当前用于生育和计划生育的排卵和黄体期跟踪方法与技术：综述。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-09-20 DOI: 10.1055/s-0044-1791190

Andrea K Wegrzynowicz, Aimee Eyvazzadeh, Amy Beckley

{"title":"Current Ovulation and Luteal Phase Tracking Methods and Technologies for Fertility and Family Planning: A Review.","authors":"Andrea K Wegrzynowicz, Aimee Eyvazzadeh, Amy Beckley","doi":"10.1055/s-0044-1791190","DOIUrl":"https://doi.org/10.1055/s-0044-1791190","url":null,"abstract":"Ovulation is critical for both conception and overall health, but many people who may ovulate are not tracking ovulation or any other part of their menstrual cycle. Failure to track ovulation, especially in those trying to conceive, can lead to fertility challenges due to absent ovulation, mistiming intercourse, or an undetected luteal phase defect. Ovulatory disorders and mistiming intercourse are both primary causes of infertility, and tracking ovulation is shown to decrease the average time to conception. While there are many tracking methods and apps available, the majority are predictive apps or ovulation predictor kits and do not test or track both successful ovulation and the health of the luteal phase, leading to missing information that could contribute to diagnosis or successful conception. Here, we review why ovulation tracking and a healthy luteal phase are important for those trying to conceive. We present currently available ovulation tracking methods that detect both ovulation and the luteal phase, including cervical mucus, urinary hormone testing, and basal body temperature, and discuss the use, advantages, and disadvantages of each. Finally, we consider the role of digital applications and tracking technologies in ovulation tracking.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the Strengths and Limitations of Online Oocyte Cryopreservation Calculators. 了解在线卵母细胞冷冻保存计算器的优势和局限性。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-07-10 DOI: 10.1055/s-0044-1788030

Amber T Wolf, Evelyn Minis, Shruthi Mahalingaiah

{"title":"Understanding the Strengths and Limitations of Online Oocyte Cryopreservation Calculators.","authors":"Amber T Wolf, Evelyn Minis, Shruthi Mahalingaiah","doi":"10.1055/s-0044-1788030","DOIUrl":"https://doi.org/10.1055/s-0044-1788030","url":null,"abstract":"Between 2010 and 2016, elective oocyte cryopreservation (OC) increased in use by 880% in the United States; however, there have been increasing reports of regret among patients after elective OC. There is a growing need for individualized counseling on the timing and number of oocytes to cryopreserve for patients to make informed choices and set realistic expectations, but currently available tools seem to be insufficient. The purpose of this review is to describe the OC calculators currently available online, identify sources of regret, and illustrate the need for unified counseling tools for improved patient care and education. OC calculators were identified via Google search. Only calculators that cite scientific literature were included in the review. Calculators for in vitro fertilization or embryo transfer were excluded. Thirteen OC calculators were found; however, only six cited literature supporting the calculator's design. When entering the same hypothetical patient parameters for age and number of oocytes cryopreserved, the calculators provided drastically different probabilities of live births. The lack of cohesive online educational materials creates confusion and stress for patients considering OC, leading to unrealistic expectations and increased feelings of regret thereafter. Physicians need tools to provide comprehensive guidance to patients seeking to cryopreserve oocytes.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Anti-Müllerian Hormone in the Central Regulation of Fertility 抗缪勒氏管激素在生育中枢调节中的作用

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2024-04-12 DOI: 10.1055/s-0044-1786050

Ludovica Cotellessa, Paolo Giacobini

{"title":"Role of Anti-Müllerian Hormone in the Central Regulation of Fertility","authors":"Ludovica Cotellessa, Paolo Giacobini","doi":"10.1055/s-0044-1786050","DOIUrl":"https://doi.org/10.1055/s-0044-1786050","url":null,"abstract":"In recent years, the expanding roles of anti-Müllerian hormone (AMH) in various aspects of reproductive health have attracted significant attention. Initially recognized for its classical role in male sexual differentiation, AMH is produced postnatally by the Sertoli cells in the male testes and by the granulosa cells in the female ovaries. Traditionally, it was believed to primarily influence gonadal development and function. However, research over the last decade has unveiled novel actions of AMH beyond the gonads, specifically all along the hypothalamic–pituitary–gonadal axis. This review will focus on the emerging roles of AMH within the hypothalamus and discusses its potential implications in reproductive physiology. Additionally, recent preclinical and clinical studies have suggested that elevated levels of AMH may disrupt the hypothalamic network regulating reproduction, which could contribute to the central pathophysiology of polycystic ovary syndrome. These findings underscore the intricate interplay between AMH and the neuroendocrine system, offering new avenues for understanding the mechanisms underlying fertility and reproductive disorders. ","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140578771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Müllerian Hormone: A Molecular Key to Unlocking Polycystic Ovary Syndrome? 抗缪勒氏管激素：解开多囊卵巢综合征的分子钥匙？

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-06-22 DOI: 10.1055/s-0044-1787525

David H Abbott, Beverly A Hutcherson, Daniel A Dumesic

{"title":"Anti-Müllerian Hormone: A Molecular Key to Unlocking Polycystic Ovary Syndrome?","authors":"David H Abbott, Beverly A Hutcherson, Daniel A Dumesic","doi":"10.1055/s-0044-1787525","DOIUrl":"10.1055/s-0044-1787525","url":null,"abstract":"Anti-Müllerian hormone (AMH) is an important component within androgen receptor (AR)-regulated pathways governing the hyperandrogenic origin of polycystic ovary syndrome (PCOS). In women with PCOS, granulosa cell AMH overexpression in developing ovarian follicles contributes to elevated circulating AMH levels beginning at birth and continuing in adolescent daughters of PCOS women. A 6 to 7% incidence among PCOS women of gene variants coding for AMH or its receptor, AMHR2, suggests genetic contributions to AMH-related pathogenesis. Discrete gestational AMH administration to pregnant mice induces hypergonadotropic hyperandrogenic, PCOS-like female offspring with high circulating AMH levels that persist over three generations, suggesting epigenetic contributions to PCOS through developmental programming. Moreover, adult-onset, selective hyperactivation of hypothalamic neurons expressing gonadotropin-releasing hormone (GnRH) induces hypergonadotropic hyperandrogenism and PCOS-like traits in female mice. Both gestational and adult AMH inductions of PCOS-like traits are prevented by GnRH antagonist coadministration, implicating luteinizing hormone-dependent ovarian theca cell testosterone (T) action, mediated through the AR in AMH-induced pathogenesis. Interestingly, gestational or peripubertal exogenous T or dihydrotestosterone induction of PCOS-like traits in female mice, rats, sheep, and monkeys fails to elicit ovarian AMH hypersecretion; thus, AMH excess per se may lead to a distinct pathogenic contribution to hyperandrogenic PCOS origins.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of Serum Anti-Müllerian Hormone Measurement as Part of Polycystic Ovary Syndrome Diagnosis. 血清抗苗勒管激素测定作为多囊卵巢综合征诊断的一部分的实用性。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-05-22 DOI: 10.1055/s-0044-1786731

Terhi T Piltonen, Johanna Viita-Aho, Ulla Saarela, Johanna Melin, Maria Forslund

{"title":"Utility of Serum Anti-Müllerian Hormone Measurement as Part of Polycystic Ovary Syndrome Diagnosis.","authors":"Terhi T Piltonen, Johanna Viita-Aho, Ulla Saarela, Johanna Melin, Maria Forslund","doi":"10.1055/s-0044-1786731","DOIUrl":"10.1055/s-0044-1786731","url":null,"abstract":"The 2023 international evidence-based guideline update for the assessment and management of polycystic ovary syndrome (PCOS) recommends using the Rotterdam criteria for the diagnosis of PCOS. The updated guideline has evidence-based recommendation for the diagnosis, and it now also includes serum anti-Müllerian hormone (AMH) measurement as an alternative tool for gynecological ultrasound to diagnose polycystic ovary morphology (PCOM). The aim of this new recommendation was to facilitate PCOS diagnostic workup in primary care and other disciplines, as currently most diagnosing is done in gynecology and infertility clinics. Here, we review factors affecting AMH levels as well as the utility of AMH in PCOS diagnosis. We identified relevant studies that report different cut-offs for AMH to diagnose PCOM as part of PCOS diagnosis. There are, however, some limitations when using AMH that should be acknowledged. These include physiological aspects like age, ethnicity, and obesity and iatrogenic causes like hormonal medication and ovarian surgery. Also reference ranges are different depending on AMH assay used. As a summary, we conclude that AMH is a usable tool in PCOM diagnostics, but it does not have a single cut-off. Therefore, further studies are needed to establish age and assay-based reference ranges.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11257749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Anti-Müllerian Hormone in Ovarian Function. 抗缪勒氏管激素在卵巢功能中的作用

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-05-23 DOI: 10.1055/s-0044-1786732

Sena Yildiz, Loes M E Moolhuijsen, Jenny A Visser

引用次数: 0

AMH in Reproductive Medicine. 生殖医学中的 AMH。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-07-18 DOI: 10.1055/s-0044-1787167

Paolo Giacobini

引用次数: 0

Anti-Mullerian Hormone Assessment in Assisted Reproductive Technique Outcome and Natural Conception. 辅助生殖技术结果和自然受孕中的抗沙勒氏激素评估。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-07-18 DOI: 10.1055/s-0044-1787273

Inès Sellami, Anne Laure Barbotin, Valérie Bernard, Geoffroy Robin, Sophie Catteau-Jonard, Charlotte Sonigo, Maeliss Peigné

{"title":"Anti-Mullerian Hormone Assessment in Assisted Reproductive Technique Outcome and Natural Conception.","authors":"Inès Sellami, Anne Laure Barbotin, Valérie Bernard, Geoffroy Robin, Sophie Catteau-Jonard, Charlotte Sonigo, Maeliss Peigné","doi":"10.1055/s-0044-1787273","DOIUrl":"10.1055/s-0044-1787273","url":null,"abstract":"In recent years, the prevalence of infertility has increased, and appears to affect approximately one in six couples. Some of them must perform assisted reproductive techniques (ART) in order to achieve pregnancy. As a result, growing interest has arisen about predictive factors of pregnancy and live birth with and without ART. Anti-Mullerian hormone (AMH) is a glycoprotein discovered in the 1950s in male embryonic sexual differentiation. Later, in 1984, its role in folliculogenesis was reported: secreted by granulosa cells, this hormone is involved in the regulation of the recruitment of primordial follicles and in follicular growth. AMH assays were developed for women in 1990s, and the serum AMH level has rapidly become a crucial element in managing women's fertility. Based mainly on its ability to be a quantitative but indirect marker of ovarian reserve, the serum AMH assay is widely used in reproductive medicine and ART. This review summarizes current knowledge of the AMH assessment in the field of reproductive medicine. We focus on the role of AMH level to predict spontaneous pregnancy occurrence, ART outcomes, and fertility preservation outcomes.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preimplantation Genetic Testing for Polygenetic Conditions: A Legal, Ethical, and Scientific Challenge. 针对多基因遗传病的植入前基因检测：法律、伦理和科学方面的挑战。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-03-22 DOI: 10.1055/s-0044-1782618

Perrine Ginod, Michael H Dahan

{"title":"Preimplantation Genetic Testing for Polygenetic Conditions: A Legal, Ethical, and Scientific Challenge.","authors":"Perrine Ginod, Michael H Dahan","doi":"10.1055/s-0044-1782618","DOIUrl":"10.1055/s-0044-1782618","url":null,"abstract":"The recent commercialization of the Embryo Health Score (EHS), determined through preimplantation genetic testing for polygenic conditions, offers the potential to select embryos with lower disease risk, thus potentially enhancing offspring longevity and health. Lately, Orchid Health company increased testing from less than 20 diseases to more than 900+ conditions for birth defects. However, the \"geneticization\" of phenotype estimates to a health state erases the environmental part, including the in vitro fertilization potential risks, questioning its scientific usefulness. EHS is utilized in countries with minimal regulatory oversight and will likely expand, while it remains illegal in other countries due to ethical and legal dilemmas it raises about reproductive autonomy, discrimination, impacts on family dynamics, and genetic diversity. The shift toward commercialized polygenic embryo screening (PES) redefines healthcare relationships, turning prospective parents into consumers and altering the physician's role. Moreover, PES could increase social inequalities, stigmatize those not born following PES, and encourage \"desirable\" phenotypic or behavioral traits selection, leading to ethical drift. Addressing these issues is essential before further implementation and requires a collaborative approach involving political, governmental, and public health, alongside geneticists, ethicists, and fertility specialists, focusing on the societal implications and acceptability of testing for polygenic traits for embryo selection.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMH in Reproductive Medicine. 生殖医学中的 AMH。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-07-18 DOI: 10.1055/s-0044-1787834

Kathleen M Hoeger, Terhi T Piltonen

引用次数: 0