Seminars in reproductive medicine最新文献_第3页

The Impact of Radiotherapy on the Uterus and Its Implications for Pregnancy. 放疗对子宫的影响及其对妊娠的影响。

IF 1.4 3区医学

Seminars in reproductive medicine Pub Date : 2025-03-01 Epub Date: 2025-05-14 DOI: 10.1055/s-0045-1809040

Anne-Lotte L F van der Kooi, Wendy van Dorp

{"title":"The Impact of Radiotherapy on the Uterus and Its Implications for Pregnancy.","authors":"Anne-Lotte L F van der Kooi, Wendy van Dorp","doi":"10.1055/s-0045-1809040","DOIUrl":"10.1055/s-0045-1809040","url":null,"abstract":"Radiotherapy is an effective treatment for various cancers, but it can cause significant side effects on various organ systems, including the reproductive organs, which is a major concern for women of reproductive age. A well-known long-term effect of oncological treatment is premature ovarian insufficiency. Another critical but sometimes overlooked organ at risk in female cancer survivors is the uterus. This review focuses on the impact of radiotherapy on uterine physiology, highlighting key issues such as the development of fibrosis and loss of elasticity, vascular damage, and hormonal disruption, all of which can compromise uterine function. These changes can negatively impact fertility and pregnancy outcomes, such as miscarriage, preterm birth, and low birth weight. Limited evidence is also available suggesting that radiotherapy may affect endometrial receptivity and contribute to abnormal placentation. We conclude by discussing strategies aimed at mitigating the damage caused by radiotherapy, such as fertility-preserving treatments and hormonal interventions. A thorough understanding of these effects is essential for healthcare providers to offer informed support to women who wish to maintain their fertility and have children following cancer treatment.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"16-22"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fertility Preservation in Women with Cervical Cancer. 子宫颈癌妇女的生育能力保存。

IF 1.4 3区医学

Seminars in reproductive medicine Pub Date : 2025-03-01 Epub Date: 2025-08-01 DOI: 10.1055/s-0045-1810055

Ines Sellami, Emine Saïs, Fatoumata Souare, Céleste Becquart, Hélène Thomas, Charlotte Sonigo, Michaël Grynberg

{"title":"Fertility Preservation in Women with Cervical Cancer.","authors":"Ines Sellami, Emine Saïs, Fatoumata Souare, Céleste Becquart, Hélène Thomas, Charlotte Sonigo, Michaël Grynberg","doi":"10.1055/s-0045-1810055","DOIUrl":"10.1055/s-0045-1810055","url":null,"abstract":"Cervical cancer (CC) is one of the most common malignancies affecting young women of childbearing age, making fertility preservation (FP) a pivotal consideration in its management. The feasibility of FP techniques depends on the cancer stage and oncological treatments. In early-stage CC, fertility-sparing surgery can be offered for young patients wishing to preserve fertility without compromising oncological safety. Neoadjuvant chemotherapy followed by fertility-sparing surgery is an alternative for patients with nonmetastatic locally advanced disease and negative lymph node status. Nevertheless, for patients with locally advanced disease requiring radical hysterectomy or pelvic radiotherapy, FP can be performed using oocyte, embryo, or ovarian tissue cryopreservation. For these patients, future pregnancy is possible through surrogacy. Recently, uterine transposition has been proposed as an alternative to preserve uterine anatomy to prevent uterine radio-induced damage and avoid surrogacy. This review provides a comprehensive overview of the FP options available for young patients with CC.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"5-10"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Hazards and Male Fertility: Why Don't We Know More? 环境危害与男性生育能力：为什么我们知之甚少？

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-02-10 DOI: 10.1055/s-0044-1801746

Makiko Mitsunami, Jaime E Hart, Jorge E Chavarro

引用次数: 0

PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics. PFAS暴露与男性生殖健康：对精子表观遗传学的影响。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-01-09 DOI: 10.1055/s-0044-1801363

DruAnne L Maxwell, Michael C Petriello, J Richard Pilsner

{"title":"PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics.","authors":"DruAnne L Maxwell, Michael C Petriello, J Richard Pilsner","doi":"10.1055/s-0044-1801363","DOIUrl":"10.1055/s-0044-1801363","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants found in human tissues and persist in the environment, posing significant risks to reproductive health. This review examines the impact of PFAS exposure on male reproductive health, with a focus on sperm epigenetics. PFASs disrupt endocrine function by altering key reproductive hormones and impairing sperm motility, quality, and viability. Epidemiologic and animal studies highlight inconsistent yet concerning associations between PFAS exposure and semen parameters, as well as altered gene expression and DNA methylation patterns. Moreover, PFAS exposure during critical windows of development has been linked to differential impacts on male versus female pubertal development, cognitive outcomes, and reproductive physiology, emphasizing the complexity of PFAS interactions. This comprehensive analysis highlights the need for continued research into the mechanisms by which PFASs influence reproductive health and development with potential implications for sperm epigenetics. The review emphasizes the importance of understanding the epigenetic mechanisms behind these disruptions, particularly DNA methylation and its role in heritable changes. Investigating the epigenetic modifications driven by PFAS exposure is crucial for elucidating the mechanisms by which these chemicals influence reproductive health. Future research should focus on understanding these epigenetic changes in both immediate fertility outcomes and transgenerational health risks.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"288-301"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environment and Reproduction. 环境与繁殖。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-03-10 DOI: 10.1055/s-0044-1800828

Audrey J Gaskins, Lidia Minguez-Alarcon

引用次数: 0

The Environment and Reproduction. 环境与繁殖。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-03-10 DOI: 10.1055/s-0044-1801397

Kathleen M Hoeger, Terhi T Piltonen

引用次数: 0

Examining the Impact of Environmental Non-Persistent Compounds: Phthalates, BPA, and Benzophenone on Endometriosis. 检查环境非持久性化合物：邻苯二甲酸盐，双酚a和二苯甲酮对子宫内膜异位症的影响。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-03-10 DOI: 10.1055/s-0045-1802986

Maggie K Fuzak, Anna Z Pollack

{"title":"Examining the Impact of Environmental Non-Persistent Compounds: Phthalates, BPA, and Benzophenone on Endometriosis.","authors":"Maggie K Fuzak, Anna Z Pollack","doi":"10.1055/s-0045-1802986","DOIUrl":"10.1055/s-0045-1802986","url":null,"abstract":"Endometriosis is a debilitating condition characterized by the growth of endometrial-like tissue outside the uterus, leading to chronic pain and inflammation. While its etiology remains complex, emerging evidence implicates environmental contaminants as potential contributors. This review explores the roles of endocrine-disrupting chemicals such as phthalates, bisphenol A (BPA), and benzophenone-like ultraviolet (UV) filters in the development and progression of endometriosis. These chemicals, commonly found in everyday products such as plastics, personal care items, and sunscreen, can mimic or interfere with hormonal functions, disrupting the hormonal balance essential for reproductive health. This review included 18 peer-reviewed studies on phthalates, BPA, and UV filters from 2003 to 2023. Evidence for UV filters was inconclusive, with only two studies available. BPA was positively associated with endometriosis in four out of seven studies. Phthalates were associated with a greater odds of endometriosis in five studies, and with a reduced odds in one study, while three studies found no association with endometriosis. This underscores the need for further research with improved timing of exposure measurement. Understanding the role of phthalates, BPA, and UV filters on endometriosis is crucial for developing effective prevention strategies, potentially reducing the burden of endometriosis.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"42 4","pages":"274-287"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine-Disrupting Chemicals and Female Reproductive Aging. 内分泌干扰化学物质与女性生殖衰老。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-01-29 DOI: 10.1055/s-0044-1801388

Jiaxin Wu, Siobán D Harlow, John F Randolph, Ellen B Gold, Sung Kyun Park

{"title":"Endocrine-Disrupting Chemicals and Female Reproductive Aging.","authors":"Jiaxin Wu, Siobán D Harlow, John F Randolph, Ellen B Gold, Sung Kyun Park","doi":"10.1055/s-0044-1801388","DOIUrl":"10.1055/s-0044-1801388","url":null,"abstract":"Female reproductive aging often affects women's emotional, physical, and physiological well-being. Ovarian aging is characterized by fluctuations in reproductive hormones and determines the age at which menopause occurs. Understanding potentially modifiable factors that influence this process is essential for addressing health disparities, improving quality of life, and informing relevant public health strategies. This review synthesizes in vivo, in vitro, and epidemiological findings about the effects of endocrine-disrupting chemicals (EDCs), specifically heavy metals and perfluoroalkyl and polyfluoroalkyl substances (PFAS) on female reproductive aging. Most in vivo and in vitro studies have demonstrated that heavy metals alter ovarian morphology, folliculogenesis, and steroidogenesis. Evidence regarding the effects of PFAS is limited and inconsistent. Epidemiological studies have consistently shown that heavy metals are associated with a higher risk of diminished ovarian reserve (indicated by decreased anti-Müllerian hormone) and earlier menopause, with limited findings regarding reproductive hormone changes. PFAS exposure has been associated with decreased estradiol and earlier menopause but not significantly with ovarian reserve. Gaps in the literature require more comprehensive epidemiological research on the effects of EDCs on female reproductive aging, including ovarian reserve, age at menopause, and vasomotor symptoms, to inform future interventions to reduce hazardous exposures and improve women's health.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"330-360"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Endocrine-Disrupting Chemicals, Climate, and Air Pollution on Pregnancy Outcomes: A Scoping Review. 内分泌干扰物、气候和空气污染对妊娠结局的影响：范围综述。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2024-12-18 DOI: 10.1055/s-0044-1800961

Shaun R Wesley, Mary Gallo, Tejumola Apata, Jane van Dis, Stefanie J Hollenbach

{"title":"Impact of Endocrine-Disrupting Chemicals, Climate, and Air Pollution on Pregnancy Outcomes: A Scoping Review.","authors":"Shaun R Wesley, Mary Gallo, Tejumola Apata, Jane van Dis, Stefanie J Hollenbach","doi":"10.1055/s-0044-1800961","DOIUrl":"10.1055/s-0044-1800961","url":null,"abstract":"Environmental pollutants, including endocrine-disrupting chemicals (EDCs), air pollution, and climate change, are increasingly recognized for their potential impact on pregnancy outcomes. EDCs, found in pesticides, industrial chemicals, and personal care products, are associated with preterm birth and fetal growth restriction, primarily through hormonal interference. Air pollution, notably PM2.5, NO2, and O3, has been linked to increased rates of preterm birth, low birth weight, and stillbirth. Climate factors, such as extreme heat, elevate risks of pregnancy loss and preterm birth, with significant impacts on vulnerable populations across diverse socioeconomic and geographic regions. These exposures contribute to adverse pregnancy outcomes through mechanisms involving oxidative stress, inflammation, and endocrine disruption. The interplay among these environmental factors underscores the need for integrated, longitudinal studies to understand their combined effects on pregnancy outcomes better. Future research should focus on region-specific impacts, cumulative exposure, and policy-driven interventions to mitigate these environmental risks, especially in vulnerable populations disproportionately affected by these hazards. This scoping review synthesizes recent findings from 2019 to 2024 to highlight these associations and identify research gaps.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"312-329"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Exposures and Polycystic Ovary Syndrome: A Review. 环境暴露与多囊卵巢综合征：综述。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-02-05 DOI: 10.1055/s-0044-1801405

Elizabeth Peebles, Shruthi Mahalingaiah

{"title":"Environmental Exposures and Polycystic Ovary Syndrome: A Review.","authors":"Elizabeth Peebles, Shruthi Mahalingaiah","doi":"10.1055/s-0044-1801405","DOIUrl":"10.1055/s-0044-1801405","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder in women of reproductive age, affecting around 5 to 10% of women and up to 21% depending on the applied diagnostic criteria and study population. People with PCOS may experience oligomenorrhea, androgen excess, and polycystic ovary morphology. The etiology of the disease is not completely understood, with genetics, epigenetics, endocrine, metabolic, lifestyle, and environmental factors contributing to its development and severity. Environmental exposures are an important, burgeoning field in menstrual research, as they potentially link to menstrual cycle disruption and the risk of reproductive disorders such as PCOS. This review examines the recent research investigating environmental exposures-air pollution, micro- and nanoplastics, heavy metals, and endocrine-disrupting chemicals-and PCOS in human and animal models, concluding with potential mechanisms, limitations, and considerations for future work. Overall, research on environmental exposures and PCOS is limited and yields heterogeneous results across studies. Specifically, exposures such as air pollutants, micro- and nanoplastics, persistent organic pollutants, and parabens have noticeably limited research. Future research can help fill the gap in understanding how environmental exposures, particularly across gestational, childhood, and reproductive adult life stages, may impact PCOS.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"253-273"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0