Seminars in reproductive medicine最新文献_第3页

The Role of Anti-Müllerian Hormone in Ovarian Function. 抗缪勒氏管激素在卵巢功能中的作用

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-05-23 DOI: 10.1055/s-0044-1786732

Sena Yildiz, Loes M E Moolhuijsen, Jenny A Visser

引用次数: 0

Anti-Müllerian Hormone: A Molecular Key to Unlocking Polycystic Ovary Syndrome? 抗缪勒氏管激素：解开多囊卵巢综合征的分子钥匙？

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-06-22 DOI: 10.1055/s-0044-1787525

David H Abbott, Beverly A Hutcherson, Daniel A Dumesic

{"title":"Anti-Müllerian Hormone: A Molecular Key to Unlocking Polycystic Ovary Syndrome?","authors":"David H Abbott, Beverly A Hutcherson, Daniel A Dumesic","doi":"10.1055/s-0044-1787525","DOIUrl":"10.1055/s-0044-1787525","url":null,"abstract":"Anti-Müllerian hormone (AMH) is an important component within androgen receptor (AR)-regulated pathways governing the hyperandrogenic origin of polycystic ovary syndrome (PCOS). In women with PCOS, granulosa cell AMH overexpression in developing ovarian follicles contributes to elevated circulating AMH levels beginning at birth and continuing in adolescent daughters of PCOS women. A 6 to 7% incidence among PCOS women of gene variants coding for AMH or its receptor, AMHR2, suggests genetic contributions to AMH-related pathogenesis. Discrete gestational AMH administration to pregnant mice induces hypergonadotropic hyperandrogenic, PCOS-like female offspring with high circulating AMH levels that persist over three generations, suggesting epigenetic contributions to PCOS through developmental programming. Moreover, adult-onset, selective hyperactivation of hypothalamic neurons expressing gonadotropin-releasing hormone (GnRH) induces hypergonadotropic hyperandrogenism and PCOS-like traits in female mice. Both gestational and adult AMH inductions of PCOS-like traits are prevented by GnRH antagonist coadministration, implicating luteinizing hormone-dependent ovarian theca cell testosterone (T) action, mediated through the AR in AMH-induced pathogenesis. Interestingly, gestational or peripubertal exogenous T or dihydrotestosterone induction of PCOS-like traits in female mice, rats, sheep, and monkeys fails to elicit ovarian AMH hypersecretion; thus, AMH excess per se may lead to a distinct pathogenic contribution to hyperandrogenic PCOS origins.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"41-48"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMH in Reproductive Medicine. 生殖医学中的 AMH。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-07-18 DOI: 10.1055/s-0044-1787167

Paolo Giacobini

引用次数: 0

Anti-Mullerian Hormone Assessment in Assisted Reproductive Technique Outcome and Natural Conception. 辅助生殖技术结果和自然受孕中的抗沙勒氏激素评估。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-07-18 DOI: 10.1055/s-0044-1787273

Inès Sellami, Anne Laure Barbotin, Valérie Bernard, Geoffroy Robin, Sophie Catteau-Jonard, Charlotte Sonigo, Maeliss Peigné

{"title":"Anti-Mullerian Hormone Assessment in Assisted Reproductive Technique Outcome and Natural Conception.","authors":"Inès Sellami, Anne Laure Barbotin, Valérie Bernard, Geoffroy Robin, Sophie Catteau-Jonard, Charlotte Sonigo, Maeliss Peigné","doi":"10.1055/s-0044-1787273","DOIUrl":"10.1055/s-0044-1787273","url":null,"abstract":"In recent years, the prevalence of infertility has increased, and appears to affect approximately one in six couples. Some of them must perform assisted reproductive techniques (ART) in order to achieve pregnancy. As a result, growing interest has arisen about predictive factors of pregnancy and live birth with and without ART. Anti-Mullerian hormone (AMH) is a glycoprotein discovered in the 1950s in male embryonic sexual differentiation. Later, in 1984, its role in folliculogenesis was reported: secreted by granulosa cells, this hormone is involved in the regulation of the recruitment of primordial follicles and in follicular growth. AMH assays were developed for women in 1990s, and the serum AMH level has rapidly become a crucial element in managing women's fertility. Based mainly on its ability to be a quantitative but indirect marker of ovarian reserve, the serum AMH assay is widely used in reproductive medicine and ART. This review summarizes current knowledge of the AMH assessment in the field of reproductive medicine. We focus on the role of AMH level to predict spontaneous pregnancy occurrence, ART outcomes, and fertility preservation outcomes.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"42 1","pages":"25-33"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preimplantation Genetic Testing for Polygenetic Conditions: A Legal, Ethical, and Scientific Challenge. 针对多基因遗传病的植入前基因检测：法律、伦理和科学方面的挑战。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-03-22 DOI: 10.1055/s-0044-1782618

Perrine Ginod, Michael H Dahan

{"title":"Preimplantation Genetic Testing for Polygenetic Conditions: A Legal, Ethical, and Scientific Challenge.","authors":"Perrine Ginod, Michael H Dahan","doi":"10.1055/s-0044-1782618","DOIUrl":"10.1055/s-0044-1782618","url":null,"abstract":"The recent commercialization of the Embryo Health Score (EHS), determined through preimplantation genetic testing for polygenic conditions, offers the potential to select embryos with lower disease risk, thus potentially enhancing offspring longevity and health. Lately, Orchid Health company increased testing from less than 20 diseases to more than 900+ conditions for birth defects. However, the \"geneticization\" of phenotype estimates to a health state erases the environmental part, including the in vitro fertilization potential risks, questioning its scientific usefulness. EHS is utilized in countries with minimal regulatory oversight and will likely expand, while it remains illegal in other countries due to ethical and legal dilemmas it raises about reproductive autonomy, discrimination, impacts on family dynamics, and genetic diversity. The shift toward commercialized polygenic embryo screening (PES) redefines healthcare relationships, turning prospective parents into consumers and altering the physician's role. Moreover, PES could increase social inequalities, stigmatize those not born following PES, and encourage \"desirable\" phenotypic or behavioral traits selection, leading to ethical drift. Addressing these issues is essential before further implementation and requires a collaborative approach involving political, governmental, and public health, alongside geneticists, ethicists, and fertility specialists, focusing on the societal implications and acceptability of testing for polygenic traits for embryo selection.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"60-68"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMH in Reproductive Medicine. 生殖医学中的 AMH。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-07-18 DOI: 10.1055/s-0044-1787834

Kathleen M Hoeger, Terhi T Piltonen

引用次数: 0

Role of Anti-Müllerian Hormone in Male Reproduction and Sperm Motility. 抗缪勒氏管激素在男性生殖和精子活力中的作用

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-03-01 Epub Date: 2024-06-24 DOI: 10.1055/s-0044-1787687

Hamza Benderradji, Julie Prasivoravong, François Marcelli, Clara Leroy

{"title":"Role of Anti-Müllerian Hormone in Male Reproduction and Sperm Motility.","authors":"Hamza Benderradji, Julie Prasivoravong, François Marcelli, Clara Leroy","doi":"10.1055/s-0044-1787687","DOIUrl":"10.1055/s-0044-1787687","url":null,"abstract":"Anti-Müllerian hormone (AMH) is secreted by Sertoli cells and is responsible for the regression of Müllerian ducts in the male fetus as part of the sexual differentiation process. Serum AMH concentrations are at their lowest levels in the first days after birth but increase after the first week, likely reflecting active Sertoli cell proliferation. AMH rises rapidly in concentration in boys during the first month, reaching a peak level at ∼6 months of age, and it remains high during childhood, then they will slowly decline during puberty, falling to low levels in adulthood. Serum AMH measurement is used by pediatric endocrinologist as a specific marker of immature Sertoli cell number and function during childhood. After puberty, AMH is released especially by the apical pole of the Sertoli cells toward the lumen of the seminiferous tubules, resulting in higher levels in the seminal plasma than in the serum. Recently, AMH has received increasing attention in research on male fertility-related disorders. This article reviews and summarizes the potential contribution of serum AMH measurement in different male fertility-related disorders.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"5-14"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gonadotropins in the Management of Couple Infertility: Toward the Rational Use of an Empirical Therapy 促性腺激素在夫妇不孕症治疗中的应用：合理使用经验疗法

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-12-29 DOI: 10.1055/s-0043-1777837

Marilina Romeo, Valeria Donno, Giorgia Spaggiari, Antonio R.M. Granata, Manuela Simoni, Antonio La Marca, Daniele Santi

{"title":"Gonadotropins in the Management of Couple Infertility: Toward the Rational Use of an Empirical Therapy","authors":"Marilina Romeo, Valeria Donno, Giorgia Spaggiari, Antonio R.M. Granata, Manuela Simoni, Antonio La Marca, Daniele Santi","doi":"10.1055/s-0043-1777837","DOIUrl":"https://doi.org/10.1055/s-0043-1777837","url":null,"abstract":"Although epidemiology shows that both men and woman can experience infertility, the female partner usually experiences most of the diagnostic and therapeutic burden. Thus, management of couple infertility is a unique example of gender inequality. The use of exogenous gonadotropins in assisted reproductive technology (ART) to induce multifollicular growth is well consolidated in women, but the same is not done with the same level of confidence and purpose in infertile men. Indeed, the treatment of idiopathic male infertility is based on an empirical approach that involves administration of the follicle-stimulating hormone (FSH) in dosages within the replacement therapy range. This treatment has so far been attempted when the endogenous FSH serum levels are within the reference ranges. According to the most recent evidence, a “substitutive” FSH administration may not be effective enough, while a stimulatory approach could boost spermatogenesis over its basal levels without adverse extragonadal effects. This article aims to describe the rationale behind the empirical application of gonadotropins in couple infertility, highlighting the need for a change in the therapeutic approach, especially for the male partner. ","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"2017 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139064998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and Miscarriage 肥胖与流产

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-12-15 DOI: 10.1055/s-0043-1777759

Samantha McLean, Christina E. Boots

引用次数: 0

Culturomics in Unraveling the Upper Female Reproductive Tract Microbiota 揭示女性上生殖道微生物群的培养组学

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-12-15 DOI: 10.1055/s-0043-1777758

Robin Vanstokstraeten, Thomas Demuyser, Denis Piérard, Ingrid Wybo, Christophe Blockeel, Shari Mackens

{"title":"Culturomics in Unraveling the Upper Female Reproductive Tract Microbiota","authors":"Robin Vanstokstraeten, Thomas Demuyser, Denis Piérard, Ingrid Wybo, Christophe Blockeel, Shari Mackens","doi":"10.1055/s-0043-1777758","DOIUrl":"https://doi.org/10.1055/s-0043-1777758","url":null,"abstract":"In recent years, the study of the human microbiome has surged, shedding light on potential connections between microbiome composition and various diseases. One specific area of intense interest within this research is the female reproductive tract, as it holds the potential to influence the process of embryo implantation. Advanced sequencing technologies have delivered unprecedented insights into the microbial communities, also known as microbiota, residing in the female reproductive tract. However, their efficacy encounters significant challenges when analyzing low-biomass microbiota, such as those present in the endometrium. These molecular techniques are susceptible to contamination from laboratory reagents and extraction kits, leading to sequencing bias that can significantly alter the perceived taxonomy of a sample. Consequently, investigating the microbiota of the upper female reproductive tract necessitates the exploration of alternative methods. In this context, the current review delves into the application of culturomics in unraveling the upper female reproductive tract microbiota. While culturomics holds value in research, its transition to routine clinical practice appears remote, at least in the foreseeable future. ","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"119 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138692185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0