A Review of Celiac Disease and Its Implications on Fertility and Pregnancy.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-21 DOI:10.1055/s-0044-1791703

Alexandra France, Amulya Penmetsa

引用次数: 0

Abstract

Celiac disease is a systemic autoimmune disorder triggered by dietary gluten ingestion. The classic clinical presentation is characterized by diarrhea with malabsorption and weight loss; however, the spectrum of possible initial symptoms is broad. Affected individuals may be asymptomatic or may suffer from extraintestinal manifestations that can include metabolic bone disorders, thyroid dysfunction, neurologic manifestations, amenorrhea, or impaired fertility. Several studies have demonstrated an association between celiac disease and infertility and worsened pregnancy outcomes. Numerous possible mechanisms through which celiac disease could be associated with women's fertility have been proposed in the literature.

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乳糜泻及其对生育和怀孕的影响综述。

乳糜泻是一种由饮食中摄入麸质引发的全身性自身免疫性疾病。典型的临床表现以腹泻、吸收不良和体重减轻为特征；然而，最初可能出现的症状范围很广。受影响的人可能没有症状，也可能出现肠道外表现，包括骨代谢紊乱、甲状腺功能障碍、神经系统表现、闭经或生育能力受损。多项研究表明，乳糜泻与不孕症和妊娠结局恶化之间存在关联。文献中提出了许多乳糜泻与妇女生育能力相关的可能机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.