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Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes 揭示精子 DNA 片段对生殖结果的影响
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-12-13 DOI: 10.1055/s-0043-1777324
Jeanett L.M. Nielsen, Ahmad Majzoub, Sandro Esteves, Peter Humaidan
{"title":"Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes","authors":"Jeanett L.M. Nielsen, Ahmad Majzoub, Sandro Esteves, Peter Humaidan","doi":"10.1055/s-0043-1777324","DOIUrl":"https://doi.org/10.1055/s-0043-1777324","url":null,"abstract":"<p>In recent years, there has been a growing interest in identifying subcellular causes of male infertility, and sperm DNA fragmentation (SDF) research has been at the forefront of this focus. DNA damage can occur during spermatogenesis due to faulty chromatin compaction or excessive abortive apoptosis. It can also happen as sperm transit through the genital tract, often induced by oxidative stress. There are several methods for SDF testing, with the sperm chromatin structure assay, terminal deoxynucleotidyl transferase d-UTI nick end labeling (TUNEL) assay, comet assay, and sperm chromatin dispersion test being the most commonly used. Numerous studies strongly support the negative impact of SDF on male fertility potential. DNA damage has been linked to various morphological and functional sperm abnormalities, ultimately affecting natural conception and assisted reproductive technology outcomes. This evidence-based review aims to explore how SDF influences male reproduction and provide insights into available therapeutic options to minimize its detrimental impact.</p> ","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"735 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138628739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uterine Microbiome: Does the Sampling Technique Matter? 子宫微生物组：取样技术重要吗？
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-12-08 DOI: 10.1055/s-0043-1777361
Kreete Lüll, Elin Org
{"title":"Uterine Microbiome: Does the Sampling Technique Matter?","authors":"Kreete Lüll, Elin Org","doi":"10.1055/s-0043-1777361","DOIUrl":"https://doi.org/10.1055/s-0043-1777361","url":null,"abstract":"<p>Studies have proven the significance of microbial communities in various parts of the human body for health. In recent years it has been discovered that the uterine cavity is not sterile, and endometrium has its own microbiome which appears to have an impact on female fertility and gynecological pathologies. <i>Lactobacillus</i> has shown to dominate the microbial profile in the uterus and is considered an indicator of a healthy uterine environment. Yet, many argue that the <i>Lactobacillus</i> dominance is due to vaginal contamination during the sampling process. To date there is no clearly defined healthy endometrial microbial profile, which is largely due to the fact that determining the microbial community from the endometrium is complicated, and there is currently no consensus on sampling methods for the endometrial microbiome. As a result, this restricts ability to replicate discoveries made in other cohorts. Here we aim to give an overview of the sampling methods used and discuss what impedes the endometrial microbiome studies as well as how to reach a consensus on the study design. This knowledge could be incorporated into the future research and the knowledge on endometrial microbiome could be included into the diagnostics and treatment of female reproductive health.</p> ","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"21 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138562669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Only the Best of the Bunch-Sperm Preparation Is Not Just about Numbers. 优中选优--精子制备不仅仅是数字问题。
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2023-12-19 DOI: 10.1055/s-0043-1777756
Meurig T Gallagher, Ingrida Krasauskaite, Jackson C Kirkman-Brown
{"title":"Only the Best of the Bunch-Sperm Preparation Is Not Just about Numbers.","authors":"Meurig T Gallagher, Ingrida Krasauskaite, Jackson C Kirkman-Brown","doi":"10.1055/s-0043-1777756","DOIUrl":"10.1055/s-0043-1777756","url":null,"abstract":"<p><p>In this <i>Seminar</i>, we present an overview of the current and emerging methods and technologies for optimizing the man and the sperm sample for fertility treatment. We argue that sperms are the secret to success, and that there are many avenues for improving both treatment and basic understanding of their role in outcomes. These outcomes encompass not just whether treatment is successful or not, but the wider intergenerational health of the offspring. We discuss outstanding challenges and opportunities of new technologies such as microfluidics and artificial intelligence, including potential pitfalls and advantages. This article aims to provide a comprehensive overview of the importance of sperm in fertility treatment and suggests future directions for research and innovation.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"273-278"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Andrology: The Male Factor. 男性学：男性因素
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-03-18 DOI: 10.1055/s-0044-1779744
Antti Perheentupa
{"title":"Andrology: The Male Factor.","authors":"Antti Perheentupa","doi":"10.1055/s-0044-1779744","DOIUrl":"10.1055/s-0044-1779744","url":null,"abstract":"","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"41 6","pages":"211-212"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deteriorating Semen Quality: The Role of the Environment. 精液质量下降：环境的作用
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-03-18 DOI: 10.1055/s-0044-1782151
Helena E Virtanen, Wiwat Rodprasert, Jorma Toppari
{"title":"Deteriorating Semen Quality: The Role of the Environment.","authors":"Helena E Virtanen, Wiwat Rodprasert, Jorma Toppari","doi":"10.1055/s-0044-1782151","DOIUrl":"10.1055/s-0044-1782151","url":null,"abstract":"<p><p>Since the end of the last century, several reports have suggested that semen quality is declining, especially in Western countries. Furthermore, cross-sectional studies using similar protocols have suggested regional differences in semen quality of young and fertile men. Reasons for these regional differences and local adverse trends in semen quality are unknown, but environmental factors are suspected to have a role. Besides adulthood environmental exposures, those occurring during testicular development may also affect semen quality. Longitudinal follow-up studies and mixture risk analyses are needed to study the effect of fetal, childhood, and adult life environment on semen quality.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"41 6","pages":"226-240"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microdissection Testicular Sperm Extraction. 显微切割睾丸精子提取术
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-01-23 DOI: 10.1055/s-0043-1777833
Aaron Brant, Peter N Schlegel
{"title":"Microdissection Testicular Sperm Extraction.","authors":"Aaron Brant, Peter N Schlegel","doi":"10.1055/s-0043-1777833","DOIUrl":"10.1055/s-0043-1777833","url":null,"abstract":"<p><p>Nonobstructive azoospermia (NOA) is among the most common causes of male infertility. For men with NOA seeking fertility treatment, microdissection testicular sperm extraction (microTESE) is the best option for retrieving sperm, which can be used with in vitro fertilization-intracytoplasmic sperm injection to achieve pregnancy in their partner. With the aid of the operating microscope, microTESE allows for thorough evaluation of the testis tissue and selection of seminiferous tubules that appear most capable of sperm production. Rates of success with microTESE vary depending on the underlying cause of NOA and the center at which the procedure is performed. Not all patients are candidates for microTESE, and those who are candidates should be counseled on the likelihood of sperm retrieval and the potential for changes in postoperative testis function.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"267-272"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small Non-Coding RNAs in Male Reproduction. 男性生殖中的小非编码 RNA。
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-02-12 DOI: 10.1055/s-0044-1779726
Opeyemi Olotu, Ammar Ahmedani, Noora Kotaja
{"title":"Small Non-Coding RNAs in Male Reproduction.","authors":"Opeyemi Olotu, Ammar Ahmedani, Noora Kotaja","doi":"10.1055/s-0044-1779726","DOIUrl":"10.1055/s-0044-1779726","url":null,"abstract":"<p><p>Male reproductive functions are strictly regulated in order to maintain sperm production and fertility. All processes are controlled by precise regulation of gene expression, which creates specific gene expression programs for different developmental stages and cell types, and forms the functional basis for the reproductive system. Small non-coding RNAs (sncRNAs) are involved in gene regulation by targeting mRNAs for translational repression and degradation through complementary base pairing to recognize their targets. This review article summarizes the current knowledge on the function of different classes of sncRNAs, in particular microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), during male germ cell differentiation, with the focus on sncRNAs expressed in the germline. Although transcriptionally inactive, mature spermatozoa contain a complex population of sncRNAs, and we also discuss the recently identified role of sperm sncRNAs in the intergenerational transmission of epigenetic information on father's environmental and lifestyle exposures to offspring. Finally, we summarize the current information on the utility of sncRNAs as potential biomarkers of infertility that may aid in the diagnosis and prediction of outcomes of medically assisted reproduction.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"213-225"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Andrology. Andrology.
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-03-18 DOI: 10.1055/s-0044-1779590
Kathleen M Hoeger, Terhi Piltonen
{"title":"Andrology.","authors":"Kathleen M Hoeger, Terhi Piltonen","doi":"10.1055/s-0044-1779590","DOIUrl":"10.1055/s-0044-1779590","url":null,"abstract":"","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"41 6","pages":"209-210"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Male Contraception. 男性避孕。
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2023-12-19 DOI: 10.1055/s-0043-1777757
John K Amory
{"title":"Male Contraception.","authors":"John K Amory","doi":"10.1055/s-0043-1777757","DOIUrl":"10.1055/s-0043-1777757","url":null,"abstract":"<p><p>Approximately 40 to 50% of pregnancies are unintended. Contraceptive use significantly reduces the risk of unintended pregnancy. Approximately 70% of couples' contraceptive use is female and 30% is male, attributable to the reliance on condoms and vasectomies. Unfortunately, many women cannot use currently available contraceptives due to medical contraindications or side effects. At the same time, men want additional safe and effective contraceptive methods. Because of this, work to develop novel, safe, and effective male contraceptives is underway. This review will briefly discuss the pros and cons of condoms and vasectomies, and then describe research into the development of novel methods of male contraception, by the mechanism of action of the contraceptive. First, we will discuss male contraceptives that block sperm transmission. Next, we will discuss male contraceptives that impair sperm production. Lastly, we will discuss male contraceptives that impair sperm function.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"279-286"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Microbiome in Human Reproductive Tract: High-Throughput Methods for the Taxonomic Characterization of Microorganisms. 探索人类生殖道微生物组：微生物分类特征的高通量方法。
IF 2.7 3区 医学
Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-02-06 DOI: 10.1055/s-0044-1779025
Eduardo Salas-Espejo, Laura C Terrón-Camero, José L Ruiz, Nerea M Molina, Eduardo Andrés-León
{"title":"Exploring the Microbiome in Human Reproductive Tract: High-Throughput Methods for the Taxonomic Characterization of Microorganisms.","authors":"Eduardo Salas-Espejo, Laura C Terrón-Camero, José L Ruiz, Nerea M Molina, Eduardo Andrés-León","doi":"10.1055/s-0044-1779025","DOIUrl":"10.1055/s-0044-1779025","url":null,"abstract":"<p><p>Microorganisms are important due to their widespread presence and multifaceted roles across various domains of life, ecology, and industries. In humans, they underlie the proper functioning of multiple systems crucial to well-being, including immunological and metabolic functions. Emerging research addressing the presence and roles of microorganisms within human reproduction is increasingly relevant. Studies implementing new methodologies (e.g., to investigate vaginal, uterine, and semen microenvironments) can now provide relevant insights into fertility, reproductive health, or pregnancy outcomes. In that sense, cutting-edge sequencing techniques, as well as others such as meta-metabolomics, culturomics, and meta-proteomics, are becoming more popular and accessible worldwide, allowing the characterization of microbiomes at unprecedented resolution. However, they frequently involve rather complex laboratory protocols and bioinformatics analyses, for which researchers may lack the required expertise. A suitable pipeline would successfully enable both taxonomic classification and functional profiling of the microbiome, providing easy-to-understand biological interpretations. However, the selection of an appropriate methodology would be crucial, as it directly impacts the reproducibility, accuracy, and quality of the results and observations. This review focuses on the different current microbiome-related techniques in the context of human reproduction, encompassing niches like vagina, endometrium, and seminal fluid. The most standard and reliable methods are 16S rRNA gene sequencing, metagenomics, and meta-transcriptomics, together with complementary approaches including meta-proteomics, meta-metabolomics, and culturomics. Finally, we also offer case examples and general recommendations about the most appropriate methods and workflows and discuss strengths and shortcomings for each technique.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"41 5","pages":"125-143"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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