Seminars in reproductive medicine最新文献_第4页

Gynecological Cancers. 妇科癌症。

IF 1.4 3区医学

Seminars in reproductive medicine Pub Date : 2025-03-01 Epub Date: 2025-10-01 DOI: 10.1055/s-0045-1811707

Kathleen M Hoeger, Terhi T Piltonen

引用次数: 0

The Safety of Hormone Replacement Therapy in Gynecological Cancer Survivors. 激素替代疗法在妇科癌症幸存者中的安全性。

IF 2.6 3区医学

Seminars in reproductive medicine Pub Date : 2025-03-01 Epub Date: 2025-03-18 DOI: 10.1055/s-0045-1802985

Victoria Dodhia, Ying Cheong

{"title":"The Safety of Hormone Replacement Therapy in Gynecological Cancer Survivors.","authors":"Victoria Dodhia, Ying Cheong","doi":"10.1055/s-0045-1802985","DOIUrl":"10.1055/s-0045-1802985","url":null,"abstract":"Treatment of gynecological cancers often induces a premature menopause. Plus advancing treatments mean more gynecological cancer survivors are living to physiological menopause. Hormone replacement therapy (HRT) has proven substantial long-term benefits in physiological menopause and premature menopause particularly. We aimed to evaluate the current evidence on the safety of HRT in gynecological cancer survivors to help clinicians counsel these patients. HRT is not contraindicated in most gynecological cancer survivors, as evidence available often shows safety or even benefit with HRT use. However, HRT is contraindicated in a few cancers-in low-grade serous ovarian carcinoma, high-risk endometrial carcinoma, and some uterine sarcomas. Caution is advised in high-grade serous, late-stage endometrioid, and granulosa ovarian carcinomas when there is substandard evidence demonstrating safety, but also a theoretical harm present. Due to deficient large randomized controlled trials and methodological biases being present in most studies, HRT use needs to be individualized in most cancers-ovarian carcinomas, endometrial carcinomas, and cervical adenocarcinomas. Justification for HRT use is strong, and HRT is not contraindicated in most gynecological cancers due to largely reassuring evidence. More robust long-term data are needed for further reliable guidance for clinicians and patients.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"54-68"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Candidates for Fertility-Sparing Surgery in Case of Ovarian Cancer. 卵巢癌保留生育能力手术的候选者。

IF 2.6 3区医学

Seminars in reproductive medicine Pub Date : 2025-03-01 Epub Date: 2025-04-28 DOI: 10.1055/s-0045-1808243

Myriam Gracia, María Alonso-Espías, Ignacio Zapardiel

{"title":"Candidates for Fertility-Sparing Surgery in Case of Ovarian Cancer.","authors":"Myriam Gracia, María Alonso-Espías, Ignacio Zapardiel","doi":"10.1055/s-0045-1808243","DOIUrl":"10.1055/s-0045-1808243","url":null,"abstract":"Ovarian cancer, a leading cause of gynecological cancer mortality, often affects women of reproductive age. Fertility-sparing surgery (FSS) has emerged as a viable option for selected patients with early-stage ovarian cancer who wish to preserve fertility. Patient and tumor selection criteria focus on preserving ovarian function and reproductive potential without compromising oncological safety. Optimal candidates are young, premenopausal women with disease confined to one ovary and favorable prognostic factors such as early FIGO stage, specific histologic subtypes, and good overall health. FSS typically involves unilateral salpingo-oophorectomy while preserving the uterus and contralateral ovary, achieving survival outcomes comparable to radical surgery in early-stage low-grade tumors. However, its application in higher-risk cases requires cautious evaluation. Multidisciplinary management, involving gynecologic oncologists and reproductive specialists, is essential for successful implementation of FSS, ensuring both oncological safety and preservation of reproductive potential. Long-term follow-up is critical to monitor recurrence and assess reproductive outcomes. Pregnancy after FSS is feasible, with timing guided by cancer type, stage, and individual circumstances. This review summarizes the current knowledge on FSS in ovarian cancer, emphasizing its relevance and the need for further research to refine patient selection and ensure optimal outcomes.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"32-40"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproduction and Gynecological Cancers. 生殖和妇科癌症。

IF 1.4 3区医学

Seminars in reproductive medicine Pub Date : 2025-03-01 Epub Date: 2025-10-01 DOI: 10.1055/s-0045-1811634

Kirsten Tryde Macklon

引用次数: 0

Fertility Preservation in Women with Cervical Cancer. 子宫颈癌妇女的生育能力保存。

IF 2.6 3区医学

Seminars in reproductive medicine Pub Date : 2025-03-01 Epub Date: 2025-08-01 DOI: 10.1055/s-0045-1810055

Ines Sellami, Emine Saïs, Fatoumata Souare, Céleste Becquart, Hélène Thomas, Charlotte Sonigo, Michaël Grynberg

{"title":"Fertility Preservation in Women with Cervical Cancer.","authors":"Ines Sellami, Emine Saïs, Fatoumata Souare, Céleste Becquart, Hélène Thomas, Charlotte Sonigo, Michaël Grynberg","doi":"10.1055/s-0045-1810055","DOIUrl":"10.1055/s-0045-1810055","url":null,"abstract":"Cervical cancer (CC) is one of the most common malignancies affecting young women of childbearing age, making fertility preservation (FP) a pivotal consideration in its management. The feasibility of FP techniques depends on the cancer stage and oncological treatments. In early-stage CC, fertility-sparing surgery can be offered for young patients wishing to preserve fertility without compromising oncological safety. Neoadjuvant chemotherapy followed by fertility-sparing surgery is an alternative for patients with nonmetastatic locally advanced disease and negative lymph node status. Nevertheless, for patients with locally advanced disease requiring radical hysterectomy or pelvic radiotherapy, FP can be performed using oocyte, embryo, or ovarian tissue cryopreservation. For these patients, future pregnancy is possible through surrogacy. Recently, uterine transposition has been proposed as an alternative to preserve uterine anatomy to prevent uterine radio-induced damage and avoid surrogacy. This review provides a comprehensive overview of the FP options available for young patients with CC.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"5-10"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Radiotherapy on the Uterus and Its Implications for Pregnancy. 放疗对子宫的影响及其对妊娠的影响。

IF 2.6 3区医学

Seminars in reproductive medicine Pub Date : 2025-03-01 Epub Date: 2025-05-14 DOI: 10.1055/s-0045-1809040

Anne-Lotte L F van der Kooi, Wendy van Dorp

{"title":"The Impact of Radiotherapy on the Uterus and Its Implications for Pregnancy.","authors":"Anne-Lotte L F van der Kooi, Wendy van Dorp","doi":"10.1055/s-0045-1809040","DOIUrl":"10.1055/s-0045-1809040","url":null,"abstract":"Radiotherapy is an effective treatment for various cancers, but it can cause significant side effects on various organ systems, including the reproductive organs, which is a major concern for women of reproductive age. A well-known long-term effect of oncological treatment is premature ovarian insufficiency. Another critical but sometimes overlooked organ at risk in female cancer survivors is the uterus. This review focuses on the impact of radiotherapy on uterine physiology, highlighting key issues such as the development of fibrosis and loss of elasticity, vascular damage, and hormonal disruption, all of which can compromise uterine function. These changes can negatively impact fertility and pregnancy outcomes, such as miscarriage, preterm birth, and low birth weight. Limited evidence is also available suggesting that radiotherapy may affect endometrial receptivity and contribute to abnormal placentation. We conclude by discussing strategies aimed at mitigating the damage caused by radiotherapy, such as fertility-preserving treatments and hormonal interventions. A thorough understanding of these effects is essential for healthcare providers to offer informed support to women who wish to maintain their fertility and have children following cancer treatment.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"16-22"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Hazards and Male Fertility: Why Don't We Know More? 环境危害与男性生育能力：为什么我们知之甚少？

IF 1.4 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-02-10 DOI: 10.1055/s-0044-1801746

Makiko Mitsunami, Jaime E Hart, Jorge E Chavarro

引用次数: 0

PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics. PFAS暴露与男性生殖健康：对精子表观遗传学的影响。

IF 1.4 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-01-09 DOI: 10.1055/s-0044-1801363

DruAnne L Maxwell, Michael C Petriello, J Richard Pilsner

{"title":"PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics.","authors":"DruAnne L Maxwell, Michael C Petriello, J Richard Pilsner","doi":"10.1055/s-0044-1801363","DOIUrl":"10.1055/s-0044-1801363","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants found in human tissues and persist in the environment, posing significant risks to reproductive health. This review examines the impact of PFAS exposure on male reproductive health, with a focus on sperm epigenetics. PFASs disrupt endocrine function by altering key reproductive hormones and impairing sperm motility, quality, and viability. Epidemiologic and animal studies highlight inconsistent yet concerning associations between PFAS exposure and semen parameters, as well as altered gene expression and DNA methylation patterns. Moreover, PFAS exposure during critical windows of development has been linked to differential impacts on male versus female pubertal development, cognitive outcomes, and reproductive physiology, emphasizing the complexity of PFAS interactions. This comprehensive analysis highlights the need for continued research into the mechanisms by which PFASs influence reproductive health and development with potential implications for sperm epigenetics. The review emphasizes the importance of understanding the epigenetic mechanisms behind these disruptions, particularly DNA methylation and its role in heritable changes. Investigating the epigenetic modifications driven by PFAS exposure is crucial for elucidating the mechanisms by which these chemicals influence reproductive health. Future research should focus on understanding these epigenetic changes in both immediate fertility outcomes and transgenerational health risks.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":" ","pages":"288-301"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Environment and Reproduction. 环境与繁殖。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-03-10 DOI: 10.1055/s-0044-1801397

Kathleen M Hoeger, Terhi T Piltonen

引用次数: 0

Environment and Reproduction. 环境与繁殖。

IF 2.6 3区医学

Seminars in reproductive medicine Pub Date : 2024-12-01 Epub Date: 2025-03-10 DOI: 10.1055/s-0044-1800828

Audrey J Gaskins, Lidia Minguez-Alarcon

引用次数: 0