Seminars in reproductive medicine最新文献_第4页

Andrology. Andrology.

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-03-18 DOI: 10.1055/s-0044-1779590

Kathleen M Hoeger, Terhi Piltonen

引用次数: 0

Small Non-Coding RNAs in Male Reproduction. 男性生殖中的小非编码 RNA。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2024-02-12 DOI: 10.1055/s-0044-1779726

Opeyemi Olotu, Ammar Ahmedani, Noora Kotaja

{"title":"Small Non-Coding RNAs in Male Reproduction.","authors":"Opeyemi Olotu, Ammar Ahmedani, Noora Kotaja","doi":"10.1055/s-0044-1779726","DOIUrl":"10.1055/s-0044-1779726","url":null,"abstract":"Male reproductive functions are strictly regulated in order to maintain sperm production and fertility. All processes are controlled by precise regulation of gene expression, which creates specific gene expression programs for different developmental stages and cell types, and forms the functional basis for the reproductive system. Small non-coding RNAs (sncRNAs) are involved in gene regulation by targeting mRNAs for translational repression and degradation through complementary base pairing to recognize their targets. This review article summarizes the current knowledge on the function of different classes of sncRNAs, in particular microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), during male germ cell differentiation, with the focus on sncRNAs expressed in the germline. Although transcriptionally inactive, mature spermatozoa contain a complex population of sncRNAs, and we also discuss the recently identified role of sperm sncRNAs in the intergenerational transmission of epigenetic information on father's environmental and lifestyle exposures to offspring. Finally, we summarize the current information on the utility of sncRNAs as potential biomarkers of infertility that may aid in the diagnosis and prediction of outcomes of medically assisted reproduction.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Male Contraception. 男性避孕。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-11-01 Epub Date: 2023-12-19 DOI: 10.1055/s-0043-1777757

John K Amory

引用次数: 0

Exploring the Microbiome in Human Reproductive Tract: High-Throughput Methods for the Taxonomic Characterization of Microorganisms. 探索人类生殖道微生物组：微生物分类特征的高通量方法。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-02-06 DOI: 10.1055/s-0044-1779025

Eduardo Salas-Espejo, Laura C Terrón-Camero, José L Ruiz, Nerea M Molina, Eduardo Andrés-León

{"title":"Exploring the Microbiome in Human Reproductive Tract: High-Throughput Methods for the Taxonomic Characterization of Microorganisms.","authors":"Eduardo Salas-Espejo, Laura C Terrón-Camero, José L Ruiz, Nerea M Molina, Eduardo Andrés-León","doi":"10.1055/s-0044-1779025","DOIUrl":"10.1055/s-0044-1779025","url":null,"abstract":"Microorganisms are important due to their widespread presence and multifaceted roles across various domains of life, ecology, and industries. In humans, they underlie the proper functioning of multiple systems crucial to well-being, including immunological and metabolic functions. Emerging research addressing the presence and roles of microorganisms within human reproduction is increasingly relevant. Studies implementing new methodologies (e.g., to investigate vaginal, uterine, and semen microenvironments) can now provide relevant insights into fertility, reproductive health, or pregnancy outcomes. In that sense, cutting-edge sequencing techniques, as well as others such as meta-metabolomics, culturomics, and meta-proteomics, are becoming more popular and accessible worldwide, allowing the characterization of microbiomes at unprecedented resolution. However, they frequently involve rather complex laboratory protocols and bioinformatics analyses, for which researchers may lack the required expertise. A suitable pipeline would successfully enable both taxonomic classification and functional profiling of the microbiome, providing easy-to-understand biological interpretations. However, the selection of an appropriate methodology would be crucial, as it directly impacts the reproducibility, accuracy, and quality of the results and observations. This review focuses on the different current microbiome-related techniques in the context of human reproduction, encompassing niches like vagina, endometrium, and seminal fluid. The most standard and reliable methods are 16S rRNA gene sequencing, metagenomics, and meta-transcriptomics, together with complementary approaches including meta-proteomics, meta-metabolomics, and culturomics. Finally, we also offer case examples and general recommendations about the most appropriate methods and workflows and discuss strengths and shortcomings for each technique.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome in Reproduction: Analysis Methods, Novel Techniques, and State-of-the-Art in Female Reproductive Health. 生殖中的微生物组：女性生殖健康的分析方法、新技术和最新技术。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-02-06 DOI: 10.1055/s-0043-1778655

Signe Altmäe

引用次数: 0

The Upper Reproductive System Microbiome: Evidence beyond the Uterus. 上生殖系统微生物组：子宫之外的证据

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-02-06 DOI: 10.1055/s-0043-1778056

Analuce Canha-Gouveia, Valentina Di Nisio, Andres Salumets, Pauliina Damdimopoulou, Pilar Coy, Signe Altmäe, Alberto Sola-Leyva

{"title":"The Upper Reproductive System Microbiome: Evidence beyond the Uterus.","authors":"Analuce Canha-Gouveia, Valentina Di Nisio, Andres Salumets, Pauliina Damdimopoulou, Pilar Coy, Signe Altmäe, Alberto Sola-Leyva","doi":"10.1055/s-0043-1778056","DOIUrl":"10.1055/s-0043-1778056","url":null,"abstract":"The microbiome of the female upper reproductive system has garnered increasing recognition and has become an area of interest in the study of women's health. This intricate ecosystem encompasses a diverse consortium of microorganisms (i.e., microbiota) and their genomes (i.e., microbiome) residing in the female upper reproductive system, including the uterus, the fallopian tubes, and ovaries. In recent years, remarkable advancements have been witnessed in sequencing technologies and microbiome research, indicating the potential importance of the microbial composition within these anatomical sites and its impact in women's reproductive health and overall well-being. Understanding the composition, dynamics, and functions of the microbiome of the female upper reproductive system opens up exciting avenues for improving fertility, treating gynecological conditions, and advancing our comprehension of the intricate interplay between the microbiome and the female reproductive system. The aim of this study is to compile currently available information on the microbial composition of the female upper reproductive system in humans, with a focus beyond the uterus, which has received more attention in recent microbiome studies compared with the fallopian tubes and ovaries. In conclusion, this review underscores the potential role of this microbiome in women's physiology, both in health and disease.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Technologies for Studying Microbiome-Female Reproductive Tract Interactions: Organoids, Organoids-on-a-Chip, and Beyond. 研究微生物与女性生殖道相互作用的先进技术：有机体、芯片有机体及其他。

IF 1.9 3区医学

Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-01-23 DOI: 10.1055/s-0043-1778067

Yosun A Kaya, Marcel R de Zoete, Gaby S Steba

{"title":"Advanced Technologies for Studying Microbiome-Female Reproductive Tract Interactions: Organoids, Organoids-on-a-Chip, and Beyond.","authors":"Yosun A Kaya, Marcel R de Zoete, Gaby S Steba","doi":"10.1055/s-0043-1778067","DOIUrl":"10.1055/s-0043-1778067","url":null,"abstract":"The female reproductive tract (FRT) is home to diverse microbial communities that play a pivotal role in reproductive health and disorders such as infertility, endometriosis, and cervical cancer. To understand the complex host-microbiota interactions within the FRT, models that authentically replicate the FRT's environment, including the interplay between the microbiota, mucus layer, immune system, and hormonal cycle, are key. Recent strides in organoid and microfluidic technologies are propelling research in this domain, offering insights into FRT-microbiota interactions and potential therapeutic avenues. This review delves into the current state of FRT organoid models and microbe integration techniques, evaluating their merits and challenges for specific research objectives. Emphasis is placed on innovative approaches and applications, including integrating organoids with microfluidics, and using patient-derived biobanks, as this offers potential for deeper mechanistic insights and personalized therapeutic strategies. Modeling various FRT properties in organoids is explored, from encompassing age-related epithelial features, oxygen levels, and hormonal effects to mucus layers, immune responses, and microbial interactions, highlighting their potential to transform reproductive health research and predict possible outcomes.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Immunome and Microbiome Interplay in Reproductive Health: Current Knowledge, Challenges, and Novel Diagnostic Tools. 探索生殖健康中免疫组和微生物组的相互作用：当前知识、挑战和新型诊断工具。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-01-23 DOI: 10.1055/s-0043-1778017

Prakash Lingasamy, Vijayachitra Modhukur, Reet Mändar, Andres Salumets

{"title":"Exploring Immunome and Microbiome Interplay in Reproductive Health: Current Knowledge, Challenges, and Novel Diagnostic Tools.","authors":"Prakash Lingasamy, Vijayachitra Modhukur, Reet Mändar, Andres Salumets","doi":"10.1055/s-0043-1778017","DOIUrl":"10.1055/s-0043-1778017","url":null,"abstract":"The dynamic interplay between the immunome and microbiome in reproductive health is a complex and rapidly advancing research field, holding tremendously vast possibilities for the development of reproductive medicine. This immunome-microbiome relationship influences the innate and adaptive immune responses, thereby affecting the onset and progression of reproductive disorders. However, the mechanisms governing these interactions remain elusive and require innovative approaches to gather more understanding. This comprehensive review examines the current knowledge on reproductive microbiomes across various parts of female reproductive tract, with special consideration of bidirectional interactions between microbiomes and the immune system. Additionally, it explores innate and adaptive immunity, focusing on immunoglobulin (Ig) A and IgM antibodies, their regulation, self-antigen tolerance mechanisms, and their roles in immune homeostasis. This review also highlights ongoing technological innovations in microbiota research, emphasizing the need for standardized detection and analysis methods. For instance, we evaluate the clinical utility of innovative technologies such as Phage ImmunoPrecipitation Sequencing (PhIP-Seq) and Microbial Flow Cytometry coupled to Next-Generation Sequencing (mFLOW-Seq). Despite ongoing advancements, we emphasize the need for further exploration in this field, as a deeper understanding of immunome-microbiome interactions holds promise for innovative diagnostic and therapeutic strategies for reproductive health, like infertility treatment and management of pregnancy.","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microenvironment of the Lower Reproductive Tract: Focus on the Cervical Mucus Plug. 下生殖道的微环境：聚焦宫颈粘液栓。

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-01-23 DOI: 10.1055/s-0043-1778661

Susana Ruiz-Durán, Celia M Tenorio, Irene Vico-Zúñiga, Sebastián Manzanares, Alberto Puertas-Prieto, Signe Altmäe, Eva Vargas

引用次数: 0

Microbiome in Reproduction. 生殖中的微生物组

IF 2.7 3区医学

Seminars in reproductive medicine Pub Date : 2023-09-01 Epub Date: 2024-02-06 DOI: 10.1055/s-0044-1779026

Kathleen Hoeger, Terhi Piltonen

引用次数: 0