Seminars in cancer biology最新文献_第3页

Integrating biomarkers, experimental models, genomics, and novel therapeutics for pancreatic cancer precision medicine 整合生物标志物、实验模型、基因组学和胰腺癌精准医学的新疗法

IF 15.7 1区医学

Seminars in cancer biology Pub Date : 2026-01-01 Epub Date: 2025-12-04 DOI: 10.1016/j.semcancer.2025.12.001

Luca Morelli

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Protein lactylation in cancer and other pathologies: Epigenetic regulation of glycolysis and its therapeutic perspectives 癌症和其他病理中的蛋白质乳酸化：糖酵解的表观遗传调控及其治疗前景。

IF 15.7 1区医学

Seminars in cancer biology Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/j.semcancer.2025.12.005

Yaowen Zhang , Jianxiang Wang , Cong Li , Zhe Lei , Xiang Zhao , Xuan Xuan , Olga Sukocheva , Edmund Tse , Junqi Liu

{"title":"Protein lactylation in cancer and other pathologies: Epigenetic regulation of glycolysis and its therapeutic perspectives","authors":"Yaowen Zhang , Jianxiang Wang , Cong Li , Zhe Lei , Xiang Zhao , Xuan Xuan , Olga Sukocheva , Edmund Tse , Junqi Liu","doi":"10.1016/j.semcancer.2025.12.005","DOIUrl":"10.1016/j.semcancer.2025.12.005","url":null,"abstract":"<div><div>Lactylation, a recently recognized post-translational protein modification, is reshaping research in epigenetics and molecular medicine. Emerging evidence indicates that lactylation plays a critical role in the onset and progression of cancer, as well as in several pre-cancerous and metabolism-associated pathologies. This review summarizes the current understanding of the mechanisms and biological roles of lactylation in cancer and other diseases. Lactate has been shown to promote carcinogenesis both as an additional energy source and as a signaling molecule. Glycolysis and glucose transport—major sources of lactate and subsequent lactylation—are frequently targeted by anti-cancer therapies. Several small-molecule glucose transporter type 1 (GLUT1) inhibitors, including STF-31, WZB-117, and BAY-876, have demonstrated efficacy in suppressing tumor growth. During lactylation, lactate is covalently attached to histone lysine residues, leading to epigenetic modifications. This process is regulated by “writer” enzymes (p300 and HBO1) and “eraser” enzymes (HDAC1–3 and SIRT1–3), which participate in nuclear signaling networks associated with oncogenic transformation. Several inhibitors targeting “writer” enzymes, such as A485 and andrographolide, have been developed and shown to suppress angiogenesis. Inhibition of tumor immune evasion has also been explored using glycolytic enzyme inhibitors, including 2-deoxy-<span>D</span>-glucose and oxalate. Despite these advances, lactylation-targeted research remains in its early stages and faces notable limitations that warrant further investigation. This review provides insights into the role of lactylation in diverse diseases and highlights emerging therapeutic strategies aimed at modulating lactylation-associated molecular targets.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"118 ","pages":"Pages 28-43"},"PeriodicalIF":15.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Lipid metabolism in cancer is regulated by the integrated natural product–miRNA–target axis 肿瘤中的脂质代谢受天然产物- mirna -靶标轴的综合调控。

IF 15.7 1区医学

Seminars in cancer biology Pub Date : 2026-01-01 Epub Date: 2025-11-29 DOI: 10.1016/j.semcancer.2025.11.024

Ya-Ting Chuang , Ching-Yu Yen , Yi-Hong Tsai , Fang-Rong Chang , Ammad Ahmad Farooqi , Hsueh-Wei Chang

{"title":"Lipid metabolism in cancer is regulated by the integrated natural product–miRNA–target axis","authors":"Ya-Ting Chuang , Ching-Yu Yen , Yi-Hong Tsai , Fang-Rong Chang , Ammad Ahmad Farooqi , Hsueh-Wei Chang","doi":"10.1016/j.semcancer.2025.11.024","DOIUrl":"10.1016/j.semcancer.2025.11.024","url":null,"abstract":"<div><div>Signaling lipids have been shown to play multifaceted roles ranging from cell proliferation, metabolism, invasion, migration, and apoptosis. Mechanistically, these enzymes and their downstream targets constitute complicated and intertwined lipid signaling networks with multiple nodes of interaction and cross-regulations. Dysregulated lipid metabolism is one of the hallmarks of cancer. Targeting such lipid metabolism is a potential anticancer strategy. Several natural products and miRNAs have been reported to modulate cancer cell fatty acid (FA) metabolisms; however, the integrated connections between these natural products, miRNAs, and targets have yet to be evaluated in detail. This review uses the bioinformatic STRING tool to explore target-target interactions between Google Scholar-retrieval targets of dysregulated FA metabolism in cancer cells. miRNAs and natural products that dysregulate FA metabolism were also retrieved and connected to the STRING–target network with Google Scholar and the bioinformatic databases (miRTarBase and miRDB), which retrieves targets for miRNAs. Moreover, the knowledge gaps between miRNA- and natural product-modulated FA metabolism are intricately connected. Consequently, this review highlights and shows interactions within the natural product–miRNA–target axis in counteracting the dysregulated FA metabolism in cancer cells.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"118 ","pages":"Pages 3-27"},"PeriodicalIF":15.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Leveraging cancer metabolism to translate into effective therapeutics 利用癌症代谢转化为有效的治疗方法。

IF 15.7 1区医学

Seminars in cancer biology Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/j.semcancer.2025.12.003

Jie Xu , Linlin Guo , Yi Wang , Xiaoping Li , Ping Yi , Chunming Cheng

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Obesity and GEP-NEN: what’s new? 肥胖和GEP-NEN：有什么新进展？

IF 15.7 1区医学

Seminars in cancer biology Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/j.semcancer.2025.12.006

M. Boschetti , I. Hasballa , I. Patelli , G. Piras , M. Albertelli

{"title":"Obesity and GEP-NEN: what’s new?","authors":"M. Boschetti , I. Hasballa , I. Patelli , G. Piras , M. Albertelli","doi":"10.1016/j.semcancer.2025.12.006","DOIUrl":"10.1016/j.semcancer.2025.12.006","url":null,"abstract":"<div><div>Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) comprise a heterogeneous group of tumors differing according to the primary lesion site, histological features, clinical status and prognosis. The etiopathogenesis of GEP-NEN is not fully elucidated, however, excessive visceral adiposity may play a role in NEN oncogenesis and pose challenges to NEN therapeutic management. The interplay between obesity and GEP-NEN is complex and the potential carcinogenic mechanisms of obesity include chronic inflammation, abnormal immune function, hormone and metabolic dysregulation. Data regarding the prognostic impact of visceral adiposity on patients’ clinical and survival outcomes is still very limited and indeterminate. Molecular evidence predominantly supports the carcinogenic effects of obesity, although some studies have documented a potential protective role of excessive adiposity, i.e. the “obesity paradox” phenomenon, in NENs. Concerning therapeutic management of obesity in the setting of GEP-NENs, the current strategies to be considered include first-line nutritional and lifestyle intervention, followed by pharmacological and surgical treatment. This review aims to explore the intricate relationship between obesity and GEP-NENs, the potential impact on NEN outcomes, the current treatment approaches and future perspectives of the therapeutic landscape of individuals affected by GEP-NEN and obesity.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"118 ","pages":"Pages 74-86"},"PeriodicalIF":15.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Expression of concern "Decoding T cell senescence in cancer: Is revisiting required?" [Semin. Cancer Biol. 108 (2025) 33-47]. “解码癌症中的T细胞衰老：是否需要重访？”[Semin。中国生物医学工程学报，2014,33(5):447 - 447。

IF 15.7 1区医学

Seminars in cancer biology Pub Date : 2025-12-01 Epub Date: 2025-11-08 DOI: 10.1016/j.semcancer.2025.11.018

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Lipid-laden macrophages in atherosclerosis and cancer 脂质巨噬细胞在动脉粥样硬化和癌症中的作用。

IF 15.7 1区医学

Seminars in cancer biology Pub Date : 2025-12-01 Epub Date: 2025-09-24 DOI: 10.1016/j.semcancer.2025.09.007

MC Martinez-Campanario , Marlies Cortés , Lu Han , Agnese Brischetto , Paloma Rivero-Soriano , Joan Font-Díaz , Joan Maurel , Vicente Andrés , Antonio Postigo

{"title":"Lipid-laden macrophages in atherosclerosis and cancer","authors":"MC Martinez-Campanario , Marlies Cortés , Lu Han , Agnese Brischetto , Paloma Rivero-Soriano , Joan Font-Díaz , Joan Maurel , Vicente Andrés , Antonio Postigo","doi":"10.1016/j.semcancer.2025.09.007","DOIUrl":"10.1016/j.semcancer.2025.09.007","url":null,"abstract":"<div><div>This review explores the dual roles of lipid-laden macrophages (LL-Macs) in inflammation, atherosclerosis and cancer, emphasizing both their shared and divergent functions across physiological and pathological conditions. Lipid metabolism regulates the polarization of macrophages in homeostasis and inflammation. In atherosclerosis, LL-Macs contribute to plaque formation and inflammation, while in cancer, LL-Macs play crucial roles in immune suppression and tumor progression. The article outlines the molecular mechanisms driving macrophage lipid accumulation in each of these scenarios and how the process is influenced by the distinct local microenvironments in inflammation, atherosclerosis and cancer. Single-cell RNA sequencing (scRNA-seq) studies have identified both common and unique gene signatures between LL-Macs in atherosclerosis and cancer, reflecting the varying microenvironmental cues that shape macrophage function and disease outcomes. Finally, we examine lipid-modulating strategies in atherosclerosis, assess their potential in cancer treatment, and highlight research gaps for developing new LL-Macs targeted therapies in cancer.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"117 ","pages":"Pages 38-56"},"PeriodicalIF":15.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The role of microbiome in immunotherapy: Insights and perspectives 微生物组在免疫治疗中的作用：见解和观点。

IF 15.7 1区医学

Seminars in cancer biology Pub Date : 2025-12-01 Epub Date: 2025-11-12 DOI: 10.1016/j.semcancer.2025.11.001

Meilin Ye , Houyu Ju , Guoxin Ren , Jingzhou Hu

{"title":"The role of microbiome in immunotherapy: Insights and perspectives","authors":"Meilin Ye , Houyu Ju , Guoxin Ren , Jingzhou Hu","doi":"10.1016/j.semcancer.2025.11.001","DOIUrl":"10.1016/j.semcancer.2025.11.001","url":null,"abstract":"<div><div>The intricate interplay between the gut microbiome and the host immune system has been recognized as a pivotal determinant of clinical outcomes in cancer immunotherapy. Mounting evidence suggests that specific microbial communities are associated with both the efficacy and toxicity of immune checkpoint inhibitors in diverse malignancies, underscoring the microbiome’s role in modulating systemic and tumour-localized immunity. Mechanistically, the microbiome shapes antitumour immunity by affecting antigen presentation, activation of effector cells, immunosuppression and adverse effects. Key microbial components and metabolites present in distinct anatomical niches have been identified as promoters or inhibitors of therapeutic responsiveness via multiple pathways. Harnessing this knowledge, microbiome-targeted strategies such as antibiotic, probiotic, fecal microbiota transplantation, and dietary modulation are regarded as potential adjuvant therapies to enhance the efficacy of anti-tumour therapies. Although significant progress has been achieved in preclinical studies, challenges persist in translating these findings into standardized clinical applications.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"117 ","pages":"Pages 131-151"},"PeriodicalIF":15.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of concern "Navigating the paradox of senescence and chemoresistance in pancreatic cancer" [Semin. Cancer Biol. 114 (2025) 60-72]. 关注表达：“胰腺癌中衰老和化疗耐药的矛盾”[Semin]。中国生物医学工程学报，2014,30(5):693 - 693。

IF 20.3 1区医学

Seminars in cancer biology Pub Date : 2025-12-01 Epub Date: 2025-11-07 DOI: 10.1016/j.semcancer.2025.11.003

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Microbial modulation as a game changer: Boosting immunotherapy efficacy in breast cancer 作为游戏规则改变者的微生物调节：提高乳腺癌免疫治疗的疗效。

IF 15.7 1区医学

Seminars in cancer biology Pub Date : 2025-12-01 Epub Date: 2025-11-05 DOI: 10.1016/j.semcancer.2025.10.006

Fada Xia , Qiaoli Yi , Zhijie Xu , Zhiyang Zhou , Hailin Tang , Kejing Zhang , Yuanliang Yan

{"title":"Microbial modulation as a game changer: Boosting immunotherapy efficacy in breast cancer","authors":"Fada Xia , Qiaoli Yi , Zhijie Xu , Zhiyang Zhou , Hailin Tang , Kejing Zhang , Yuanliang Yan","doi":"10.1016/j.semcancer.2025.10.006","DOIUrl":"10.1016/j.semcancer.2025.10.006","url":null,"abstract":"<div><div>Breast cancer is generally regarded as an immunologically cold tumor, characterized by limited T cell infiltration and poor responsiveness to immune checkpoint inhibitors. Increasing evidence suggests that the human microbiome, including both gut and tumor-associated microbial communities, serves as a critical regulator of systemic and local antitumor immunity, with potential to convert inert tumors into immune-responsive states. Gut microbiota influence systemic immune homeostasis through metabolites such as lipids, lactic acid, and trimethylamine N-oxide, which modulate T lymphocytes, dendritic cells, leukocytes, and stromal components. Tumor-resident microbiota further shape the tumor immune microenvironment by regulating CD4⁺ and CD8⁺ T cells, NKT cells, Tregs, and macrophages, thereby impacting the efficacy of immune checkpoint blockade. Emerging strategies to sensitize cold breast tumors through microbiome modulation include dietary phytochemicals, bariatric surgery induced microbial shifts, probiotics and postbiotics, polyvalent microbial antigen vaccines, and nanotechnology-based platforms. Clinical challenges remain, particularly interindividual microbial heterogeneity, safety and regulatory considerations, and the need for reliable microbial and immune biomarkers. This review summarizes current advances in microbiota–immune interactions in breast cancer and discusses opportunities for microbiome-targeted strategies to enhance immunotherapy outcomes.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"117 ","pages":"Pages 152-167"},"PeriodicalIF":15.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145459792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0