Seminars in cancer biology最新文献_第4页

The dual function of autophagy in doxorubicin-induced cardiotoxicity: Mechanism and natural products 自噬在阿霉素诱导的心脏毒性中的双重功能：机制和天然产物。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2025-02-01 DOI: 10.1016/j.semcancer.2025.01.004

Nannan Tan , Hanwen Luo , Weili Li , Guanjing Ling , Yan Wei , Wei Wang , Yong Wang

引用次数: 0

Decoding T cell senescence in cancer: Is revisiting required? 解码癌症中的T细胞衰老：需要重访吗？

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2025-01-01 DOI: 10.1016/j.semcancer.2024.11.003

Sophia Magkouta , Efrosyni Markaki , Konstantinos Evangelou , Russell Petty , Panayotis Verginis , Vassilis Gorgoulis

{"title":"Decoding T cell senescence in cancer: Is revisiting required?","authors":"Sophia Magkouta , Efrosyni Markaki , Konstantinos Evangelou , Russell Petty , Panayotis Verginis , Vassilis Gorgoulis","doi":"10.1016/j.semcancer.2024.11.003","DOIUrl":"10.1016/j.semcancer.2024.11.003","url":null,"abstract":"<div><div>Senescence is an inherent cellular mechanism triggered as a response to stressful insults. It associates with several aspects of cancer progression and therapy. Senescent cells constitute a highly heterogeneous cellular population and their identification can be very challenging. In fact, the term “senescence” has been often misused. This is also true in the case of immune cells. While several studies indicate the presence of senescent-like features (mainly in T cells), senescent immune cells are poorly described. Under this prism, we herein review the current literature on what has been characterized as T cell senescence and provide insights on how to accurately discriminate senescent cells against exhausted or anergic ones. We also summarize the major metabolic and epigenetic modifications associated with T cell senescence and underline the role of senescent T cells in the tumor microenvironment (TME). Moreover, we discuss how these cells associate with standard clinical therapeutic interventions and how they impact their efficacy. Finally, we underline the importance of precise identification and thorough characterization of “truly” senescent T cells in order to design successful therapeutic manipulations that would delay cancer incidence and maximize efficacy of immunotherapy.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"108 ","pages":"Pages 33-47"},"PeriodicalIF":12.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Immune senescence: A key player in cancer biology 免疫衰老：癌症生物学中的一个关键角色。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2025-01-01 DOI: 10.1016/j.semcancer.2024.12.001

Yanru Yang, Linni Fan, Mingyang Li, Zhe Wang

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Theoretical framework and emerging challenges of lipid metabolism in cancer 癌症中脂质代谢的理论框架和新挑战。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2025-01-01 DOI: 10.1016/j.semcancer.2024.12.002

Qiuying Gu , Yuan Wang , Ping Yi , Chunming Cheng

{"title":"Theoretical framework and emerging challenges of lipid metabolism in cancer","authors":"Qiuying Gu , Yuan Wang , Ping Yi , Chunming Cheng","doi":"10.1016/j.semcancer.2024.12.002","DOIUrl":"10.1016/j.semcancer.2024.12.002","url":null,"abstract":"<div><div>Elevated lipid metabolism is one of hallmarks of malignant tumors. Lipids not only serve as essential structural components of biological membranes but also provide energy and substrates for the proliferation of cancer cells and tumor growth. Cancer cells meet their lipid needs by coordinating the processes of lipid absorption, synthesis, transport, storage, and catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial for scientists to stay informed about the developments of cancer lipid metabolism. In this review, we first discuss relevant concepts and theories or assumptions that help us understand the lipid metabolism and -based cancer therapies. We then systematically summarize the latest advancements in lipid metabolism including new mechanisms, novel targets, and up-to-date pre-clinical and clinical investigations of anti-cancer treatment with lipid metabolism targeted drugs. Finally, we emphasize emerging research directions and therapeutic strategies, and discuss future prospective and emerging challenges. This review aims to provide the latest insights and guidance for research in the field of cancer lipid metabolism.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"108 ","pages":"Pages 48-70"},"PeriodicalIF":12.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer 宫颈癌细胞衰老和免疫衰老对肿瘤微环境的重塑

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-11-23 DOI: 10.1016/j.semcancer.2024.11.002

Yijiang He , Yue Qiu , Xiansong Yang , Guimei Lu , Shan-Shan Zhao

{"title":"Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer","authors":"Yijiang He , Yue Qiu , Xiansong Yang , Guimei Lu , Shan-Shan Zhao","doi":"10.1016/j.semcancer.2024.11.002","DOIUrl":"10.1016/j.semcancer.2024.11.002","url":null,"abstract":"<div><div>Cellular senescence is a response to various stress signals, which is characterized by stable cell cycle arrest, alterations in cellular morphology, metabolic reprogramming and production of senescence-associated secretory phenotype (SASP). When it occurs in the immune system, it is called immunosenescence. Cervical cancer is a common gynecological malignancy, and cervical cancer screening is generally recommended before the age of 65. Elderly women (≥65 years) are more often diagnosed with advanced disease and have poorer prognosis compared to younger patients. Despite extensive research, the tumor microenvironment requires more in-depth exploration, particularly in elderly patients. In cervical cancer, senescent cells have a double-edged sword effect on tumor progression. Induction of preneoplastic cell senescence prevents tumor initiation, and several treatment approaches of cervical cancer act in part by inducing cancer cell senescence. However, senescent immune cell populations within the tumor microenvironment facilitate tumor development, recurrence, treatment resistance, etc. Amplification of beneficial effects and inhibition of aging-related pro-tumorigenic pathways contribute to improving antitumor effects. This review discusses senescent cancer and immune cells present in the tumor microenvironment of cervical cancer and how these senescent cells and their SASP remodel the tumor microenvironment, influence antitumor immunity and tumor initiation and development. Moreover, we discuss the significance of senotherapeutics that enable to eliminate senescent cells and prevent tumor progression and development through improving antitumor immunity and affecting the tumor microenvironment.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"108 ","pages":"Pages 17-32"},"PeriodicalIF":12.1,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between cell death and senescence in cancer 癌症中细胞死亡与衰老之间的相互作用。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-11-16 DOI: 10.1016/j.semcancer.2024.11.001

Kouhei Shimizu , Hiroyuki Inuzuka , Fuminori Tokunaga

{"title":"The interplay between cell death and senescence in cancer","authors":"Kouhei Shimizu , Hiroyuki Inuzuka , Fuminori Tokunaga","doi":"10.1016/j.semcancer.2024.11.001","DOIUrl":"10.1016/j.semcancer.2024.11.001","url":null,"abstract":"<div><div>Cellular senescence is a state of permanent proliferative arrest that occurs in response to DNA damage-inducing endogenous and exogenous stresses, and is often accompanied by dynamic molecular changes such as a senescence-associated secretory phenotype (SASP). Accumulating evidence indicates that age-associated increases in the upstream and downstream signals of regulated cell death, including apoptosis, necroptosis, pyroptosis, and ferroptosis, are closely related to the induction of cellular senescence and its phenotype. Furthermore, elevated levels of pro-inflammatory SASP factors with aging can be both a cause and consequence of several cell death modes, suggesting the reciprocal effects of cellular senescence and cells undergoing regulated cell death. Here, we review the critical molecular pathways of the regulated cell death forms and describe the crosstalk between aging-related signals and cancer. In addition, we discuss how targeting regulated cell death could be harnessed in therapeutic interventions for cancer.</div></div><div><h3>Abbreviations</h3><div>Abbreviations that are not standard in this field are defined at their first occurrence in the article and are used consistently throughout the article.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"108 ","pages":"Pages 1-16"},"PeriodicalIF":12.1,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of cardiovascular toxicities induced by cancer immune therapies: Underlying mechanisms, clinical manifestations and therapeutic approaches 癌症免疫疗法诱发心血管毒性的系统综述：潜在机制、临床表现和治疗方法。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-11-01 DOI: 10.1016/j.semcancer.2024.10.004

Li Liu , Wentao Yao , Mi Wang , Baohui Wang , Fanming Kong , Zhongguo Fan , Guanwei Fan

{"title":"A systematic review of cardiovascular toxicities induced by cancer immune therapies: Underlying mechanisms, clinical manifestations and therapeutic approaches","authors":"Li Liu , Wentao Yao , Mi Wang , Baohui Wang , Fanming Kong , Zhongguo Fan , Guanwei Fan","doi":"10.1016/j.semcancer.2024.10.004","DOIUrl":"10.1016/j.semcancer.2024.10.004","url":null,"abstract":"<div><div>Immunotherapy has revolutionized the management of various types of cancers, even those previously deemed untreatable. Nonetheless, these medications have been associated with inflammation and damage across various organs. These challenges are exemplified by the adverse cardiovascular impacts of cancer immunotherapy, which need comprehensive understanding, clarification, and management integrated into the overall care of cancer patients. Numerous anticancer immunotherapies have been linked to the prevalence and severity of cardiovascular toxicity. These challenges emphasize the importance of conducting fundamental and applied research to elucidate disease causes, discover prognostic indicators, enhance diagnostic methods, and create successful therapies. Despite the acknowledged importance of T cells, there remains a knowledge gap regarding the inciting antigens, the reasons for their recognition, and the mechanisms of how they contribute to cardiac cell injury. In this review, we summarize the molecular mechanism, epidemiology, diagnosis, pathophysiology and corresponding treatment of cardiovascular toxicity induced by immunotherapy, including immune checkpoint inhibitors (ICIs), adoptive cell therapies (ACT), and bi-specific T-cell engagers (BiTEs) among others. By elucidating these aspects, we aim to provide a better understanding of immunotherapies in cancer treatment and offer guidance for their clinical application.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 179-191"},"PeriodicalIF":12.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the complexities of resistance mechanism in pancreatic cancer: Insights from in vitro and ex-vivo model systems 揭示胰腺癌抗药性机制的复杂性：体外和体内模型系统的启示。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-11-01 DOI: 10.1016/j.semcancer.2024.09.002

Giulia Lencioni , Alessandro Gregori , Belén Toledo , Rita Rebelo , Benoît Immordino , Manoj Amrutkar , Cristina P.R. Xavier , Anja Kocijančič , Deo Prakash Pandey , Macarena Perán , Justo P. Castaño , Naomi Walsh , Elisa Giovannetti

{"title":"Unravelling the complexities of resistance mechanism in pancreatic cancer: Insights from in vitro and ex-vivo model systems","authors":"Giulia Lencioni , Alessandro Gregori , Belén Toledo , Rita Rebelo , Benoît Immordino , Manoj Amrutkar , Cristina P.R. Xavier , Anja Kocijančič , Deo Prakash Pandey , Macarena Perán , Justo P. Castaño , Naomi Walsh , Elisa Giovannetti","doi":"10.1016/j.semcancer.2024.09.002","DOIUrl":"10.1016/j.semcancer.2024.09.002","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis and rising global deaths. Late diagnosis, due to absent early symptoms and biomarkers, limits treatment mainly to chemotherapy, which soon encounters resistance. PDAC treatment innovation is hampered by its complex and heterogeneous resistant nature, including mutations in key genes and a stromal-rich, immunosuppressive tumour microenvironment. Recent studies on PDAC resistance stress the need for suitable in vitro and ex vivo models to replicate its complex molecular and microenvironmental landscape. This review summarises advances in these models, which can aid in combating chemoresistance and serve as platforms for discovering new therapeutics. Immortalised cell lines offer homogeneity, unlimited proliferation, and reproducibility, but while many gemcitabine-resistant PDAC cell lines exist, fewer models are available for resistance to other drugs. Organoids from PDAC patients show promise in mimicking tumour heterogeneity and chemosensitivity. Bioreactors, co-culture systems and organotypic slices, incorporating stromal and immune cells, are being developed to understand tumour-stroma interactions and the tumour microenvironment's role in drug resistance. Lastly, another innovative approach is three-dimensional bioprinting, which creates tissue-like structures resembling PDAC architecture, allowing for drug screening. These advanced models can guide researchers in selecting optimal in vitro tests, potentially improving therapeutic strategies and patient outcomes.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 217-233"},"PeriodicalIF":12.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunosenescence in digestive system cancers: Mechanisms, research advances, and therapeutic strategies 消化系统癌症中的免疫衰老：机制、研究进展和治疗策略。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-11-01 DOI: 10.1016/j.semcancer.2024.10.006

Junyan Zhang , Xiaojiao Guan , Xinwen Zhong

{"title":"Immunosenescence in digestive system cancers: Mechanisms, research advances, and therapeutic strategies","authors":"Junyan Zhang , Xiaojiao Guan , Xinwen Zhong","doi":"10.1016/j.semcancer.2024.10.006","DOIUrl":"10.1016/j.semcancer.2024.10.006","url":null,"abstract":"<div><div>Increasing lifespans and external environmental factors have contributed to the increase of age-related diseases, particularly cancer. A decrease in immune surveillance and clearance of cancer cells is the result of immunosenescence, which involves the remodeling of immune organs, the changes and functional decline of immune cell subsets, in association with systemic low-grade chronic inflammation. Stem cells aging in bone marrow and thymic involution are the most important causes of immunosenescence. Senescent cancer cells promote the differentiation, recruitment, and functional upregulation of immune-suppressive cell subsets e.g. regulatory T cells (Tregs), myeloid-derived suppressor cell (MDSC), tumor-associated macrophages (TAMS) through senescence-associated secretory phenotype (SASP) further exacerbating the immunosuppressive microenvironment. For digestive system cancers, age-related damage to the intestinal mucosal barrier, the aging of gut-associated lymphoid tissue (GALT), exposure to xenobiotic stimuli throughout life, and dysbiosis make the local immune microenvironment more vulnerable. This article systematically reviews the research progress of immunosenescence and immune microenvironment in digestive system cancers, as well as the exploration of related therapy strategies, hoping to point out new directions for research in the digestive system cancers.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 234-250"},"PeriodicalIF":12.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BubR1 and SIRT2: Insights into aneuploidy, aging, and cancer BubR1 和 SIRT2：对非整倍体、衰老和癌症的见解

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-11-01 DOI: 10.1016/j.semcancer.2024.10.005

Renju Pun , Niti Kumari , Rodaina Hazem Monieb, Sachin Wagh, Brian J. North

{"title":"BubR1 and SIRT2: Insights into aneuploidy, aging, and cancer","authors":"Renju Pun , Niti Kumari , Rodaina Hazem Monieb, Sachin Wagh, Brian J. North","doi":"10.1016/j.semcancer.2024.10.005","DOIUrl":"10.1016/j.semcancer.2024.10.005","url":null,"abstract":"<div><div>Aging is a significant risk factor for cancer which is due, in part, to heightened genomic instability. Mitotic surveillance proteins such as BubR1 play a pivotal role in ensuring accurate chromosomal segregation and preventing aneuploidy. BubR1 levels have been shown to naturally decline with age and its loss is associated with various age-related pathologies. Sirtuins, a class of NAD<sup>+</sup>-dependent deacylases, are implicated in cancer and genomic instability. Among them, SIRT2 acts as an upstream regulator of BubR1, offering a critical pathway that can potentially mitigate age-related diseases, including cancer. In this review, we explore BubR1 as a key regulator of cellular processes crucial for aging-related phenotypes. We delve into the intricate mechanisms through which BubR1 influences genomic stability and cellular senescence. Moreover, we highlight the role of NAD<sup>+</sup> and SIRT2 in modulating BubR1 expression and function, emphasizing its potential as a therapeutic target. The interaction between BubR1 and SIRT2 not only serves as a fundamental regulatory pathway in cellular homeostasis but also represents a promising avenue for developing targeted therapies against age-related diseases, particularly cancer.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 201-216"},"PeriodicalIF":12.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0