Seminars in cancer biology最新文献_第10页

Ferroptosis and immunosenescence in colorectal cancer 结直肠癌中的铁蛋白沉积症和免疫衰老

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-10-16 DOI: 10.1016/j.semcancer.2024.10.003

Yao Wang , Xinran Cao , Chunbaixue Yang , Jianchun Fan , Xingmei Zhang , Xueliang Wu , Wei Guo , Shoutian Sun , Ming Liu , Lifen Zhang , Tian Li

{"title":"Ferroptosis and immunosenescence in colorectal cancer","authors":"Yao Wang , Xinran Cao , Chunbaixue Yang , Jianchun Fan , Xingmei Zhang , Xueliang Wu , Wei Guo , Shoutian Sun , Ming Liu , Lifen Zhang , Tian Li","doi":"10.1016/j.semcancer.2024.10.003","DOIUrl":"10.1016/j.semcancer.2024.10.003","url":null,"abstract":"<div><div>Colorectal cancer (CRC), ranked as the globe’s third leading malignancy. Despite advancements in therapeutic approaches, the mortality rate remains distressingly high for those afflicted with advanced stages of the disease. Ferroptosis is a programmed form of cell death. The ways of ferroptosis mainly include promoting the accumulation of cellular ROS and increasing the level of cellular Labile iron pool (LIP). Immunosenescence is characterized by a gradual deterioration of the immune system’s ability to respond to pathogens and maintain surveillance against cancer cells. In CRC, this decline is exacerbated by the tumor microenvironment, which can suppress the immune response and promote tumor progression. This paper reviews the relationship between iron prolapse and immune senescence in colorectal cancer, focusing on the following aspects: firstly, the different pathways that induce iron prolapse in colorectal cancer; secondly, immune-immune senescence in colorectal cancer; and lastly, the interactions between immune senescence and iron prolapse in colorectal cancer, e.g., immune-immune senescent cells often exhibit increased oxidative stress, leading to the accumulation of ROS, and consequently to lipid peroxidation and induction of iron-induced cell death. At the same time, ferroptosis induces immune cell senescence as well as alterations in the immune microenvironment by promoting the death of damaged or diseased cells and leading to the inflammation usually associated with it. In conclusion, by exploring the potential targets of ferroptosis and immune senescence in colorectal cancer therapy, we hope to provide a reference for future research.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 156-165"},"PeriodicalIF":12.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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PROTAC as a novel anti-cancer strategy by targeting aging-related signaling 以衰老相关信号为靶点，将 PROTAC 作为一种新型抗癌策略。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-10-03 DOI: 10.1016/j.semcancer.2024.09.004

Yunhua Peng , Donghua Liu , Daoyuan Huang , Hiroyuki Inuzuka , Jing Liu

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DAMPs in immunosenescence and cancer 免疫衰老和癌症中的 DAMPs。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-09-29 DOI: 10.1016/j.semcancer.2024.09.005

Fangquan Chen , Hu Tang , Xiutao Cai , Junhao Lin , Rui Kang , Daolin Tang , Jiao Liu

{"title":"DAMPs in immunosenescence and cancer","authors":"Fangquan Chen , Hu Tang , Xiutao Cai , Junhao Lin , Rui Kang , Daolin Tang , Jiao Liu","doi":"10.1016/j.semcancer.2024.09.005","DOIUrl":"10.1016/j.semcancer.2024.09.005","url":null,"abstract":"<div><div>Damage-associated molecular patterns (DAMPs) are endogenous molecules released by cells in response to injury or stress, recognized by host pattern recognition receptors that assess the immunological significance of cellular damage. The interaction between DAMPs and innate immune receptors triggers sterile inflammation, which serves a dual purpose: promoting tissue repair and contributing to pathological conditions, including age-related diseases. Chronic inflammation mediated by DAMPs accelerates immunosenescence and influences both tumor progression and anti-tumor immunity, underscoring the critical role of DAMPs in the nexus between aging and cancer. This review explores the characteristics of immunosenescence and its impact on age-related cancers, investigates the various types of DAMPs, their release mechanisms during cell death, and the immune activation pathways they initiate. Additionally, we examine the therapeutic potential of targeting DAMPs in age-related diseases. A detailed understanding of DAMP-induced signal transduction could provide critical insights into immune regulation and support the development of innovative therapeutic strategies.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 123-142"},"PeriodicalIF":12.1,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Interplay of ferroptosis, cuproptosis, and PANoptosis in cancer treatment-induced cardiotoxicity: Mechanisms and therapeutic implications 铁凋亡、杯凋亡和泛凋亡在癌症治疗诱发的心脏毒性中的相互作用：机制和治疗意义。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-09-17 DOI: 10.1016/j.semcancer.2024.09.003

Fan Yang , Guoxia Zhang , Na An , Qianqian Dai , William Cho , Hongcai Shang , Yanwei Xing

{"title":"Interplay of ferroptosis, cuproptosis, and PANoptosis in cancer treatment-induced cardiotoxicity: Mechanisms and therapeutic implications","authors":"Fan Yang , Guoxia Zhang , Na An , Qianqian Dai , William Cho , Hongcai Shang , Yanwei Xing","doi":"10.1016/j.semcancer.2024.09.003","DOIUrl":"10.1016/j.semcancer.2024.09.003","url":null,"abstract":"<div><div>With the prolonged survival of individuals with cancer, the emergence of cardiovascular diseases (CVD) induced by cancer treatment has become a significant concern, ranking as the second leading cause of death among cancer survivors. This review explores three distinct types of programmed cell death (PCD): ferroptosis, cuproptosis, and PANoptosis, focusing on their roles in chemotherapy-induced cardiotoxicity. While ferroptosis and cuproptosis are triggered by excess iron and copper (Cu), PANoptosis is an inflammatory PCD with features of pyroptosis, apoptosis, and necroptosis. Recent studies reveal intricate connections among these PCD types, emphasizing the interplay between cuproptosis and ferroptosis. Notably, the role of intracellular Cu in promoting ferroptosis through GPX4 is highlighted. Additionally, ROS-induced PANoptosis is influenced by ferroptosis and cuproptosis, suggesting a complex interrelationship. This review provides insights into the molecular mechanisms of these PCD modalities and their distinct contributions to chemotherapy-induced cardiotoxicity. Furthermore, we discuss the potential application of cardioprotective drugs in managing these PCD types. This comprehensive analysis aims to advance the understanding, diagnosis, and therapeutic strategies for cardiotoxicity associated with cancer treatment.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 106-122"},"PeriodicalIF":12.1,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1044579X24000762/pdfft?md5=5884b2ff524461c2c003d3fe87a0a037&pid=1-s2.0-S1044579X24000762-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Extracellular vesicles and biomarker discovery 细胞外囊泡和生物标记物的发现。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-09-06 DOI: 10.1016/j.semcancer.2024.09.001

Marco Falasca, Marcello Manfredi

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cGAS/STING signalling pathway in senescence and oncogenesis cGAS/STING 信号通路在衰老和肿瘤发生中的作用。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-31 DOI: 10.1016/j.semcancer.2024.08.007

Le Yu , Pengda Liu

{"title":"cGAS/STING signalling pathway in senescence and oncogenesis","authors":"Le Yu , Pengda Liu","doi":"10.1016/j.semcancer.2024.08.007","DOIUrl":"10.1016/j.semcancer.2024.08.007","url":null,"abstract":"<div><p>The cGAS/STING signaling pathway is a crucial component of the innate immune system, playing significant roles in sensing cytosolic DNA, regulating cellular senescence, and contributing to oncogenesis. Recent advances have shed new lights into the molecular mechanisms governing pathway activation in multiple pathophysiological settings, the indispensable roles of cGAS/STING signaling in cellular senescence, and its context-dependent roles in cancer development and suppression. This review summarizes current knowledge related to the biology of cGAS/STING signaling pathway and its participations into senescence and oncogenesis. We further explore the clinical implications and therapeutic potential for cGAS/STING targeted therapies, and faced challenges in the field. With a focus on molecular mechanisms and emerging pharmacological targets, this review underscores the importance of future studies to harness the therapeutic potential of the cGAS/STING pathway in treating senescence-related disorders and cancer. Advanced understanding of the regulatory mechanisms of cGAS/STING signaling, along with the associated deregulations in diseases, combined with the development of new classes of cGAS/STING modulators, hold great promises for creating novel and effective therapeutic strategies. These advancements could address current treatment challenges and unlock the full potential of cGAS/STING in treating senescence-related disorders and oncogenesis.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 87-102"},"PeriodicalIF":12.1,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1044579X24000737/pdfft?md5=fa48450dabde76a86f3ba96bc030265f&pid=1-s2.0-S1044579X24000737-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer 联合靶向衰老细胞和衰老巨噬细胞：综合治疗肺癌的新思路。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-29 DOI: 10.1016/j.semcancer.2024.08.006

Ming Gu , Yang Liu , Wenhui Zheng , Zuoqian Jing , Xiang Li , Wei Guo , Zimo Zhao , Xu Yang , Zhe Liu , Xinwang Zhu , Wei Gao

{"title":"Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer","authors":"Ming Gu , Yang Liu , Wenhui Zheng , Zuoqian Jing , Xiang Li , Wei Guo , Zimo Zhao , Xu Yang , Zhe Liu , Xinwang Zhu , Wei Gao","doi":"10.1016/j.semcancer.2024.08.006","DOIUrl":"10.1016/j.semcancer.2024.08.006","url":null,"abstract":"<div><p>Lung cancer is one of the most common cancers worldwide and a leading cause of cancer-related deaths. Macrophages play a key role in the immune response and the tumour microenvironment. As an important member of the immune system, macrophages have multiple functions, including phagocytosis and clearance of pathogens, modulation of inflammatory responses, and participation in tissue repair and regeneration. In lung cancer, macrophages are considered to be the major cellular component of the tumor-associated inflammatory response and are closely associated with tumorigenesis, progression and metastasis. However, macrophages gradually undergo a senescence process with age and changes in pathological states. Macrophage senescence is an important change in the functional and metabolic state of macrophages and may have a significant impact on lung cancer development. In lung cancer, senescent macrophages interact with other cells in the tumor microenvironment (TME) by secreting senescence-associated secretory phenotype (SASP) factors, which can either promote the proliferation, invasion and metastasis of tumor cells or exert anti-tumor effects through reprogramming or clearance under specific conditions. Therefore, senescent macrophages are considered important potential targets for lung cancer therapy. In this paper, a systematic review of macrophages and their senescence process, and their role in tumors is presented. A variety of inhibitory strategies against senescent macrophages, including enhancing autophagy, inhibiting SASP, reducing DNA damage, and modulating metabolic pathways, were also explored. These strategies are expected to improve lung cancer treatment outcomes by restoring the anti-tumor function of macrophages.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 43-57"},"PeriodicalIF":12.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Erratum to “RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer” [Semin. Cancer Biol. 102–103 (2024) 4–16] 癌症中控制 TGF-β 信号转导和 EMT 的 RNA 调控机制》的勘误 [Semin.

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-28 DOI: 10.1016/j.semcancer.2024.08.005

Cameron P. Bracken , Gregory J. Goodall , Philip A. Gregory

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Unveiling the role of PIK3R1 in cancer: A comprehensive review of regulatory signaling and therapeutic implications 揭示 PIK3R1 在癌症中的作用：调控信号和治疗意义的全面回顾》。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-26 DOI: 10.1016/j.semcancer.2024.08.004

Ishita Gupta , Daria A. Gaykalova

{"title":"Unveiling the role of PIK3R1 in cancer: A comprehensive review of regulatory signaling and therapeutic implications","authors":"Ishita Gupta , Daria A. Gaykalova","doi":"10.1016/j.semcancer.2024.08.004","DOIUrl":"10.1016/j.semcancer.2024.08.004","url":null,"abstract":"<div><p>Phosphoinositide 3-kinase (PI3K) is responsible for phosphorylating phosphoinositides to generate secondary signaling molecules crucial for regulating various cellular processes, including cell growth, survival, and metabolism. The PI3K is a heterodimeric enzyme complex comprising of a catalytic subunit (p110α, p110β, or p110δ) and a regulatory subunit (p85). The binding of the regulatory subunit, p85, with the catalytic subunit, p110, forms an integral component of the PI3K enzyme. <em>PIK3R1</em> (phosphoinositide-3-kinase regulatory subunit 1) belongs to class IA of the PI3K family. <em>PIK3R1</em> exhibits structural complexity due to alternative splicing, giving rise to distinct isoforms, prominently p85α and p55α. While the primary p85α isoform comprises multiple domains, including Src homology 3 (SH3) domains, a Breakpoint Cluster Region Homology (BH) domain, and Src homology 2 (SH2) domains (iSH2 and nSH2), the shorter isoform, p55α, lacks certain domains present in p85α. In this review, we will highlight the intricate regulatory mechanisms governing PI3K signaling along with the impact of <em>PIK3R1</em> alterations on cellular processes. We will further delve into the clinical significance of <em>PIK3R1</em> mutations in various cancer types and their implications for prognosis and treatment outcomes. Additionally, we will discuss the evolving landscape of targeted therapies aimed at modulating PI3K-associated pathways. Overall, this review will provide insights into the dynamic interplay of <em>PIK3R1</em> in cancer, fostering advancements in precision medicine and the development of targeted interventions.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 58-86"},"PeriodicalIF":12.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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AMPK: The energy sensor at the crossroads of aging and cancer AMPK：衰老与癌症交叉路口的能量传感器

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-26 DOI: 10.1016/j.semcancer.2024.08.002

Vasudevarao Penugurti , Rajesh Kumar Manne , Ling Bai , Rajni Kant , Hui-Kuan Lin

{"title":"AMPK: The energy sensor at the crossroads of aging and cancer","authors":"Vasudevarao Penugurti , Rajesh Kumar Manne , Ling Bai , Rajni Kant , Hui-Kuan Lin","doi":"10.1016/j.semcancer.2024.08.002","DOIUrl":"10.1016/j.semcancer.2024.08.002","url":null,"abstract":"<div><p>AMP-activated protein kinase (AMPK) is a protein kinase that plays versatile roles in response to a variety of physiological stresses, including glucose deprivation, hypoxia, and ischemia. As a kinase with pleiotropic functions, it plays a complex role in tumor progression, exhibiting both tumor-promoting and tumor-suppressing activities. On one hand, AMPK enhances cancer cell proliferation and survival, promotes cancer metastasis, and impairs anti-tumor immunity. On the other hand, AMPK inhibits cancer cell growth and survival and stimulates immune responses in a context-dependent manner. Apart from these functions, AMPK plays a key role in orchestrating aging and aging-related disorders, including cardiovascular diseases (CVD), Osteoarthritis (OA), and Diabetes. In this review article, we summarized the functions of AMPK pathway based on its oncogenic and tumor-suppressive roles and highlighted the importance of AMPK pathway in regulating cellular aging. We also spotlighted the significant role of various signaling pathways, activators, and inhibitors of AMPK in serving as therapeutic strategies for anti-cancer and anti-aging therapy.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 15-27"},"PeriodicalIF":12.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0