Seminars in cancer biology最新文献_第10页

Artificial intelligence-aided optical imaging for cancer theranostics 人工智能辅助光学成像在癌症治疗中的应用

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2023-09-01 DOI: 10.1016/j.semcancer.2023.06.003

Mengze Xu , Zhiyi Chen , Junxiao Zheng , Qi Zhao , Zhen Yuan

{"title":"Artificial intelligence-aided optical imaging for cancer theranostics","authors":"Mengze Xu , Zhiyi Chen , Junxiao Zheng , Qi Zhao , Zhen Yuan","doi":"10.1016/j.semcancer.2023.06.003","DOIUrl":"10.1016/j.semcancer.2023.06.003","url":null,"abstract":"<div><p><span>The use of artificial intelligence (AI) to assist biomedical imaging have demonstrated its high accuracy and high efficiency in medical decision-making for individualized cancer medicine. In particular, optical imaging<span> methods are able to visualize both the structural and functional information of tumors tissues with high contrast, low cost, and noninvasive property. However, no systematic work has been performed to inspect the recent advances on AI-aided optical imaging for cancer theranostics. In this review, we demonstrated how AI can guide optical imaging methods to improve the accuracy on tumor detection, automated analysis and prediction of its histopathological section, its monitoring during treatment, and its prognosis by using computer vision, deep learning and natural language processing. By contrast, the </span></span>optical imaging techniques<span> involved mainly consisted of various tomography and microscopy imaging methods such as optical endoscopy imaging, optical coherence tomography, photoacoustic imaging, diffuse optical tomography, optical microscopy imaging, Raman imaging, and fluorescent imaging. Meanwhile, existing problems, possible challenges and future prospects for AI-aided optical imaging protocol for cancer theranostics were also discussed. It is expected that the present work can open a new avenue for precision oncology by using AI and optical imaging tools.</span></p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"94 ","pages":"Pages 62-80"},"PeriodicalIF":14.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9799720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Artificial intelligence in digital pathology of cutaneous lymphomas: A review of the current state and future perspectives 人工智能在皮肤淋巴瘤数字病理学中的应用现状与展望

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2023-09-01 DOI: 10.1016/j.semcancer.2023.06.004

Thom Doeleman , Liesbeth M. Hondelink , Maarten H. Vermeer , Marijke R. van Dijk , Anne M.R. Schrader

{"title":"Artificial intelligence in digital pathology of cutaneous lymphomas: A review of the current state and future perspectives","authors":"Thom Doeleman , Liesbeth M. Hondelink , Maarten H. Vermeer , Marijke R. van Dijk , Anne M.R. Schrader","doi":"10.1016/j.semcancer.2023.06.004","DOIUrl":"10.1016/j.semcancer.2023.06.004","url":null,"abstract":"<div><p>Primary cutaneous lymphomas (CLs) represent a heterogeneous group of T-cell lymphomas and B-cell lymphomas that present in the skin without evidence of extracutaneous involvement at time of diagnosis. CLs are largely distinct from their systemic counterparts in clinical presentation, histopathology, and biological behavior and, therefore, require different therapeutic management. Additional diagnostic burden is added by the fact that several benign inflammatory dermatoses mimic CL subtypes, requiring clinicopathological correlation for definitive diagnosis. Due to the heterogeneity and rarity of CL, adjunct diagnostic tools are welcomed, especially by pathologists without expertise in this field or with limited access to a centralized specialist panel. The transition into digital pathology workflows enables artificial intelligence (AI)-based analysis of patients’ whole-slide pathology images (WSIs). AI can be used to automate manual processes in histopathology but, more importantly, can be applied to complex diagnostic tasks, especially suitable for rare disease like CL. To date, AI-based applications for CL have been minimally explored in literature. However, in other skin cancers and systemic lymphomas, disciplines that are recognized here as the building blocks for CLs, several studies demonstrated promising results using AI for disease diagnosis and subclassification, cancer detection, specimen triaging, and outcome prediction. Additionally, AI allows discovery of novel biomarkers or may help to quantify established biomarkers. This review summarizes and blends applications of AI in pathology of skin cancer and lymphoma and proposes how these findings can be applied to diagnostics of CL.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"94 ","pages":"Pages 81-88"},"PeriodicalIF":14.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9801193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in biology and novel treatments of SCLC SCLC的生物学进展及新治疗方法

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2023-08-21 DOI: 10.1016/j.semcancer.2023.08.003

Tian Li, Giuseppe Giaccone

引用次数: 0

Advancements in small cell lung cancer 小细胞肺癌癌症的研究进展

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2023-08-01 DOI: 10.1016/j.semcancer.2023.05.008

Jung-hoon Lee, Ashish Saxena, Giuseppe Giaccone

引用次数: 4

Nonalcoholic fatty liver disease and hepatocellular carcinoma:Insights in epidemiology, pathogenesis, imaging, prevention and therapy 非酒精性脂肪性肝病和肝细胞癌:流行病学、发病机制、影像学、预防和治疗的见解

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2023-08-01 DOI: 10.1016/j.semcancer.2023.04.010

Stergios A. Polyzos , Lampros Chrysavgis , Ilias D. Vachliotis , Evangelos Chartampilas , Evangelos Cholongitas

{"title":"Nonalcoholic fatty liver disease and hepatocellular carcinoma:Insights in epidemiology, pathogenesis, imaging, prevention and therapy","authors":"Stergios A. Polyzos , Lampros Chrysavgis , Ilias D. Vachliotis , Evangelos Chartampilas , Evangelos Cholongitas","doi":"10.1016/j.semcancer.2023.04.010","DOIUrl":"10.1016/j.semcancer.2023.04.010","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) is estimated to be the third leading cause of cancer-related mortality and is characterized by low survival rates. Nonalcoholic fatty liver disease (NAFLD) is emerging as a leading cause of HCC, whose rates are increasing, owing to the increasing prevalence of NAFLD. The pathogenesis of NAFLD-associated HCC is multifactorial: insulin resistance, obesity, diabetes and the low-grade hepatic inflammation, which characterizes NAFLD, seem to play key roles in the development and progression of HCC. The diagnosis of NAFLD-associated HCC is based on imaging in the presence of liver cirrhosis, preferably computerized tomography or magnetic resonance imaging, but liver biopsy for histological confirmation is usually required in the absence of liver cirrhosis. Some preventive measures have been recommended for NAFLD-associated HCC, including weight loss, cessation of even moderate alcohol drinking and smoking, as well as the use of metformin, statins and aspirin. However, these preventive measures are mainly based on observational studies, thus they need validation in trials of different design before introducing in clinical practice. The treatment of NAFLD should be tailored on an individual basis and should be ideally determined by a multidisciplinary team. In the last two decades, new medications, including tyrosine kinase inhibitors and immune checkpoints inhibitors, have improved the survival of patients with advanced HCC, but trials specifically designed for patients with NAFLD-associated HCC are scarce. The aim of this review was to overview evidence on the epidemiology and pathophysiology of NAFLD-associated HCC, then to comment on imaging tools for its appropriate screening and diagnosis, and finally to critically summarize the currently available options for its prevention and treatment.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"93 ","pages":"Pages 20-35"},"PeriodicalIF":14.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9597766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism 肥胖诱导的癌症细胞及其微环境变化：管理脂质代谢失调的机制和治疗前景

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2023-08-01 DOI: 10.1016/j.semcancer.2023.05.002

Miriam Lee-Rueckert , Marina Canyelles , Mireia Tondo , Noemi Rotllan , Petri T. Kovanen , Vicenta Llorente-Cortes , Joan Carles Escolà-Gil

{"title":"Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism","authors":"Miriam Lee-Rueckert , Marina Canyelles , Mireia Tondo , Noemi Rotllan , Petri T. Kovanen , Vicenta Llorente-Cortes , Joan Carles Escolà-Gil","doi":"10.1016/j.semcancer.2023.05.002","DOIUrl":"10.1016/j.semcancer.2023.05.002","url":null,"abstract":"<div><p><span><span>Obesity has been closely related to cancer progression, recurrence, metastasis, and treatment resistance. We aim to review recent progress in the knowledge on the obese macroenvironment and the generated adipose tumor microenvironment (TME) inducing lipid<span> metabolic dysregulation and their influence on carcinogenic processes. Visceral white adipose tissue expansion during obesity exerts systemic or macroenvironmental effects on tumor initiation, growth, and invasion by promoting inflammation, hyperinsulinemia, growth-factor release, and dyslipidemia. The dynamic relationship between cancer and </span></span>stromal cells of the obese adipose TME is critical for cancer cell survival and proliferation as well. Experimental evidence shows that secreted paracrine signals from cancer cells can induce </span>lipolysis<span> in cancer-associated adipocytes, causing them to release free fatty acids and acquire a fibroblast-like phenotype. Such adipocyte delipidation and phenotypic change is accompanied by an increased secretion of cytokines by cancer-associated adipocytes and tumor-associated macrophages in the TME. Mechanistically, the availability of adipose TME free fatty acids and tumorigenic cytokines concomitant with the activation of angiogenic processes creates an environment that favors a shift in the cancer cells toward an aggressive phenotype associated with increased invasiveness. We conclude that restoring the aberrant metabolic alterations in the host macroenvironment and in adipose TME of obese subjects would be a therapeutic option to prevent cancer development. Several dietary, lipid-based, and oral antidiabetic pharmacological therapies could potentially prevent tumorigenic processes associated with the dysregulated lipid metabolism closely linked to obesity.</span></p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"93 ","pages":"Pages 36-51"},"PeriodicalIF":14.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9978585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tumor-derived nanoseeds condition the soil for metastatic organotropism 肿瘤衍生的纳米种子为转移性嗜器官性调节土壤

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2023-08-01 DOI: 10.1016/j.semcancer.2023.05.003

Mengying Hu , Candia M. Kenific , Nancy Boudreau, David Lyden

{"title":"Tumor-derived nanoseeds condition the soil for metastatic organotropism","authors":"Mengying Hu , Candia M. Kenific , Nancy Boudreau, David Lyden","doi":"10.1016/j.semcancer.2023.05.003","DOIUrl":"10.1016/j.semcancer.2023.05.003","url":null,"abstract":"<div><p><span>Primary tumors secrete a variety of factors to turn distant microenvironments into favorable and fertile ‘soil’ for subsequent metastases. Among these ‘seeding’ factors that initiate pre-metastatic niche (PMN) formation, tumor-derived extracellular vesicles (EVs) are of particular interest as tumor EVs can direct organotropism depending on their surface integrin<span> profiles. In addition, EVs also contain versatile, bioactive cargo, which include proteins, metabolites, lipids, </span></span>RNA<span>, and DNA<span> fragments. The cargo incorporated into EVs is collectively shed from cancer cells and cancer-associated stromal cells. Increased understanding of how tumor EVs promote PMN establishment and detection of EVs in bodily fluids highlight how tumor EVs could serve as potential diagnostic and prognostic biomarkers, as well as provide a therapeutic target for metastasis prevention. This review focuses on tumor-derived EVs and how they direct organotropism and subsequently modulate stromal and immune microenvironments at distal sites to facilitate PMN formation. We also outline the progress made thus far towards clinical applications of tumor EVs.</span></span></p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"93 ","pages":"Pages 70-82"},"PeriodicalIF":14.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10237451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Special issue: Modulation of immune checkpoint proteins and their networks in cancer progression 特刊:免疫检查点蛋白及其网络在癌症进展中的调节

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2023-08-01 DOI: 10.1016/j.semcancer.2023.04.001

Sanjay K. Srivastava , Sung-Hoon Kim

引用次数: 0

Radiomics and artificial intelligence for precision medicine in lung cancer treatment 放射组学和人工智能在肺癌治疗中的精准医疗

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2023-08-01 DOI: 10.1016/j.semcancer.2023.05.004

Mitchell Chen , Susan J. Copley , Patrizia Viola , Haonan Lu , Eric O. Aboagye

引用次数: 3

Emerging role of pancreatic stellate cell-derived extracellular vesicles in pancreatic cancer 胰腺星状细胞来源的细胞外囊泡在胰腺癌中的新作用

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2023-08-01 DOI: 10.1016/j.semcancer.2023.05.007

Rohit Sarkar , Zhihong Xu , Chamini J. Perera , Minoti V. Apte

{"title":"Emerging role of pancreatic stellate cell-derived extracellular vesicles in pancreatic cancer","authors":"Rohit Sarkar , Zhihong Xu , Chamini J. Perera , Minoti V. Apte","doi":"10.1016/j.semcancer.2023.05.007","DOIUrl":"10.1016/j.semcancer.2023.05.007","url":null,"abstract":"<div><p>Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer that is characterised by a prominent collagenous stromal reaction/desmoplasia surrounding tumour cells. Pancreatic stellate cells (PSCs) are responsible for the production of this stroma and have been shown to facilitate PDAC progression. Recently, extracellular vesicles (EVs), in particular, small extracellular vesicles (exosomes) have been a topic of interest in the field of cancer research for their emerging roles in cancer progression and diagnosis. EVs act as a form of intercellular communication by carrying their molecular cargo from one cell to another, regulating functions of the recipient cells. Although the knowledge of the bi-directional interactions between the PSCs and cancer cells that promote disease progression has advanced significantly over the past decade, studies on PSC-derived EVs in PDAC are currently rather limited. This review provides an overview of PDAC, pancreatic stellate cells and their interactions with cancer cells, as well as the currently known role of extracellular vesicles derived from PSCs in PDAC progression.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"93 ","pages":"Pages 114-122"},"PeriodicalIF":14.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3