Seminars in cancer biology最新文献

{"title":"Evolutionary trajectories of myelodysplastic syndromes/neoplasms","authors":"Maria Creignou ,&nbsp;Martina Sarchi ,&nbsp;Elsa Bernard ,&nbsp;Luca Malcovati","doi":"10.1016/j.semcancer.2026.01.006","DOIUrl":"10.1016/j.semcancer.2026.01.006","url":null,"abstract":"<div><div>Myelodysplastic syndromes/neoplasms (MDS) are a heterogeneous group of myeloid malignancies characterized by clonality, cytopenia, bone marrow dysplasia, and a variable risk of progression to acute myeloid leukemia (AML). With few therapeutic advances beyond the introduction of hypomethylating agents twenty years ago, MDS remains associated with poor overall survival, limited curative options, and frequent relapse or resistance to available treatments. Breakthroughs in genomic and single-cell technologies have transformed our understanding of MDS pathogenesis, revealing that disease initiation and progression follow stereotyped evolutionary trajectories driven by distinct constellations of somatic mutations and modulated by both endogenous and exogenous factors. In this review, we synthesize current knowledge of the genetic landscape of MDS and dissect the clonal path of the disease from precursor states to AML transformation. We further discuss how germline predisposition, bone marrow microenvironmental remodeling, and exposure to environmental or genotoxic stressors impact the selection, expansion, and transformation potential of the hematopoietic clone. Finally, we outline how these insights have underpinned a conceptual shift toward a molecular taxonomy of myeloid neoplasms, redefining diagnostic boundaries between MDS and AML, improving prognostic stratification, and enabling a biology-driven framework for personalized treatment of MDS.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"120 ","pages":"Pages 16-30"},"PeriodicalIF":15.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratumor heterogeneity and clonal evolution in sarcomas: Molecular, cellular, and functional drivers of therapy resistance","authors":"Thomas G.P. Grünewald ,&nbsp;Ina Oehme ,&nbsp;Johanna Wagner ,&nbsp;Stefan Fröhling","doi":"10.1016/j.semcancer.2026.02.001","DOIUrl":"10.1016/j.semcancer.2026.02.001","url":null,"abstract":"<div><div>Sarcomas, malignant neoplasms of mesenchymal origin, comprise more than 100 entities and numerous histologic subtypes. Their relative rarity compared with carcinomas, interpatient diversity, and pronounced intratumor heterogeneity (ITH) make sarcomas clinically challenging. Yet, they also provide excellent models for studying the molecular and cellular underpinnings of ITH and how it translates into diverse clinical outcomes. New single-cell and spatial omics technologies have revealed the complex architecture of sarcomas with unprecedented resolution. In this review, we use five representative entities – two genomically complex (osteosarcoma, dedifferentiated liposarcoma) and three fusion-driven, genomically “quieter” (Ewing sarcoma, synovial sarcoma, alveolar rhabdomyosarcoma) sarcomas – to showcase recent advances in the field of ITH and the temporal evolution of sarcomas. Specifically, we review how clonal and subclonal molecular alterations, fluctuations in oncogene activity and other forms of cellular plasticity, as well as the formation of complex intratumor ecosystems, drive sarcoma progression and shape therapy resistance. We also provide an overview of recent advances in modeling ITH in sarcomas, as well as in evaluating functional diversity and assessing patient-specific treatment responses. Finally, we outline future directions in ITH research and its clinical implications.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"120 ","pages":"Pages 31-47"},"PeriodicalIF":15.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy metabolism, nutrition and cancer","authors":"E. Camajani ,&nbsp;S. Gorini ,&nbsp;A. Feraco ,&nbsp;A. Armani ,&nbsp;M. Caprio","doi":"10.1016/j.semcancer.2026.01.005","DOIUrl":"10.1016/j.semcancer.2026.01.005","url":null,"abstract":"<div><div>Cancer is a complex group of diseases characterized by the uncontrolled growth and spread of abnormal cells, and it remains a major global health concern. In order to meet the increased energy and biosynthetic requirements of rapid growth, cancer cells undergo metabolic reprogramming. In this setting, nutrition exerts a crucial influence on nutrients availability and increasing evidence highlights the significant role of nutrition in the prevention, development, and management of cancer. Dietary patterns and nutrient intake can influence cancer risk through various biological mechanisms, including inflammation, oxidative stress, immune modulation, and hormonal regulation. Diets high in processed foods, red meats, saturated fats and added sugars, have been associated with an increased risk of several cancers. Such diets may contribute to chronic inflammation, insulin resistance, and obesity—conditions known as major risk factors for cancer. Obesity itself is considered a significant contributor to cancer incidence and mortality, linking excess body fat to hormonal imbalances and altered metabolic pathways. Conversely, balanced diets rich in fruits, vegetables, whole grains, legumes, healthy fats and low refined carbohydrates, provide essential vitamins, minerals, fiber, and phytochemicals that have protective properties. These components can help the scavenging of free radicals, reduce DNA damage, and regulate cell growth, potentially lowering the risk of developing certain types of cancer. Nutritional needs in patients with cancer become complex, because of changes in metabolism and tolerance, frequently associated with cancer progression and treatment. Personalized nutritional support can help maintain body weight, preserve muscle mass, and improve treatment tolerance, potentially enhancing overall performance status and survival. While nutrition is not a cure for cancer, it is an essential component of an integrative approach to prevention and care. Further research is necessary to explore how diet can be optimized to support long-term health, reduce recurrence, and improve outcomes in cancer.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"120 ","pages":"Pages 4-15"},"PeriodicalIF":15.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer therapy-related cardiovascular toxicity: Current progress and future perspectives","authors":"Hongcai Shang,&nbsp;William Cho,&nbsp;Yanwei Xing","doi":"10.1016/j.semcancer.2026.01.004","DOIUrl":"10.1016/j.semcancer.2026.01.004","url":null,"abstract":"","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"120 ","pages":"Pages 1-3"},"PeriodicalIF":15.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The biology and evolution of Richter transformation in chronic lymphocytic leukemia","authors":"Ferran Nadeu ,&nbsp;Dimitar G. Efremov","doi":"10.1016/j.semcancer.2026.02.002","DOIUrl":"10.1016/j.semcancer.2026.02.002","url":null,"abstract":"<div><div>Richter transformation (RT) is a relatively rare but clinically challenging event in the natural history of chronic lymphocytic leukemia (CLL), characterized by the abrupt transformation of CLL into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). RT is diagnosed through histopathological confirmation, often prompted by clinical signs such as rapid lymph node enlargement, B symptoms, and elevated metabolic activity on PET-CT. Its incidence ranges from 2 % to 10 % over the CLL course, with higher risk in patients harboring specific high-risk (immuno)genetic features. Clonal relationship to the original CLL clone is crucial to understand the biology of the disease and may guide treatment decisions and anticipate RT evolution. Biologically, RT is driven by genomic instability, loss of cell cycle control, MYC activation, NOTCH alterations, and immune evasion mechanisms, including PD-1/PD-L1 upregulation. Transformation timing varies, occurring either early or late in the CLL course, may be preceded by a phase of accelerated disease, and their seeds may be traced back years before their clinical manifestation. Preclinical models, including genetically engineered mice and patient-derived xenografts, have been instrumental in elucidating the molecular underpinnings of RT, assess its interactions with the tumor microenvironment –including through the B-cell receptor–, and offer platforms for testing novel therapeutic strategies. In this review, we will deepen into the biology and evolution of DLBCL-type RT, revisiting recent publications and discussing new avenues for research in this paradigmatic evolution of CLL.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"120 ","pages":"Pages 48-60"},"PeriodicalIF":15.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid metabolic alterations in cancer: Common pathophysiology with cardiovascular disease","authors":"Maria Llena-Meler ,&nbsp;Alberto Canfran-Duque ,&nbsp;Julio Madrigal-Matute ,&nbsp;Noemi Rotllan","doi":"10.1016/j.semcancer.2026.01.003","DOIUrl":"10.1016/j.semcancer.2026.01.003","url":null,"abstract":"<div><div>Obesity-induced chronic inflammation and lipid metabolic imbalance form a pivotal nexus linking cardiovascular disease and cancer. Dysfunctional adipose tissue establishes a pro-inflammatory environment through hypoxia-driven macrophage polarization, oxidative stress, aberrant lipid signaling, and endocrine crosstalk, mechanisms that collectively foster atherogenesis and tumor promotion. Yet, a comprehensive integration of metabolic and immunological dynamics at the molecular level remains elusive. In this review, we synthesize emerging evidence that metabolic stressors, particularly excessive intake of oxidized and omega-6-enriched lipids, activate NF-κB and NLRP3-dependent inflammatory pathways in macrophages, thereby fostering a pro-tumorigenic and pro-atherogenic microenvironment. We underscore the emerging role of microRNAs as functional mediators connecting lipid metabolism, inflammation, and cellular plasticity across atherosclerotic and neoplastic tissues. These non-coding RNAs modulate key signaling pathways, including the critical PI3K/Akt, NFκB, and TGFβ axes, thereby promoting macrophage phenotype shifts, endothelial dysfunction, aberrant proliferation, and immune evasion. Importantly, interventions aimed at restoring lipid homeostasis, including Mediterranean-style diets, caloric restriction, and regular physical activity, act as important regulators of systemic and tissue-specific inflammation. Nutritional interventions increase monounsaturated and omega-3 fatty acid content and limit oxidized lipid exposure. We propose that combining metabolic modulation with RNA-based therapies, such as miRNA mimics or inhibitors delivered through nanoparticles or pH-responsive peptide systems, may offer synergistic avenues for controlling metabolic inflammation in both cancer and cardiovascular disease. Future research should focus on the targeted and context-dependent regulation of non-coding RNA networks within immuno-metabolic circuits, advancing precision medicine in cardio-oncology.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"119 ","pages":"Pages 83-105"},"PeriodicalIF":15.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid dysregulation in renal cancer: Drivers of tumor growth and determinants of treatment-induced toxicity","authors":"Mohammed Alnukhali ,&nbsp;Alessia Fornoni ,&nbsp;Alan Pollack ,&nbsp;Anis Ahmad","doi":"10.1016/j.semcancer.2025.12.010","DOIUrl":"10.1016/j.semcancer.2025.12.010","url":null,"abstract":"<div><h3>Background</h3><div>Clear cell renal cell carcinoma (ccRCC) exhibits a distinctive metabolic signature marked by the excessive buildup of cholesterol and neutral lipids. This phenotype stems largely from the loss of the von Hippel–Lindau (VHL) tumor suppressor and the resulting stabilization of hypoxia-inducible factors (HIFs). The altered lipid environment enables ccRCC cells to sustain growth, evade immune surveillance, and withstand contemporary systemic therapies. Increasing evidence indicates that similar disturbances in lipid metabolism contribute to kidney injury during cancer treatment, suggesting that dysregulated cholesterol handling represents a shared pathologic foundation linking tumor progression with therapy-induced nephrotoxicity.</div></div><div><h3>Scope of review</h3><div>This review brings together mechanistic, preclinical, and translational findings that illuminate how defective cholesterol regulation—particularly diminished ABCA1-mediated efflux promotes tumor aggressiveness while heightening renal vulnerability to radiation therapy, tyrosine kinase inhibitors (TKIs), and immune checkpoint inhibitors (ICIs). We examine lipid droplet dynamics, cholesteryl ester biology, and mitochondrial perturbations in ccRCC cells and renal parenchymal cells exposed to therapeutic stress.</div></div><div><h3>Major conclusions</h3><div>Across ccRCC therapies, lipid accumulation drives renal injury, with lipid-sensitive cells, particularly podocytes, undergoing cytoskeletal and slit-diaphragm disruption, proteinuria, and progressive glomerular damage in response to cholesterol overload, oxidative stress, and inflammatory signaling. Within the tumor, suppression of ABCA1 perpetuates lipid droplet expansion, reinforces resistance to therapy, and intensifies metabolic strain within the microenvironment.</div></div><div><h3>Future directions</h3><div>Restoring cholesterol balance through LXR agonists, cyclodextrins, or strategies that enhance ABCA1 function holds promise for limiting renal toxicity while simultaneously impairing tumor survival mechanisms. Advances in lipidomics, metabolic imaging, and biomarker-driven stratification may facilitate precision approaches that integrate metabolic correction with effective oncologic care.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"119 ","pages":"Pages 54-64"},"PeriodicalIF":15.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145945838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative spatial omics and artificial intelligence: transforming cancer research with omics data and AI","authors":"Maddison McKenzie ,&nbsp;Sergio Erdel Irac ,&nbsp;Zhian Chen ,&nbsp;Afshin Moradi ,&nbsp;Adrianne Jenner ,&nbsp;Quan Nguyen ,&nbsp;Behnam Rashidieh","doi":"10.1016/j.semcancer.2026.01.002","DOIUrl":"10.1016/j.semcancer.2026.01.002","url":null,"abstract":"<div><div>The integration of multi-omics data, including genomics, transcriptomics, proteomics, epigenomics, and metabolomics, coupled with histological spatial data has transformed biomedical research, offering unprecedented insights into cellular functions and disease mechanisms. However, the sheer volume and complexity of these datasets present a significant challenge in terms of interpretation and clinical translation. Artificial intelligence (AI) and machine learning (ML) are transforming data analysis, enabling the extraction of meaningful patterns from high-dimensional datasets and facilitating the development of predictive models. This shift is particularly transformative in cancer research, where understanding the tumor microenvironment (TME) and its spatial dynamics is crucial for improving therapeutic outcomes. This review explores recent advancements in spatial omics (SO) including spatial transcriptomics (ST) and spatial proteomics (SP), and AI-driven computational models, focusing on their applications in oncology. We discuss key methodologies, including spatial barcoding, in situ sequencing, and digital spatial profiling, and highlight major platforms. AI-powered tools, including deep learning models and spatial graph-based analyses, enhance data interpretation, allowing for robust predictive modeling, biomarker discovery, and personalized therapeutic strategies. Despite their transformative potential, ST and AI-driven approaches face challenges, including high-dimensional data complexity, computational constraints, and standardization of analytical pipelines. Addressing these challenges requires advanced mathematical frameworks such as spatial graph theory, topological data analysis, and agent-based modeling, which refine data integration and improve biological insights. Future research should focus on enhancing spatial resolution, cross-platform data harmonization, and AI-driven predictive models to advance precision oncology. By integrating ST, SP, and AI, researchers can develop dynamic, patient-specific treatment strategies, ultimately improving clinical outcomes and deepening our understanding of cancer progression and immune system interactions.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"119 ","pages":"Pages 65-82"},"PeriodicalIF":15.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heartbreakers and healers: RNA rebels in cardio-oncology","authors":"Celestina Agyemang-Dua ,&nbsp;Charles S. Chung ,&nbsp;Cristina Espinosa-Diez","doi":"10.1016/j.semcancer.2025.12.008","DOIUrl":"10.1016/j.semcancer.2025.12.008","url":null,"abstract":"<div><div>Cancer therapies save lives but often “break hearts” by damaging the cardiovascular system. As survival improves, therapy-induced cardiotoxicity has become a defining challenge of modern oncology. Recent discoveries reveal that long non-coding RNAs (lncRNAs), once dismissed as genomic noise, are the “RNA rebels” orchestrating cellular responses to cancer treatments. These molecules act as both heartbreakers and healers, amplifying or counteracting oxidative stress, mitochondrial dysfunction, apoptosis, and vascular injury. In anthracycline, radiation, and VEGF-targeted therapies, lncRNAs govern key processes that dictate whether cells succumb to damage or mount protective repair responses. Pro-injury lncRNAs exacerbate senescence and inflammation, while protective ones preserve mitochondrial homeostasis and limit cell death. Beyond mechanistic insight, these molecules hold clinical promise as biomarkers and therapeutic targets, guiding RNA-based strategies to predict, prevent, and treat cardiotoxicity. Understanding how they blur the line between protection and harm may redefine how we safeguard the heart in the era of precision cardio oncology.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"119 ","pages":"Pages 1-11"},"PeriodicalIF":15.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome-modulated immunotherapy in oncology: Current applications and future prospects","authors":"Yu Liu ,&nbsp;Keyan Miao ,&nbsp;Xi Yang","doi":"10.1016/j.semcancer.2026.01.001","DOIUrl":"10.1016/j.semcancer.2026.01.001","url":null,"abstract":"<div><div>Cancer immunotherapy has transformed oncology, yet therapeutic efficacy remains heterogeneous and frequently limited by primary or acquired resistance. Increasing evidence demonstrates that both intra- and extratumoral microbiota critically modulate antitumor immunity, influencing clinical responses of immunotherapy and immune-related adverse events (irAEs). Microbial communities regulate the tumor immune microenvironment through multiple mechanisms, including microbe-associated molecular patterns, microbial metabolites, and outer membrane vesicles, acting on tumor or immune cells. These insights have fostered the development of microbiome-based applications in oncology, ranging from predictive biomarkers to therapeutic interventions such as engineered bacteria, fecal microbiota transplantation, probiotics, prebiotics, outer membrane vesicles, bacteriophages, and dietary modulation. Early-phase clinical studies indicate that microbiota-targeted strategies can enhance immunotherapy efficacy or mitigate irAEs, although strain specificity, interindividual variability, and safety remain significant challenges. Future progress will require mechanistic elucidation, integration of multi-omics analyses, standardization of methodologies, and personalized intervention frameworks to translate microbiome modulation into clinically actionable, precision immunotherapy.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"119 ","pages":"Pages 38-53"},"PeriodicalIF":15.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}