Seminars in cancer biology最新文献

Multi-omic markers of intraductal papillary mucinous neoplasms progression into pancreatic cancer.

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-12-27 DOI: 10.1016/j.semcancer.2024.12.005

Chiara Corradi, Manuel Gentiluomo, Volkan Adsay, Juan Sainz, Paolo Riccardo Camisa, Barbara Wlodarczyk, Stefano Crippa, Francesca Tavano, Gabriele Capurso, Daniele Campa

{"title":"Multi-omic markers of intraductal papillary mucinous neoplasms progression into pancreatic cancer.","authors":"Chiara Corradi, Manuel Gentiluomo, Volkan Adsay, Juan Sainz, Paolo Riccardo Camisa, Barbara Wlodarczyk, Stefano Crippa, Francesca Tavano, Gabriele Capurso, Daniele Campa","doi":"10.1016/j.semcancer.2024.12.005","DOIUrl":"10.1016/j.semcancer.2024.12.005","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) is the most lethal and common form of pancreatic cancer, it has no specific symptoms, and most of the patients are diagnosed when the disease is already at an advanced stage. Chemotherapy typically has only a modest effect, making surgery the most effective treatment option. However, only a small percentage of patients are amenable to surgery. One viable strategy to reduce PDAC death burden associated with the disease is to focus on precursor lesions and identify markers able to predict who will evolve into PDAC. While most PDACs are believed to be preceded by pancreatic intraepithelial neoplasms (PanINs), 5-10 % arise from Intraductal papillary mucinous neoplasms (IPMNs), which are mass-forming cystic lesions that are very common in the general population. IPMNs offer an invaluable model of pancreatic carcinogenesis for researchers to analyse, as well as a target population for PDAC early detection by clinicians. The evolution of IPMN into cancer is a complex and multistep process, therefore the identification of individual markers will not be the solution. In recent years, multiple omics technologies have been instrumental to identify possible biomarkers of IPMN progression and carcinogenesis. The only foreseeable strategy will be to integrate multi-omics data, alongside clinical and morphological features, into a progression score or signature using either standard epidemiologic tools or artificial intelligence. The aim of this manuscript is to review the current knowledge on genetic biomarkers and to briefly mention also additional omics, such as metabolomics, the exposome, the miRNome and epigenomics of IPMNs.</p>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":" ","pages":"25-43"},"PeriodicalIF":12.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organoids, tissue slices and organotypic cultures: Advancing our understanding of pancreatic ductal adenocarcinoma through in vitro and ex vivo models.

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-12-25 DOI: 10.1016/j.semcancer.2024.12.003

Secil Ak Aksoy, Julie Earl, Jelena Grahovac, Didem Karakas, Giulia Lencioni, Sıla Sığırlı, Maarten F Bijlsma

{"title":"Organoids, tissue slices and organotypic cultures: Advancing our understanding of pancreatic ductal adenocarcinoma through in vitro and ex vivo models.","authors":"Secil Ak Aksoy, Julie Earl, Jelena Grahovac, Didem Karakas, Giulia Lencioni, Sıla Sığırlı, Maarten F Bijlsma","doi":"10.1016/j.semcancer.2024.12.003","DOIUrl":"10.1016/j.semcancer.2024.12.003","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses of all common solid cancers. For the large majority of PDAC patients, only systemic therapies with very limited efficacy are indicated. In addition, immunotherapies have not brought the advances seen in other cancer types. Several key characteristics of PDAC contribute to poor treatment outcomes, and in this review, we will discuss how these characteristics are best captured in currently available ex vivo or in vitro model systems. For instance, PDAC is hallmarked by a highly desmoplastic and immune-suppressed tumor microenvironment that impacts disease progression and therapy resistance. Also, large differences in tumor biology exist between and within tumors, complicating treatment decisions. Furthermore, PDAC has a very high propensity for locally invasive and metastatic growth. The use of animal models is often not desirable or feasible and several in vitro and ex vivo model systems have been developed, such as organotypic cocultures and tissue slices, among others. However, the absence of a full host organism impacts the ability of these models to accurately capture the characteristics that contribute to poor outcomes in PDAC. We will discuss the caveats and advantages of these model systems in the context of PDAC's key characteristics and provide recommendations on model choice and the possibilities for optimization. These considerations should be of use to researchers aiming to study PDAC in the in vitro setting.</p>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":" ","pages":"10-24"},"PeriodicalIF":12.1,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer cell populations.

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-12-20 DOI: 10.1016/j.semcancer.2024.12.004

Frederick R Adler, Herbert Levine, Amy Brock

引用次数: 0

Immune senescence: A key player in cancer biology.

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-12-13 DOI: 10.1016/j.semcancer.2024.12.001

Yanru Yang, Linni Fan, Mingyang Li, Zhe Wang

引用次数: 0

RB functions as a key regulator of senescence and tumor suppression.

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-12-13 DOI: 10.1016/j.semcancer.2024.11.004

Minling Gao, Haiou Li, Jinfang Zhang

引用次数: 0

Theoretical framework and emerging challenges of lipid metabolism in cancer. 癌症中脂质代谢的理论框架和新挑战。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-12-12 DOI: 10.1016/j.semcancer.2024.12.002

Qiuying Gu, Yuan Wang, Ping Yi, Chunming Cheng

{"title":"Theoretical framework and emerging challenges of lipid metabolism in cancer.","authors":"Qiuying Gu, Yuan Wang, Ping Yi, Chunming Cheng","doi":"10.1016/j.semcancer.2024.12.002","DOIUrl":"10.1016/j.semcancer.2024.12.002","url":null,"abstract":"<p><p>Elevated lipid metabolism is one of hallmarks of malignant tumors. Lipids not only serve as essential structural components of biological membranes but also provide energy and substrates for the proliferation of cancer cells and tumor growth. Cancer cells meet their lipid needs by coordinating the processes of lipid absorption, synthesis, transport, storage, and catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial for scientists to stay informed about the developments of cancer lipid metabolism. In this review, we first discuss relevant concepts and theories or assumptions that help us understand the lipid metabolism and -based cancer therapies. We then systematically summarize the latest advancements in lipid metabolism including new mechanisms, novel targets, and up-to-date pre-clinical and clinical investigations of anti-cancer treatment with lipid metabolism targeted drugs. Finally, we emphasize emerging research directions and therapeutic strategies, and discuss future prospective and emerging challenges. This review aims to provide the latest insights and guidance for research in the field of cancer lipid metabolism.</p>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":" ","pages":"48-70"},"PeriodicalIF":12.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding T cell senescence in cancer: Is revisiting required?

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-11-29 DOI: 10.1016/j.semcancer.2024.11.003

Sophia Magkouta, Efrosyni Markaki, Konstantinos Evangelou, Russell Petty, Panayotis Verginis, Vassilis Gorgoulis

{"title":"Decoding T cell senescence in cancer: Is revisiting required?","authors":"Sophia Magkouta, Efrosyni Markaki, Konstantinos Evangelou, Russell Petty, Panayotis Verginis, Vassilis Gorgoulis","doi":"10.1016/j.semcancer.2024.11.003","DOIUrl":"10.1016/j.semcancer.2024.11.003","url":null,"abstract":"<p><p>Senescence is an inherent cellular mechanism triggered as a response to stressful insults. It associates with several aspects of cancer progression and therapy. Senescent cells constitute a highly heterogeneous cellular population and their identification can be very challenging. In fact, the term \"senescence\" has been often misused. This is also true in the case of immune cells. While several studies indicate the presence of senescent-like features (mainly in T cells), senescent immune cells are poorly described. Under this prism, we herein review the current literature on what has been characterized as T cell senescence and provide insights on how to accurately discriminate senescent cells against exhausted or anergic ones. We also summarize the major metabolic and epigenetic modifications associated with T cell senescence and underline the role of senescent T cells in the tumor microenvironment (TME). Moreover, we discuss how these cells associate with standard clinical therapeutic interventions and how they impact their efficacy. Finally, we underline the importance of precise identification and thorough characterization of \"truly\" senescent T cells in order to design successful therapeutic manipulations that would delay cancer incidence and maximize efficacy of immunotherapy.</p>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":" ","pages":"33-47"},"PeriodicalIF":12.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer 宫颈癌细胞衰老和免疫衰老对肿瘤微环境的重塑

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-11-23 DOI: 10.1016/j.semcancer.2024.11.002

Yijiang He , Yue Qiu , Xiansong Yang , Guimei Lu , Shan-Shan Zhao

{"title":"Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer","authors":"Yijiang He , Yue Qiu , Xiansong Yang , Guimei Lu , Shan-Shan Zhao","doi":"10.1016/j.semcancer.2024.11.002","DOIUrl":"10.1016/j.semcancer.2024.11.002","url":null,"abstract":"<div><div>Cellular senescence is a response to various stress signals, which is characterized by stable cell cycle arrest, alterations in cellular morphology, metabolic reprogramming and production of senescence-associated secretory phenotype (SASP). When it occurs in the immune system, it is called immunosenescence. Cervical cancer is a common gynecological malignancy, and cervical cancer screening is generally recommended before the age of 65. Elderly women (≥65 years) are more often diagnosed with advanced disease and have poorer prognosis compared to younger patients. Despite extensive research, the tumor microenvironment requires more in-depth exploration, particularly in elderly patients. In cervical cancer, senescent cells have a double-edged sword effect on tumor progression. Induction of preneoplastic cell senescence prevents tumor initiation, and several treatment approaches of cervical cancer act in part by inducing cancer cell senescence. However, senescent immune cell populations within the tumor microenvironment facilitate tumor development, recurrence, treatment resistance, etc. Amplification of beneficial effects and inhibition of aging-related pro-tumorigenic pathways contribute to improving antitumor effects. This review discusses senescent cancer and immune cells present in the tumor microenvironment of cervical cancer and how these senescent cells and their SASP remodel the tumor microenvironment, influence antitumor immunity and tumor initiation and development. Moreover, we discuss the significance of senotherapeutics that enable to eliminate senescent cells and prevent tumor progression and development through improving antitumor immunity and affecting the tumor microenvironment.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"108 ","pages":"Pages 17-32"},"PeriodicalIF":12.1,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between cell death and senescence in cancer 癌症中细胞死亡与衰老之间的相互作用。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-11-16 DOI: 10.1016/j.semcancer.2024.11.001

Kouhei Shimizu , Hiroyuki Inuzuka , Fuminori Tokunaga

{"title":"The interplay between cell death and senescence in cancer","authors":"Kouhei Shimizu , Hiroyuki Inuzuka , Fuminori Tokunaga","doi":"10.1016/j.semcancer.2024.11.001","DOIUrl":"10.1016/j.semcancer.2024.11.001","url":null,"abstract":"<div><div>Cellular senescence is a state of permanent proliferative arrest that occurs in response to DNA damage-inducing endogenous and exogenous stresses, and is often accompanied by dynamic molecular changes such as a senescence-associated secretory phenotype (SASP). Accumulating evidence indicates that age-associated increases in the upstream and downstream signals of regulated cell death, including apoptosis, necroptosis, pyroptosis, and ferroptosis, are closely related to the induction of cellular senescence and its phenotype. Furthermore, elevated levels of pro-inflammatory SASP factors with aging can be both a cause and consequence of several cell death modes, suggesting the reciprocal effects of cellular senescence and cells undergoing regulated cell death. Here, we review the critical molecular pathways of the regulated cell death forms and describe the crosstalk between aging-related signals and cancer. In addition, we discuss how targeting regulated cell death could be harnessed in therapeutic interventions for cancer.</div></div><div><h3>Abbreviations</h3><div>Abbreviations that are not standard in this field are defined at their first occurrence in the article and are used consistently throughout the article.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"108 ","pages":"Pages 1-16"},"PeriodicalIF":12.1,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of cardiovascular toxicities induced by cancer immune therapies: Underlying mechanisms, clinical manifestations and therapeutic approaches 癌症免疫疗法诱发心血管毒性的系统综述：潜在机制、临床表现和治疗方法。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-11-01 DOI: 10.1016/j.semcancer.2024.10.004

Li Liu , Wentao Yao , Mi Wang , Baohui Wang , Fanming Kong , Zhongguo Fan , Guanwei Fan

{"title":"A systematic review of cardiovascular toxicities induced by cancer immune therapies: Underlying mechanisms, clinical manifestations and therapeutic approaches","authors":"Li Liu , Wentao Yao , Mi Wang , Baohui Wang , Fanming Kong , Zhongguo Fan , Guanwei Fan","doi":"10.1016/j.semcancer.2024.10.004","DOIUrl":"10.1016/j.semcancer.2024.10.004","url":null,"abstract":"<div><div>Immunotherapy has revolutionized the management of various types of cancers, even those previously deemed untreatable. Nonetheless, these medications have been associated with inflammation and damage across various organs. These challenges are exemplified by the adverse cardiovascular impacts of cancer immunotherapy, which need comprehensive understanding, clarification, and management integrated into the overall care of cancer patients. Numerous anticancer immunotherapies have been linked to the prevalence and severity of cardiovascular toxicity. These challenges emphasize the importance of conducting fundamental and applied research to elucidate disease causes, discover prognostic indicators, enhance diagnostic methods, and create successful therapies. Despite the acknowledged importance of T cells, there remains a knowledge gap regarding the inciting antigens, the reasons for their recognition, and the mechanisms of how they contribute to cardiac cell injury. In this review, we summarize the molecular mechanism, epidemiology, diagnosis, pathophysiology and corresponding treatment of cardiovascular toxicity induced by immunotherapy, including immune checkpoint inhibitors (ICIs), adoptive cell therapies (ACT), and bi-specific T-cell engagers (BiTEs) among others. By elucidating these aspects, we aim to provide a better understanding of immunotherapies in cancer treatment and offer guidance for their clinical application.</div></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"106 ","pages":"Pages 179-191"},"PeriodicalIF":12.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0