Seminars in cancer biology最新文献_第2页

cGAS/STING signalling pathway in senescence and oncogenesis cGAS/STING 信号通路在衰老和肿瘤发生中的作用。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-31 DOI: 10.1016/j.semcancer.2024.08.007

Le Yu , Pengda Liu

{"title":"cGAS/STING signalling pathway in senescence and oncogenesis","authors":"Le Yu , Pengda Liu","doi":"10.1016/j.semcancer.2024.08.007","DOIUrl":"10.1016/j.semcancer.2024.08.007","url":null,"abstract":"<div><p>The cGAS/STING signaling pathway is a crucial component of the innate immune system, playing significant roles in sensing cytosolic DNA, regulating cellular senescence, and contributing to oncogenesis. Recent advances have shed new lights into the molecular mechanisms governing pathway activation in multiple pathophysiological settings, the indispensable roles of cGAS/STING signaling in cellular senescence, and its context-dependent roles in cancer development and suppression. This review summarizes current knowledge related to the biology of cGAS/STING signaling pathway and its participations into senescence and oncogenesis. We further explore the clinical implications and therapeutic potential for cGAS/STING targeted therapies, and faced challenges in the field. With a focus on molecular mechanisms and emerging pharmacological targets, this review underscores the importance of future studies to harness the therapeutic potential of the cGAS/STING pathway in treating senescence-related disorders and cancer. Advanced understanding of the regulatory mechanisms of cGAS/STING signaling, along with the associated deregulations in diseases, combined with the development of new classes of cGAS/STING modulators, hold great promises for creating novel and effective therapeutic strategies. These advancements could address current treatment challenges and unlock the full potential of cGAS/STING in treating senescence-related disorders and oncogenesis.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":null,"pages":null},"PeriodicalIF":12.1,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1044579X24000737/pdfft?md5=fa48450dabde76a86f3ba96bc030265f&pid=1-s2.0-S1044579X24000737-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer 联合靶向衰老细胞和衰老巨噬细胞：综合治疗肺癌的新思路。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-29 DOI: 10.1016/j.semcancer.2024.08.006

Ming Gu , Yang Liu , Wenhui Zheng , Zuoqian Jing , Xiang Li , Wei Guo , Zimo Zhao , Xu Yang , Zhe Liu , Xinwang Zhu , Wei Gao

{"title":"Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer","authors":"Ming Gu , Yang Liu , Wenhui Zheng , Zuoqian Jing , Xiang Li , Wei Guo , Zimo Zhao , Xu Yang , Zhe Liu , Xinwang Zhu , Wei Gao","doi":"10.1016/j.semcancer.2024.08.006","DOIUrl":"10.1016/j.semcancer.2024.08.006","url":null,"abstract":"<div><p>Lung cancer is one of the most common cancers worldwide and a leading cause of cancer-related deaths. Macrophages play a key role in the immune response and the tumour microenvironment. As an important member of the immune system, macrophages have multiple functions, including phagocytosis and clearance of pathogens, modulation of inflammatory responses, and participation in tissue repair and regeneration. In lung cancer, macrophages are considered to be the major cellular component of the tumor-associated inflammatory response and are closely associated with tumorigenesis, progression and metastasis. However, macrophages gradually undergo a senescence process with age and changes in pathological states. Macrophage senescence is an important change in the functional and metabolic state of macrophages and may have a significant impact on lung cancer development. In lung cancer, senescent macrophages interact with other cells in the tumor microenvironment (TME) by secreting senescence-associated secretory phenotype (SASP) factors, which can either promote the proliferation, invasion and metastasis of tumor cells or exert anti-tumor effects through reprogramming or clearance under specific conditions. Therefore, senescent macrophages are considered important potential targets for lung cancer therapy. In this paper, a systematic review of macrophages and their senescence process, and their role in tumors is presented. A variety of inhibitory strategies against senescent macrophages, including enhancing autophagy, inhibiting SASP, reducing DNA damage, and modulating metabolic pathways, were also explored. These strategies are expected to improve lung cancer treatment outcomes by restoring the anti-tumor function of macrophages.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":null,"pages":null},"PeriodicalIF":12.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to “RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer” [Semin. Cancer Biol. 102–103 (2024) 4–16] 癌症中控制 TGF-β 信号转导和 EMT 的 RNA 调控机制》的勘误 [Semin.

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-28 DOI: 10.1016/j.semcancer.2024.08.005

Cameron P. Bracken , Gregory J. Goodall , Philip A. Gregory

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Unveiling the role of PIK3R1 in cancer: A comprehensive review of regulatory signaling and therapeutic implications 揭示 PIK3R1 在癌症中的作用：调控信号和治疗意义的全面回顾》。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-26 DOI: 10.1016/j.semcancer.2024.08.004

Ishita Gupta , Daria A. Gaykalova

{"title":"Unveiling the role of PIK3R1 in cancer: A comprehensive review of regulatory signaling and therapeutic implications","authors":"Ishita Gupta , Daria A. Gaykalova","doi":"10.1016/j.semcancer.2024.08.004","DOIUrl":"10.1016/j.semcancer.2024.08.004","url":null,"abstract":"<div><p>Phosphoinositide 3-kinase (PI3K) is responsible for phosphorylating phosphoinositides to generate secondary signaling molecules crucial for regulating various cellular processes, including cell growth, survival, and metabolism. The PI3K is a heterodimeric enzyme complex comprising of a catalytic subunit (p110α, p110β, or p110δ) and a regulatory subunit (p85). The binding of the regulatory subunit, p85, with the catalytic subunit, p110, forms an integral component of the PI3K enzyme. <em>PIK3R1</em> (phosphoinositide-3-kinase regulatory subunit 1) belongs to class IA of the PI3K family. <em>PIK3R1</em> exhibits structural complexity due to alternative splicing, giving rise to distinct isoforms, prominently p85α and p55α. While the primary p85α isoform comprises multiple domains, including Src homology 3 (SH3) domains, a Breakpoint Cluster Region Homology (BH) domain, and Src homology 2 (SH2) domains (iSH2 and nSH2), the shorter isoform, p55α, lacks certain domains present in p85α. In this review, we will highlight the intricate regulatory mechanisms governing PI3K signaling along with the impact of <em>PIK3R1</em> alterations on cellular processes. We will further delve into the clinical significance of <em>PIK3R1</em> mutations in various cancer types and their implications for prognosis and treatment outcomes. Additionally, we will discuss the evolving landscape of targeted therapies aimed at modulating PI3K-associated pathways. Overall, this review will provide insights into the dynamic interplay of <em>PIK3R1</em> in cancer, fostering advancements in precision medicine and the development of targeted interventions.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":null,"pages":null},"PeriodicalIF":12.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMPK: The energy sensor at the crossroads of aging and cancer AMPK：衰老与癌症交叉路口的能量传感器

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-26 DOI: 10.1016/j.semcancer.2024.08.002

Vasudevarao Penugurti , Rajesh Kumar Manne , Ling Bai , Rajni Kant , Hui-Kuan Lin

{"title":"AMPK: The energy sensor at the crossroads of aging and cancer","authors":"Vasudevarao Penugurti , Rajesh Kumar Manne , Ling Bai , Rajni Kant , Hui-Kuan Lin","doi":"10.1016/j.semcancer.2024.08.002","DOIUrl":"10.1016/j.semcancer.2024.08.002","url":null,"abstract":"<div><p>AMP-activated protein kinase (AMPK) is a protein kinase that plays versatile roles in response to a variety of physiological stresses, including glucose deprivation, hypoxia, and ischemia. As a kinase with pleiotropic functions, it plays a complex role in tumor progression, exhibiting both tumor-promoting and tumor-suppressing activities. On one hand, AMPK enhances cancer cell proliferation and survival, promotes cancer metastasis, and impairs anti-tumor immunity. On the other hand, AMPK inhibits cancer cell growth and survival and stimulates immune responses in a context-dependent manner. Apart from these functions, AMPK plays a key role in orchestrating aging and aging-related disorders, including cardiovascular diseases (CVD), Osteoarthritis (OA), and Diabetes. In this review article, we summarized the functions of AMPK pathway based on its oncogenic and tumor-suppressive roles and highlighted the importance of AMPK pathway in regulating cellular aging. We also spotlighted the significant role of various signaling pathways, activators, and inhibitors of AMPK in serving as therapeutic strategies for anti-cancer and anti-aging therapy.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":null,"pages":null},"PeriodicalIF":12.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular signaling and clinical implications in the human aging-cancer cycle 人类衰老-癌症周期中的分子信号和临床意义。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-26 DOI: 10.1016/j.semcancer.2024.08.003

Abdol-Hossein Rezaeian, Wenyi Wei

{"title":"Molecular signaling and clinical implications in the human aging-cancer cycle","authors":"Abdol-Hossein Rezaeian, Wenyi Wei","doi":"10.1016/j.semcancer.2024.08.003","DOIUrl":"10.1016/j.semcancer.2024.08.003","url":null,"abstract":"<div><p>It is well documented that aging is associated with cancer, and likewise, cancer survivors display accelerated aging. As the number of aging individuals and cancer survivors continues to grow, it raises additional concerns across society. Therefore, unraveling the molecular mechanisms of aging in tissues is essential to developing effective therapies to fight the aging and cancer diseases in cancer survivors and cancer patients. Indeed, cellular senescence is a critical response, or a natural barrier to suppress the transition of normal cells into cancer cells, however, hypoxia which is physiologically required to maintain the stem cell niche, is increased by aging and inhibits senescence in tissues. Interestingly, oxygen restriction or hypoxia increases longevity and slows the aging process in humans, but hypoxia can also drive angiogenesis to facilitate cancer progression. In addition, cancer treatment is considered as one of the major reasons that drive cellular senescence, subsequently followed by accelerated aging. Several clinical trials have recently evaluated inhibitors to eliminate senescent cells. However, some mechanisms of aging typically can also retard cancer cell growth and progression, which might require careful strategy for better clinical outcomes. Here we describe the molecular regulation of aging and cancer in crosstalk with DNA damage and hypoxia signaling pathways in cancer patients and cancer survivors. We also update several therapeutic strategies that might be critical in reversing the cancer treatment-associated aging process.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":null,"pages":null},"PeriodicalIF":12.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Nutrient sensing of mTORC1 signaling in cancer and aging 癌症和衰老过程中 mTORC1 信号的营养传感。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-15 DOI: 10.1016/j.semcancer.2024.08.001

Cong Jiang , Xiao Tan , Ning Liu , Peiqiang Yan , Tao Hou , Wenyi Wei

引用次数: 0

Gut microbiota and immunosenescence in cancer 癌症中的肠道微生物群和免疫衰老。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-08 DOI: 10.1016/j.semcancer.2024.07.004

Yaozheng Xu , Chuan He , Ying Xi , Yue Zhang , Yibo Bai

{"title":"Gut microbiota and immunosenescence in cancer","authors":"Yaozheng Xu , Chuan He , Ying Xi , Yue Zhang , Yibo Bai","doi":"10.1016/j.semcancer.2024.07.004","DOIUrl":"10.1016/j.semcancer.2024.07.004","url":null,"abstract":"<div><p>Cancer is generally defined as a disease of aging. With aging, the composition, diversity and functional characteristics of the gut microbiota occur changes, with a decline of beneficial commensal microbes triggered by intrinsic and extrinsic factors (e.g., diet, drugs and chronic health conditions). Nowadays, dysbiosis of the gut microbiota is recognized as a hallmark of cancer. At the same time, aging is accompanied by changes in innate and adaptive immunity, known as immunosenescence, as well as chronic low-grade inflammation, known as inflammaging. The elevated cancer incidence and mortality in the elderly are linked with aging-associated alterations in the gut microbiota that elicit systemic metabolic alterations, leading to immune dysregulation with potentially tumorigenic effects. The gut microbiota and immunosenescence might both affect the response to treatment in cancer patients. In-depth understanding of age-associated alterations in the gut microbiota and immunity will shed light on the risk of cancer development and progression in the elderly. Here, we describe the aging-associated changes of the gut microbiota in cancer, and review the evolving understanding of the gut microbiota-targeted intervention strategies. Furthermore, we summarize the knowledge on the cellular and molecular mechanisms of immunosenescence and its impact on cancer. Finally, we discuss the latest knowledge about the relationships between gut microbiota and immunosenescence, with implications for cancer therapy. Intervention strategies targeting the gut microbiota may attenuate inflammaging and rejuvenate immune function to provide antitumor benefits in elderly patients.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":null,"pages":null},"PeriodicalIF":12.1,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain macrophage senescence in glioma 胶质瘤中脑巨噬细胞的衰老。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-08-02 DOI: 10.1016/j.semcancer.2024.07.005

Lu Li , Tianhe Zhang , Meiling Xiao , Yu Lu , Lin Gao

{"title":"Brain macrophage senescence in glioma","authors":"Lu Li , Tianhe Zhang , Meiling Xiao , Yu Lu , Lin Gao","doi":"10.1016/j.semcancer.2024.07.005","DOIUrl":"10.1016/j.semcancer.2024.07.005","url":null,"abstract":"<div><p>Gliomas are a diverse group of primary central nervous system neoplasms with no curative therapies available. Brain macrophages comprise microglia in the brain parenchyma, border-associated macrophages in the meningeal-choroid plexus-perivascular space and monocyte-derived macrophages infiltrating the brain. With the great improvement of our recognition of brain macrophages, diverse macrophage populations have been found in the context of glioma, which exhibit functional and phenotypic heterogeneity. We have long thought that brain macrophage senescence is detrimental, manifested by specialized forms of persistent cell cycle arrest and chronic low-grade inflammation. Persistent senescence of macrophages may result in immune dysfunction, potentially contributing to glioma initiation and development. Given the crucial roles played by brain macrophages in glioma, we unravel how brain macrophages undergo reprogramming and their contribution to glioma. We outline general molecular alterations and specific biomarkers in senescent brain macrophages, as well as functional changes (such as metabolism, autophagy, phagocytosis, antigen presentation, and infiltration and recruitment). In addition, recent advances in genetic regulation and mechanisms linked to senescent brain macrophages are discussed. In particular, this review emphasizes the contribution of senescent brain macrophages to glioma, which may drive translational efforts to utilize brain macrophages as a prognostic marker or/and treatment target in glioma. An in-depth comprehending of how brain macrophage senescence functionally influences the tumor microenvironment will be key to our development of innovative therapeutics for glioma.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":null,"pages":null},"PeriodicalIF":12.1,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles proteins for early cancer diagnosis: From omics to biomarkers 用于早期癌症诊断的细胞外囊泡蛋白质：从分子生物学到生物标记物。

IF 12.1 1区医学

Seminars in cancer biology Pub Date : 2024-07-27 DOI: 10.1016/j.semcancer.2024.07.003

Veronica De Giorgis , Elettra Barberis , Marcello Manfredi

{"title":"Extracellular vesicles proteins for early cancer diagnosis: From omics to biomarkers","authors":"Veronica De Giorgis , Elettra Barberis , Marcello Manfredi","doi":"10.1016/j.semcancer.2024.07.003","DOIUrl":"10.1016/j.semcancer.2024.07.003","url":null,"abstract":"<div><p>Extracellular vesicles (EVs) are a promising source of early biomarkers for cancer diagnosis. They are enriched with diverse molecular content, such as proteins, DNA, mRNA, miRNA, lipids, and metabolites. EV proteins have been widely investigated as potential biomarkers since they reflect specific patient conditions. However, although many markers have been validated and confirmed using external cohorts of patients and different analytical approaches, no EV protein markers are approved for diagnostic use. This review presents the primary strategies adopted using mass spectrometry and immune-based techniques to identify and validate EV protein biomarkers. We report and discuss recent scientific research focusing on cancer biomarker discovery through EVs, emphasizing their significant potential for the tempestive diagnosis of several cancer typologies. Finally, recent advancements in the standardization of EV isolation and quantitation through the development of easy-to-use and high-throughput kits for sample preparation—that should make protein EV biomarkers more reliable and accessible—are presented. The data reported here showed that there are still several challenges to be addressed before a protein vesicle marker becomes an essential tool in diagnosing cancer.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":null,"pages":null},"PeriodicalIF":12.1,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0