Seminars in cancer biology最新文献_第5页

p53/MDM2 signaling pathway in aging, senescence and tumorigenesis. p53/MDM2 信号通路在衰老、衰老和肿瘤发生中的作用。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-05-17 DOI: 10.1016/j.semcancer.2024.05.001

Youyi Huang, Xiaofang Che, Peter W Wang, Xiujuan Qu

{"title":"p53/MDM2 signaling pathway in aging, senescence and tumorigenesis.","authors":"Youyi Huang, Xiaofang Che, Peter W Wang, Xiujuan Qu","doi":"10.1016/j.semcancer.2024.05.001","DOIUrl":"10.1016/j.semcancer.2024.05.001","url":null,"abstract":"<p><p>A wealth of evidence has emerged that there is an association between aging, senescence and tumorigenesis. Senescence, a biological process by which cells cease to divide and enter a status of permanent cell cycle arrest, contributes to aging and aging-related diseases, including cancer. Aging populations have the higher incidence of cancer due to a lifetime of exposure to cancer-causing agents, reduction of repairing DNA damage, accumulated genetic mutations, and decreased immune system efficiency. Cancer patients undergoing cytotoxic therapies, such as chemotherapy and radiotherapy, accelerate aging. There is growing evidence that p53/MDM2 (murine double minute 2) axis is critically involved in regulation of aging, senescence and oncogenesis. Therefore, in this review, we describe the functions and mechanisms of p53/MDM2-mediated senescence, aging and carcinogenesis. Moreover, we highlight the small molecular inhibitors, natural compounds and PROTACs (proteolysis targeting chimeras) that target p53/MDM2 pathway to influence aging and cancer. Modification of p53/MDM2 could be a potential strategy for treatment of aging, senescence and tumorigenesis.</p>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":" ","pages":"44-57"},"PeriodicalIF":14.5,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p53/MDM2 signaling pathway in aging, senescence and tumorigenesis p53/MDM2 信号通路在衰老、衰老和肿瘤发生中的作用

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-05-17 DOI: 10.1016/j.semcancer.2024.05.001

Youyi Huang , Xiaofang Che , Peter W. Wang , Xiujuan Qu

{"title":"p53/MDM2 signaling pathway in aging, senescence and tumorigenesis","authors":"Youyi Huang , Xiaofang Che , Peter W. Wang , Xiujuan Qu","doi":"10.1016/j.semcancer.2024.05.001","DOIUrl":"10.1016/j.semcancer.2024.05.001","url":null,"abstract":"<div><p>A wealth of evidence has emerged that there is an association between aging, senescence and tumorigenesis. Senescence, a biological process by which cells cease to divide and enter a status of permanent cell cycle arrest, contributes to aging and aging-related diseases, including cancer. Aging populations have the higher incidence of cancer due to a lifetime of exposure to cancer-causing agents, reduction of repairing DNA damage, accumulated genetic mutations, and decreased immune system efficiency. Cancer patients undergoing cytotoxic therapies, such as chemotherapy and radiotherapy, accelerate aging. There is growing evidence that p53/MDM2 (murine double minute 2) axis is critically involved in regulation of aging, senescence and oncogenesis. Therefore, in this review, we describe the functions and mechanisms of p53/MDM2-mediated senescence, aging and carcinogenesis. Moreover, we highlight the small molecular inhibitors, natural compounds and PROTACs (proteolysis targeting chimeras) that target p53/MDM2 pathway to influence aging and cancer. Modification of p53/MDM2 could be a potential strategy for treatment of aging, senescence and tumorigenesis.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"101 ","pages":"Pages 44-57"},"PeriodicalIF":14.5,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141035897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles in glioblastoma: Biomarkers and therapeutic tools 胶质母细胞瘤中的细胞外小泡：生物标记物和治疗工具。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-05-14 DOI: 10.1016/j.semcancer.2024.04.003

Ilaria Cela , Emily Capone , Gianluca Trevisi , Gianluca Sala

{"title":"Extracellular vesicles in glioblastoma: Biomarkers and therapeutic tools","authors":"Ilaria Cela , Emily Capone , Gianluca Trevisi , Gianluca Sala","doi":"10.1016/j.semcancer.2024.04.003","DOIUrl":"10.1016/j.semcancer.2024.04.003","url":null,"abstract":"<div><p>Glioblastoma (GBM) is the most aggressive tumor among the gliomas and intracranial tumors and to date prognosis for GBM patients remains poor, with a median survival typically measured in months to a few years depending on various factors. Although standardized therapies are routinely employed, it is clear that these strategies are unable to cope with heterogeneity and invasiveness of GBM. Furthermore, diagnosis and monitoring of responses to therapies are directly dependent on tissue biopsies or magnetic resonance imaging (MRI) techniques. From this point of view, liquid biopsies are arising as key sources of a variety of biomarkers with the advantage of being easily accessible and monitorable. In this context, extracellular vesicles (EVs), physiologically shed into body fluids by virtually all cells, are gaining increasing interest both as natural carriers of biomarkers and as specific signatures even for GBM. What makes these vesicles particularly attractive is they are also emerging as therapeutical vehicles to treat GBM given their native ability to cross the blood-brain barrier (BBB). Here, we reviewed recent advances on the use of EVs as biomarker for liquid biopsy and nanocarriers for targeted delivery of anticancer drugs in glioblastoma.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"101 ","pages":"Pages 25-43"},"PeriodicalIF":14.5,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1044579X24000348/pdfft?md5=8d0c3ccb77f687de9a64eecf6020aea8&pid=1-s2.0-S1044579X24000348-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141036332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of the minimal information for studies of extracellular vesicles guidelines: Advancements and implications for extracellular vesicle research 细胞外囊泡研究最低限度信息指南的比较分析》：细胞外囊泡研究的进展和意义。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-04-23 DOI: 10.1016/j.semcancer.2024.04.002

Elisavet Maria Vaiaki, Marco Falasca

{"title":"Comparative analysis of the minimal information for studies of extracellular vesicles guidelines: Advancements and implications for extracellular vesicle research","authors":"Elisavet Maria Vaiaki, Marco Falasca","doi":"10.1016/j.semcancer.2024.04.002","DOIUrl":"10.1016/j.semcancer.2024.04.002","url":null,"abstract":"<div><p>In 2014, the International Society for Extracellular Vesicles (ISEV) introduced the Minimal Information for Studies of Extracellular Vesicles (MISEV) guidelines to establish standards for extracellular vesicle (EV) research. These guidelines aimed to enhance reliability and reproducibility, addressing the expanding field of EV science. EVs, membrane-bound particles released by cells, play crucial roles in intercellular communication and are potential biomarkers for various conditions. Over the years, the EV landscape witnessed a surge in publications, emphasizing their roles in cancer and immune modulation. In response, the MISEV guidelines underwent evolution, leading to the MISEV2018 update. This version, generated through community outreach, provided a comprehensive framework for EV research methodologies, emphasizing separation, characterization, reporting standards, and community engagement. The MISEV2018 guidelines reflected responsiveness to feedback, acknowledging the evolving EV research landscape. The guidelines served as a testament to the commitment of the scientific community to rigorous standards and the collective discernment of experts. The present article compares previous MISEV guidelines with its 2023 counterpart, highlighting advancements, changes, and impacts on EV research standardization. The 2023 guidelines build upon the 2018 principles, offering new recommendations for emerging areas. This comparative exploration contributes to understanding the transformative journey in EV research, emphasizing MISEV's pivotal role and the scientific community's adaptability to challenges.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"101 ","pages":"Pages 12-24"},"PeriodicalIF":14.5,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1044579X24000336/pdfft?md5=5d1df6bf520734384dc1f8a2ec67eb1b&pid=1-s2.0-S1044579X24000336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alternative splicing in EMT and TGF-β signaling during cancer progression 癌症进展过程中 EMT 和 TGF-β 信号传递中的替代剪接

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-04-15 DOI: 10.1016/j.semcancer.2024.04.001

Ying E. Zhang, Christina H. Stuelten

{"title":"Alternative splicing in EMT and TGF-β signaling during cancer progression","authors":"Ying E. Zhang, Christina H. Stuelten","doi":"10.1016/j.semcancer.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.semcancer.2024.04.001","url":null,"abstract":"<div><p>Epithelial to mesenchymal transition (EMT) is a physiological process during development where epithelial cells transform to acquire mesenchymal characteristics, which allows them to migrate and colonize secondary tissues. Many cellular signaling pathways and master transcriptional factors exert a myriad of controls to fine tune this vital process to meet various developmental and physiological needs. Adding to the complexity of this network are post-transcriptional and post-translational regulations. Among them, alternative splicing has been shown to play important roles to drive EMT-associated phenotypic changes, including actin cytoskeleton remodeling, cell-cell junction changes, cell motility and invasiveness. In advanced cancers, transforming growth factor-β (TGF-β) is a major inducer of EMT and is associated with tumor cell metastasis, cancer stem cell self-renewal, and drug resistance. This review aims to provide an overview of recent discoveries regarding alternative splicing events and the involvement of splicing factors in the EMT and TGF-β signaling. It will emphasize the importance of various splicing factors involved in EMT and explore their regulatory mechanisms.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"101 ","pages":"Pages 1-11"},"PeriodicalIF":14.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxic adaptation of mitochondria and its impact on tumor cell function 线粒体的低氧适应性及其对肿瘤细胞功能的影响

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-03-30 DOI: 10.1016/j.semcancer.2024.03.004

Martin Benej , Ioanna Papandreou , Nicholas C. Denko

{"title":"Hypoxic adaptation of mitochondria and its impact on tumor cell function","authors":"Martin Benej , Ioanna Papandreou , Nicholas C. Denko","doi":"10.1016/j.semcancer.2024.03.004","DOIUrl":"10.1016/j.semcancer.2024.03.004","url":null,"abstract":"<div><p>Mitochondria are the major sink for oxygen in the cell, consuming it during ATP production. Therefore, when environmental oxygen levels drop in the tumor, significant adaptation is required. Mitochondrial activity is also a major producer of biosynthetic precursors and a regulator of cellular oxidative and reductive balance. Because of the complex biochemistry, mitochondrial adaptation to hypoxia occurs through multiple mechanisms and has significant impact on other cellular processes such as macromolecule synthesis and gene regulation. In tumor hypoxia, mitochondria shift their location in the cell and accelerate the fission and quality control pathways. Hypoxic mitochondria also undergo significant changes to fundamental metabolic pathways of carbon metabolism and electron transport. These metabolic changes further impact the nuclear epigenome because mitochondrial metabolites are used as enzymatic substrates for modifying chromatin. This coordinated response delivers physiological flexibility and increased tumor cell robustness during the environmental stress of low oxygen.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"100 ","pages":"Pages 28-38"},"PeriodicalIF":14.5,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1044579X24000221/pdfft?md5=e97fd4671caea21daf3822c0f7a9c5d1&pid=1-s2.0-S1044579X24000221-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxia-targeting bacteria in cancer therapy 癌症治疗中的低氧靶向细菌

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-03-29 DOI: 10.1016/j.semcancer.2024.03.003

Verena Staedtke , Nihao Sun , Renyuan Bai

引用次数: 0

Exploiting transcription factors to target EMT and cancer stem cells for tumor modulation and therapy 利用转录因子靶向 EMT 和癌症干细胞进行肿瘤调节和治疗。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-03-19 DOI: 10.1016/j.semcancer.2024.03.002

Abdul Q. Khan , Adria Hasan , Snober S. Mir , Khalid Rashid , Shahab Uddin , Martin Steinhoff

{"title":"Exploiting transcription factors to target EMT and cancer stem cells for tumor modulation and therapy","authors":"Abdul Q. Khan , Adria Hasan , Snober S. Mir , Khalid Rashid , Shahab Uddin , Martin Steinhoff","doi":"10.1016/j.semcancer.2024.03.002","DOIUrl":"10.1016/j.semcancer.2024.03.002","url":null,"abstract":"<div><p>Transcription factors (TFs) are essential in controlling gene regulatory networks that determine cellular fate during embryogenesis and tumor development. TFs are the major players in promoting cancer stemness by regulating the function of cancer stem cells (CSCs). Understanding how TFs interact with their downstream targets for determining cell fate during embryogenesis and tumor development is a critical area of research. CSCs are increasingly recognized for their significance in tumorigenesis and patient prognosis, as they play a significant role in cancer initiation, progression, metastasis, and treatment resistance. However, traditional therapies have limited effectiveness in eliminating this subset of cells, allowing CSCs to persist and potentially form secondary tumors. Recent studies have revealed that cancer cells and tumors with CSC-like features also exhibit genes related to the epithelial-to-mesenchymal transition (EMT). EMT-associated transcription factors (EMT-TFs) like TWIST and Snail/Slug can upregulate EMT-related genes and reprogram cancer cells into a stem-like phenotype. Importantly, the regulation of EMT-TFs, particularly through post-translational modifications (PTMs), plays a significant role in cancer metastasis and the acquisition of stem cell-like features. PTMs, including phosphorylation, ubiquitination, and SUMOylation, can alter the stability, localization, and activity of EMT-TFs, thereby modulating their ability to drive EMT and stemness properties in cancer cells. Although targeting EMT-TFs holds potential in tackling CSCs, current pharmacological approaches to do so directly are unavailable. Therefore, this review aims to explore the role of EMT- and CSC-TFs, their connection and impact in cellular development and cancer, emphasizing the potential of TF networks as targets for therapeutic intervention.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"100 ","pages":"Pages 1-16"},"PeriodicalIF":14.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLUT and HK: Two primary and essential key players in tumor glycolysis GLUT 和 HK：肿瘤糖酵解过程中两个重要的关键角色。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-03-15 DOI: 10.1016/j.semcancer.2024.03.001

Dhiraj Yadav , Anubha Yadav , Sujata Bhattacharya , Akansha Dagar , Vinit Kumar , Reshma Rani

{"title":"GLUT and HK: Two primary and essential key players in tumor glycolysis","authors":"Dhiraj Yadav , Anubha Yadav , Sujata Bhattacharya , Akansha Dagar , Vinit Kumar , Reshma Rani","doi":"10.1016/j.semcancer.2024.03.001","DOIUrl":"10.1016/j.semcancer.2024.03.001","url":null,"abstract":"<div><p>Cancer cells reprogram their metabolism to become \"glycolysis-dominant,\" which enables them to meet their energy and macromolecule needs and enhancing their rate of survival. This glycolytic-dominancy is known as the “Warburg effect”, a significant factor in the growth and invasion of malignant tumors. Many studies confirmed that members of the GLUT family, specifically HK-II from the HK family play a pivotal role in the Warburg effect, and are closely associated with glucose transportation followed by glucose metabolism in cancer cells. Overexpression of GLUTs and HK-II correlates with aggressive tumor behaviour and tumor microenvironment making them attractive therapeutic targets. Several studies have proven that the regulation of GLUTs and HK-II expression improves the treatment outcome for various tumors. Therefore, small molecule inhibitors targeting GLUT and HK-II show promise in sensitizing cancer cells to treatment, either alone or in combination with existing therapies including chemotherapy, radiotherapy, immunotherapy, and photodynamic therapy. Despite existing therapies, viable methods to target the glycolysis of cancer cells are currently lacking to increase the effectiveness of cancer treatment. This review explores the current understanding of GLUT and HK-II in cancer metabolism, recent inhibitor developments, and strategies for future drug development, offering insights into improving cancer treatment efficacy.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"100 ","pages":"Pages 17-27"},"PeriodicalIF":14.5,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cell cycle revisited: DNA replication past S phase preserves genome integrity 细胞周期重温：过了 S 期的 DNA 复制可保持基因组的完整性。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-02-01 DOI: 10.1016/j.semcancer.2024.02.002

Spyridoula Bournaka , Nibal Badra-Fajardo , Marina Arbi , Stavros Taraviras , Zoi Lygerou

引用次数: 0