Scandinavian Journal of Immunology最新文献_第6页

Immunological Dynamics of Helminth Infections: From Host Defence and Immune Evasion Mechanisms to Vaccine Strategies. 蠕虫感染的免疫动力学：从宿主防御和免疫逃避机制到疫苗策略。

IF 2.4 4区医学

Scandinavian Journal of Immunology Pub Date : 2026-02-01 DOI: 10.1111/sji.70098

Héctor Serrano-Coll

引用次数: 0

Fifty Years of Natural Killer Cells: Milestones and Future Horizons. 自然杀伤细胞的五十年：里程碑和未来的视野。

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2026-02-01 DOI: 10.1111/sji.70091

Andreas Lundqvist, Arnika K Wagner, Benedict J Chambers, Carin I M Dahlberg, Jonas Sundbäck, Angelica Cuapio, Evren Alici, Hans-Gustaf Ljunggren

{"title":"Fifty Years of Natural Killer Cells: Milestones and Future Horizons.","authors":"Andreas Lundqvist, Arnika K Wagner, Benedict J Chambers, Carin I M Dahlberg, Jonas Sundbäck, Angelica Cuapio, Evren Alici, Hans-Gustaf Ljunggren","doi":"10.1111/sji.70091","DOIUrl":"10.1111/sji.70091","url":null,"abstract":"The discovery of natural killer (NK) cells stands among the fundamental milestones in modern immunology. To mark the 50-year anniversary of the first publications on NK cells in 1975, a symposium was held at Karolinska Institutet in Stockholm, Sweden, on October 14, 2025. The symposium brought together scientists from across generations to reflect on the field's historical roots and future directions. The meeting traced NK cell research from its serendipitous beginnings with the identification of a previously unknown lymphocyte population capable of mediating spontaneous cytotoxicity to the conceptual proposal of 'missing self' recognition. Subsequent studies established the role of the first inhibitory receptor Ly49A. This was followed by the discovery of NK cell killer-cell immunoglobulin-like receptors (KIRs), along with a range of associated inhibitory and activating receptors, providing further insights into NK cell target recognition. The symposium then highlighted how advances in genetics, cell imaging and single-cell technologies have revealed NK cell diversity, tissue specialisation and adaptive potential. It showcased insights from rare immunodeficiencies, tumour immunology, viral immunology and systems-level analyses, underscoring NK cells' dual roles in cytotoxic defence and immune regulation. Increasingly, artificial intelligence (AI) is being leveraged in NK cell research. Translational developments described have bridged fundamental knowledge with clinical application, exemplified by current clinical studies of engineered NK cells, NK cell engagers and checkpoint blockade strategies. Together, these reflections underscored how five decades of NK cell research, rooted in seminal Scandinavian discoveries, have transformed from an unexpected observation into a cornerstone of immunotherapeutic potential.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"103 2","pages":"e70091"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12831646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotherapy for Type 2 Diabetes: Mechanisms and Therapeutic Advances. 2型糖尿病的免疫治疗：机制和治疗进展。

IF 2.4 4区医学

Scandinavian Journal of Immunology Pub Date : 2026-02-01 DOI: 10.1111/sji.70095

Ravichandran Sanjai, Kunka Mohanram Ramkumar

{"title":"Immunotherapy for Type 2 Diabetes: Mechanisms and Therapeutic Advances.","authors":"Ravichandran Sanjai, Kunka Mohanram Ramkumar","doi":"10.1111/sji.70095","DOIUrl":"10.1111/sji.70095","url":null,"abstract":"Diabetes mellitus (DM) is a chronic metabolic disorder characterised by persistent hyperglycemia, systemic metabolic dysfunction and insulin resistance (IR). Recent progress in the interplay between the immune system and metabolism highlights the critical role of immune dysregulation in the pathogenesis of IR and type 2 diabetes mellitus (T2DM). This review explores the immunopathogenic mechanisms underlying IR and the potential immunotherapies to modulate these pathways, with a focus on immune cells, inflammatory mediators and immune checkpoint regulation. Recent advances in immunotherapy have opened new avenues for restoring metabolic homeostasis and improving insulin sensitivity. Targeted approaches, including monoclonal antibodies against TNF-α, IL-1β and IL-6, have been reported to have antifibrotic and anti-inflammatory effects, reducing inflammation-driven insulin resistance. Additionally, inhibitors of NF-κB, JAK/STAT and JNK signalling pathways have been reported to enhance insulin sensitivity. Immunoregulatory therapeutics using MSC (mesenchymal stem cell) and Treg (regulatory T cell) therapy and cytokine vaccine-based vaccines are emerging as innovative therapeutic options for T2DM. Despite these advances, problems such as immune-related toxic reactions, patient and individual-specific variability, and the requirement for precision medicine approaches persist as obstacles to translational application from the clinics to industry levels. In this review, an overview of preclinical and clinical evidence for immunotherapeutic approaches to IR is described, and recommendations for future developments in integrating these therapies into personalised diabetes management are provided. Targeting immune-mediated inflammation with immunotherapies can lead to a new era in T2DM therapy, which will provide new approaches to enhance insulin sensitivity and glycemic control.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"103 2","pages":"e70095"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting NgR1/NogoA Signalling Enhances Natural Killer Cell Cytotoxicity and Alters Immune and Oncogenic Pathways in TNBC Cells. 靶向NgR1/NogoA信号增强TNBC细胞的自然杀伤细胞毒性并改变免疫和致癌途径

IF 2.4 4区医学

Scandinavian Journal of Immunology Pub Date : 2026-02-01 DOI: 10.1111/sji.70085

Tuğcan Korak, Merve Gulsen Bal Albayrak, Murat Kasap, Sevinc Yanar, Gurler Akpinar

{"title":"Targeting NgR1/NogoA Signalling Enhances Natural Killer Cell Cytotoxicity and Alters Immune and Oncogenic Pathways in TNBC Cells.","authors":"Tuğcan Korak, Merve Gulsen Bal Albayrak, Murat Kasap, Sevinc Yanar, Gurler Akpinar","doi":"10.1111/sji.70085","DOIUrl":"10.1111/sji.70085","url":null,"abstract":"Triple-negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options, and impairment of natural killer (NK) cell cytotoxicity within the tumour microenvironment remains a major challenge. The present study investigated the role of the NogoA/Nogo receptor 1 (NgR1) axis in modulating NK cell-mediated cytotoxicity against TNBC cells. NK-92 and MDA-MB-231 cells were co-cultured at optimised effector-to-target ratios, followed by treatment with the NgR1 antagonist NEP1-40. Cell viability was assessed by WST-1 assay, apoptosis was evaluated using AO/DAPI staining, gene expression was analysed by RT-PCR, and downstream pathways together with immune infiltration were examined in silico. Blockade of NogoA/NgR1 signalling increased NK-92-mediated cytotoxicity (p < 0.0001). NEP1-40 reduced tumour cell viability from approximately 81% to 50% and significantly increased apoptotic cell death (p < 0.0001). Expression analysis revealed repression of oncogenic and migration-associated genes, including CDK4, MYC, NF-κB1, VEGFA, FGF1, N-cadherin and CD155, consistent with enhanced NK cell-mediated cytotoxicity and reduced tumour immune evasion. Functional annotation identified the PI3K/AKT pathway alongside cell cycle-related processes as candidate downstream mechanisms, while correlation analysis showed that most NogoA-regulated genes were significantly negatively associated with NK cell infiltration (p < 0.05), highlighting their role in immune escape. These findings suggest that NogoA regulates both tumour behaviour and immune remodelling in TNBC by enhancing NK cell-mediated cytotoxicity, promoting apoptosis and suppressing immune evasion pathways. Targeting the NgR1/NogoA axis may therefore represent a promising approach to strengthen NK cell-based immunotherapy, offering a novel therapeutic avenue in TNBC.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"103 2","pages":"e70085"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of CXCR3 and CXCR6 on Circulating T Cells in Patients With Parkinson's Disease. CXCR3和CXCR6在帕金森病患者循环T细胞中的作用

IF 2.4 4区医学

Scandinavian Journal of Immunology Pub Date : 2026-02-01 DOI: 10.1111/sji.70090

Yufeng Zhang, Zhuangzhuang Ren, Shuangshuang Jia, Jinming Han, Xiaoling Zhong, Bo Fu, Haoran Wang, Shiping Xu, Tingting Li, Feng Qiu

{"title":"Role of CXCR3 and CXCR6 on Circulating T Cells in Patients With Parkinson's Disease.","authors":"Yufeng Zhang, Zhuangzhuang Ren, Shuangshuang Jia, Jinming Han, Xiaoling Zhong, Bo Fu, Haoran Wang, Shiping Xu, Tingting Li, Feng Qiu","doi":"10.1111/sji.70090","DOIUrl":"10.1111/sji.70090","url":null,"abstract":"Immune dysregulation is involved in Parkinson's disease (PD), but the roles of C-X-C motif chemokine receptor 3 (CXCR3)/chemokine receptor 6 (CXCR6) on T cells and their correlation with peripheral inflammation remain unclear. This study investigated their expression on peripheral blood T cells and correlation with inflammation in PD. A total of 36 PD patients and 26 healthy controls were enrolled; their clinical information and laboratory test results (including the systemic immunoinflammatory index [SII], neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR], platelet-to-lymphocyte ratio [PLR], monocyte-to-high-density lipoprotein ratio [MHR], and erythrocyte distribution width over platelets ratio [RPR]) were recorded. Meanwhile, a multicolour flow cytometry protocol using six cell surface antibodies (CD3, CD4, CD8, CD45RO, CXCR3, and CXCR6) was applied. The results showed that CD8+ T cells were significantly reduced in the PD group compared with healthy controls (p < 0.001), and CXCR3 expression was significantly increased on peripheral blood CD4+ effector T cells and CD8+ T cells of PD patients (p < 0.001). Additionally, CXCR6 expression was significantly elevated on cytotoxic T lymphocytes (CTLs) (p < 0.0001) but showed no significant difference on CD4+ T cells between PD patients and controls (p > 0.05). Compared with healthy controls, PD patients had significantly increased peripheral blood C-reactive protein (CRP) levels (p < 0.001) but remarkably decreased monocytes, lymphocytes, and MHR (p < 0.01). Collectively, the upregulated expression of CXCR3 and CXCR6 predominantly on CD8+ T lymphocytes may contribute to PD pathogenesis, though no significant correlation between the expression of these receptors and peripheral inflammation was observed.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"103 2","pages":"e70090"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12883700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.4 4区医学

Scandinavian Journal of Immunology Pub Date : 2026-02-01 DOI: 10.1111/sji.70094

Teun J de Vries, Sergio Bizzarro, Irene Di Ceglie, Doran Y Sol, Peter L E M van Lent, Ton Schoenmaker

{"title":"Similar Individual Serum Levels of MCP-1, TNF-α, and IL-6 From Periodontitis Patients Before and 1 Year After Treatment.","authors":"Teun J de Vries, Sergio Bizzarro, Irene Di Ceglie, Doran Y Sol, Peter L E M van Lent, Ton Schoenmaker","doi":"10.1111/sji.70094","DOIUrl":"10.1111/sji.70094","url":null,"abstract":"Treatment of periodontitis may lower the inflammation status as measured in sera from patients. To investigate this in a biological assay, we co-cultured periodontal ligament fibroblasts (PDLFs) from a healthy donor and peripheral blood mononuclear cells (PBMCs) as a source for osteoclasts. PDLFs were primed for 3 days with serum from periodontitis patients before and from 1 year after successful treatment of periodontitis (n = 13). After priming, PBMCs were added. No significant differences in the number of osteoclasts that formed after 3 weeks were found between baseline and after-treatment serum priming. To find an explanation, we analysed the serum composition on the presence of inflammatory, pro-osteoclastogenic cytokines. We found no differences between before and after treatment for cytokines MCP-1, TNF-α, and IL-6. Interestingly, these levels of cytokines at baseline and after treatment strongly correlated per individual (correlation p-value between p = 0.03 and p < 0.0001, correlation r2 between 0.37 and 0.89). Strikingly, between each other, MCP-1, TNF-α, and IL-6 did not correlate. These results show that over the 1-year time frame a cytokine equilibrium, the relatively similar levels of cytokines over a longer period, exists that is unique per individual. This suggests that the immune system is a constant for these cytokines, adapted to the needs of the individual. Larger cohorts, the inclusion of healthy individuals and longer time intervals need to be studied to further establish the true magnitude of these intriguing findings.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"103 2","pages":"e70094"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12831644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Immunodeficiency Associated With MAP2K1 p.Tyr130His Variant in Cardiofaciocutaneous Syndrome: A Case Report With Literature-Based Phenotypic Comparison. 联合免疫缺陷与MAP2K1 p.Tyr130His在心皮肤综合征中的变异相关：一个基于文献表型比较的病例报告

IF 2.4 4区医学

Scandinavian Journal of Immunology Pub Date : 2026-02-01 DOI: 10.1111/sji.70101

Şefika İlknur Kökcü Karadağ, Aslı Berivan Topçak, Yelda Türkmenoğlu, Biray Ertürk, Nilay Çalışkan, Hamit Bologur, Güler Yıldırım, Hilal Güngör, Merve Karaca Şahin, Muhammed Fatih Erbay, Deniz Özçeker

引用次数: 0

Non-Neutralising Antibodies and T Cell Responses to SARS-CoV-2 Detected in Unvaccinated SARS-CoV-2-Naive Spanish Adolescents. 未接种SARS-CoV-2疫苗的西班牙青少年对SARS-CoV-2的非中和抗体和T细胞反应

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2026-01-01 DOI: 10.1111/sji.70082

Hector F Pelaez-Prestel, Tara Fiyouzi, Sara Alonso Fernandez, Andres Bodas-Pinedo, Esther M Lafuente, Pedro A Reche

{"title":"Non-Neutralising Antibodies and T Cell Responses to SARS-CoV-2 Detected in Unvaccinated SARS-CoV-2-Naive Spanish Adolescents.","authors":"Hector F Pelaez-Prestel, Tara Fiyouzi, Sara Alonso Fernandez, Andres Bodas-Pinedo, Esther M Lafuente, Pedro A Reche","doi":"10.1111/sji.70082","DOIUrl":"https://doi.org/10.1111/sji.70082","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents usually follows a mild or asymptomatic course. In this brief report, we investigated the cellular and humoral responses to SARS-CoV-2 in six healthy Spanish female adolescents, aged 14 to 16, using blood samples collected early in 2021, well before COVID-19 vaccinations. Using IFNγ-ELISPOT assays, we detected T cell recall responses in four of these adolescents to a peptide pool encompassing the SARS-CoV-2 Spike protein. The same subjects also exhibited IgM antibodies against the Nucleocapsid and Spike proteins as determined by ELISA in sera samples. However, no IgG antibodies were detected against Spike protein and none of the sera samples were capable of blocking viral entry in a spike-dependent infection assay using SARS-CoV-2 pseudoviruses. The detected immune responses are consistent with the presence of pre-existing cross-reactive immunity to SARS-CoV-2 in children/adolescents, which could have contributed to protect this segment of the population.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"103 1","pages":"e70082"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients Suffering From Post-COVID-19 Syndrome Feature Enhanced Antibody Reactivity Towards Specific Linear Epitopes Within EBV EBNA1. covid -19后综合征患者对EBV EBNA1特异性线性表位的抗体反应性增强

IF 2.4 4区医学

Scandinavian Journal of Immunology Pub Date : 2026-01-01 DOI: 10.1111/sji.70088

Peter Lorenz, Felix Steinbeck, Florian Fricke, Franz Mai, Wendy Bergmann-Ewert, Christine Wossidlo, Emil C Reisinger, Brigitte Müller-Hilke

{"title":"Patients Suffering From Post-COVID-19 Syndrome Feature Enhanced Antibody Reactivity Towards Specific Linear Epitopes Within EBV EBNA1.","authors":"Peter Lorenz, Felix Steinbeck, Florian Fricke, Franz Mai, Wendy Bergmann-Ewert, Christine Wossidlo, Emil C Reisinger, Brigitte Müller-Hilke","doi":"10.1111/sji.70088","DOIUrl":"10.1111/sji.70088","url":null,"abstract":"Post-COVID-19 syndrome (PCS; also known as post-acute sequelae of COVID-19, PASC and Long COVID) manifests with various clinical symptoms of unclear aetiology that persist or develop months after acute infection with SARS-CoV-2. Potential triggers for PCS include reactivation of latent viruses and autoimmune reactions. In our retrospective cross-sectional and explorative study we compared 48 PCS patients with 48 individuals that recovered fully from COVID-19 (convalescents, CC). We focused on characterising humoral immunity by recording IgG antibody reactivity patterns against Epstein-Barr virus (EBV) EBNA1 antigen using peptide microarray and ELISA methodology as well as determining the presence of autoantibodies. The overall binding landscape of IgG antibodies for the EBV EBNA1 protein was similar for the patients with sequelae versus the convalescents. However, the PCS patients displayed stronger reactivity for epitopes contained within the glycine-alanine repeat region of EBNA1, in particular residues 90-325, and within the central part, amino acids 393-420. Intriguingly, in the latter case, the EBNA1 peptide (residues 405-419) that discriminated the PCS and CC cohorts was localised in a different segment C-terminal from the sequence proposed to be mechanistically associated with multiple sclerosis. The screening for autoantibodies against nuclear/cytoplasmic antigens in HEp-2 cells and against CRYAB, cardiolipin, beta-2-glycoprotein I, IFN-alpha2, IFN-omega, and IL-15 antigens did neither reveal higher prevalence nor increased reactivity in the PCS patients compared to the convalescents. In conclusion, elevated antibody levels against linear peptides derived from residues 90-325 and 405-419 of EBV EBNA1 were the most distinctive characteristics in our cohort of post-COVID-19 syndrome patients.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"103 1","pages":"e70088"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12789987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145945822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LTB4 Activates the MAP Kinase Pathway in Endothelial Cells to Cause Long-Lasting Neutrophil Tethering, MCP-1 and NO Releases. LTB4激活内皮细胞MAP激酶通路，引起长时间中性粒细胞捆绑、MCP-1和NO释放

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2026-01-01 DOI: 10.1111/sji.70083

Anne-Sofie Johansson, Jesper Z Haeggström, Jan Palmblad

{"title":"LTB4 Activates the MAP Kinase Pathway in Endothelial Cells to Cause Long-Lasting Neutrophil Tethering, MCP-1 and NO Releases.","authors":"Anne-Sofie Johansson, Jesper Z Haeggström, Jan Palmblad","doi":"10.1111/sji.70083","DOIUrl":"10.1111/sji.70083","url":null,"abstract":"Leukotriene B4 (LTB4), a potent chemotactic and immune-modulating eicosanoid, signals via two receptors (BLT1 and BLT2), leading to rapid but transient migratory, adhesive and secretory responses in phagocytes. Previously, we reported that BLT1 is the predominating BLT in human umbilical vein endothelial cells (HUVEC). However, little is known about how ligation of these receptors affects adhesive and secretory endothelial responses over time. Here, we demonstrate that in HUVEC, LTB4 dose-dependently and stereospecifically causes a biphasic tethering of neutrophils, where the second phase is robust, similar to that induced by lipopolysaccharide, and persists for 3-8 h. LTB4 also causes up-regulation of E-selectin, ICAM-1 and VCAM-1 and release of MCP-1 and nitric oxide (but not of IL-8 or HMGB1). These responses appeared to be mediated via BLT1 and BLT2 as judged by BLT1 shRNA gene silencing and/or treatment with BLT1 and BLT2 specific antagonists prior to LTB4 activation of HUVEC. Moreover, LTB4 responses used primarily the MAP kinase/Erk pathway. Our findings suggest a new role for LTB4 not only in early but also in late vascular inflammatory responses.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"103 1","pages":"e70083"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12759030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0