IgA monoclonal gammopathies are accompanied by higher total TGF-β1 levels than IgG or IgM monoclonal gammopathies.

IF 4.1 4区 医学 Q2 IMMUNOLOGY
Scandinavian Journal of Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI:10.1111/sji.13422
Irina Maslovarić, Dejana Kosanović, Dragana Marković, Milan Prodanović, Olivera Savić, Ana Janjušević, Vesna Ilić, Rajna Minić
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Abstract

The progression of monoclonal gammopathies is affected by a range of factors, including the microenvironment surrounding plasma cells. It is recognized that TGF-β1 plays a distinct role in stimulating IgA production. Hence, this study aims to investigate whether individuals with serum IgA monoclonal immunoglobulins (paraproteins) exhibit elevated total TGF-β1 levels compared to those with IgG or IgM paraproteins. To achieve this goal, individuals with a positive laboratory finding of monoclonal gammopathy were segregated according to the paraprotein class as well as according to the type of the light chain. Total TGF-β1 levels were assessed in blood serum samples containing IgG (n = 50), IgA (n = 46), and IgM (n = 31) paraproteins. Elevated level of TGF-β1 was confirmed in sera with IgA paraproteins (median 25.8 ng/mL; interquartile range IQR: 19.0-33.7) compared to those having IgG (median: 18.2 ng/mL; IQR: 14.3-22.1; p < 0.001) or IgM paraproteins (21.5 ng/mL; IQR: 15.0-27.4; p = 0.043). Also, a higher TGF-β1 level was detected in sera with IgMλ than those with IgMκ paraproteins (p = 0.043). This research affirms the role of TGF-β1 in the pathophysiology of IgA monoclonal gammopathies and the potential switch towards the IgA isotype, known for a less favourable prognosis.

与 IgG 或 IgM 单克隆丙种球蛋白病相比,IgA 单克隆丙种球蛋白病的 TGF-β1 总含量更高。
单克隆抗体病的发展受到一系列因素的影响,包括浆细胞周围的微环境。人们认识到,TGF-β1 在刺激 IgA 生成方面发挥着独特的作用。因此,本研究旨在探讨与 IgG 或 IgM 副蛋白患者相比,血清中 IgA 单克隆免疫球蛋白(副蛋白)患者是否表现出总 TGF-β1 水平升高。为了实现这一目标,我们根据副蛋白类别和轻链类型对实验室发现单克隆抗体阳性的个体进行了分离。在含有 IgG(50 人)、IgA(46 人)和 IgM(31 人)副蛋白的血清样本中评估 TGF-β1 总含量。与含有 IgG 的血清(中位数:18.2 ng/mL;四分位间距 IQR:19.0-33.7)相比,含有 IgA 副蛋白的血清中 TGF-β1 水平升高(中位数:25.8 ng/mL;四分位间距 IQR:19.0-33.7):18.2纳克/毫升;四分位数间距:14.3-22.1;p
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来源期刊
CiteScore
7.70
自引率
5.40%
发文量
109
审稿时长
1 months
期刊介绍: This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.
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