Scandinavian Journal of Immunology最新文献_第5页

IFIH1 loss of function predisposes to inflammatory and SARS-CoV-2-related infectious diseases. IFIH1 功能缺失易引发炎症和与 SARS-CoV-2 相关的传染病。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-16 DOI: 10.1111/sji.13373

Rania Najm, Lemis Yavuz, Ruchi Jain, Maha El Naofal, Sathishkumar Ramaswamy, Walid Abuhammour, Tom Loney, Norbert Nowotny, Alawi Alsheikh-Ali, Ahmad Abou Tayoun, Richard K Kandasamy

{"title":"IFIH1 loss of function predisposes to inflammatory and SARS-CoV-2-related infectious diseases.","authors":"Rania Najm, Lemis Yavuz, Ruchi Jain, Maha El Naofal, Sathishkumar Ramaswamy, Walid Abuhammour, Tom Loney, Norbert Nowotny, Alawi Alsheikh-Ali, Ahmad Abou Tayoun, Richard K Kandasamy","doi":"10.1111/sji.13373","DOIUrl":"10.1111/sji.13373","url":null,"abstract":"The IFIH1 gene, encoding melanoma differentiation-associated protein 5 (MDA5), is an indispensable innate immune regulator involved in the early detection of viral infections. Previous studies described MDA5 dysregulation in weakened immunological responses, and increased susceptibility to microbial infections and autoimmune disorders. Monoallelic gain-of-function of the IFIH1 gene has been associated with multisystem disorders, namely Aicardi-Goutieres and Singleton-Merten syndromes, while biallelic loss causes immunodeficiency. In this study, nine patients suffering from recurrent infections, inflammatory diseases, severe COVID-19 or multisystem inflammatory syndrome in children (MIS-C) were identified with putative loss-of-function IFIH1 variants by whole-exome sequencing. All patients revealed signs of lymphopaenia and an increase in inflammatory markers, including CRP, amyloid A, ferritin and IL-6. One patient with a pathogenic homozygous variant c.2807+1G>A was the most severe case showing immunodeficiency and glomerulonephritis. The c.1641+1G>C variant was identified in the heterozygous state in patients suffering from periodic fever, COVID-19 or MIS-C, while the c.2016delA variant was identified in two patients with inflammatory bowel disease or MIS-C. There was a significant association between IFIH1 monoallelic loss of function and susceptibility to infections in males. Expression analysis showed that PBMCs of one patient with a c.2016delA variant had a significant decrease in ISG15, IFNA and IFNG transcript levels, compared to normal PBMCs, upon stimulation with Poly(I:C), suggesting that MDA5 receptor truncation disrupts the immune response. Our findings accentuate the implication of rare monogenic IFIH1 loss-of-function variants in altering the immune response, and severely predisposing patients to inflammatory and infectious diseases, including SARS-CoV-2-related disorders.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13373"},"PeriodicalIF":4.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of AKR1B10 in inflammatory diseases. AKR1B10 在炎症性疾病中的作用

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-20 DOI: 10.1111/sji.13390

Min Guo, Tao Wang, Wenjun Ge, Chenran Ren, Ben Chi-Bun Ko, Xi Zeng, Deliang Cao

{"title":"Role of AKR1B10 in inflammatory diseases.","authors":"Min Guo, Tao Wang, Wenjun Ge, Chenran Ren, Ben Chi-Bun Ko, Xi Zeng, Deliang Cao","doi":"10.1111/sji.13390","DOIUrl":"10.1111/sji.13390","url":null,"abstract":"Inflammation is an important pathophysiological process in many diseases; it has beneficial and harmful effects. When exposed to various stimuli, the body triggers an inflammatory response to eliminate invaded pathogens and damaged tissues to maintain homeostasis. However, uncontrollable persistent or excessive inflammatory responses may damage tissues and induce various diseases, such as metabolic diseases (e.g. diabetes), autoimmune diseases, nervous system-related diseases, digestive system-related diseases, and even tumours. Aldo-keto reductase 1B10 (AKR1B10) is an important player in the development and progression of multiple diseases, such as tumours and inflammatory diseases. AKR1B10 is upregulated in solid tumours, such as hepatocellular carcinoma (HCC), non-small cell lung carcinoma, and breast cancer, and is a reliable serum marker. However, information on the role of AKR1B10 in inflammation is limited. In this study, we summarized the role of AKR1B10 in inflammatory diseases, including its expression, functional contribution to inflammatory responses, and regulation of signalling pathways related to inflammation. We also discussed the role of AKR1B10 in glucose and lipid metabolism and oxidative stress. This study provides novel information and increases the understanding of clinical inflammatory diseases.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13390"},"PeriodicalIF":4.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mite-negative allergic rhinitis: A model of the regulation mechanism of atopy onset. 螨阴性过敏性鼻炎：过敏性鼻炎发病调节机制模型。

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-31 DOI: 10.1111/sji.13367

Yasuhiro Horiuchi

引用次数: 0

Major low-energy trauma results in non-specific immunoglobulin generation without evidence for specific autoantibody production: A prospective cohort study. 重大低能量创伤会导致非特异性免疫球蛋白生成，但无证据表明会产生特异性自身抗体：一项前瞻性队列研究。

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-25 DOI: 10.1111/sji.13368

Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova

{"title":"Major low-energy trauma results in non-specific immunoglobulin generation without evidence for specific autoantibody production: A prospective cohort study.","authors":"Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova","doi":"10.1111/sji.13368","DOIUrl":"10.1111/sji.13368","url":null,"abstract":"Cellular debris resulting from large trauma might overwhelm the scavenger mechanisms and lead to autoimmune reactions. We analysed whether a major well-defined trauma in humans induces laboratory signs of transient autoimmunity in the months after the insult. We included 50 patients with pertrochanteric femur fracture undergoing intramedullary nail osteosynthesis in a prospective cohort study and followed them at 3-4 days, 6 weeks, 12 weeks and 12 months postoperatively. By standard techniques, we assessed levels of total immunoglobulins, anti-nuclear antibodies (ANA), anti-cardiolipin antibodies, anti-dsDNA antibodies and anti-C1q antibodies, as well as antibodies against cytomegalovirus (CMV) as a control. Blood leukocyte differential and lymphocyte subpopulations were determined at baseline and in the first two postoperative samples. The mean age of the patients reached 80.1 years, and 23 (46%) completed all visits. Serum concentrations of total IgG, IgM and IgA increased at all follow-up time points. The ANA fluorescence light intensity units increased at 12 weeks and 12 months postoperatively (p < 0.0001), but the proportion of ANA-positive patients did not change (35%). The values of anti-C1q mildly increased at all follow-up visits, but not the ratio to total IgG. Anti-dsDNA remained negative in all patients, and anti-cardiolipin IgG/IgM antibodies did not change. Anti-CMV IgG antibodies increased significantly at all follow-up visits, without change in the ratio to total IgG. Flow cytometry showed an increased proportion of B-cells 3-4 days postoperatively. In conclusion, major musculoskeletal trauma in elderly patients induces a generalized non-specific increase in immunoglobulin production without laboratory signs for enhanced systemic autoimmunity.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13368"},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoliquiritigenin limits inflammasome activation of macrophage via docking into Syk to alleviate murine non‐alcoholic fatty liver disease Isoliquiritigenin 通过与 Syk 对接限制巨噬细胞炎性体的激活，从而缓解小鼠非酒精性脂肪肝的病情

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-04-27 DOI: 10.1111/sji.13371

Xiangyu Hu, Chunmiao Hu, Liting Liao, Huimin Zhang, Xingmeng Xu, Jie Xiang, Guotao Lu, Xiaoqin Jia, Hongwei Xu, Weijuan Gong

{"title":"Isoliquiritigenin limits inflammasome activation of macrophage via docking into Syk to alleviate murine non‐alcoholic fatty liver disease","authors":"Xiangyu Hu, Chunmiao Hu, Liting Liao, Huimin Zhang, Xingmeng Xu, Jie Xiang, Guotao Lu, Xiaoqin Jia, Hongwei Xu, Weijuan Gong","doi":"10.1111/sji.13371","DOIUrl":"https://doi.org/10.1111/sji.13371","url":null,"abstract":"Isoliquiritigenin (ISL) is a chalcone‐type flavonoid derived from the root of licorice with antioxidant, anti‐inflammatory, anti‐tumour and neuroprotective properties. ISL has been proven to downregulate the productions of IL‐1β, TNF‐α and IL‐6 by macrophages. However, detailed molecular mechanisms of this modulation remain elusive. Here, ISL suppressed Syk phosphorylation and CD80, CD86, IL‐1β, TNF‐α and IL‐6 expressions in lipopolysaccharide‐stimulated macrophages ex vivo. ApoC3‐transgenic (ApoC3TG) mice had more activated macrophages. ISL was also able to downregulate the inflammatory activities of macrophages from ApoC3TG mice. Administration of ISL inhibited Syk activation and inflammatory activities of macrophages in ApoC3TG mice in vivo. The treatment of ISL further alleviated MCD‐induced non‐alcoholic fatty liver disease (NAFLD) in wild‐type and ApoC3TG mice, accompanied by less recruitment and activation of liver macrophages. Due to the inhibition of Syk phosphorylation, ISL‐treated macrophages displayed less production of cytoplasmic ROS, NLRP3, cleaved‐GSDMD and cleaved‐IL‐1β, suggesting less inflammasome activation. Finally, the molecular docking study demonstrated that ISL bound to Syk directly with the Kd of 1.273 × 10−8 M. When the Syk expression was knocked down by its shRNA, the inhibitory effects of ISL on activated macrophages disappeared, indicating that Syk was at least one of key docking‐molecules of ISL. Collectively, ISL could alleviate MCD‐induced NAFLD in mice involved with the inhibition of macrophage inflammatory activity by the blockade of Syk‐induced inflammasome activation.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"75 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymptomatic SARS‐CoV‐2 infection: A possible role of platelet HLA class I expression level 无症状 SARS-CoV-2 感染：血小板 HLA I 类表达水平的可能作用

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-04-08 DOI: 10.1111/sji.13370

Rocco Cantisani, Adriano Spreafico, Giuseppe Marotta

引用次数: 0

Elevated levels of anti‐Golgi antibodies: An early sign of seronegative rheumatoid arthritis 抗高尔基体抗体水平升高：血清阴性类风湿性关节炎的早期征兆

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-04-03 DOI: 10.1111/sji.13369

Emrah Salman, Bedia Dinç

{"title":"Elevated levels of anti‐Golgi antibodies: An early sign of seronegative rheumatoid arthritis","authors":"Emrah Salman, Bedia Dinç","doi":"10.1111/sji.13369","DOIUrl":"https://doi.org/10.1111/sji.13369","url":null,"abstract":"Anti‐Golgi antibodies are uncommon antibodies that exhibit specific, polarized cytoplasmic staining on the Hep‐2 substrate. The objective of our study was to identify the clinical and laboratory features associated with anti‐Golgi antibodies. We examined 4.5 years of data from a Turkish tertiary hospital in this retrospective cohort analysis. The indirect immunofluorescence staining patterns, antinuclear antibody (ANA) titres and clinical data of all patients were obtained from the hospital record system. A total of 146,055 ANAs were detected, of which 224 patients (0.15%) exhibited anti‐Golgi antibody staining. In total, 39.4% of diagnosed patients had autoimmune diseases (AIDs). Of the AIDs, 26 (46.4%) were rheumatoid arthritis (RA). This is a very high rate and another remarkable point is that 17 (65.3%) of these patients had seronegative RA. High‐titre results (1 ≥ 1/320) were more common in patients with AID. Anti‐Ro52 was prevalent in 50% of extractable nuclear antigen (ENA)‐positive patients, making it a remarkable finding. The majority of individuals with high‐titre anti‐Golgi antibodies had AID, particularly RA. The majority of these patients also tested negative for anti‐cyclic citrullinated peptide (anti‐CCP) and rheumatoid factor (RF). Finally, high‐titre anti‐Golgi antibodies may be an important serologic marker for seronegative RA in the Turkish population.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"37 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140574511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of bile acid receptor TGR5 in regulating inflammatory signalling. 胆汁酸受体 TGR5 在调节炎症信号中的作用

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-04-01 Epub Date: 2024-02-02 DOI: 10.1111/sji.13361

Daijiao Ye, Jiayao He, Xiaofei He

引用次数: 0

Systematic analysis of mucosal‐associated invariant T cells in haematological malignancies 对血液恶性肿瘤中粘膜相关不变 T 细胞的系统分析

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-03-06 DOI: 10.1111/sji.13364

Barbora Bacova, Jakub Cierny, Lucia Nemcekova, Jitka Smetanova/Brozova, Jan Novak

{"title":"Systematic analysis of mucosal‐associated invariant T cells in haematological malignancies","authors":"Barbora Bacova, Jakub Cierny, Lucia Nemcekova, Jitka Smetanova/Brozova, Jan Novak","doi":"10.1111/sji.13364","DOIUrl":"https://doi.org/10.1111/sji.13364","url":null,"abstract":"Mucosal‐associated invariant T‐cells (MAIT) are unconventional T‐cells with cytotoxic and pro‐inflammatory properties. Previous research has reported contradictory findings on their role in cancerogenesis with data being even scarcer in haematological malignancies. Here, we report the results of a systematic analysis of MAIT cells in treatment‐naïve patients with a broad range of haematological malignancies. We analysed peripheral blood of 204 patients and 50 healthy subjects. The pool of haematological patients had a statistically significant lower both the absolute value (median values, 0.01 × 109/L vs. 0.05 × 109/L) of MAIT cells and their percentage (median values 0.94% vs. 2.56%) among T‐cells compared to the control group. Separate analysis showed that the decrease in the absolute number of MAIT cells is significant in patients with acute myeloid leukaemia, myeloproliferative neoplasms, plasma cell myeloma, B‐cell non‐Hodgkin lymphomas, otherwise not specified, diffuse large B‐cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma compared to the control population. Furthermore, in haematological malignancies, MAIT cells overexpress PD‐1 (average values, 51.7% vs. 6.7%), HLA‐DR (average values, 40.2% vs. 7%), CD38 (average values, 25.9% vs. 4.9%) and CD69 (average values, 40.2% vs. 9.2%). Similar results were obtained when comparing patients with individual malignancies to the control population. Our data show that the depletion of circulating MAIT cells is a common observation in a broad spectrum of haematological malignancies. In addition to their reduced numbers, MAIT cells acquire an activated/exhausted phenotype.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"18 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140053698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in serum immunoglobulin G glycosylation patterns for antiphospholipid syndrome patients with lectin microarray 利用凝集素芯片分析抗磷脂综合征患者血清免疫球蛋白 G 糖基化模式的变化

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-03-05 DOI: 10.1111/sji.13366

Yifei Wang, Siting Li, Jingjing Meng, Rui Yu, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng, Jiulang Zhao, Chaojun Hu

{"title":"Changes in serum immunoglobulin G glycosylation patterns for antiphospholipid syndrome patients with lectin microarray","authors":"Yifei Wang, Siting Li, Jingjing Meng, Rui Yu, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng, Jiulang Zhao, Chaojun Hu","doi":"10.1111/sji.13366","DOIUrl":"https://doi.org/10.1111/sji.13366","url":null,"abstract":"Antiphospholipid syndrome is a rare autoimmune disease characterized by persistent antiphospholipid antibodies. Immunoglobulin G plays a vital role in disease progression, with its structure and function affected by glycosylation. We aimed to investigate the changes in the serum immunoglobulin G glycosylation pattern in antiphospholipid syndrome patients. We applied lectin microarray on samples from 178 antiphospholipid syndrome patients, 135 disease controls (including Takayasu arteritis, rheumatoid arthritis and cardiovascular disease) and 100 healthy controls. Lectin blots were performed for validation of significant differences. Here, we show an increased immunoglobulin G‐binding level of soybean agglutinin (p = 0.047, preferring N‐acetylgalactosamine) in antiphospholipid syndrome patients compared with healthy and disease controls. Additionally, the immunoglobulin G from antiphospholipid syndrome patients diagnosed with pregnancy events had lower levels of fucosylation (p = 0.001, recognized by Lotus tetragonolobus) and sialylation (p = 0.030, recognized by Sambucus nigra I) than those with simple thrombotic events. These results suggest the unique serum immunoglobulin G glycosylation profile of antiphospholipid syndrome patients, which may inform future studies to design biomarkers for more accurate diagnosis of antiphospholipid syndrome and even for the prediction of clinical symptoms in patients.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"4 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140046310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0